WO2002024647A1 - Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine - Google Patents

Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine Download PDF

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Publication number
WO2002024647A1
WO2002024647A1 PCT/JP2001/008176 JP0108176W WO0224647A1 WO 2002024647 A1 WO2002024647 A1 WO 2002024647A1 JP 0108176 W JP0108176 W JP 0108176W WO 0224647 A1 WO0224647 A1 WO 0224647A1
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disease
syndrome
active ingredient
diseases
receptor agonists
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PCT/JP2001/008176
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English (en)
Japanese (ja)
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Tohru Maruyama
Kaoru Kobayashi
Takayuki Maruyama
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Ono Pharmaceutical Co., Ltd.
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Priority to AU2001290250A priority Critical patent/AU2001290250A1/en
Publication of WO2002024647A1 publication Critical patent/WO2002024647A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

L'invention porte sur des agonistes du récepteur de l'EP4 comprenant comme principe actif des dérivés de la 8-azaprostaglandine de formule générale (I) dont les symboles sont définis dans la description. Les composés de formule générale (I) sont utilisables à titre préventif ou curatif comme remèdes contre les maladies immunitaires, l'asthme, les troubles associés à une décroissance de la masse osseuse, la mort des cellules nerveuses, les lésions des poumons, la fibrose pulmonaire, l'emphysème pulmonaire, la bronchite, la broncho-pneumopathie chronique, les lésions du foie, l'hépatite aiguë, les néphrites, l'insuffisance rénale, l'hypertension, l'ischémie du myocarde, le syndrome inflammatoire systémique, les sepsies, le syndrome hémophage, le syndrome d'activation des macrophages, la maladie de Still, la maladie de Kawasaki, les brûlures, le granulaume systémique, la colite ulcéreuse, la maladie de Crohn, l'hypercytokinémie en dialyse, les insuffisances multiorganiques, les chocs, les ulcères digestifs, les stomatites, les troubles du sommeil, et les thromboses; ou comme promoteurs de l'ostéogenèse.
PCT/JP2001/008176 2000-09-21 2001-09-20 Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine WO2002024647A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001290250A AU2001290250A1 (en) 2000-09-21 2001-09-20 Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-286696 2000-09-21
JP2000286696 2000-09-21

Publications (1)

Publication Number Publication Date
WO2002024647A1 true WO2002024647A1 (fr) 2002-03-28

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PCT/JP2001/008176 WO2002024647A1 (fr) 2000-09-21 2001-09-20 Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine

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AU (1) AU2001290250A1 (fr)
WO (1) WO2002024647A1 (fr)

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003074483A1 (fr) * 2002-03-05 2003-09-12 Ono Pharmaceutical Co., Ltd. Composes derives de 8 azaprostaglandine et medicaments contenant ceux-ci comme principe actif
WO2003077910A1 (fr) * 2002-03-18 2003-09-25 Pfizer Products Inc. Procedes de traitement au moyen d'agonistes selectifs du recepteur ep4
WO2003103772A1 (fr) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co. Derives de pyrrolid-2-one 1,5 disubstitues utilises comme agonistes de recepteur ep4 pour traiter des maladies oculaires telles que le glaucome
WO2003103664A1 (fr) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co. Derives d'imidazolidine-2-one disubstitues en 1,5 utiles en tant qu'agonistes du recepteur ep4 dans le traitement de troubles oculaires et de maladies osseuses
US6734206B1 (en) 2003-06-02 2004-05-11 Allergan, Inc. 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure
US6734201B1 (en) 2003-06-02 2004-05-11 Allergan, Inc. 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents
WO2004037786A3 (fr) * 2002-10-25 2004-09-30 Merck Frosst Canada Inc Agonistes des recepteurs ep4
US6849657B2 (en) 2001-07-16 2005-02-01 Syntex (U.S.A.) Llc 2-pyrrolidone derivatives as prostanoid agonists
US6900336B2 (en) 2001-07-16 2005-05-31 Syntex (U.S.A.) Llc 8-aza-11-deoxy prostaglandin analogues
US6906097B2 (en) 2002-05-14 2005-06-14 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
EP1586564A1 (fr) * 2003-01-21 2005-10-19 Ono Pharmaceutical Co., Ltd. Derives de 8-azaprostalangine et utilisations de ces derives en tant que medicaments
US7053085B2 (en) 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
WO2007017687A2 (fr) 2005-08-09 2007-02-15 Asterand Uk Limited Agonistes des recepteurs ep2
US7196082B2 (en) 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
WO2007064664A2 (fr) * 2005-11-30 2007-06-07 Allergan, Inc. Procedes therapeutiques mettant en oeuvre des composants agonistes ep4 de prostaglandine
US7276531B2 (en) 2003-03-03 2007-10-02 Applied Research Systems Ars Holding N.V. G-lactam derivatives as prostaglandin agonists
US7326732B2 (en) 2004-02-12 2008-02-05 Pharmagene Laboratories Limited EP2 receptor agonists
US7410992B2 (en) 2003-09-04 2008-08-12 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7419999B2 (en) 2002-06-10 2008-09-02 Applied Research Systems Ars Holding N.V. Gamma lactams as prostaglandin agonists and use thereof
US7465755B2 (en) 2003-07-18 2008-12-16 Laboratoires Serono Sa Hydrazide derivatives as prostaglandin receptors modulators
US7494983B2 (en) 2003-09-04 2009-02-24 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7528163B2 (en) 2002-11-08 2009-05-05 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7531533B2 (en) 2005-01-27 2009-05-12 Asahi Kasei Pharma Corporation 6-Membered heterocyclic compound and use thereof
US7563816B2 (en) 2004-07-20 2009-07-21 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7576122B2 (en) 2003-09-02 2009-08-18 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7608637B2 (en) 2001-07-23 2009-10-27 Ono Pharmaceutical Co., Ltd. Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as the active ingredient
JP2010047580A (ja) * 2003-01-10 2010-03-04 F Hoffmann La Roche Ag プロスタグランジンアゴニストとしての２−ピペリドン誘導体
US7696243B2 (en) 2004-12-06 2010-04-13 Merck Serono, S.A. Pyrrolidin-2-one derivatives for use as DP1 receptor agonists
WO2010113957A1 (fr) 2009-03-30 2010-10-07 宇部興産株式会社 Composition pharmaceutique pour la prévention ou le traitement du glaucome
CN101133037B (zh) * 2005-01-27 2012-05-09 旭化成制药株式会社 六元杂环化合物及其用途
US8648097B2 (en) 2008-03-12 2014-02-11 Ube Industries, Ltd. Pyridylaminoacetic acid compound
US9180116B2 (en) 2012-07-19 2015-11-10 Cayman Chemical Company, Inc. Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
US9394520B2 (en) 2006-12-08 2016-07-19 University Of Rochester Expansion of hematopoietic stem cells
WO2016199111A1 (fr) 2015-06-12 2016-12-15 Simon Fraser University Composés agoniste d'ep4-bisphosphonate à liaison amide et leurs utilisations
US9611284B2 (en) 2010-05-28 2017-04-04 Simon Fraser University Prostaglandin-bisphosphonate conjugate compounds, methods of making same, and uses thereof
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
US9676712B2 (en) 2013-03-15 2017-06-13 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
US9688627B2 (en) 2013-03-15 2017-06-27 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
WO2019131582A1 (fr) 2017-12-25 2019-07-04 旭化成ファーマ株式会社 Composé cyclique à six chaînons contenant de l'azote
US10729810B2 (en) 2013-07-19 2020-08-04 Cayman Chemical Company, Inc Methods, systems, and compositions for promoting bone growth

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JPH10265454A (ja) * 1997-01-27 1998-10-06 Ono Pharmaceut Co Ltd ３，７−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤
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Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
JPS525764A (en) * 1975-06-27 1977-01-17 Hoechst Ag Production of pyrrolidone
JPS52133975A (en) * 1976-05-04 1977-11-09 Hoechst Ag Pyrrolidones and their preparation
JPS5321159A (en) * 1976-08-06 1978-02-27 Pfizer 1*55disubstitutedd22pyrrolidones
JPS5754166A (en) * 1980-08-11 1982-03-31 Du Pont 88azaa16 166jifuruorupurosutanoido
JPH10265454A (ja) * 1997-01-27 1998-10-06 Ono Pharmaceut Co Ltd ３，７−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤
JP2001233792A (ja) * 2000-01-31 2001-08-28 Pfizer Prod Inc 急性及び慢性腎不全の処置のためのプロスタグランジン（ｐｇｅ２）受容体４（ｅｐ４）選択的アゴニストの使用

Cited By (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900336B2 (en) 2001-07-16 2005-05-31 Syntex (U.S.A.) Llc 8-aza-11-deoxy prostaglandin analogues
US6849657B2 (en) 2001-07-16 2005-02-01 Syntex (U.S.A.) Llc 2-pyrrolidone derivatives as prostanoid agonists
US8207223B2 (en) 2001-07-23 2012-06-26 Ono Pharmaceutical Co., Ltd. Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as active ingredient
US7608637B2 (en) 2001-07-23 2009-10-27 Ono Pharmaceutical Co., Ltd. Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as the active ingredient
JP2012111767A (ja) * 2001-07-23 2012-06-14 Ono Pharmaceut Co Ltd Ｅｐ４アゴニストを有効成分とする骨量低下疾患の治療剤
WO2003074483A1 (fr) * 2002-03-05 2003-09-12 Ono Pharmaceutical Co., Ltd. Composes derives de 8 azaprostaglandine et medicaments contenant ceux-ci comme principe actif
US8026273B2 (en) 2002-03-05 2011-09-27 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient
US7402605B2 (en) 2002-03-05 2008-07-22 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
US7683094B2 (en) 2002-03-05 2010-03-23 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient
WO2003077910A1 (fr) * 2002-03-18 2003-09-25 Pfizer Products Inc. Procedes de traitement au moyen d'agonistes selectifs du recepteur ep4
JP2005530796A (ja) * 2002-05-14 2005-10-13 アラーガン、インコーポレイテッド 眼圧降下剤としての８−アザプロスタグランジン類似体
US6906097B2 (en) 2002-05-14 2005-06-14 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
JP2011116768A (ja) * 2002-05-14 2011-06-16 Allergan Inc 眼圧降下剤としての８−アザプロスタグランジン類似体
US20130317013A1 (en) * 2002-06-06 2013-11-28 Xavier Billot Ep4 receptor agonist, compositions and methods thereof
JP2005537235A (ja) * 2002-06-06 2005-12-08 メルク フロスト カナダ アンド カンパニー Ｅｐ４受容体作動薬、組成物及びその方法
JP4766875B2 (ja) * 2002-06-06 2011-09-07 メルク フロスト カナダ リミテツド Ｅｐ４受容体作動薬、組成物及びその方法
WO2003103664A1 (fr) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co. Derives d'imidazolidine-2-one disubstitues en 1,5 utiles en tant qu'agonistes du recepteur ep4 dans le traitement de troubles oculaires et de maladies osseuses
WO2003103772A1 (fr) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co. Derives de pyrrolid-2-one 1,5 disubstitues utilises comme agonistes de recepteur ep4 pour traiter des maladies oculaires telles que le glaucome
US7419999B2 (en) 2002-06-10 2008-09-02 Applied Research Systems Ars Holding N.V. Gamma lactams as prostaglandin agonists and use thereof
WO2004037786A3 (fr) * 2002-10-25 2004-09-30 Merck Frosst Canada Inc Agonistes des recepteurs ep4
US7196082B2 (en) 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7547720B2 (en) 2002-11-08 2009-06-16 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7528163B2 (en) 2002-11-08 2009-05-05 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7238710B2 (en) 2002-12-04 2007-07-03 Merck Frosst Canada, Ltd. EP4 receptor agonist, compositions and methods thereof
JP2010047580A (ja) * 2003-01-10 2010-03-04 F Hoffmann La Roche Ag プロスタグランジンアゴニストとしての２−ピペリドン誘導体
EP1586564A4 (fr) * 2003-01-21 2008-04-30 Ono Pharmaceutical Co Derives de 8-azaprostalangine et utilisations de ces derives en tant que medicaments
EP1586564A1 (fr) * 2003-01-21 2005-10-19 Ono Pharmaceutical Co., Ltd. Derives de 8-azaprostalangine et utilisations de ces derives en tant que medicaments
US7276531B2 (en) 2003-03-03 2007-10-02 Applied Research Systems Ars Holding N.V. G-lactam derivatives as prostaglandin agonists
USRE42562E1 (en) 2003-03-26 2011-07-19 Merck Frosst Canada EP4 receptor agonist, compositions and methods thereof
US7053085B2 (en) 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
US6812240B1 (en) 2003-06-02 2004-11-02 Allergan, Inc. 8-azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents
US6734206B1 (en) 2003-06-02 2004-05-11 Allergan, Inc. 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure
US6734201B1 (en) 2003-06-02 2004-05-11 Allergan, Inc. 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents
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