DK1654002T3 - Sammensætninger til fremføring af terapeutiske midler til øjnene og fremgangsmåder og anvendelser deraf - Google Patents

Sammensætninger til fremføring af terapeutiske midler til øjnene og fremgangsmåder og anvendelser deraf

Info

Publication number
DK1654002T3
DK1654002T3 DK04780382.0T DK04780382T DK1654002T3 DK 1654002 T3 DK1654002 T3 DK 1654002T3 DK 04780382 T DK04780382 T DK 04780382T DK 1654002 T3 DK1654002 T3 DK 1654002T3
Authority
DK
Denmark
Prior art keywords
compositions
eyes
applications
methods
therapeutic agents
Prior art date
Application number
DK04780382.0T
Other languages
English (en)
Other versions
DK1654002T4 (da
Inventor
Joseph G Vehige
James N Chang
Richard Graham
Robert T Lyons
Teresa H Kuan
Chin-Ming Chang
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34138742&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1654002(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of DK1654002T3 publication Critical patent/DK1654002T3/da
Publication of DK1654002T4 publication Critical patent/DK1654002T4/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK04780382.0T 2003-08-07 2004-08-05 Sammensætninger til fremføring af terapeutiske midler til øjnene DK1654002T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49318803P 2003-08-07 2003-08-07
US49317803P 2003-08-07 2003-08-07
PCT/US2004/025540 WO2005014046A2 (en) 2003-08-07 2004-08-05 Compositions for delivery of therapeutics into the eyes and methods for making and using the same

Publications (2)

Publication Number Publication Date
DK1654002T3 true DK1654002T3 (da) 2010-02-01
DK1654002T4 DK1654002T4 (da) 2014-02-17

Family

ID=34138742

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04780382.0T DK1654002T4 (da) 2003-08-07 2004-08-05 Sammensætninger til fremføring af terapeutiske midler til øjnene

Country Status (12)

Country Link
US (4) US8512717B2 (da)
EP (2) EP2113246B1 (da)
JP (1) JP2007501799A (da)
AT (1) ATE444732T1 (da)
AU (1) AU2004263149B2 (da)
BR (1) BRPI0413381A (da)
CA (1) CA2534484A1 (da)
DE (1) DE602004023516D1 (da)
DK (1) DK1654002T4 (da)
ES (2) ES2332049T5 (da)
PL (1) PL1654002T5 (da)
WO (1) WO2005014046A2 (da)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1173790A2 (en) * 1999-03-01 2002-01-23 Boston Innovative Optics, Inc. System and method for increasing the depth of focus of the human eye
US20050031652A1 (en) * 2003-02-25 2005-02-10 Allergan, Inc. Compositions and methods comprising memantine and polyanionic polymers
US7628810B2 (en) * 2003-05-28 2009-12-08 Acufocus, Inc. Mask configured to maintain nutrient transport without producing visible diffraction patterns
US20050046794A1 (en) * 2003-06-17 2005-03-03 Silvestrini Thomas A. Method and apparatus for aligning a mask with the visual axis of an eye
WO2005014046A2 (en) 2003-08-07 2005-02-17 Allergan, Inc. Compositions for delivery of therapeutics into the eyes and methods for making and using the same
CA2560559C (en) * 2004-11-05 2013-07-02 Senju Pharmaceutical Co., Ltd. Aqueous intraocular penetration-promoting eye drop
US7976577B2 (en) 2005-04-14 2011-07-12 Acufocus, Inc. Corneal optic formed of degradation resistant polymer
US7893040B2 (en) 2005-07-22 2011-02-22 Oculis Ehf Cyclodextrin nanotechnology for ophthalmic drug delivery
US7976833B2 (en) * 2005-10-14 2011-07-12 Aspen Biomedical Research, Llc Ophthalmic surgical irrigating solutions containing hyaluronidase and method for preventing post-operative intraocular pressure increases
US20070167526A1 (en) * 2005-12-19 2007-07-19 Xiaoming Zhang Topical mecamylamine formulations for ocular administration and uses thereof
US20080107713A1 (en) * 2006-11-08 2008-05-08 Orilla Werhner C Contact lens as a sustained drug delivery implant
US20080317819A1 (en) * 2007-06-21 2008-12-25 Orilla Werhner C Iop lowering drug combination or non-combination loaded contact lens with zonal drug delivery areas
WO2009048929A1 (en) 2007-10-08 2009-04-16 Lux Biosciences, Inc. Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors
US9192571B2 (en) 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
US7842714B2 (en) * 2008-03-03 2010-11-30 Allergan, Inc. Ketorolac tromethamine compositions for treating ocular pain
TW201039815A (en) 2009-04-13 2010-11-16 Resolvyx Pharmaceuticals Inc Compositions and methods for the treatment of inflammation
CN102458370A (zh) * 2009-06-09 2012-05-16 卢克斯生物科技公司 用于眼科用途的表面药物递送系统
EP3290003B1 (en) * 2009-08-13 2023-12-13 AcuFocus, Inc. Method of manufacturing masked intraocular implants and lenses
USD656526S1 (en) 2009-11-10 2012-03-27 Acufocus, Inc. Ocular mask
EP2506831B1 (en) 2009-12-03 2013-11-20 Alcon Research, Ltd. Carboxyvinyl polymer-containing nanoparticle suspensions
RU2452478C1 (ru) * 2011-02-21 2012-06-10 Общество с ограниченной ответственностью "Научно-производственная компания Уралбиофарм" Многофункциональный раствор для эпибульбарных инстилляций
SG10201607685SA (en) 2011-11-21 2016-11-29 Calithera Biosciences Inc Heterocyclic inhibitors of glutaminase
US9545303B2 (en) 2011-12-02 2017-01-17 Acufocus, Inc. Ocular mask having selective spectral transmission
EP2690607B1 (en) 2012-07-24 2024-03-27 Scan Coin Ab Apparatus, method and computer program for flexible dispensing of coins in a coin handling apparatus
EP2690604B1 (en) 2012-07-24 2021-05-26 Scan Coin Ab Coin deposit and dispensing apparatus
EP2690605B1 (en) 2012-07-24 2015-04-29 Scan Coin Ab Dispensers for coin handling apparatus
SG10201801222YA (en) 2012-07-26 2018-04-27 Allergan Inc Dual cap system for container-closures to maintain tip sterility during shelf storage
PL2920168T3 (pl) 2012-11-16 2022-01-03 Calithera Biosciences, Inc. Heterocykliczne inhibitory glutaminazy
US9204962B2 (en) 2013-03-13 2015-12-08 Acufocus, Inc. In situ adjustable optical mask
US9427922B2 (en) 2013-03-14 2016-08-30 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
BR112016014404A2 (pt) * 2013-12-18 2017-08-08 Gnt Llc Composições e métodos para tratamento de glaucoma
JP6798890B2 (ja) 2014-06-13 2020-12-09 キャリセラ バイオサイエンシーズ, インコーポレイテッド グルタミナーゼ阻害剤との併用療法
WO2016022969A1 (en) 2014-08-07 2016-02-11 Calithera Biosciences, Inc. Crystal forms of glutaminase inhibitors
EP3180332B1 (en) 2014-08-13 2021-10-27 Eolas Therapeutics Inc. Difluoropyrrolidines as orexin receptor modulators
CN114044760A (zh) 2015-03-10 2022-02-15 奥瑞基尼探索技术有限公司 作为免疫调节剂的1,2,4-噁二唑和噻二唑化合物
US10143699B2 (en) 2015-06-23 2018-12-04 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
CA3000996A1 (en) 2015-10-05 2017-04-13 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors and immuno-oncology agents
SG10201911406TA (en) 2015-10-30 2020-01-30 Calithera Biosciences Inc Compositions and methods for inhibiting arginase activity
MX2018005872A (es) 2015-11-16 2019-05-16 Ichorion Therapeutics Inc Profarmacos de acido nucleico.
KR20180107232A (ko) 2016-02-12 2018-10-01 아스트라제네카 아베 오렉신 수용체 조정제로서의 할로-치환된 피페리딘
WO2017210565A1 (en) 2016-06-03 2017-12-07 Prisident And Fellows Of Harvard College Antifungal compounds
AU2017310520A1 (en) 2016-08-12 2019-03-21 Silk Technologies, Ltd. Silk-derived protein for treating inflammation
WO2018033792A2 (en) 2016-08-19 2018-02-22 Orasis Pharmaceuticals Ltd. Ophthalmic pharmaceutical compositions and uses relating thereto
US10980767B2 (en) 2016-09-09 2021-04-20 The Regents Of The University Of California Estrogen receptor ligands, compositions and methods related thereto
EP3510040A4 (en) 2016-09-09 2020-06-03 Calithera Biosciences, Inc. ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE
JP2019533643A (ja) 2016-09-14 2019-11-21 ヴァンダービルト ユニバーシティーVanderbilt University Bmpシグナル伝達の阻害、その化合物、組成物および使用
WO2018058029A1 (en) 2016-09-26 2018-03-29 Dana-Farber Cancer Institute, Inc. Chromobox protein inhibitors and uses thereof
AU2017356942A1 (en) 2016-11-08 2019-05-23 Calithera Biosciences, Inc. Arginase inhibitor combination therapies
ES2970715T3 (es) 2016-12-22 2024-05-30 Prec Pharmaceuticals Inc Composiciones y métodos para inhibir la actividad de la arginasa
CN110430880A (zh) 2017-01-18 2019-11-08 范德比尔特大学 作为选择性bmp抑制剂的稠合杂环化合物
MX2019010096A (es) 2017-02-24 2020-01-09 Merck Patent Gmbh Derivados de 1, 4, 6-trisustituidos-2-alquil-1h-benzo[d]imidazol como inhibidores de dihidroorotato oxigenasa.
WO2018209288A1 (en) 2017-05-12 2018-11-15 Massachusetts Institute Of Technology Argonaute protein-double stranded rna complexes and uses related thereto
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
WO2018223032A1 (en) 2017-06-02 2018-12-06 Stealth Biotherapeutics Corp. Crystalline salt forms of sbt-20
WO2019018539A1 (en) 2017-07-19 2019-01-24 California Institute Of Technology PROCESSES FOR PREPARING COMPOUNDS CONTAINING BIS-TETRAHYDROISOQUINOLINE
EA202090536A1 (ru) 2017-10-11 2020-07-22 Ориджен Дискавери Текнолоджис Лимитед Кристаллические формы 3-замещенного 1,2,4-оксадиазола
CN111372584A (zh) 2017-11-03 2020-07-03 奥瑞基尼探索技术有限公司 Tim-3和pd-1途径的双重抑制剂
EP3706798A1 (en) 2017-11-06 2020-09-16 Aurigene Discovery Technologies Limited Conjoint therapies for immunomodulation
AR113995A1 (es) 2017-12-22 2020-07-08 Medimmune Ltd Moduladores de molécula pequeña del domino de btb de keap1
US10745400B2 (en) 2018-03-14 2020-08-18 Vanderbuilt University Inhibition of BMP signaling, compounds, compositions and uses thereof
SG11202100429TA (en) 2018-07-27 2021-02-25 California Inst Of Techn Cdk inhibitors and uses thereof
AU2019336698A1 (en) 2018-09-05 2021-03-25 Aztherapies, Inc. Methods of treating cytokine release syndrome
CA3117695A1 (en) 2018-10-26 2020-04-30 Keros Therapeutics, Inc. Crystal forms of an alk2 inhibitor
US20220062222A1 (en) 2018-12-10 2022-03-03 The General Hospital Corporation Cromolyn esters and uses thereof
CN113574055B (zh) 2019-01-18 2024-07-23 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法
CN113573709A (zh) 2019-03-14 2021-10-29 阿斯利康(瑞典)有限公司 用于体重减轻的兰比斯特
CN113874375A (zh) 2019-06-03 2021-12-31 株式会社大分大学先端医学研究所 用于治疗狂犬病的环状酰胺化合物及其方法
CA3157798A1 (en) 2019-11-12 2021-05-20 Zhongli Gao 6-membered heteroarylaminosulfonamides for treating diseases and conditions mediated by deficient cftr activity
WO2021113809A1 (en) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides and methods of use thereof
WO2021113806A1 (en) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides and methods of use thereof
CN114901290A (zh) 2019-12-16 2022-08-12 蔚山科学技术院 抑制血管新生因子的化合物及其用途
EP4323356A1 (en) 2021-04-13 2024-02-21 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations
EP4396176A1 (en) 2021-09-03 2024-07-10 Genzyme Corporation Indole compounds and uses thereof in the treatement of cystic fibrosis
KR20240076791A (ko) 2021-09-03 2024-05-30 젠자임 코포레이션 인돌 화합물 및 사용 방법
IL311444A (en) 2021-10-01 2024-05-01 Nuvalent Inc Solid forms, pharmaceutical preparations and preparation of macrocyclic heteroaromatic ether compounds
KR20240095536A (ko) 2021-10-01 2024-06-25 뉴베일런트, 아이엔씨. 헤테로방향족 매크로사이클릭 에테르 화합물을 사용한 고형 종양의 치료 방법
TW202400608A (zh) 2022-04-07 2024-01-01 美商努法倫特公司 雜芳族巨環醚化合物之固體形式、醫藥組合物及製備
WO2023196910A1 (en) 2022-04-07 2023-10-12 Nuvalent, Inc Methods of treating solid tumor using (19r)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(24),2(6),4,8,11,13,15,17,21(25),22-decaen-22-amine
WO2024036097A1 (en) 2022-08-12 2024-02-15 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds and isotopologues thereof
WO2024036098A1 (en) 2022-08-12 2024-02-15 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds
WO2024086634A1 (en) 2022-10-19 2024-04-25 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1781701A (en) 1928-05-16 1930-11-18 Phillips Morris Godfrey Philip Machine for removing flags and other adhering leaf from the stalks of tobacco leaves
US3278447A (en) 1963-12-02 1966-10-11 Cloro Bac Products Inc Process for stabilizing chlorine dioxide solution
BE795970A (fr) 1972-02-29 1973-08-27 Pfizer Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US4089969A (en) 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4474787A (en) 1977-05-04 1984-10-02 Fisons Limited 7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and anti-allergic use thereof
JPS6056684B2 (ja) * 1977-11-07 1985-12-11 東興薬品工業株式会社 点眼剤
GB2013084B (en) * 1978-01-25 1982-07-28 Alcon Lab Inc Ophthalmic drug dosage
US4407792A (en) * 1979-05-09 1983-10-04 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
US4454151A (en) 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
GB8500310D0 (en) * 1985-01-07 1985-02-13 Leo Pharm Prod Ltd Pharmaceutical preparation
US6255299B1 (en) 1985-01-07 2001-07-03 Leo Pharmaceutical Products Ltd. Opthalmic gel composition and method of treating eye infections
IL80298A (en) 1986-10-14 1993-01-31 Res & Dev Co Ltd Eye drops
US5089509A (en) 1988-09-15 1992-02-18 Allergan, Inc. Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
US5414011A (en) 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
JPH0696542B2 (ja) 1987-09-11 1994-11-30 シンテックス(ユー・エス・エイ)インコーポレイテッド 眼用保存製剤およびその製法
US5110493A (en) * 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
US6174999B1 (en) 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5017229A (en) 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5527893A (en) * 1987-09-18 1996-06-18 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5705485A (en) * 1987-09-18 1998-01-06 Ethicon, Inc. Gel formulations containing growth factors
US4861514A (en) 1988-06-08 1989-08-29 The Drackett Company Compositions containing chlorine dioxide and their preparation
US5281591A (en) 1989-05-22 1994-01-25 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
CA2063576C (en) 1989-06-07 1994-01-25 Gail S. Bazzano Slow release vehicles for minimizing skin irritancy of topical compositions
US5045121A (en) 1989-06-21 1991-09-03 Gte Products Corporation Method for removing carbon from cemented tungsten carbide articles
US5112822A (en) * 1989-10-12 1992-05-12 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
US5077292A (en) * 1989-10-12 1991-12-31 Allergan, Inc. (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same
US5231096A (en) * 1989-10-12 1993-07-27 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5021416A (en) 1989-10-31 1991-06-04 Allergan, Inc. Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
US5215991A (en) 1990-01-26 1993-06-01 Allergan, Inc. Combination of selective alpha-adrenergic agonists and Na+ /H+ ex
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
IT1250691B (it) 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
US5460834A (en) 1991-12-13 1995-10-24 Alcon Laboratories, Inc. Combinations of polymers for use in physiological tear compositions
WO1993017664A1 (en) * 1992-03-02 1993-09-16 Alcon Laboratories, Inc. Combinations of cellulosic polymers and carboxy vinyl polymers and their use in pharmaceutical compositions
US5459133A (en) 1992-06-05 1995-10-17 Telor Ophthalmic Pharmaceuticals, Inc. Methods and products for treating presbyopia
AU4560493A (en) * 1992-07-06 1994-01-31 Hansen Transmissions International Nv Series of gear units
AU666957B2 (en) 1992-08-28 1996-02-29 Alcon Laboratories, Inc. Use of certain anionic surfactants to enhance antimicrobial effectiveness of ophthalmic compositions
US5688819A (en) 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5922773A (en) 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
US5382591A (en) 1992-12-17 1995-01-17 Sepracor Inc. Antipyretic and analgesic methods using optically pure R-ketorolac
US5648074A (en) 1993-05-25 1997-07-15 Allergan Compositions and methods for disinfecting contact lenses and reducing proteinaceous deposit formation
WO1995005803A1 (en) * 1993-08-20 1995-03-02 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
JP3683908B2 (ja) 1993-10-13 2005-08-17 アラーガン、インコーポレイテッド (2−イミダゾリン−2−イルアミノ)キノキサリン誘導体の使用方法
CA2134376C (en) * 1993-12-20 2001-10-23 Haresh G. Bhagat Combinations of polymers for use in physiological tear compositions
US6294202B1 (en) 1994-10-06 2001-09-25 Genzyme Corporation Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers
US5558876A (en) 1995-03-29 1996-09-24 Alcon Laboratories, Inc. Topical ophthalmic acidic drug formulations
IT1283911B1 (it) * 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US5807541A (en) 1996-04-22 1998-09-15 Sepracor, Inc. NSAID/fluoride periodontal compositions and methods
US5888493A (en) * 1996-12-05 1999-03-30 Sawaya; Assad S. Ophthalmic aqueous gel formulation and related methods
US5811446A (en) * 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US5858346A (en) 1997-05-09 1999-01-12 Allergan Compositions and methods for enhancing contact lens wearability
US6646001B2 (en) 1997-12-19 2003-11-11 Alcon Manufacturing, Ltd. Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
US6066671A (en) * 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
AU3886600A (en) 1999-03-15 2000-10-04 Trustees Of Boston University Angiogenesis inhibition
ITMI991453A1 (it) 1999-07-01 2001-01-01 Farmila Farma Milano Composizioni oftalmiche in forma di gel acquosi
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
JP4132599B2 (ja) * 2000-07-07 2008-08-13 日本板硝子株式会社 画像形成装置
RU2311928C2 (ru) 2000-07-14 2007-12-10 Аллерган Инк. Композиции, содержащие альфа-2-адренергические агонисты
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
US20020198210A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Alpha-2-adrenergic agonist/fatty acid compositions
TWI298257B (en) 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
US7045121B2 (en) * 2001-12-14 2006-05-16 Allergan, Inc. Ophthalmic compositions for lubricating eyes and methods for making and using same
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US20040224010A1 (en) 2002-11-15 2004-11-11 Optime Therapeutics, Inc. Ophthalmic liposome compositions and uses thereof
US8008338B2 (en) 2003-06-03 2011-08-30 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
TWI336257B (en) 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
WO2005014046A2 (en) 2003-08-07 2005-02-17 Allergan, Inc. Compositions for delivery of therapeutics into the eyes and methods for making and using the same
WO2005101982A2 (en) 2004-03-24 2005-11-03 Sun Pharmaceutical Industries Limited A stable ophthalmic composition
KR20070091682A (ko) 2004-12-23 2007-09-11 록스로 파마 인코퍼레이티드 케토롤락의 비내 투여용 치료 조성물
US20080039398A1 (en) 2006-01-25 2008-02-14 Ousler George W Iii Formulations and methods for treating dry eye
US20070299124A1 (en) 2006-01-25 2007-12-27 Ousler George W Iii Formulations and methods for treating dry eye
EP1981491A4 (en) 2006-01-25 2009-09-23 Aciex Inc COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DROUGHT
US20070287741A1 (en) 2006-06-13 2007-12-13 Uri Herzberg Compositions and methods for preventing or reducing postoperative ileus and gastric stasis in mammals
WO2008153746A1 (en) 2007-05-24 2008-12-18 Aciex Therapeutics, Inc. Formulations and methods for treating dry eye
US7842714B2 (en) 2008-03-03 2010-11-30 Allergan, Inc. Ketorolac tromethamine compositions for treating ocular pain
RU2543379C2 (ru) 2008-04-24 2015-02-27 Аллерган, Инк. Замещенные гамма-лактамы в качестве терапевтических агентов
US20080275118A1 (en) 2008-06-12 2008-11-06 Shaw Mari M Health and cosmetic composition and regime for stimulating hair growth and thickening on the head, including the scalp, eyelashes, and eyebrows, and which discourages hair loss

Also Published As

Publication number Publication date
US20210251961A1 (en) 2021-08-19
PL1654002T3 (pl) 2010-03-31
ES2593113T3 (es) 2016-12-05
ES2332049T5 (es) 2014-03-27
AU2004263149A1 (en) 2005-02-17
WO2005014046A2 (en) 2005-02-17
US8512717B2 (en) 2013-08-20
PL1654002T5 (pl) 2014-06-30
EP2113246B1 (en) 2016-06-22
US20050031697A1 (en) 2005-02-10
EP2113246A1 (en) 2009-11-04
EP1654002B2 (en) 2014-01-29
EP1654002B1 (en) 2009-10-07
US20150164863A1 (en) 2015-06-18
JP2007501799A (ja) 2007-02-01
BRPI0413381A (pt) 2006-10-17
CA2534484A1 (en) 2005-02-17
WO2005014046A3 (en) 2006-06-01
US8992952B2 (en) 2015-03-31
EP1654002A2 (en) 2006-05-10
ATE444732T1 (de) 2009-10-15
DK1654002T4 (da) 2014-02-17
AU2004263149B2 (en) 2010-08-19
DE602004023516D1 (de) 2009-11-19
ES2332049T3 (es) 2010-01-25
US20130296396A1 (en) 2013-11-07

Similar Documents

Publication Publication Date Title
DK1654002T3 (da) Sammensætninger til fremføring af terapeutiske midler til øjnene og fremgangsmåder og anvendelser deraf
WO2006039467A3 (en) Biomedical devices containing amphiphilic block copolymers
AR070855A1 (es) Lentes de contacto rotacionalmente estabilizados y los metodos para su diseno
DE69943051D1 (de) Augentropfen enthaltend Ketotifen
WO2005002520A3 (en) Ophthalmic compositions for treating ocular hypertension
DE60334385D1 (de) Optisches Implantat für die Hornhaut
IS7215A (is) Aðferðir til að meðhöndla nýæðarsjúkdóma í augum
DK1553953T3 (da) Fremgangsmåde og præparat omfattende latanoprost til behandling af okulær hypertension og glaucom
MXPA05013290A (es) Composiciones oftalmicas que contienen una combinacion sinergistica de dos polimeros.
BRPI0512858A (pt) dispositivo de inserção de lente oftalmológica
DK1404324T4 (da) Prolægemidler af GABA analoger, sammensætninger og anvendelser deraf
ATE540332T1 (de) Augenoptische linsen
AU2001298057A8 (en) Extended depth field optics for human vision
WO2006105403A3 (en) Treatment of eye disorders with sirtuin modulators
FR2891375B1 (fr) Lentille ophtalmique polarisante adaptee au comportement oeil/tete d'un porteur.
CY1117666T1 (el) 4-((ΦΑΙΝΟΞΥΑΛΚΥΛΟ)ΘΕΙΟ)-ΦΑΙΝΟΞΥΟΞΙΚΑ ΟΞΕΑ ΓΙΑ ΧΡΗΣΗ ΣΤΗΝ ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ PPARδ ΔΙΑΜΕΣΟΛΑΒΟΥΜΕΝΩΝ ΠΑΘΗΣΕΩΝ
BRPI0406879A (pt) Dispositivo de liberação sustentada e método para a liberação ocular de agentes adrenérgicos
DOP2003000747A (es) Composiciones oftalmicas para el tratamiento de la hipertension ocular
WO2004043354A3 (en) Ophthalmic compositions for treating ocular hypertension
HK1063601A1 (en) Compositions and methods for treating hyperimmune response in the eye
EP1251862A4 (en) ORTHALMOLOGICAL COMPOSITIONS FOR THE TREATMENT OF OCULAR HYPERTENSION
PE20070102A1 (es) Amidas sustituidas con heteroarilo que comprenden un grupo enlazador saturado como moduladores de la oxido nitrico sintasa
WO2004031839A3 (en) Eyecup for glasses
EP1482922A4 (en) AGENTS FOR CORNEAL OR INTRASTROMAL ADMINISTRATION FOR TREATING OR PREVENTING OCULAR DISORDERS
MY128882A (en) Novel use of substituted aminomethyl chromans