DOP2003000747A - Composiciones oftalmicas para el tratamiento de la hipertension ocular - Google Patents
Composiciones oftalmicas para el tratamiento de la hipertension ocularInfo
- Publication number
- DOP2003000747A DOP2003000747A DO2003000747A DO2003000747A DOP2003000747A DO P2003000747 A DOP2003000747 A DO P2003000747A DO 2003000747 A DO2003000747 A DO 2003000747A DO 2003000747 A DO2003000747 A DO 2003000747A DO P2003000747 A DOP2003000747 A DO P2003000747A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- treatment
- eye
- ophthalmic compositions
- eye hypertension
- compounds
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 206010020772 Hypertension Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 102000004257 Potassium Channel Human genes 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000004406 elevated intraocular pressure Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 108020001213 potassium channel Proteins 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Esta invención se relaciona con compuestos potentes bloqueadores del canal de potasio de formula I o una formulación de ellos para el tratamiento del glaucoma y otras condiciones las cuales conducen a elevar la presión intraocular en el ojo de un paciente. Estas invención tambien se relaciona con el uso de tales compuestos para dar un efecto neuroprotector al ojo de especies mamíferas, particularmente humanos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42480802P | 2002-11-08 | 2002-11-08 | |
US50009103P | 2003-09-04 | 2003-09-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2003000747A true DOP2003000747A (es) | 2004-05-31 |
Family
ID=32314559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2003000747A DOP2003000747A (es) | 2002-11-08 | 2003-11-07 | Composiciones oftalmicas para el tratamiento de la hipertension ocular |
Country Status (22)
Country | Link |
---|---|
US (2) | US7196082B2 (es) |
EP (1) | EP1562909B1 (es) |
JP (2) | JP4456072B2 (es) |
KR (1) | KR20050072805A (es) |
AR (1) | AR041991A1 (es) |
AU (2) | AU2003287506B8 (es) |
BR (1) | BR0316040A (es) |
CA (1) | CA2505086C (es) |
CL (1) | CL2003002293A1 (es) |
DO (1) | DOP2003000747A (es) |
EC (1) | ECSP055781A (es) |
HR (1) | HRP20050409A2 (es) |
IS (1) | IS7822A (es) |
MA (1) | MA27497A1 (es) |
MX (1) | MXPA05004889A (es) |
NO (1) | NO20052751L (es) |
NZ (1) | NZ539593A (es) |
PE (1) | PE20040692A1 (es) |
PL (1) | PL377172A1 (es) |
RU (1) | RU2005117627A (es) |
TW (1) | TWI250873B (es) |
WO (2) | WO2004043932A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040028469A (ko) | 2002-09-30 | 2004-04-03 | 엘지전자 주식회사 | 1 회 기록 가능한 광디스크의 디펙트 영역 관리방법 |
US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
KR20060090801A (ko) * | 2003-09-04 | 2006-08-16 | 머크 앤드 캄파니 인코포레이티드 | 고안압증 치료용 안용 조성물 |
CN1988903A (zh) * | 2004-07-20 | 2007-06-27 | 默克公司 | 用于治疗高眼压症的眼用组合物 |
EP1647549A1 (en) | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents |
ATE542800T1 (de) * | 2006-01-31 | 2012-02-15 | Array Biopharma Inc | Kinasehemmer und ihre anwendungsverfahren |
AU2007227664A1 (en) * | 2006-03-13 | 2007-09-27 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
JP5255559B2 (ja) * | 2006-03-31 | 2013-08-07 | アボット・ラボラトリーズ | インダゾール化合物 |
EP2352501B1 (en) * | 2008-11-03 | 2014-01-01 | ChemoCentryx, Inc. | Compounds for use in the treatment of osteoporosis |
WO2012071369A2 (en) | 2010-11-24 | 2012-05-31 | The Trustees Of Columbia University In The City Of New York | A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease |
US9333202B2 (en) | 2012-05-01 | 2016-05-10 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease |
US9944644B2 (en) | 2013-03-14 | 2018-04-17 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles their preparation and use |
US9637450B2 (en) | 2013-03-14 | 2017-05-02 | The Trustees Of Columbia University In The City Of New York | Octahydrocyclopentapyrroles, their preparation and use |
US9938291B2 (en) | 2013-03-14 | 2018-04-10 | The Trustess Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
EP3495357B1 (en) * | 2013-03-14 | 2021-05-05 | The Trustees of Columbia University in the City of New York | 4-phenylpiperidines, their preparation and use |
CA2947174C (en) | 2014-04-30 | 2023-02-28 | The Trustees Of Columbia University In The City Of New York | Substituted 4-phenylpiperidines, their preparaiton and use |
CN104211638A (zh) * | 2014-08-13 | 2014-12-17 | 李增 | 一种脂肪氨基取代的芸香碱类衍生物及其制备和作为抗阿尔兹海默症的药物中的应用 |
EP3402780A1 (en) | 2016-01-14 | 2018-11-21 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2534580A1 (fr) * | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
US5151444B1 (en) * | 1987-09-18 | 1999-07-06 | R Tech Ueno Ltd | Ocular hypotensive agents |
AU3693789A (en) | 1988-05-10 | 1989-11-29 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | New ophthalmic preparation for treating glaucoma |
EP0569046B1 (en) * | 1988-09-06 | 2002-11-13 | Pharmacia Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
US5296504A (en) * | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
US5922773A (en) | 1992-12-04 | 1999-07-13 | The Children's Medical Center Corp. | Glaucoma treatment |
FR2701026B1 (fr) * | 1993-02-02 | 1995-03-31 | Adir | Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
JP3208210B2 (ja) * | 1993-03-17 | 2001-09-10 | 旭化成株式会社 | 結晶性芳香族ポリカーボネートプレポリマーの製造方法及び芳香族ポリカーボネートの製造方法 |
EP0724443A4 (en) | 1993-06-08 | 1997-09-10 | Vide Pharmaceuticals | METHOD AND PREPARATIONS FOR LOWERING THE EYE PRESSURE |
US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
US5573758A (en) | 1995-04-28 | 1996-11-12 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers |
AP2001002304A0 (en) * | 1996-05-03 | 2001-12-31 | Pfizer | Substituted indazole derivatives and related compounds |
US5925342A (en) * | 1996-11-13 | 1999-07-20 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers |
GB2321455A (en) * | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Lipophilic derivatives of biologically active compounds |
WO2000015608A1 (en) | 1998-09-14 | 2000-03-23 | Ono Pharmaceutical Co., Ltd. | φ-SUBSTITUTED PHENYL-PROSTAGLANDIN E DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT |
MXPA02006322A (es) | 1999-12-22 | 2002-12-13 | Pfizer Prod Inc | Agonistas selectivos del receptor ep4 en el tratamiento de la osteoporosis. |
EP1251862B1 (en) | 2000-01-18 | 2008-10-01 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
KR20030095183A (ko) | 2000-03-17 | 2003-12-18 | 알콘, 인코퍼레이티드 | 녹내장 치료용 5-하이드록시 인다졸 유도체 |
AU2001216072A1 (en) | 2000-03-17 | 2001-10-03 | Alcon, Inc. | 6-hydroxy-indazole derivatives for treating glaucoma |
US6956036B1 (en) * | 2000-03-17 | 2005-10-18 | Alcon, Inc. | 6-hydroxy-indazole derivatives for treating glaucoma |
CN1366458A (zh) | 2000-03-31 | 2002-08-28 | 东丽株式会社 | 毛发生长和毛发形成调节剂 |
WO2002024647A1 (fr) | 2000-09-21 | 2002-03-28 | Ono Pharmaceutical Co., Ltd. | Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine |
ATE374182T1 (de) | 2000-11-27 | 2007-10-15 | Pfizer Prod Inc | Selektive agonisten des ep4 rezeptors für die behandlung von osteoporose |
FR2827861B1 (fr) | 2001-07-27 | 2004-04-02 | Aventis Pharma Sa | Derives des indazoles ou des indoles, leur utilisation en medecine humaine et plus particulierement en cancerologie |
-
2003
- 2003-10-14 US US10/684,990 patent/US7196082B2/en active Active
- 2003-11-03 TW TW092130678A patent/TWI250873B/zh not_active IP Right Cessation
- 2003-11-04 AR ARP030104032A patent/AR041991A1/es not_active Application Discontinuation
- 2003-11-04 AU AU2003287506A patent/AU2003287506B8/en not_active Ceased
- 2003-11-04 BR BR0316040-8A patent/BR0316040A/pt not_active IP Right Cessation
- 2003-11-04 MX MXPA05004889A patent/MXPA05004889A/es unknown
- 2003-11-04 PL PL377172A patent/PL377172A1/pl not_active Application Discontinuation
- 2003-11-04 KR KR1020057008142A patent/KR20050072805A/ko not_active Application Discontinuation
- 2003-11-04 EP EP03781747A patent/EP1562909B1/en not_active Expired - Lifetime
- 2003-11-04 WO PCT/US2003/035078 patent/WO2004043932A1/en active Application Filing
- 2003-11-04 AU AU2003286884A patent/AU2003286884A1/en not_active Abandoned
- 2003-11-04 NZ NZ539593A patent/NZ539593A/en unknown
- 2003-11-04 WO PCT/US2003/035080 patent/WO2004043933A1/en not_active Application Discontinuation
- 2003-11-04 CA CA002505086A patent/CA2505086C/en not_active Expired - Fee Related
- 2003-11-04 RU RU2005117627/04A patent/RU2005117627A/ru not_active Application Discontinuation
- 2003-11-04 JP JP2005507086A patent/JP4456072B2/ja not_active Expired - Fee Related
- 2003-11-05 PE PE2003001115A patent/PE20040692A1/es not_active Application Discontinuation
- 2003-11-07 DO DO2003000747A patent/DOP2003000747A/es unknown
- 2003-11-07 CL CL200302293A patent/CL2003002293A1/es unknown
-
2005
- 2005-04-25 IS IS7822A patent/IS7822A/is unknown
- 2005-05-06 EC EC2005005781A patent/ECSP055781A/es unknown
- 2005-05-06 HR HR20050409A patent/HRP20050409A2/hr not_active Application Discontinuation
- 2005-06-07 MA MA28316A patent/MA27497A1/fr unknown
- 2005-06-07 NO NO20052751A patent/NO20052751L/no unknown
-
2006
- 2006-12-19 US US11/641,212 patent/US7547720B2/en not_active Expired - Lifetime
-
2009
- 2009-08-24 JP JP2009192691A patent/JP5061293B2/ja not_active Expired - Fee Related
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