ES8106723A1 - Un metodo para la preparacion de derivados de ftalimidina - Google Patents
Un metodo para la preparacion de derivados de ftalimidinaInfo
- Publication number
- ES8106723A1 ES8106723A1 ES494508A ES494508A ES8106723A1 ES 8106723 A1 ES8106723 A1 ES 8106723A1 ES 494508 A ES494508 A ES 494508A ES 494508 A ES494508 A ES 494508A ES 8106723 A1 ES8106723 A1 ES 8106723A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- carbon atoms
- phthalimidine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE FTALIMIDINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R, R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE AMIDIFICACION ENTRE UN COMPUESTO DE FORMULA (II) Y UN COMPUESTO DE FORMULA (III), EN LAS QUE R, R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN DISOLUCION DE METANOL/AGUA, BAJO PRESION A UNA TEMPERATURA PROXIMA A 160 GC. EL PRODUCTO OBTENIDO SE SEPARA Y PURIFICA SIGUIENDO METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS ANTIPSICOTICOS Y ANTINEUROLEPTICOS. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7907121A SE7907121L (sv) | 1979-08-27 | 1979-08-27 | Ftalimidinderivat |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8106723A1 true ES8106723A1 (es) | 1981-08-01 |
ES494508A0 ES494508A0 (es) | 1981-08-01 |
Family
ID=20338703
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES494508A Granted ES494508A0 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
ES494505A Granted ES494505A0 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
ES494502A Expired ES8103743A1 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
ES494504A Granted ES494504A0 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
ES494506A Granted ES494506A0 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
ES494507A Granted ES494507A0 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES494505A Granted ES494505A0 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
ES494502A Expired ES8103743A1 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
ES494504A Granted ES494504A0 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
ES494506A Granted ES494506A0 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
ES494507A Granted ES494507A0 (es) | 1979-08-27 | 1980-08-26 | Un metodo para la preparacion de derivados de ftalimidina |
Country Status (12)
Country | Link |
---|---|
US (1) | US4289781A (es) |
EP (1) | EP0026749A1 (es) |
JP (1) | JPS5634679A (es) |
AU (1) | AU6151380A (es) |
DK (1) | DK365280A (es) |
ES (6) | ES494508A0 (es) |
FI (1) | FI802686A (es) |
IL (1) | IL60478A0 (es) |
NO (1) | NO802215L (es) |
SE (1) | SE7907121L (es) |
SU (1) | SU969164A3 (es) |
ZA (1) | ZA804057B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1169078A (en) * | 1980-12-29 | 1984-06-12 | Michael J. Fifolt | Method for the preparation of fluorophthalamic compounds |
ZA83508B (en) * | 1982-01-27 | 1983-10-26 | Britax Wingard Ltd | Ferrule attachment |
EP0093488A3 (en) * | 1982-03-18 | 1984-05-23 | Beecham Group Plc | Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them |
US4600758A (en) * | 1982-11-12 | 1986-07-15 | Mead Johnson & Company | Isoindole derivatives |
US4495194A (en) * | 1982-11-12 | 1985-01-22 | Mead Johnson & Company | Antihypertensive isoindole derivatives |
US4505911A (en) * | 1983-10-13 | 1985-03-19 | Mead Johnson & Company | Isoindole diuretic derivatives, compositions and use |
US4585773A (en) * | 1984-07-11 | 1986-04-29 | Bristol-Myers Company | Isoindolinyl-alkyl-piperazines |
JPS6169773A (ja) * | 1984-09-14 | 1986-04-10 | Takeda Chem Ind Ltd | イソインドリノン誘導体 |
FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
EP0351283A1 (fr) * | 1988-07-12 | 1990-01-17 | Synthelabo | Dérivés de [(pipéridinyl-4) méthyl]-2 dihydro-2,3 1H-isoindole et tétrahydro-2,3,4,5 1H-benzazépines, leur préparation et leur application en thérapeutique |
US5070094A (en) * | 1989-09-05 | 1991-12-03 | G. D. Searle & Co. | N-benzyltropaneamides |
US5210090A (en) * | 1989-09-05 | 1993-05-11 | G. D. Searle & Co. | Substituted N-benzylpiperidine amides and cardiac regulatory compositions thereof |
US5098915A (en) * | 1989-09-05 | 1992-03-24 | G. D. Searle & Co. | Substituted N-benzylpiperidine amides |
US5028616A (en) * | 1989-09-05 | 1991-07-02 | G. D. Searle & Co. | N-benzylpiperidine amides |
US4992446A (en) * | 1989-09-05 | 1991-02-12 | G. D. Searle & Co. | Tricyclic quinolizine amides |
US5053413A (en) * | 1989-09-05 | 1991-10-01 | G. D. Searle & Co. | N-benzylpiperidineisoindolinones |
US5356906A (en) * | 1989-10-27 | 1994-10-18 | The Du Pont Merck Pharmaceutical Company | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis |
WO1991006297A1 (en) * | 1989-10-27 | 1991-05-16 | The Du Pont Merck Pharmaceutical Company | (n-phthalimidoalkyl) piperidines |
JP2807577B2 (ja) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
US5162341A (en) * | 1991-02-22 | 1992-11-10 | Du Pont Merck Pharmaceutical Company | Use of sigma receptor antagonists for treatment of amphetamine abuse |
US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
US5567718A (en) * | 1994-08-11 | 1996-10-22 | Hoechst Marion Roussel Inc. | 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors |
US5827875A (en) * | 1996-05-10 | 1998-10-27 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
US5885983A (en) * | 1996-05-10 | 1999-03-23 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
US5883109A (en) * | 1996-07-24 | 1999-03-16 | Bristol-Myers Squibb Company | Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug |
US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
WO2000000472A1 (en) * | 1998-06-30 | 2000-01-06 | Du Pont Pharmaceuticals Company | 5-ht7 receptor antagonists |
FI20021421A0 (fi) * | 2002-07-30 | 2002-07-30 | Orion Corp Fermion | Valmistusmenetelmä |
US6881815B2 (en) * | 2002-09-25 | 2005-04-19 | General Electric Company | Method for the preparation poly(etherimide)s |
TW200918062A (en) * | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
US8278302B2 (en) * | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
UA109290C2 (uk) | 2010-10-07 | 2015-08-10 | Спільні кристали і солі інгібіторів ccr3 | |
US8680280B2 (en) | 2012-04-02 | 2014-03-25 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of CRR inhibitors |
US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL34317A0 (en) | 1969-04-23 | 1970-06-17 | Kabi Ab | Substituted acetamides,their preparation and pharmaceutical compositions containing them |
SE333734B (es) | 1969-04-23 | 1971-03-29 | Kabi Ab | |
US4053615A (en) * | 1972-10-21 | 1977-10-11 | John Wyeth & Brother Limited | Phthalimidopiperidines and anti-convulsant compositions thereof |
GB1425578A (en) * | 1972-10-21 | 1976-02-18 | Wyeth John & Brother Ltd | Piperidine derivatives |
GB1486104A (en) | 1975-01-23 | 1977-09-21 | Wyeth John & Brother Ltd | Phthalimidopiperidine derivatives |
US4000287A (en) * | 1974-12-16 | 1976-12-28 | Ciba-Geigy Corporation | Isoindolinopiperidines |
-
1979
- 1979-08-27 SE SE7907121A patent/SE7907121L/xx not_active Application Discontinuation
-
1980
- 1980-06-26 EP EP80850104A patent/EP0026749A1/en not_active Ceased
- 1980-07-03 IL IL60478A patent/IL60478A0/xx unknown
- 1980-07-04 ZA ZA00804057A patent/ZA804057B/xx unknown
- 1980-07-23 NO NO802215A patent/NO802215L/no unknown
- 1980-08-14 US US06/177,888 patent/US4289781A/en not_active Expired - Lifetime
- 1980-08-15 AU AU61513/80A patent/AU6151380A/en not_active Abandoned
- 1980-08-26 DK DK365280A patent/DK365280A/da unknown
- 1980-08-26 ES ES494508A patent/ES494508A0/es active Granted
- 1980-08-26 ES ES494505A patent/ES494505A0/es active Granted
- 1980-08-26 SU SU802969263A patent/SU969164A3/ru active
- 1980-08-26 ES ES494502A patent/ES8103743A1/es not_active Expired
- 1980-08-26 ES ES494504A patent/ES494504A0/es active Granted
- 1980-08-26 FI FI802686A patent/FI802686A/fi not_active Application Discontinuation
- 1980-08-26 ES ES494506A patent/ES494506A0/es active Granted
- 1980-08-26 ES ES494507A patent/ES494507A0/es active Granted
- 1980-08-27 JP JP11716580A patent/JPS5634679A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DK365280A (da) | 1981-02-28 |
ES8104275A1 (es) | 1981-04-01 |
AU6151380A (en) | 1981-03-05 |
SU969164A3 (ru) | 1982-10-23 |
ES8103744A1 (es) | 1981-03-16 |
EP0026749A1 (en) | 1981-04-08 |
NO802215L (no) | 1981-03-02 |
IL60478A0 (en) | 1980-09-16 |
FI802686A (fi) | 1981-02-28 |
ES8106721A1 (es) | 1981-08-01 |
ES494502A0 (es) | 1981-03-16 |
ES8106722A1 (es) | 1981-08-01 |
ES494505A0 (es) | 1981-08-01 |
SE7907121L (sv) | 1981-02-28 |
ES494507A0 (es) | 1981-04-01 |
ES8103743A1 (es) | 1981-03-16 |
ZA804057B (en) | 1981-07-29 |
US4289781A (en) | 1981-09-15 |
ES494508A0 (es) | 1981-08-01 |
ES494504A0 (es) | 1981-03-16 |
JPS5634679A (en) | 1981-04-06 |
ES494506A0 (es) | 1981-08-01 |
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