YU42422B - Process for preparing the compounds 9-halo-7-oxo-2,3-dihydro-7h-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acid - Google Patents

Process for preparing the compounds 9-halo-7-oxo-2,3-dihydro-7h-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acid

Info

Publication number
YU42422B
YU42422B YU2109/81A YU210981A YU42422B YU 42422 B YU42422 B YU 42422B YU 2109/81 A YU2109/81 A YU 2109/81A YU 210981 A YU210981 A YU 210981A YU 42422 B YU42422 B YU 42422B
Authority
YU
Yugoslavia
Prior art keywords
pyrido
carbon atoms
benzoxazine
dihydro
halo
Prior art date
Application number
YU2109/81A
Other languages
English (en)
Other versions
YU210981A (en
Inventor
I Hayakawa
T Hiramitsu
Y Tanaka
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14813767&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU42422(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Priority to SI8112109A priority Critical patent/SI8112109A8/sl
Publication of YU210981A publication Critical patent/YU210981A/xx
Publication of YU42422B publication Critical patent/YU42422B/xx
Priority to BA970190A priority patent/BA97190B1/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
YU2109/81A 1980-09-02 1981-09-01 Process for preparing the compounds 9-halo-7-oxo-2,3-dihydro-7h-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acid YU42422B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8112109A SI8112109A8 (sl) 1980-09-02 1981-09-01 Postopek za pripravo spojine 9-halo-7-okso-2,3-dihidro-7h-pirido/1,2,3-de/ /1,4/benzoksazin-6-karboksilne kisline
BA970190A BA97190B1 (bs) 1980-09-02 1997-08-19 Postupak za dobijanje jedinjenja 9-halo-7-okso-2,3-dihidro-7H-pirido(1,2,3-DE)(1,4) benzoksazin-6-karboksilne kiseline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55121540A JPS5746986A (en) 1980-09-02 1980-09-02 Pyrido(1,2,3-de)(1,4)benzoxazine derivative

Publications (2)

Publication Number Publication Date
YU210981A YU210981A (en) 1983-06-30
YU42422B true YU42422B (en) 1988-08-31

Family

ID=14813767

Family Applications (2)

Application Number Title Priority Date Filing Date
YU2109/81A YU42422B (en) 1980-09-02 1981-09-01 Process for preparing the compounds 9-halo-7-oxo-2,3-dihydro-7h-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acid
YU74788A YU47193B (sh) 1980-09-02 1988-04-14 7,8-difluoro-3-metil-2,3-dihidro-4h-1,4-benzoksazin i postupak za njegovo dobijanje

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU74788A YU47193B (sh) 1980-09-02 1988-04-14 7,8-difluoro-3-metil-2,3-dihidro-4h-1,4-benzoksazin i postupak za njegovo dobijanje

Country Status (21)

Country Link
US (1) US4382892A (no)
EP (1) EP0047005B1 (no)
JP (1) JPS5746986A (no)
KR (1) KR840002141B1 (no)
AT (1) ATE10282T1 (no)
AU (1) AU529263B2 (no)
CA (1) CA1167840A (no)
DE (1) DE3167216D1 (no)
DK (2) DK158267C (no)
ES (1) ES505116A0 (no)
FI (1) FI71155C (no)
GR (1) GR74637B (no)
HK (1) HK82186A (no)
IL (1) IL63613A (no)
IN (1) IN155680B (no)
MY (1) MY8600712A (no)
NO (1) NO158507C (no)
NZ (1) NZ198224A (no)
PH (1) PH18276A (no)
YU (2) YU42422B (no)
ZA (1) ZA815604B (no)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58210092A (ja) * 1982-05-31 1983-12-07 Dai Ichi Seiyaku Co Ltd ピリドベンズオキサジン誘導体およびその製造法
PH22140A (en) 1982-06-29 1988-06-01 Daiichi Seiyaku Co Tricyclic compounds
JPS591489A (ja) * 1982-06-29 1984-01-06 Dai Ichi Seiyaku Co Ltd ピリドベンゾオキサジン誘導体
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US5281612A (en) * 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
JPS59116217A (ja) * 1982-12-22 1984-07-05 Dai Ichi Seiyaku Co Ltd マイコプラズマ感染症用薬
JPS59105303U (ja) * 1982-12-28 1984-07-16 埼玉機器株式会社 切削加工用刃物
US4473568A (en) * 1983-03-01 1984-09-25 Warner Lambert Company Antibacterial thiazolidine or thiomorpholine substituted quinolines
JPS6020840A (ja) * 1983-07-14 1985-02-02 Toshiba Mach Co Ltd 工作機械の油温制御装置
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
DE3333719A1 (de) * 1983-09-17 1985-04-04 Bayer Ag Loesungen milchsaurer salze von piperazinylchinolon- und piperazinyl-azachinoloncarbonsaeuren
US4551456A (en) * 1983-11-14 1985-11-05 Merck & Co., Inc. Ophthalmic use of norfloxacin and related antibiotics
US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
DE3580183D1 (de) * 1984-04-26 1990-11-29 Abbott Lab Antibakterielle chinobenzoxazin-verbindungen.
US4529725A (en) * 1984-04-26 1985-07-16 Abbott Laboratories 1-Pyridine substituted quino-benzothiazine
US4528285A (en) * 1984-04-26 1985-07-09 Abbott Laboratories Methylenedioxy quino-benzothiazine derivatives
US4542133A (en) * 1984-04-26 1985-09-17 Abbott Laboratories Methylenedioxy quino-benoxazine derivatives and antibacterial use
US4607032A (en) * 1984-04-26 1986-08-19 Abbott Laboratories Quino-benoxazine antibacterial compounds
US4533663A (en) * 1984-04-26 1985-08-06 Abbott Laboratories Quino-benzothiazine antibacterial compounds
US4540694A (en) * 1984-04-26 1985-09-10 Abbott Laboratories 1-Pyridine substituted quino-benoxazines and antibacterial use
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US5097032A (en) * 1984-07-20 1992-03-17 Warner-Lambert Company Antibacterial agents - II
US4550104A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial thiazolo-quinolines and thiazolo-naphthyridines
US4550103A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial 1-oxo-benzoquinolizine-2-carboxylic acids
EP0184384B1 (en) * 1984-12-06 1989-08-02 Pfizer Inc. Substituted dihydroquinolone carboxylic acids, anti-bacterial compositions containing them
JPS61180771A (ja) * 1985-01-05 1986-08-13 バイエル・アクチエンゲゼルシヤフト 安定な抗バクテリア剤水溶液
DE3517709A1 (de) * 1985-01-05 1986-07-10 Bayer Ag Basische zubereitungen von chinoloncarbonsaeuren
CA1253154A (en) * 1985-05-24 1989-04-25 Atsushi Takagi Benzo¬ij|quinolizine-2-carboxylic acid derivatives
ZA864518B (en) * 1985-06-20 1987-03-25 Daiichi Seiyaku Co Optically active pyridobenzoxazine derivatives and intermediates thereof
AU585995B2 (en) * 1985-06-20 1989-06-29 Daiichi Pharmaceutical Co., Ltd. Optically active pyridobenzoxazine derivatives and intermediates thereof
DK170473B1 (da) * 1985-06-20 1995-09-11 Daiichi Seiyaku Co S(-)-pyridobenzoxazinforbindelser
DE3522406A1 (de) * 1985-06-22 1987-01-02 Bayer Ag Verfahren zur herstellung von 1,8-verbrueckten 4-chinolon-3-carbonsaeuren
DE3522405A1 (de) * 1985-06-22 1987-01-02 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
IN166416B (no) * 1985-09-18 1990-05-05 Pfizer
CA1306750C (en) 1985-12-09 1992-08-25 Istvan Hermecz Process for the preparation of quinoline carboxylic acide
US5237060A (en) * 1985-12-10 1993-08-17 Bayer Aktiengesellschaft Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
DE3543513A1 (de) * 1985-12-10 1987-06-11 Bayer Ag Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US4692454A (en) * 1986-02-03 1987-09-08 Warner-Lambert Company Opthalmic use of quinolone antibiotics
US5153204A (en) * 1986-03-01 1992-10-06 Bayer Aktiengesellschaft 7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives
DE3606698A1 (de) * 1986-03-01 1987-09-03 Bayer Ag 7-(1-pyrrolidinyl)-chinoloncarbonsaeure -derivate
DE3623757A1 (de) * 1986-07-15 1988-01-21 Bayer Ag Neue 1,8-verbrueckte 4-chinoloncarbonsaeuren und diese enthaltende arzneimittel
EP0259804B1 (de) * 1986-09-12 1993-11-18 F. Hoffmann-La Roche Ag Pyrido [3,2,1-ij]-1,3,4-benzoxadiazinderivate, Verfahren zu deren Herstellung, entsprechende pharmazeutische Präparate und im Verfahren verwendbare Zwischenprodukte
US4864023A (en) * 1986-09-12 1989-09-05 Hoffmann-La Roche Inc. Pyrido(3,2,1-IJ)-1,3,4-benzoxadiazine derivatives
JP2558107B2 (ja) * 1986-12-18 1996-11-27 第一製薬株式会社 外用剤
ES2061481T3 (es) * 1986-12-25 1994-12-16 Daiichi Seiyaku Co Derivados de 3,4-dihidrobenzoazina opticamente activos y procedimiento para la preparacion de los mismos.
DE3881939T2 (de) * 1987-02-26 1993-09-30 Daiichi Seiyaku Co Verwendung von Ofloxacin zur lokalen Behandlung oder Prophylaxe von Beschwerden der Wurzelhaut der Zähne.
JPH01199979A (ja) * 1987-04-07 1989-08-11 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
FI883600A (fi) * 1987-08-03 1989-02-04 Daiichi Seiyaku Co Heterocykliska foereningar.
JP2800939B2 (ja) * 1987-08-31 1998-09-21 大日本製薬株式会社 三環式化合物、そのエステルおよびその塩
US4839355A (en) * 1987-09-09 1989-06-13 Sterling Drug Inc. Tricyclic-pyridinylquinoline compounds, their preparation and use
US4889857A (en) * 1987-10-12 1989-12-26 Yoshitomi Pharmaceutical Industries, Ltd. Quinolonecarboxylic acid compounds and pharmaceutical use thereof
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
NO172846C (no) * 1987-12-25 1993-09-15 Daiichi Seiyaku Co Fremgangsmaate for fremstilling av 7,8-dihalogen-3-metyl-2,3-dihydro-2m-benzoksazinderivater og propoksybenzenderivater for utoevelse av fremgangsmaaten.
FR2625200A1 (en) * 1987-12-29 1989-06-30 Esteve Labor Dr 7-(1-Azetidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their application as medicaments
FR2634483B2 (fr) * 1987-12-29 1994-03-04 Esteve Labor Dr Derives des acides 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoleine-3-carboxyliques, leur preparation et leur application en tant que medicaments
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
JPH01258620A (ja) * 1988-04-08 1989-10-16 Dai Ichi Seiyaku Co Ltd 耳疾患用局所製剤
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
KR910003630B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 벤조일 아세틱 에스테르 유도체 및 그 제조방법
MY104139A (en) * 1988-08-09 1994-02-28 Daiichi Seiyaku Co Antimicrobial agent for animals
US5175160A (en) * 1988-08-09 1992-12-29 Daiichi Pharmaceutical Co., Ltd. Antimicrobial agent for animals
JPH02157282A (ja) * 1988-12-12 1990-06-18 Wakunaga Pharmaceut Co Ltd 新規ピリドベンゾオキサジン誘導体
FR2644455B1 (fr) * 1989-03-16 1994-09-23 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicaments
FR2654728B2 (fr) * 1989-03-16 1994-09-23 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament.
FR2649106A2 (fr) * 1989-06-29 1991-01-04 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament
NO177302C (no) * 1989-03-16 1995-08-23 Esteve Labor Dr Analogifremgangsmåte til fremstilling av terapeutisk aktive substituerte azetidinylkinolon(naftyridon)karboksylsyrederivater
US5214051A (en) * 1989-08-01 1993-05-25 Pfizer Inc. Thiazolyl and oxazolyl[5,4-c]piperidyl-substituted quinolone-carboxylic acid and related analogs thereof having antibacterial properties are disclosed
US5385913A (en) * 1989-10-06 1995-01-31 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
FR2655545B1 (fr) * 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
TW208013B (no) * 1990-03-01 1993-06-21 Daiichi Co Ltd
US5166203A (en) * 1990-08-30 1992-11-24 Kanebo, Ltd. Quinolinecarboxylic acid derivatives, antibacterial agent containing the same
US5308843A (en) * 1990-09-11 1994-05-03 Sterling Drug Inc. Method of inhibiting mammalian topoisomerase II and malignant cell growth in mammals, with substituted (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4 ]-benzoxazine(and-benzothiazine)-6-carboxylic acids
FR2676445B1 (fr) * 1991-05-16 1995-02-03 Esteve Labor Dr Derives de pyridone amino acide azetidinyl substitues, leur preparation et leur application en tant que medicaments.
DE4120646A1 (de) * 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
ES2111083T3 (es) * 1991-09-17 1998-03-01 Alcon Lab Inc Composiciones que contienen antibioticos de quinolona y poli(sulfonato de estireno).
KR0131914B1 (ko) * 1992-10-07 1998-04-17 조아퀸 가리데 센트멘나트 오플로옥사진, 레보플로옥사진과 이 유도체의 합성에 이용될 수 있는 벤조옥사진의 수득과정
AU4272793A (en) * 1993-04-24 1994-11-21 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
DE4424369A1 (de) * 1994-07-11 1996-01-18 Bayer Ag Pyrido[3,2,1.i,j][3,1]benzoxazinderivate
US5910498A (en) * 1994-10-20 1999-06-08 Wakunaga Seiyaku Kabushiki Kaisha Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient
US5644056A (en) * 1995-06-07 1997-07-01 Hoechst Celanese Corporation Method of preparing 7,8-difluoro-2,3-dihydro-3-methyl-4H-1, 4-benzoxazine
PT897919E (pt) 1996-04-19 2004-11-30 Wakunaga Pharma Co Ltd Novos derivados do acido piridonacarboxilico ou seus sais e agentes anti-bacterianos contendo-os como ingrediente activo
KR100309871B1 (ko) 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
RU2270695C2 (ru) 1999-03-17 2006-02-27 Дайити Фармасьютикал Ко., Лтд. Фармацевтическая композиция
US6166012A (en) * 1999-07-30 2000-12-26 Allergan Sales, Inc. Antibiotic compositions and method for using same
US6552020B1 (en) 1999-07-30 2003-04-22 Allergan, Inc. Compositions including antibiotics and methods for using same
JP3477466B2 (ja) 1999-09-02 2003-12-10 湧永製薬株式会社 キノリンカルボン酸誘導体又はその塩
SE9904108D0 (sv) 1999-11-15 1999-11-15 New Pharma Research Ab Nya föreningar
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
EP2153819B1 (en) 2000-07-14 2012-09-05 Allergan, Inc. Use of a solubility enhancing component in an aqueous composition comprising brimonidine tartrate
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
ES2256331T3 (es) 2000-12-21 2006-07-16 PHARMACIA & UPJOHN COMPANY LLC Derivados de quinolina antimicrobianos y uso de los mismos para tratar infecciones bacterianas.
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) * 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
IL161164A0 (en) 2001-10-03 2004-08-31 Teva Pharma Preparation of levofloxacin and forms thereof
NZ534104A (en) * 2001-12-24 2007-03-30 Teva Pharma Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US6664267B1 (en) 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
US20040191332A1 (en) * 2003-03-27 2004-09-30 Allergan, Inc. Preserved ophthalmic compositions
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
DK1654002T4 (da) 2003-08-07 2014-02-17 Allergan Inc Sammensætninger til fremføring af terapeutiske midler til øjnene
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7164023B2 (en) * 2003-09-04 2007-01-16 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
CN100412075C (zh) * 2004-06-22 2008-08-20 浙江医药股份有限公司新昌制药厂 左旋氧氟沙星和氧氟沙星的制备方法
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7498307B2 (en) * 2005-06-17 2009-03-03 Michael Alan Sturgess Combinations of DnaK inhibitors with known antibacterial agents
WO2007095187A2 (en) * 2006-02-13 2007-08-23 Trustees Of Boston University Compositions and methods for antibiotic potentiation and drug discovery
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
WO2008019292A2 (en) * 2006-08-04 2008-02-14 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
US20100029938A1 (en) * 2006-12-22 2010-02-04 Farmaprojects, S. A. Process for the preparation of an antibacterial quinolone compound
EP1939206A1 (en) * 2006-12-22 2008-07-02 Farmaprojects, S.A. Process for the preparation of an antibacterial quinolone compound
DE102007026550A1 (de) * 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
DE102007055341A1 (de) 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
US9192571B2 (en) * 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
US7842714B2 (en) * 2008-03-03 2010-11-30 Allergan, Inc. Ketorolac tromethamine compositions for treating ocular pain
ES2809177T3 (es) 2008-10-07 2021-03-03 Horizon Orphan Llc Inhalación de levofloxacino para reducir la inflamación pulmonar
JP2012505223A (ja) 2008-10-07 2012-03-01 エムペックス・ファーマシューティカルズ・インコーポレーテッド 薬物動態の改善のためのエアゾールフルオロキノロン配合物
EP2379505A4 (en) 2008-12-05 2012-10-17 Designmedix Inc MODIFIED CHLOROQUINE WITH SINGLE RING UNIT OR CONDENSED RING UNIT
MX2011012134A (es) 2009-05-15 2012-02-08 Redx Pharma Ltd Derivados de farmaco de oxido-reduccion.
CA2773033C (en) 2009-09-04 2016-10-11 Mpex Pharmaceuticals, Inc. Use of aerosolized levofloxacin for treating cystic fibrosis
WO2011034971A1 (en) * 2009-09-15 2011-03-24 Designmedix, Inc. Modified fluoroquinolone compounds and methods of using the same
CN101747382B (zh) * 2009-12-29 2012-06-27 广东药学院 一种以喹诺酮类化合物为配体的钌多吡啶配合物及其制备方法和应用
EP2555750A2 (en) 2010-04-07 2013-02-13 Allergan, Inc. Combinations of preservative compositions for ophthalmic formulations
WO2011127151A2 (en) 2010-04-07 2011-10-13 Allergan, Inc. Combinations of preservatives for ophthalmic compositions
CN101880288B (zh) * 2010-07-12 2012-02-22 浙江东亚药业有限公司 一种氧氟沙星的合成方法
AU2011315555B2 (en) 2010-10-12 2016-03-10 Elanco Animal Health Gmbh Non-starch based soft chewables
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
US10543170B2 (en) 2012-12-19 2020-01-28 Bayer Animal Health Gmbh Tablets with improved acceptance and good storage stability
CN104098588B (zh) * 2013-04-02 2016-05-25 广州白云山医药集团股份有限公司白云山制药总厂 一类三环喹诺酮衍生物及其制备方法和用途
MD4291C1 (ro) * 2013-12-27 2015-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Preparat medicamentos pentru tratamentul otitelor
CN104402917A (zh) * 2014-12-02 2015-03-11 千辉药业（安徽）有限责任公司 一种新氧氟沙星中间体的制备方法
CN105037388A (zh) * 2015-08-28 2015-11-11 安徽环球药业股份有限公司 一种安妥沙星的制备方法
CN106674254B (zh) * 2016-12-21 2019-03-15 广东省中医院 一类喹诺酮羧酸化合物及其中间体、制备方法以及应用
CN106632444A (zh) * 2016-12-29 2017-05-10 千辉药业（安徽）有限责任公司 一种新氧氟沙星中间体的合成方法
GB201708606D0 (en) 2017-05-30 2017-07-12 King S College London Antibiotic resistance breakers
ES2962526T3 (es) 2017-06-22 2024-03-19 Cipla Ltd Secretagogos PAR-4 para el tratamiento del cáncer
JOP20180097B1 (ar) * 2018-10-22 2023-03-28 Univ Of Jordan مشتقات 1.8 - نفثاريدين الغلايكوزيلية و طرق تحضيرها و استخدامها في معالجة الالتهابات الميكروبية
WO2020202239A1 (en) * 2019-04-04 2020-10-08 The University Of Jordan Glycosylated 3-substituted fluoroquinolone derivatives, preparation methods thereof, and their use in the treatment of antimicrobial infections
CN114727622A (zh) * 2019-09-06 2022-07-08 礼蓝美国公司 适口颗粒状兽用药组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883522A (en) 1974-02-11 1975-05-13 Riker Laboratories Inc Substituted pyrido(1,2,3-de)-1,4-benzoxazines
US3984548A (en) 1974-02-11 1976-10-05 Riker Laboratories, Inc. Substituted pyrido[1,2,3,-de]-1,4-benzoxazines as bactericides
US4133954A (en) * 1976-11-16 1979-01-09 Ciba-Geigy Corporation Pyrrolo- and pyrido-1,4-benzoxazin-3-(2H)-one derivatives as microbicides
JPS5476875A (en) 1977-11-29 1979-06-19 Matsushita Electric Ind Co Ltd Juicer
DE2953974C2 (no) * 1978-04-12 1992-06-25 Otsuka Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp
JPS54138582A (en) 1978-04-19 1979-10-27 Kyorin Seiyaku Kk Substituted quinolinecarboxylic acid
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体

Also Published As

Publication number Publication date
IN155680B (no) 1985-02-23
DE3167216D1 (de) 1984-12-20
GR74637B (no) 1984-06-29
YU47193B (sh) 1995-01-31
YU74788A (en) 1989-08-31
YU210981A (en) 1983-06-30
FI812693L (fi) 1982-03-03
US4382892A (en) 1983-05-10
NZ198224A (en) 1984-02-03
FI71155B (fi) 1986-08-14
NO812956L (no) 1982-03-03
NO158507C (no) 1988-09-21
CA1167840A (en) 1984-05-22
KR830006303A (ko) 1983-09-20
ZA815604B (en) 1982-08-25
NO158507B (no) 1988-06-13
MY8600712A (en) 1986-12-31
ES8301977A1 (es) 1983-01-01
FI71155C (fi) 1986-11-24
EP0047005B1 (en) 1984-11-14
EP0047005A1 (en) 1982-03-10
DK158267B (da) 1990-04-23
IL63613A0 (en) 1981-11-30
DK204488A (da) 1988-04-14
ATE10282T1 (de) 1984-11-15
AU529263B2 (en) 1983-06-02
PH18276A (en) 1985-05-17
DK158267C (da) 1990-10-15
HK82186A (en) 1986-11-07
IL63613A (en) 1984-10-31
JPS6111955B2 (no) 1986-04-05
KR840002141B1 (ko) 1984-11-23
ES505116A0 (es) 1983-01-01
AU7487881A (en) 1982-03-11
DK388981A (da) 1982-03-03
DK204488D0 (da) 1988-04-14
JPS5746986A (en) 1982-03-17

Similar Documents

Publication Publication Date Title
YU42422B (en) Process for preparing the compounds 9-halo-7-oxo-2,3-dihydro-7h-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acid
ES8106723A1 (es) Un metodo para la preparacion de derivados de ftalimidina
ES8203883A1 (es) Un procedimiento para la preparacion de derivados de imida- zol
DE3070227D1 (en) Benzothiazole derivatives, pharmaceutical compositions containing them and process for their preparation
PL251768A1 (en) Process for preparing novel derivatives of neutral salts of aminopyridinium hydroxide
ES8407052A1 (es) Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas
ES8504190A1 (es) Procedimiento para la preparacion de nuevos derivados del acido quinolicincarboxilico.
DE3069173D1 (en) Substituted phenylamino-2-imidazoline-2 derivatives, their acid addition salts, medicaments containing them and process for their preparation
YU265482A (en) Process for obtaining cephalosporins substituted in position 3 by a heterocyclic thiomethy group
ES8304956A1 (es) Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina.
IL77583A (en) N-sulphonyl-n'-phosphonomethyl glycine derivatives,process for the preparation thereof and herbicidal compositions comprising the same
DE3365933D1 (en) Substituted thienobenzodiazepinones, process for their preparation and medicines containing these compounds
EP0144441A4 (en) BLOOD PRESSURE REGULATING AGENCY.
ES483304A1 (es) Un procedimiento para la preparacion de derivados de benzo- diacepina
ES485333A1 (es) Procedimiento para preparar derivados 5,6,7,8-tetrahidro-4 (3h)-quinazolinonicos y sus sales
KR900014383A (ko) 피롤로퀴놀린 유도체, 이의 제조방법 및 이를 사용한 항균제
ES417091A2 (es) Un procedimiento de preparacion de nuevas sales de monoes- teres de piridoxina.