DK1654002T4 - Sammensætninger til fremføring af terapeutiske midler til øjnene - Google Patents
Sammensætninger til fremføring af terapeutiske midler til øjnene Download PDFInfo
- Publication number
- DK1654002T4 DK1654002T4 DK04780382.0T DK04780382T DK1654002T4 DK 1654002 T4 DK1654002 T4 DK 1654002T4 DK 04780382 T DK04780382 T DK 04780382T DK 1654002 T4 DK1654002 T4 DK 1654002T4
- Authority
- DK
- Denmark
- Prior art keywords
- compositions
- eyes
- therapeutic agents
- increase
- component
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49318803P | 2003-08-07 | 2003-08-07 | |
US49317803P | 2003-08-07 | 2003-08-07 | |
PCT/US2004/025540 WO2005014046A2 (en) | 2003-08-07 | 2004-08-05 | Compositions for delivery of therapeutics into the eyes and methods for making and using the same |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1654002T3 DK1654002T3 (da) | 2010-02-01 |
DK1654002T4 true DK1654002T4 (da) | 2014-02-17 |
Family
ID=34138742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04780382.0T DK1654002T4 (da) | 2003-08-07 | 2004-08-05 | Sammensætninger til fremføring af terapeutiske midler til øjnene |
Country Status (12)
Country | Link |
---|---|
US (4) | US8512717B2 (da) |
EP (2) | EP2113246B1 (da) |
JP (1) | JP2007501799A (da) |
AT (1) | ATE444732T1 (da) |
AU (1) | AU2004263149B2 (da) |
BR (1) | BRPI0413381A (da) |
CA (1) | CA2534484A1 (da) |
DE (1) | DE602004023516D1 (da) |
DK (1) | DK1654002T4 (da) |
ES (2) | ES2593113T3 (da) |
PL (1) | PL1654002T5 (da) |
WO (1) | WO2005014046A2 (da) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1173790A2 (en) * | 1999-03-01 | 2002-01-23 | Boston Innovative Optics, Inc. | System and method for increasing the depth of focus of the human eye |
US20050031652A1 (en) * | 2003-02-25 | 2005-02-10 | Allergan, Inc. | Compositions and methods comprising memantine and polyanionic polymers |
US7628810B2 (en) * | 2003-05-28 | 2009-12-08 | Acufocus, Inc. | Mask configured to maintain nutrient transport without producing visible diffraction patterns |
US20050046794A1 (en) * | 2003-06-17 | 2005-03-03 | Silvestrini Thomas A. | Method and apparatus for aligning a mask with the visual axis of an eye |
DK1654002T4 (da) * | 2003-08-07 | 2014-02-17 | Allergan Inc | Sammensætninger til fremføring af terapeutiske midler til øjnene |
PL1808170T3 (pl) * | 2004-11-05 | 2011-12-30 | Senju Pharma Co | Wodne krople do oczu z przyśpieszoną migracją wewnątrzgałkową |
US7976577B2 (en) | 2005-04-14 | 2011-07-12 | Acufocus, Inc. | Corneal optic formed of degradation resistant polymer |
US7893040B2 (en) | 2005-07-22 | 2011-02-22 | Oculis Ehf | Cyclodextrin nanotechnology for ophthalmic drug delivery |
WO2007047242A2 (en) * | 2005-10-14 | 2007-04-26 | Soll David B | Ophthalmic surgical irrigating solutions containing hyaluronidase |
CA2633655A1 (en) * | 2005-12-19 | 2007-07-05 | Comentis, Inc. | Topical mecamylamine formulations for ocular administration and uses therof |
US20080107713A1 (en) * | 2006-11-08 | 2008-05-08 | Orilla Werhner C | Contact lens as a sustained drug delivery implant |
US20080317819A1 (en) * | 2007-06-21 | 2008-12-25 | Orilla Werhner C | Iop lowering drug combination or non-combination loaded contact lens with zonal drug delivery areas |
AU2008310956B2 (en) | 2007-10-08 | 2014-08-07 | Aurinia Pharmaceuticals Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors |
US7842714B2 (en) * | 2008-03-03 | 2010-11-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating ocular pain |
US9192571B2 (en) * | 2008-03-03 | 2015-11-24 | Allergan, Inc. | Ketorolac tromethamine compositions for treating or preventing ocular pain |
TW201039815A (en) | 2009-04-13 | 2010-11-16 | Resolvyx Pharmaceuticals Inc | Compositions and methods for the treatment of inflammation |
US9017725B2 (en) * | 2009-06-09 | 2015-04-28 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
AU2010282311B2 (en) | 2009-08-13 | 2015-08-13 | Acufocus, Inc. | Masked intraocular implants and lenses |
USD656526S1 (en) | 2009-11-10 | 2012-03-27 | Acufocus, Inc. | Ocular mask |
WO2011068872A2 (en) | 2009-12-03 | 2011-06-09 | Alcon Research, Ltd. | Carboxyvinyl polymer-containing nanoparticle suspension |
RU2452478C1 (ru) * | 2011-02-21 | 2012-06-10 | Общество с ограниченной ответственностью "Научно-производственная компания Уралбиофарм" | Многофункциональный раствор для эпибульбарных инстилляций |
CA2856386C (en) | 2011-11-21 | 2022-05-31 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
WO2013082545A1 (en) | 2011-12-02 | 2013-06-06 | Acufocus, Inc. | Ocular mask having selective spectral transmission |
PL2690607T3 (pl) | 2012-07-24 | 2024-07-29 | Scan Coin Ab | Urządzenie, sposób i program komputerowy do elastycznego wydawania monet w urządzeniu do obsługiwania monet |
EP2690604B1 (en) | 2012-07-24 | 2021-05-26 | Scan Coin Ab | Coin deposit and dispensing apparatus |
ES2543182T3 (es) | 2012-07-24 | 2015-08-17 | Scan Coin Ab | Dispensadores para aparatos de manipulación de monedas |
SG10201801222YA (en) | 2012-07-26 | 2018-04-27 | Allergan Inc | Dual cap system for container-closures to maintain tip sterility during shelf storage |
EP3954686A1 (en) | 2012-11-16 | 2022-02-16 | Calithera Biosciences, Inc. | Heterocyclic glutaminase inhibitors |
US9204962B2 (en) | 2013-03-13 | 2015-12-08 | Acufocus, Inc. | In situ adjustable optical mask |
US9427922B2 (en) | 2013-03-14 | 2016-08-30 | Acufocus, Inc. | Process for manufacturing an intraocular lens with an embedded mask |
CN106455567A (zh) * | 2013-12-18 | 2017-02-22 | Gnt有限责任公司 | 用于治疗青光眼的组合物和方法 |
JP6798890B2 (ja) | 2014-06-13 | 2020-12-09 | キャリセラ バイオサイエンシーズ, インコーポレイテッド | グルタミナーゼ阻害剤との併用療法 |
CA2957225A1 (en) | 2014-08-07 | 2016-02-11 | Calithera Biosciences, Inc. | Crystal forms of glutaminase inhibitors |
ES2901418T3 (es) | 2014-08-13 | 2022-03-22 | Eolas Therapeutics Inc | Difluoropirrolidinas como moduladores del receptor de orexina |
CN114213356A (zh) | 2015-03-10 | 2022-03-22 | 奥瑞基尼探索技术有限公司 | 作为免疫调节剂的1,2,4-噁二唑和噻二唑化合物 |
WO2016210106A1 (en) | 2015-06-23 | 2016-12-29 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
CA3000996A1 (en) | 2015-10-05 | 2017-04-13 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors and immuno-oncology agents |
SI3368541T1 (sl) | 2015-10-30 | 2020-10-30 | Calithera Biosciences, Inc. | Sestavki in postopki za zaviranje arginazne dejavnosti |
MX2018005872A (es) * | 2015-11-16 | 2019-05-16 | Ichorion Therapeutics Inc | Profarmacos de acido nucleico. |
WO2017139603A1 (en) | 2016-02-12 | 2017-08-17 | Astrazeneca Ab | Halo-substituted piperidines as orexin receptor modulators |
WO2017210565A1 (en) | 2016-06-03 | 2017-12-07 | Prisident And Fellows Of Harvard College | Antifungal compounds |
KR102275012B1 (ko) | 2016-08-12 | 2021-07-07 | 실크 테크놀로지스 리미티드 | 염증 치료용 실크 유래 단백질 |
BR112019002967A2 (pt) | 2016-08-19 | 2019-05-14 | Orasis Pharmaceuticals Ltd. | composição farmacêutica oftálmica, métodos de corrigir presbiopia, de reduzir o tamanho de uma pupila, de induzir miose, de aumentar a profundidade de campo, de diminuir a grandeza de aberrações de ordem superior e de melhorar a acuidade visual não corrigida de perto e de longe, implante, e, kit. |
CN110234656B (zh) | 2016-09-09 | 2023-02-28 | 卡利泰拉生物科技公司 | 外核苷酸酶抑制剂及其使用方法 |
EP3509583B1 (en) | 2016-09-09 | 2021-06-30 | The Regents of the University of California | Estrogen receptor ligands, compositions and methods related thereto |
BR112019004992A2 (pt) | 2016-09-14 | 2019-06-04 | Univ Vanderbilt | inibição da sinalização de bmp, compostos, composições e usos destes |
EP4275759A3 (en) | 2016-09-26 | 2024-01-17 | Dana-Farber Cancer Institute, Inc. | Quinoline derivatives as chromobox (cbx) protein inhibitors for treating cancer |
WO2018089490A1 (en) | 2016-11-08 | 2018-05-17 | Calithera Biosciences, Inc. | Arginase inhibitor combination therapies |
PT3559009T (pt) | 2016-12-22 | 2021-05-04 | Calithera Biosciences Inc | Composições e métodos para inibir a atividade da arginase |
US20200054643A1 (en) | 2017-01-18 | 2020-02-20 | Vanderbilt University | Fused heterocyclic compounds as selective bmp inhibitors |
MA47593A (fr) | 2017-02-24 | 2020-01-01 | Merck Patent Gmbh | Dérivés de 1, 4, 6-trisubstitué-2-alkyl-1h-benzo[d]imidazole en tant qu'inhibiteurs de dihydroorotate oxygénase |
US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
US10994025B2 (en) | 2017-05-12 | 2021-05-04 | Massachusetts Institute Of Technology | Argonaute protein-double stranded RNA complexes and uses related thereto |
US11325943B2 (en) | 2017-06-02 | 2022-05-10 | Stealth Biotherapeutics Inc. | Crystalline salt forms of SBT-20 |
US10526334B2 (en) | 2017-07-19 | 2020-01-07 | California Institute Of Technology | Methods for preparing bis-tetrahydroisoquinoline-containing compounds |
SG11202003081WA (en) | 2017-10-11 | 2020-05-28 | Aurigene Discovery Tech Ltd | Crystalline forms of 3-substituted 1,2,4-oxadiazole |
WO2019087087A1 (en) | 2017-11-03 | 2019-05-09 | Aurigene Discovery Technologies Limited | Dual inhibitors of tim-3 and pd-1 pathways |
EP3706798A1 (en) | 2017-11-06 | 2020-09-16 | Aurigene Discovery Technologies Limited | Conjoint therapies for immunomodulation |
WO2019122265A1 (en) | 2017-12-22 | 2019-06-27 | Medimmune Limited | Small molecule modulators of the btb domain of keap1 |
WO2019178383A1 (en) | 2018-03-14 | 2019-09-19 | Vanderbilt University | Inhibition of bmp signaling, compounds, compositions and uses thereof |
WO2020023917A1 (en) | 2018-07-27 | 2020-01-30 | California Institute Of Technology | Cdk inhibitors and uses thereof |
WO2020051322A1 (en) | 2018-09-05 | 2020-03-12 | The General Hospital Corporation | Methods of treating cytokine release syndrome |
CN114269345A (zh) | 2018-10-26 | 2022-04-01 | 科乐斯疗法公司 | Alk2抑制剂的晶体形式 |
AU2019397436A1 (en) | 2018-12-10 | 2021-07-22 | The General Hospital Corporation | Cromolyn esters and uses thereof |
WO2020150473A2 (en) | 2019-01-18 | 2020-07-23 | Dogma Therapeutics, Inc. | Pcsk9 inhibitors and methods of use thereof |
CA3131753A1 (en) | 2019-03-14 | 2020-09-17 | Astrazeneca Ab | Lanabecestat for weight loss |
WO2020246503A1 (ja) | 2019-06-03 | 2020-12-10 | 株式会社大分大学先端医学研究所 | 狂犬病治療のための環状アミド化合物およびその方法 |
US12097209B2 (en) | 2019-07-01 | 2024-09-24 | Oculis Operations Sàrl | Diabetic retinopathy treatment with stabilized dexamethasone |
IL292965A (en) | 2019-11-12 | 2022-07-01 | Genzyme Corp | Heteroarylaminosulfonamides with 6 positions and methods of using them |
WO2021113809A1 (en) | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Arylamides and methods of use thereof |
WO2021113806A1 (en) | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Arylamides and methods of use thereof |
WO2021125800A1 (ko) | 2019-12-16 | 2021-06-24 | 울산과학기술원 | 신생혈관형성인자의 억제를 위한 화합물 및 그 용도 |
AU2021268664A1 (en) | 2020-05-05 | 2022-10-20 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
PE20240327A1 (es) | 2021-04-13 | 2024-02-22 | Nuvalent Inc | Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfr |
WO2023034992A1 (en) | 2021-09-03 | 2023-03-09 | Genzyme Corporation | Indole compounds and methods of use |
EP4396176A1 (en) | 2021-09-03 | 2024-07-10 | Genzyme Corporation | Indole compounds and uses thereof in the treatement of cystic fibrosis |
WO2023056405A1 (en) | 2021-10-01 | 2023-04-06 | Nuvalent, Inc. | Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds |
WO2023056431A1 (en) | 2021-10-01 | 2023-04-06 | Nuvalent, Inc. | Methods of treating solid tumor using heteroaromatic macrocyclic ether compounds |
WO2023196910A1 (en) | 2022-04-07 | 2023-10-12 | Nuvalent, Inc | Methods of treating solid tumor using (19r)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(24),2(6),4,8,11,13,15,17,21(25),22-decaen-22-amine |
WO2023196900A1 (en) | 2022-04-07 | 2023-10-12 | Nuvalent, Inc. | Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds |
WO2024036098A1 (en) | 2022-08-12 | 2024-02-15 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether compounds |
WO2024036097A1 (en) | 2022-08-12 | 2024-02-15 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether compounds and isotopologues thereof |
WO2024086634A1 (en) | 2022-10-19 | 2024-04-25 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1781701A (en) | 1928-05-16 | 1930-11-18 | Phillips Morris Godfrey Philip | Machine for removing flags and other adhering leaf from the stalks of tobacco leaves |
US3278447A (en) | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
US4089969A (en) | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
US4474787A (en) | 1977-05-04 | 1984-10-02 | Fisons Limited | 7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and anti-allergic use thereof |
JPS6056684B2 (ja) * | 1977-11-07 | 1985-12-11 | 東興薬品工業株式会社 | 点眼剤 |
GB2013084B (en) * | 1978-01-25 | 1982-07-28 | Alcon Lab Inc | Ophthalmic drug dosage |
US4407792A (en) | 1979-05-09 | 1983-10-04 | Alcon Laboratories, Inc. | Sustained release ophthalmic drug dosage |
JPS5746986A (en) | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
US4454151A (en) | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
US6255299B1 (en) * | 1985-01-07 | 2001-07-03 | Leo Pharmaceutical Products Ltd. | Opthalmic gel composition and method of treating eye infections |
GB8500310D0 (en) * | 1985-01-07 | 1985-02-13 | Leo Pharm Prod Ltd | Pharmaceutical preparation |
IL80298A (en) | 1986-10-14 | 1993-01-31 | Res & Dev Co Ltd | Eye drops |
US5089509A (en) | 1988-09-15 | 1992-02-18 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
US5110493A (en) * | 1987-09-11 | 1992-05-05 | Syntex (U.S.A.) Inc. | Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant |
US5414011A (en) | 1987-09-11 | 1995-05-09 | Syntex (U.S.A.) Inc. | Preservative system for ophthalmic formulations |
NZ226100A (en) | 1987-09-11 | 1990-12-21 | Syntex Inc | Stabilised ophthalmic formulation containing non-steroidal anti-inflammatory drug |
US6174999B1 (en) | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
US5705485A (en) * | 1987-09-18 | 1998-01-06 | Ethicon, Inc. | Gel formulations containing growth factors |
US5527893A (en) | 1987-09-18 | 1996-06-18 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
US5017229A (en) | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
US4861514A (en) | 1988-06-08 | 1989-08-29 | The Drackett Company | Compositions containing chlorine dioxide and their preparation |
US5281591A (en) | 1989-05-22 | 1994-01-25 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
DE69029804T2 (de) | 1989-06-07 | 1997-09-04 | Gail S Bazzano | VEHIKEL MIT LANGSAMER FREISETZUNG ZUR VERMINDERUNG DER HAUTREIZUNG TOPISCHER retinoidhaltiger MITTEL |
US5045121A (en) | 1989-06-21 | 1991-09-03 | Gte Products Corporation | Method for removing carbon from cemented tungsten carbide articles |
US5231096A (en) * | 1989-10-12 | 1993-07-27 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
US5077292A (en) * | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
US5112822A (en) | 1989-10-12 | 1992-05-12 | Allergan, Inc. | (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same |
US5021416A (en) | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
US5215991A (en) | 1990-01-26 | 1993-06-01 | Allergan, Inc. | Combination of selective alpha-adrenergic agonists and Na+ /H+ ex |
US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
IT1250691B (it) | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
US5460834A (en) | 1991-12-13 | 1995-10-24 | Alcon Laboratories, Inc. | Combinations of polymers for use in physiological tear compositions |
WO1993017664A1 (en) * | 1992-03-02 | 1993-09-16 | Alcon Laboratories, Inc. | Combinations of cellulosic polymers and carboxy vinyl polymers and their use in pharmaceutical compositions |
US5459133A (en) * | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
KR100187555B1 (ko) * | 1992-07-06 | 1999-06-01 | 루이스 앨버트 드 워치터 | 기어 유닛 |
AU666957B2 (en) | 1992-08-28 | 1996-02-29 | Alcon Laboratories, Inc. | Use of certain anionic surfactants to enhance antimicrobial effectiveness of ophthalmic compositions |
US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
US5922773A (en) | 1992-12-04 | 1999-07-13 | The Children's Medical Center Corp. | Glaucoma treatment |
US5382591A (en) | 1992-12-17 | 1995-01-17 | Sepracor Inc. | Antipyretic and analgesic methods using optically pure R-ketorolac |
US5648074A (en) | 1993-05-25 | 1997-07-15 | Allergan | Compositions and methods for disinfecting contact lenses and reducing proteinaceous deposit formation |
WO1995005803A1 (en) * | 1993-08-20 | 1995-03-02 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
EP1285657A3 (en) | 1993-10-13 | 2003-08-20 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
CA2134376C (en) * | 1993-12-20 | 2001-10-23 | Haresh G. Bhagat | Combinations of polymers for use in physiological tear compositions |
US6294202B1 (en) | 1994-10-06 | 2001-09-25 | Genzyme Corporation | Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers |
US5558876A (en) | 1995-03-29 | 1996-09-24 | Alcon Laboratories, Inc. | Topical ophthalmic acidic drug formulations |
IT1283911B1 (it) * | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
US5807541A (en) | 1996-04-22 | 1998-09-15 | Sepracor, Inc. | NSAID/fluoride periodontal compositions and methods |
US5888493A (en) * | 1996-12-05 | 1999-03-30 | Sawaya; Assad S. | Ophthalmic aqueous gel formulation and related methods |
US5811446A (en) * | 1997-04-18 | 1998-09-22 | Cytos Pharmaceuticals Llc | Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor |
US5858346A (en) | 1997-05-09 | 1999-01-12 | Allergan | Compositions and methods for enhancing contact lens wearability |
US6646001B2 (en) * | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
JP2002539157A (ja) * | 1999-03-15 | 2002-11-19 | トラスティーズ オブ ボストン ユニバーシティ | 血管新生阻害 |
ITMI991453A1 (it) | 1999-07-01 | 2001-01-01 | Farmila Farma Milano | Composizioni oftalmiche in forma di gel acquosi |
US7141607B1 (en) | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
JP4132599B2 (ja) * | 2000-07-07 | 2008-08-13 | 日本板硝子株式会社 | 画像形成装置 |
HUP0303197A3 (en) | 2000-07-14 | 2008-03-28 | Allergan Inc | Compositions containing alpha-2 adrenergic agonist components |
US20020198210A1 (en) | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Alpha-2-adrenergic agonist/fatty acid compositions |
US20020198209A1 (en) | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
TWI298257B (en) | 2001-05-31 | 2008-07-01 | Allergan Inc | Hypotensive lipid and timolol compositions and methods of using same |
US7045121B2 (en) | 2001-12-14 | 2006-05-16 | Allergan, Inc. | Ophthalmic compositions for lubricating eyes and methods for making and using same |
US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
US20040224010A1 (en) | 2002-11-15 | 2004-11-11 | Optime Therapeutics, Inc. | Ophthalmic liposome compositions and uses thereof |
US8008338B2 (en) | 2003-06-03 | 2011-08-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating or preventing ocular pain |
TWI336257B (en) | 2003-06-13 | 2011-01-21 | Alcon Inc | Ophthalmic compositions containing a synergistic combination of three polymers |
DK1654002T4 (da) | 2003-08-07 | 2014-02-17 | Allergan Inc | Sammensætninger til fremføring af terapeutiske midler til øjnene |
WO2005101982A2 (en) | 2004-03-24 | 2005-11-03 | Sun Pharmaceutical Industries Limited | A stable ophthalmic composition |
AU2005322305B2 (en) | 2004-12-23 | 2010-09-16 | Roxro Pharma, Inc. | Therapeutic compositions for intranasal administration of ketorolac |
EP1981491A4 (en) | 2006-01-25 | 2009-09-23 | Aciex Inc | COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DROUGHT |
US20070299124A1 (en) | 2006-01-25 | 2007-12-27 | Ousler George W Iii | Formulations and methods for treating dry eye |
US20080039398A1 (en) | 2006-01-25 | 2008-02-14 | Ousler George W Iii | Formulations and methods for treating dry eye |
US20070287741A1 (en) | 2006-06-13 | 2007-12-13 | Uri Herzberg | Compositions and methods for preventing or reducing postoperative ileus and gastric stasis in mammals |
CA2687717A1 (en) | 2007-05-24 | 2008-12-18 | Aciex Therapeutics, Inc. | Formulations and methods for treating dry eye |
US7842714B2 (en) * | 2008-03-03 | 2010-11-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating ocular pain |
PL2291368T3 (pl) | 2008-04-24 | 2013-05-31 | Allergan Inc | Podstawione gama laktamy jako środki terapeutyczne |
US20080275118A1 (en) | 2008-06-12 | 2008-11-06 | Shaw Mari M | Health and cosmetic composition and regime for stimulating hair growth and thickening on the head, including the scalp, eyelashes, and eyebrows, and which discourages hair loss |
-
2004
- 2004-08-05 DK DK04780382.0T patent/DK1654002T4/da active
- 2004-08-05 AU AU2004263149A patent/AU2004263149B2/en not_active Expired
- 2004-08-05 BR BRPI0413381-1A patent/BRPI0413381A/pt not_active Application Discontinuation
- 2004-08-05 CA CA002534484A patent/CA2534484A1/en not_active Abandoned
- 2004-08-05 AT AT04780382T patent/ATE444732T1/de active
- 2004-08-05 ES ES09010226.0T patent/ES2593113T3/es not_active Expired - Lifetime
- 2004-08-05 EP EP09010226.0A patent/EP2113246B1/en not_active Expired - Lifetime
- 2004-08-05 EP EP04780382.0A patent/EP1654002B2/en not_active Expired - Lifetime
- 2004-08-05 WO PCT/US2004/025540 patent/WO2005014046A2/en active Application Filing
- 2004-08-05 JP JP2006522767A patent/JP2007501799A/ja active Pending
- 2004-08-05 PL PL04780382T patent/PL1654002T5/pl unknown
- 2004-08-05 ES ES04780382.0T patent/ES2332049T5/es not_active Expired - Lifetime
- 2004-08-05 DE DE602004023516T patent/DE602004023516D1/de not_active Expired - Lifetime
- 2004-08-05 US US10/911,966 patent/US8512717B2/en active Active
-
2013
- 2013-07-02 US US13/933,807 patent/US8992952B2/en not_active Expired - Lifetime
-
2015
- 2015-02-24 US US14/629,652 patent/US20150164863A1/en not_active Abandoned
-
2020
- 2020-12-23 US US17/132,246 patent/US20210251961A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BRPI0413381A (pt) | 2006-10-17 |
ES2593113T3 (es) | 2016-12-05 |
US8512717B2 (en) | 2013-08-20 |
EP1654002B2 (en) | 2014-01-29 |
PL1654002T3 (pl) | 2010-03-31 |
US20130296396A1 (en) | 2013-11-07 |
AU2004263149B2 (en) | 2010-08-19 |
ATE444732T1 (de) | 2009-10-15 |
WO2005014046A3 (en) | 2006-06-01 |
ES2332049T5 (es) | 2014-03-27 |
DE602004023516D1 (de) | 2009-11-19 |
EP2113246B1 (en) | 2016-06-22 |
JP2007501799A (ja) | 2007-02-01 |
US20150164863A1 (en) | 2015-06-18 |
PL1654002T5 (pl) | 2014-06-30 |
DK1654002T3 (da) | 2010-02-01 |
CA2534484A1 (en) | 2005-02-17 |
EP1654002B1 (en) | 2009-10-07 |
EP1654002A2 (en) | 2006-05-10 |
US20050031697A1 (en) | 2005-02-10 |
ES2332049T3 (es) | 2010-01-25 |
AU2004263149A1 (en) | 2005-02-17 |
US20210251961A1 (en) | 2021-08-19 |
EP2113246A1 (en) | 2009-11-04 |
WO2005014046A2 (en) | 2005-02-17 |
US8992952B2 (en) | 2015-03-31 |
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