MA27497A1 - Compositions ophtalmiques pour le traitement de l'hypertension oculaire. - Google Patents

Compositions ophtalmiques pour le traitement de l'hypertension oculaire.

Info

Publication number
MA27497A1
MA27497A1 MA28316A MA28316A MA27497A1 MA 27497 A1 MA27497 A1 MA 27497A1 MA 28316 A MA28316 A MA 28316A MA 28316 A MA28316 A MA 28316A MA 27497 A1 MA27497 A1 MA 27497A1
Authority
MA
Morocco
Prior art keywords
agent
eye
treatment
vagomimetic
compounds
Prior art date
Application number
MA28316A
Other languages
English (en)
Inventor
James B Doherty
Meng-Hsin Chen
Luping Liu
Swaminathan R Natarajan
Robert M Tynebor
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MA27497A1 publication Critical patent/MA27497A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Abstract

sous forme de solution ou suspension et contenant facultativement de la gomme xanthane ou de la gomme gellane. 11. Une composition conformément à la Revendication 9 oé un ingrédient actif appartient à la famille consistant de: agent bloquant adrénolytique-(beta), agent para-vagomimétique, agent vagomimétique, inhibiteur de l'anhydrase carbonique, agoniste EP4, une prostaglandine ou un dérivé de celle-ci, lipide hypotenseur, neuroprotecteur, et/ou un agoniste du récepteur 5-HT2 est ajouté. L'invention concerne des composés puissants de blocage du canal de potassium de formule I ou une préparation correspondante destinée au traitement de glaucome ou d'autres troubles qui débouchent sur une pression intraoculaire élevée dans l'oeil d'un patient. Cette invention a aussi trait à l'utilisation de tels composés de manière à engendrer un effet neuroprotecteur destiné à l'oeil d'espèces mammaliennes, notamment, des êtres humains
MA28316A 2002-11-08 2005-06-07 Compositions ophtalmiques pour le traitement de l'hypertension oculaire. MA27497A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42480802P 2002-11-08 2002-11-08
US50009103P 2003-09-04 2003-09-04

Publications (1)

Publication Number Publication Date
MA27497A1 true MA27497A1 (fr) 2005-08-01

Family

ID=32314559

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28316A MA27497A1 (fr) 2002-11-08 2005-06-07 Compositions ophtalmiques pour le traitement de l'hypertension oculaire.

Country Status (22)

Country Link
US (2) US7196082B2 (fr)
EP (1) EP1562909B1 (fr)
JP (2) JP4456072B2 (fr)
KR (1) KR20050072805A (fr)
AR (1) AR041991A1 (fr)
AU (2) AU2003287506B8 (fr)
BR (1) BR0316040A (fr)
CA (1) CA2505086C (fr)
CL (1) CL2003002293A1 (fr)
DO (1) DOP2003000747A (fr)
EC (1) ECSP055781A (fr)
HR (1) HRP20050409A2 (fr)
IS (1) IS7822A (fr)
MA (1) MA27497A1 (fr)
MX (1) MXPA05004889A (fr)
NO (1) NO20052751L (fr)
NZ (1) NZ539593A (fr)
PE (1) PE20040692A1 (fr)
PL (1) PL377172A1 (fr)
RU (1) RU2005117627A (fr)
TW (1) TWI250873B (fr)
WO (2) WO2004043932A1 (fr)

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Publication number Priority date Publication date Assignee Title
KR20040028469A (ko) 2002-09-30 2004-04-03 엘지전자 주식회사 1 회 기록 가능한 광디스크의 디펙트 영역 관리방법
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
CN1845904A (zh) * 2003-09-04 2006-10-11 默克公司 用于治疗高眼压的眼用组合物
AU2005274972A1 (en) * 2004-07-20 2006-02-23 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
EP1647549A1 (fr) * 2004-10-14 2006-04-19 Laboratoire Theramex Indazoles, benzisoxazoles et benzisothiazoles en tant qu'agents oestrogéniques
JP5131990B2 (ja) * 2006-01-31 2013-01-30 アレイ バイオファーマ、インコーポレイテッド キナーゼ阻害剤およびその使用方法
EP2004193A2 (fr) * 2006-03-13 2008-12-24 Merck & Co., Inc. Compositions ophtalmiques pour le traitement de l'hypertension oculaire
JP5255559B2 (ja) * 2006-03-31 2013-08-07 アボット・ラボラトリーズ インダゾール化合物
AU2009308687A1 (en) * 2008-11-03 2010-05-06 Chemocentryx, Inc. Compounds for the treatment of osteoporosis and cancers
US8980924B2 (en) 2010-11-24 2015-03-17 The Trustees Of Columbia University In The City Of New York Non-retinoid RBP4 antagonist for treatment of age-related macular degeneration and stargardt disease
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
US9944644B2 (en) 2013-03-14 2018-04-17 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles their preparation and use
US10273243B2 (en) 2013-03-14 2019-04-30 The Trustees Of Columbia University In The City Of New York 4-phenylpiperidines, their preparation and use
ES2700541T3 (es) 2013-03-14 2019-02-18 Univ Columbia Octahidrociclopentapirroles, su preparación y uso
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
WO2015168286A1 (fr) 2014-04-30 2015-11-05 The Trustees Of Columbia University In The City Of New York 4-phénylepipéridines substituées, leur préparation et utilisation
CN104211638A (zh) * 2014-08-13 2014-12-17 李增 一种脂肪氨基取代的芸香碱类衍生物及其制备和作为抗阿尔兹海默症的药物中的应用
CA3010615C (fr) 2016-01-14 2024-02-20 Beth Israel Deaconess Medical Center, Inc. Modulateurs de mastocytes et leurs utilisations

Family Cites Families (25)

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Publication number Priority date Publication date Assignee Title
FR2534580A1 (fr) 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
US5151444B1 (en) 1987-09-18 1999-07-06 R Tech Ueno Ltd Ocular hypotensive agents
WO1989010757A1 (fr) 1988-05-10 1989-11-16 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis Nouvelle preparation ophtalmique pour le traitement de glaucomes
US5296504A (en) 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
WO1990002553A1 (fr) 1988-09-06 1990-03-22 Pharmacia Ab Derives de prostaglandine servant au traitement des glaucomes ou de l'hypertension oculaire
US5352708A (en) 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5922773A (en) 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
FR2701026B1 (fr) 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
JP3208210B2 (ja) * 1993-03-17 2001-09-10 旭化成株式会社 結晶性芳香族ポリカーボネートプレポリマーの製造方法及び芳香族ポリカーボネートの製造方法
CA2164733A1 (fr) 1993-06-08 1994-12-22 Nino Sorgente Methodes et compositions pour abaisser la pression intraoculaire
US5510383A (en) 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US5573758A (en) 1995-04-28 1996-11-12 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
US5925342A (en) 1996-11-13 1999-07-20 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
GB2321455A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Lipophilic derivatives of biologically active compounds
WO2000015608A1 (fr) 1998-09-14 2000-03-23 Ono Pharmaceutical Co., Ltd. Derives e de phenyl-prostaglandine a substitution-φ et medicaments les contenant comme ingredient actif
AU1293101A (en) 1999-12-22 2001-07-03 Pfizer Products Inc. Ep4 receptor selective agonists in the treatment of osteoporosis
ATE409491T1 (de) 2000-01-18 2008-10-15 Merck & Co Inc Orhthalmologische zusammenstellungen zur behandlung von ocularer hypertension
KR20030065304A (ko) 2000-03-17 2003-08-06 알콘, 인코퍼레이티드 녹내장 치료용 6-하이드록시-인다졸 유도체
US6956036B1 (en) * 2000-03-17 2005-10-18 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
MXPA02008825A (es) 2000-03-17 2004-10-15 Alcon Inc Derivados 5-hidroxi indazol para tratamiento de glaucoma.
EP1186287A1 (fr) 2000-03-31 2002-03-13 Toray Industries, Inc. Agents de regulation de la pousse du cheveu ou de sa formation
WO2002024647A1 (fr) 2000-09-21 2002-03-28 Ono Pharmaceutical Co., Ltd. Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine
CA2429850C (fr) 2000-11-27 2008-12-30 Pfizer Products Inc. Agonistes selectifs au recepteur ep4 dans le traitement de l'osteoporose
FR2827861B1 (fr) 2001-07-27 2004-04-02 Aventis Pharma Sa Derives des indazoles ou des indoles, leur utilisation en medecine humaine et plus particulierement en cancerologie

Also Published As

Publication number Publication date
KR20050072805A (ko) 2005-07-12
JP5061293B2 (ja) 2012-10-31
EP1562909B1 (fr) 2012-06-27
US20040097575A1 (en) 2004-05-20
CA2505086C (fr) 2009-08-25
AU2003287506A1 (en) 2004-06-03
CA2505086A1 (fr) 2004-05-27
AU2003286884A1 (en) 2004-06-03
DOP2003000747A (es) 2004-05-31
AU2003287506B2 (en) 2009-04-23
IS7822A (is) 2005-04-25
JP2006508190A (ja) 2006-03-09
NZ539593A (en) 2006-12-22
RU2005117627A (ru) 2006-01-20
AR041991A1 (es) 2005-06-08
PE20040692A1 (es) 2004-10-08
US7196082B2 (en) 2007-03-27
PL377172A1 (pl) 2006-01-23
TWI250873B (en) 2006-03-11
HRP20050409A2 (en) 2006-02-28
BR0316040A (pt) 2005-09-13
US7547720B2 (en) 2009-06-16
CL2003002293A1 (es) 2005-01-14
AU2003287506B8 (en) 2009-05-28
ECSP055781A (es) 2005-09-20
WO2004043933A1 (fr) 2004-05-27
NO20052751D0 (no) 2005-06-07
MXPA05004889A (es) 2005-07-22
EP1562909A1 (fr) 2005-08-17
TW200501949A (en) 2005-01-16
US20070129418A1 (en) 2007-06-07
JP2010006825A (ja) 2010-01-14
WO2004043932A1 (fr) 2004-05-27
JP4456072B2 (ja) 2010-04-28
NO20052751L (no) 2005-06-07

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