WO2012152054A1 - 含有海藻酸盐膜层的薄膜及其制造方法 - Google Patents

含有海藻酸盐膜层的薄膜及其制造方法 Download PDF

Info

Publication number
WO2012152054A1
WO2012152054A1 PCT/CN2012/000350 CN2012000350W WO2012152054A1 WO 2012152054 A1 WO2012152054 A1 WO 2012152054A1 CN 2012000350 W CN2012000350 W CN 2012000350W WO 2012152054 A1 WO2012152054 A1 WO 2012152054A1
Authority
WO
WIPO (PCT)
Prior art keywords
alginate
solution
film
aqueous
thin layer
Prior art date
Application number
PCT/CN2012/000350
Other languages
English (en)
French (fr)
Inventor
林宇岳
邱耀中
Original Assignee
Lin Yu-Yueh
Chiu Yao-Chung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ616735A priority Critical patent/NZ616735B2/en
Application filed by Lin Yu-Yueh, Chiu Yao-Chung filed Critical Lin Yu-Yueh
Priority to RU2013148631/15A priority patent/RU2597778C2/ru
Priority to KR1020167012043A priority patent/KR20160055973A/ko
Priority to SG2013082284A priority patent/SG194817A1/en
Priority to AU2012253120A priority patent/AU2012253120B2/en
Priority to EP12782257.5A priority patent/EP2711028B1/en
Priority to BR112013028076A priority patent/BR112013028076A2/pt
Priority to ES12782257T priority patent/ES2731930T3/es
Priority to JP2014509584A priority patent/JP2014513188A/ja
Priority to KR1020167012044A priority patent/KR20160055974A/ko
Priority to KR1020137029260A priority patent/KR20140005322A/ko
Publication of WO2012152054A1 publication Critical patent/WO2012152054A1/zh
Priority to ZA2013/07801A priority patent/ZA201307801B/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/1214—Chemically bonded layers, e.g. cross-linking
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
    • D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
    • D06M15/03—Polysaccharides or derivatives thereof
    • D06M15/13—Alginic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0006—Organic membrane manufacture by chemical reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0088—Physical treatment with compounds, e.g. swelling, coating or impregnation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B01D69/107—Organic support material
    • B01D69/1071—Woven, non-woven or net mesh
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/1213—Laminated layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/08—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2323/00—Details relating to membrane preparation
    • B01D2323/30—Cross-linking
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M23/00—Treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, characterised by the process
    • D06M23/06—Processes in which the treating agent is dispersed in a gas, e.g. aerosols

Definitions

  • the present invention relates to a film and a method of manufacturing the same, and, in particular, to a film comprising an alginate film layer and a method of producing the same. Background technique
  • Alginic acid is a natural polymer that can form a variety of alginate with metal ions in salt compounds and is used for commercial purposes, such as water-soluble sodium alginate and salts.
  • the action of divalent calcium ions in the compound forms an insoluble calcium alginate colloid.
  • the main products are sodium alginate, potassium alginate, ammonium alginate and other forms of alginate, which can be applied to medical skin wound dressings or cosmetic masks.
  • a method and related technology for forming a colloid of sodium alginate is known, and includes:
  • Dialysis/diffusion method The most common method is to form a colloid by contact with an aqueous solution of sodium alginate in contact with externally introduced calcium ions to form a colloid.
  • a primary object of the present invention is to provide a film having an alginate film layer which can be produced at a low yield and which is inexpensive to manufacture and a method for producing the same.
  • the film comprises a thin layer carrier and at least one alginate film layer, wherein the thin layer carrier may be in the form of a non-woven fabric (non-woven fabric), a fabric, a porous sponge-like film or the like or a plastic film; the composition of the thin layer carrier may be It is a single one or a combination of two of synthetic fibers or natural fibers; wherein the synthetic fibers comprise, for example, polyester (PET), nylon (Nylon), polymethyl methacrylate (Acrylics), polypropylene ( PP), polylactic acid (PLA), the natural fiber such as cotton, hemp, wool, silk, etc.; wherein the alginate film layer is a hydrogel type complex film layer having a network structure, and the preparation method thereof comprises the following Step: providing an aqueous solution of alginate containing sodium alginate or potassium alginate in an appropriate weight percentage (wt%) and an aqueous solution of a salt compound containing a divalent metal ion such as calcium ion in an appropriate
  • Another object of the present invention is to provide a film having an alginate film layer and a method for producing the same, wherein when the surface of the thin layer carrier is a rough surface, such as the form of the thin layer carrier is a non-woven fabric (nonwoven fabric) , a fabric or a porous sponge-like film or the like having a rough surface, the formed alginate film layer is integrated with the thin layer carrier and is not easily separated; when the surface of the thin layer carrier is a smooth surface, such as the thin layer
  • the type of the carrier is a plastic film having a smooth surface, etc., and the alginate film layer formed can be combined with a thin layer. Body separation to meet subsequent application needs.
  • FIG. 1 is a schematic cross-sectional view showing a preferred embodiment of a film containing an alginate film layer of the present invention (the alginate film layer is provided on the surface of the thin layer carrier);
  • FIG. 2 is a schematic cross-sectional view showing another preferred embodiment of a film containing an alginate film layer of the present invention
  • the alginate film layer is disposed on the surface of the thin layer carrier and the inner surface layer
  • FIG. 3 is a schematic view showing the arrangement of equipment for coating operation in the manufacturing process of the present invention.
  • FIG. 4 is a schematic view showing a manufacturing process of a film containing an alginate film layer of the present invention
  • FIG. 5 is a schematic view showing a manufacturing process of a film containing an alginate film layer according to the present invention
  • FIG. 6 is a schematic view showing another preferred embodiment of a manufacturing process of a film containing an alginate film layer of the present invention. Description of the reference signs:
  • FIG. 1 and 2 there are respectively schematic cross-sectional structures of a film containing an alginate film layer in two preferred embodiments of the present invention.
  • This embodiment is a film 1 comprising an alginate film layer comprising a thin layer carrier 10 capable of adsorbing a liquid and at least one alginate film layer 20.
  • the thin layer carrier 10 is a liquid-adsorbing carrier, which may be a rough surface or a plastic film such as a non-woven fabric (non-woven fabric), a fabric or a porous sponge-like layer, and has a smooth surface but is not limited;
  • the composition of the carrier 10 may be a single type or a combination of two kinds of synthetic fibers or natural fibers;
  • the synthetic fiber comprises, but is not limited to, polyester (PET), nylon (Nylon), polyacrylic acid acrylate (Acrylics), polypropylene (PP), polylactic acid (PLA), etc., the natural fiber comprises cotton, hemp, wool , silk, etc. but not limited.
  • the surface 11 of the thin layer carrier 10 is selected to be a rough or smooth surface depending on the needs of the actual application.
  • the alginate film layer 20 is a water-gel type complex film layer having a network structure. As shown in Fig. 3, the preparation method is carried out according to the following steps:
  • a layer of seaweed is separately coated on at least one surface 11 of the thin layer carrier 10 by at least two separate, sequential sequential operation procedures.
  • the alginate in the aqueous alginate solution 21 is crosslinked with the divalent metal ions in the aqueous salt solution 22 of the salt compound on the surface 11 of the thin layer carrier 10 to include the surface 11 on the surface 11 of the thin layer carrier 10.
  • a hydrogel-type complex film layer 20 having a network structure is formed; as shown in Figures 1 and 2, the alginate film The layer 20 is formed in a network-like staggered state by alginate (indicated by a solid line) of the aqueous alginate solution 21 and divalent metal ions (indicated by dotted lines) in the aqueous solution 22 of the salt compound.
  • the present invention utilizes a thin layer carrier 10 capable of adsorbing a liquid, and carries the aqueous alginate solution 21 and the aqueous salt compound solution 22 on the surface 11 thereof so as to be continuous on the surface 11 of the thin layer carrier 10 and
  • the film 20 of alginate such as calcium alginate is rapidly mass-produced, thereby achieving the purpose of producing the alginate film layer and reducing the production cost of the alginate film layer.
  • FIG. 3 and FIG. 4 it is a schematic diagram of the arrangement of equipment and a manufacturing process diagram of the coating operation procedure in the manufacturing process of the film containing the alginate film layer of the present invention.
  • the method for producing the film 1 containing the alginate film layer of the present invention is as shown in Fig. 4, and comprises the following steps:
  • FIG. 6 is a flow chart for manufacturing a film containing an alginate film layer according to two preferred embodiments of the present invention, respectively, as follows:
  • the layer 1 of the alginate solution is coated on at least one surface 11 of the thin layer carrier 10, and then on the layer of the alginate solution 21.
  • a layer 22 of the aqueous salt compound is applied, the divalent metal ions in the aqueous solution 22 of the salt compound and the alginate in the aqueous solution of the alginate 21 are crosslinked on the surface 11 of the thin layer carrier 10.
  • the divalent metal ions in the aqueous salt solution 22 of the salt compound generally penetrate into the inner layer of the surface 11 to crosslink, so that the surface 11 of the thin layer carrier 10, the surface 11 is contained, and the surface 11 is more infiltrated.
  • the inner layer of the surface 11 forms a water-gel type complex film layer 20 having a network structure. as shown in picture 2.
  • the alginate film layer 20 is further infiltrated into the infiltration surface 12, but the depth of penetration of the infiltration surface 12 into the inner surface 11 of the thin layer carrier 10 is not limited, generally with the layer alginate.
  • the relative concentration between the aqueous solution 21 and the aqueous salt solution 22 is related. In the present embodiment, the alginate film layer 20 is not easily separated from the thin layer carrier 10.
  • the coating layer 22 of the salt compound is first coated on at least one surface 11 of the thin layer carrier 10, and then on the aqueous layer 22 of the salt compound.
  • the aqueous acid salt solution 21 is generally crosslinked on the surface 11 of the thin layer carrier 10 to directly form the water gel type complex film layer 20 having a higher density, so that the infiltration surface 12 stays on the surface 11 without
  • the inner layer penetrating into the surface 11 is crosslinked with the divalent metal ions in the aqueous salt solution 22 of the inner layer of the thin layer carrier 10, so that it is formed only on the surface 11 of the thin layer carrier 10.
  • the previous coating operation procedure can be performed by using the immersion method, and the subsequent coating operation procedure is performed.
  • the spraying method can be adopted; here, the equipment arrangement of the coating operation program shown in FIG. 3 is taken as an example: Using a bundle of a thin layer carrier 10 having a relatively long length of adsorbable liquid, the strip-shaped thin layer carrier 10 is passed through a tank containing aqueous alginate solution 21 by means of a conveying device, that is, as shown in FIG. Soaking operation A.
  • the aqueous alginate solution 21 is an aqueous solution of alginate containing an appropriate percentage by weight of sodium alginate, wherein the sodium alginate is contained in an amount ranging from 0.01 to 20% by weight, preferably from 1 to 5% by weight. .
  • the upper and lower surfaces 11 of the thin layer carrier 10 are uniformly coated with a layer of sodium alginate solution (21);
  • the thin layer carrier 10, which has been impregnated with the sodium alginate solution, is sprayed through a spraying operation B to form an aqueous solution 22 of a salt compound containing a divalent metal ion in an appropriate weight percentage.
  • the salt is used.
  • the aqueous compound solution 22 is a divalent calcium ion, and the aqueous solution 22 (i.e., divalent metal ion) of the salt compound is contained in an amount of from 0.01 to 50% by weight, preferably from 1 to 10% by weight. Then, the aqueous salt solution 22 of the salt compound can be sprayed on the surface of the thin layer carrier 10 to form a layer of sodium alginate solution. Further, the aqueous solution 22 of the salt compound containing divalent metal ions is further infiltrated into the inner layer of the thin layer carrier 10 to further crosslink with the sodium alginate solution in the inner layer of the thin layer carrier 10 as shown in Fig. 2.
  • each group of spraying operations C includes at least one spraying operation capable of spraying the aqueous alginate solution 21.
  • C1 and at least one spraying operation C2 capable of spraying the aqueous solution 22 of the salt compound, whereby after the action of the spraying operation B is completed, the alginate aqueous solution 21 and the aqueous salt solution 22 may be further in the order of the thin One or both sides of the layer carrier 10 are successively sprayed until the desired thickness of the alginate film layer 20 is reached.
  • a nonwoven fabric made of polypropylene (PP) is used as a thin layer carrier 10 capable of adsorbing liquid, for absorbing about 4% by weight of calcium lactate as an aqueous solution 22 of the salt compound, and then coating About 2% by weight of sodium alginate solution is used as the alginate solution 21, and the thickness is 1.1 mm. After cross-linking, an alginate film layer having a thickness of about 1 mm can be formed on the polypropylene (PP) nonwoven fabric. 20, that is, a layer of a hydrocolloid complex film having a network structure.
  • the formed alginate film layer 20 is combined with the nonwoven fabric, that is, the thin layer carrier 10. And if the non-woven fabric made of the polypropylene (PP) has a smooth surface non-woven fabric as a crosslinked contact surface, the formed alginate film layer 20 can be separated from the non-woven fabric, that is, the thin layer carrier 10. .
  • Non-woven fabric made of polypropylene (PP) and nylon (Nylon) with a thickness of 0.42 mm is used as a thin layer carrier 10 capable of adsorbing liquid, and immersed in 2% by weight of sodium alginate in a continuous soaking manner. Solution; after scraping off the excess solution on the surface 11 of the non-woven fabric (ie, the thin layer carrier 10), spraying 4% by weight of the calcium lactate solution on the upper and lower surfaces 11 to continuously produce a cloth having a thickness of about 0.72 mm. Film 1 containing alginate film layer 20.
  • the sodium alginate and the calcium lactate are sequentially sprayed on one or both sides of the completed film 1 and the mixture is applied. The effect is to achieve the desired thickness of the film 1.
  • a non-woven fabric made of a mixture of polypropylene (PP) and nylon (Nylon) having a thickness of 0.42 mm is used as the thin layer carrier 10 for adsorbing liquid, and immersed in 4% by weight of calcium lactate in a continuous soaking manner. Solution; after scraping off the excess solution on the surface 11 of the non-woven fabric (ie, the thin layer carrier 10), spraying the upper and lower surfaces 11 with 2% (by weight) sodium alginate solution to continuously produce a cloth thickness of about 0.72 mm.
  • the film 1 containing the alginate film layer 20 is used as the thin layer carrier 10 for adsorbing liquid, and immersed in 4% by weight of calcium lactate in a continuous soaking manner. Solution; after scraping off the excess solution on the surface 11 of the non-woven fabric (ie, the thin layer carrier 10), spraying the upper and lower surfaces 11 with 2% (by weight) sodium alginate solution to continuously produce a cloth thickness of about 0.72 mm.
  • the calcium phosphate and sodium alginate are sequentially sprayed on one or both sides of the completed film 1 and then sprayed. Cross-linking action to achieve the desired thickness of the film 1.
  • additives may be further added to the aqueous alginate solution 21 according to actual use requirements, and the filling may include: Use nutrient solution, beauty serum, cosmetic liquid or medicated ingredient shield or other decorative coloring materials, such as: animal / plant extracts, vitamins, growth factors, peptides, proteins, minerals .
  • the spraying operation may be further performed on one or both sides of the thin-layer carrier in the order of the aqueous solution of the alginate and the aqueous solution of the salt compound, for the thin layer carrier Performing one or more cross-linking on the surface to increase the thickness of the alginate film layer, to control the thickness of the alginate film layer, and to enhance the film of the alginate film layer of the present invention.
  • Use efficiency and application range The above are only the preferred embodiments of the present invention, and are merely illustrative and not restrictive. It will be apparent to those skilled in the art that many changes, modifications, and equivalents may be made within the spirit and scope of the invention as defined by the appended claims.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Textile Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Laminated Bodies (AREA)
  • Medicinal Preparation (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Jellies, Jams, And Syrups (AREA)

Description

含有海藻酸盐膜层的薄膜及其制造方法
技术领域
本发明涉及一种薄膜及其制造方法， 特别涉及一种含有海藻酸盐膜层的薄 膜及其制造方法。 背景技术
海藻酸为一种天然的高分子物， 可以和盐类化合物中的金属离子形成各种 不同的海藻酸盐类 （alginate ) , 供应用于商业用途上， 如水溶性的海藻酸钠可 以和盐类化合物中的二价钙离子作用， 形成不溶性的海藻酸钙胶体。 商业用途 上主要的产品有海藻酸钠、 海藻酸钾、 海藻酸铵及其它不同形态的海藻酸盐产 '品， 可应用于医疗用皮肤创伤敷材或美容用面膜。 目前已知海藻酸钠形成胶体 的方法及相关技术， 包含有：
( 1 )渗析 /扩散法： 最常用的方法， 以海藻酸钠水溶液与外部进来的钙离子 接触而产生交联， 形成胶体。
( 2 )原位法： 以溶解度较低的钙盐与海藻酸钠溶液充分混合后， 再加入具 有緩释效果的弱酸。 钙离子在酸的作用下被释放出来， 然后与海藻酸钠形成交 联产生海藻酸钙胶体。
( 3 )冷却法： 在高温溶液中钙离子不能与海藻酸结合， 所以将钙离子与海 藻酸钠在高温下混合后， 经过冷却形成胶体。 、
( 4 ) 交联法： 利用环氧氯丙烷 (epicholorohydrin, ECH), 和海藻酸的氢基 来交联， 海藻酸在交联后失去可溶性形成胶体。
目前在海藻酸盐或类似物品或相关的应用如医疗用皮肤创伤敷材或美容用 面膜等技术领域中， 已存在一些相关的先前技术， 如： 美国发明专利 US 6,080,420、 US 6,258,995、 US 6,203,845、 US 6,201, 164、 US 6,372,248、 US 6,326,524. US 5,144,016, US 5,230,853 US 5,622,666 > US 5,660,857、US 5,675,957 等； 英国专利 GB 9419572、 GB 9501514、 GB 9516930等， PCT/ GB 9502284 (公 开号 WO96/10106 )、 PCT/ GB 9601719(公开号 WO97/03710 )、 PCT/ GB 9701098 (公开号 WO97/39781 ) 、 PCT/ DK 9700292 (公开号 WO98/ 02196 ) 、 WO2008/072817等； 及中国台湾 TW 95218502、 TW公开号 201 100119A1、 TW 1265814等。 然而， 上述该等先前技术的诉求重点或技术特征大都是属于物品的 组成成分或该等组成成分之间的重量百分比（wt%, % by weight )关系， 实际上 而言， 该等先前技术并未针对海藻酸盐膜层在生产制造上的问题或需要， 尤其 是如何产量化该海藻酸盐膜层或如何降低该海藻酸盐膜层的制作成本， 而提出 有效地解决问题的技术。 发明内容
本发明主要目的在于提供一种能够产量化生产并且制造成本低的具有海藻 酸盐膜层的薄膜及其制造方法。
该薄膜包含一薄层载体及至少一海藻酸盐膜层， 其中该薄层载体的形式可 为不织布 (无纺布）、 织品、 多孔海绵状薄膜等或塑料薄膜； 该薄层载体的成分可 为合成纤维或天然纤维中的单一种或两种的任意组合； 其中， 该合成纤维包含 如聚酯 (PET)、 尼龙 (Nylon)、 聚甲基丙浠酸甲酯 (Acrylics)、 聚丙烯 (PP)、 聚乳酸 (PLA), 该天然纤维如棉、 麻、 毛、 丝等； 其中该海藻酸盐膜层为一具有网状结 构的水胶型络合物膜层， 其制备方法包括以下步骤： 提供一含海藻酸钠或海藻 酸钾适当重量百分比（wt% )的海藻酸盐水溶液及一含二价金属离子如钙离子适 当重量百分比的盐类化合物水溶液如乳酸钙、 氯化钙、 葡萄醣钙、 聚麸胺酸钙、 碳酸钙或硫酸钙等水溶液； 再利用至少两个分开但前后依序连续的作业程序， 分别地在该薄层载体的至少一表面上涂布一层所述海藻酸盐水溶液及一层所述 盐类化合物水溶液， 也就是将该海藻酸盐水溶液或该盐类化合物水溶液涂布在 该薄层载体的至少一表面上的先后次序并不限制； 再使该海藻酸盐与该盐类化 合物中的二价金属离子进行交联（crosslinking ) , 以使在该薄层载体的表面， 可包含表面上或更渗入表面内层， 形成一具有网状结构的水胶型络合物膜层； 凭借此方法， 可连续地、 快速地、 大量地生产一具海藻酸盐的薄膜， 而达到产 量化生产该海藻酸盐膜层及降低制作成本的目的。
本发明的另一目的在于提供一种具有海藻酸盐膜层的薄膜及其制造方法， 其中当该薄层载体的表面为粗糙面时， 如该薄层载体的形式为不织布 (无纺布）、 织品或多孔海绵状薄膜等具有粗糙的表面， 则所形成的海藻酸盐膜层会和该薄 层载体结合成一体而不易分离； 当薄层载体的表面为光滑面时， 如该薄层载体 的型式为具有光滑表面的塑料薄膜等， 则所形成的海藻酸盐膜层可以和薄层载 体分离， 用以符合后续的应用需要。
本发明另一目的在于提供一种具海藻酸盐膜层的薄膜及其制造方法， 其中 当交联作用完成后， 进一步可再以该海藻酸盐水溶液及该盐类化合物水溶液的 顺序， 在该薄层载体的一面或两面上接续进行喷涂作业， 以便在该薄层载体的 表面上再进行一次或一次以上的交联作用， 用来增加该海藻酸盐膜层的厚度。 附图说明 图 1为本发明含有海藻酸盐膜层的薄膜一较佳实施例的剖面结构示意图 （该 海藻酸盐膜层设在该薄层载体的表面上） ；
图 2 为本发明含有海藻酸盐膜层的薄膜另一较佳实施例的剖面结构示意图
(该海藻酸盐膜层设在该薄层载体的表面上及表面内层） ；
图 3为本发明的制造流程中涂布作业的设备安排示意图；
图 4为本发明含有海藻酸盐膜层的薄膜的制造工艺流程示意图；
图 5为本发明含有海藻酸盐膜层的薄膜的制造流程一较佳实施例示意图； 图 6为本发明含有海藻酸盐膜层的薄膜的制造流程另一较佳实施例示意图。 附图标记说明：
1 -具海藻酸盐膜层的薄膜； 10 -薄层载体； 11 -表面； 12 -渗入面； 20 - 海藻酸盐膜层； 21 -海藻酸盐水溶液； 22 -盐类化合物水溶液； A -浸泡作业； B、 C、 Cl、 C2 -喷涂作业。 具体实施方式
以下结合附图和实施例， 对本发明上述的和另外的技术特征和优点作更详 细的说明， 应该理解的是， 这些实施例仅用于例证的目的， 决不限制本发明的 保护范围。
如图 1、 2所示， 其分别为本发明两个较佳实施例的含有海藻酸盐膜层的薄 膜的剖面结构示意图。 本实施例是含有海藻酸盐膜层的薄膜 1， 其包含一可吸附 液体的薄层载体 10及至少一海藻酸盐膜层 20。
薄层栽体 10为一可吸附液体的载体， 其构成可为不织布 (无纺布）、 织品或 多孔海绵状薄层等具有粗糙的表面或塑料薄膜而具有光滑的表面但不限制； 薄 层载体 10的成分可为合成纤维或天然纤维中单一种或两种的任意组合； 其中， 该合成纤维包含聚酯 (PET)、 尼龙 (Nylon)、 聚曱基丙烯酸曱酯 (Acrylics)、 聚丙烯 (PP)、 聚乳酸 (PLA) 等但不限制， 该天然纤维包含棉、 麻、 毛、 丝等但不限制。 薄层载体 10的表面 11可视实际应用需要而选择为粗糙面或光滑面。
该海藻酸盐膜层 20为一具有网状结构的水胶型络合物膜层， 如图 3所示， 其制备方法按照以下步骤实施：
提供一含海藻酸钠或海藻酸钾适当重量百分比 （wt% ) 的海藻酸盐水溶液 21及一含二价金属离子如钙离子适当重量百分比的盐类化合物水溶液 22;
再使用上述海藻酸盐水溶液 21及上述盐类化合物水溶液 22,通过至少两个 分开但前后依序连续的作业程序， 分别地在薄层载体 10的至少一表面 11上均 勾涂布一层海藻酸盐水溶液 21及一层盐类化合物水溶液 22;
使海藻酸盐水溶液 21 中的海藻酸盐与盐类化合物水溶液 22 中的二价金属 离子在薄层载体 10的表面 11进行交联作用， 以在该薄层载体 10的表面 11 , 包 含表面 11上如图 1所示或更渗入该表面 11 内层如图 2所示， 形成一具有网状 结构的水胶型络合物膜层 20; 如图 1、 2所示， 该海藻酸盐膜层 20为由海藻酸 盐水溶液 21 的海藻酸盐 （以实线表示） 及该盐类化合物水溶液 22 中的二价金 属离子 （以点线表示） 形成网状交错状态。
由上可知， 本发明是利用一可吸附液体的薄层载体 10， 并以其表面 11来承 载海藻酸盐水溶液 21及盐类化合物水溶液 22, 从而可在薄层载体 10的表面 11 上连续且快速地大量生产海藻酸盐如海藻酸钙的薄膜 20, 因此达到产量化生产 该海藻酸盐膜层及降低该海藻酸盐膜层的制作成本的目的。
如图 3、 图 4所示， 其分别为本发明含有海藻酸盐膜层的薄膜的制造流程中 涂布作业程序的设备安排示意图及制造流程示意图。 本发明含有海藻酸盐膜层 的薄膜 1的制造方法如图 4所示， 包含下列步骤：
( a )提供一可吸附液体的薄层载体 10、 一含海藻酸钠或海藻酸钾适当重量 百分比 （wt% ) 的海藻酸盐水溶液 21及一含二价金属离子如钙离子适当重量百 分比的盐类化合物水溶液 22;
( b )利用至少两个分开但前后依序连续的涂布作业程序， 以分别地在该薄 层载体 10的至少一表面 11上均勾涂布一层海藻酸盐水溶液 21及一层盐类化合 物水溶液 22;
( c )使该海藻酸盐水溶液 21中的海藻酸盐与该盐类化合物水溶液 22中的 二价金属离子在该薄层载体 10的表面 11上进行交联作用， 以在该薄层载体 10 的表面 11, 包含表面 11上如图 1所示或更渗入该表面 11 内层如图 2所示， 形 成一具有网状结构的水胶型络合物膜层 20。
在上述涂布作业程序步骤 （b) 中， 将该海藻酸盐水溶液 21 或该盐类化合 物水溶液 22涂布在该薄层载体 10的至少一表面 11上的先后次序并不限制； 如 图 5及图 6所示， 其分别为本发明两个较佳实施例的含有海藻酸盐膜层的薄膜 的制造流程图， 分别说明如下：
如图 5所示的步骤（b) 中， 其为在该薄层载体 10的至少一表面 11上先涂 布一层该海藻酸盐水溶液 21,之后再于该层海藻酸盐水溶液 21上再涂布一层该 盐类化合物水溶液 22，则当该盐类化合物水溶液 22中的二价金属离子与该海藻 酸盐水溶液 21中的海藻酸盐在该薄层载体 10的表面 11上进行交联作用时， 该 盐类化合物水溶液 22 中的二价金属离子一般会更渗入该表面 11 的内层进行交 联作用， 故可在该薄层载体 10的表面 11， 包含表面 11上及更渗入该表面 11内 层， 形成一具有网状结构的水胶型络合物膜层 20。 如图 2所示。 在图 2中， 该 海藻酸盐膜层 20更渗入至渗入面 12,但该渗入面 12渗入该薄层载体 10的表面 11 内层的深浅程度并不限制，一般是与该层海藻酸盐水溶液 21及该盐类化合物 水溶液 22之间的相对浓度有关。 而以本实施例而言， 该海藻酸盐膜层 20就不 易与该薄层载体 10分离。
如图 6所示的步骤（b) 中， 其为在该薄层载体 10的至少一表面 11上先涂 布一层该盐类化合物水溶液 22，之后再于该层盐类化合物水溶液 22上再涂布一 层该海藻酸盐水溶液 21, 则当该海藻酸盐水溶液 21 与该盐类化合物水溶液 22 中的二价金属离子在该薄层载体 10的表面 11上进行交联作用时， 该海藻酸盐 水溶液 21—般会在该薄层载体 10的表面 11上进行交联而直接先形成密度较大 的水胶型络合物膜层 20, 致使该渗入面 12停留在表面 11上而不会渗入该表面 11的内层与该薄层载体 10内层的该盐类化合物水溶液 22中的二价金属离子进 行交联 （ crosslinking ) 作用， 故只在该薄层载体 10的表面 11 上形成一具有网 状结构的水胶型络合物膜层 20, 如图 1所示。 在图 1中， 该海藻酸盐膜层 20即 形成在该薄层载体 10的表面 11上， 而以本实施例而言， 该海藻酸盐膜层 20容 易与该薄层载体 10分离。
此外， 根据一般涂布作业程序的设备安排需要及作业进行的方便性而言， 在步骤 （b) 中， 进行在前的涂布作业程序可采用浸泡方式， 而进行在后的涂布 作业程序可采用喷涂方式； 在此以图 3所示涂布作业程序的设备安排为例说明： 利用一捆具有相当长度的可吸附液体的薄层载体 10， 再通过输送装置使该长条 式薄层载体 10以浸泡方式行经一含海藻酸盐水溶液 21的容槽， 即图 3所示的 浸泡作业 A。 在本实施例中该海藻酸盐水溶液 21为含海藻酸钠适当重量百分比 的海藻酸盐水溶液，其中该海藻酸钠的含量范围为 0.01-20重量百分比，并以 1-5 重量百分比为较佳。 则在该薄层载体 10的至少一表面 11上， 在本实施例中包 含该薄层载体 10的上、下两个表面 11上，先均匀涂布一层海藻酸钠溶液（21 ) ; 再通过输送装置使该已含浸有海藻酸钠溶液的薄层载体 10以喷涂方式行经一喷 涂作业 B， 使含二价金属离子适当重量百分比的盐类化合物水溶液 22， 在本实 施例中该盐类化合物水溶液 22 为含二价钙离子， 其中该盐类化合物水溶液 22 (即二价金属离子） 的含量范围为 0.01-50重量百分比， 并以 1-10重量百分比 为较佳。 则该盐类化合物水溶液 22可喷涂在该薄层载体 10的表面 11上所浸泡 所成的一层海藻酸钠溶液上。 并且含二价金属离子的盐类化合物水溶液 22更渗 入该薄层载体 10的内层以进一步与该薄层载体 10 内层的海藻酸钠溶液进行交 联 ( crosslinking ) 如图 2所示。
此外， 另可依海藻酸盐膜层 20的厚度需要， 进一步可在喷涂作业 B之后， 再设置多组喷涂作业 C; 各组喷涂作业 C 包含至少一可喷涂该海藻酸盐水溶液 21的喷涂作业 C1及至少一可喷涂该盐类化合物水溶液 22的喷涂作业 C2，藉以 , 在喷涂作业 B的作用完成后，可再以该海藻酸盐水溶液 21及该盐类化合物水溶 液 22的顺序， 在该薄层载体 10的一面或两面上接续进行喷涂作业， 直至达到 所需的较厚的海藻酸盐膜层 20厚度为止。
兹以下列实施例， 来说明本发明含有海藻酸盐膜层的薄膜的结构型态及形 成方法：
<实施例 1 >
利用以聚丙烯 (PP) 做成的无纺布当作可吸附液体的薄层载体 10， 用以吸收 约 4 % (重量百分比） 的乳酸钙当作该盐类化合物水溶液 22, 再涂布以约 2 % (重量百分比） 的海藻酸钠溶液当作该海藻酸盐水溶液 21， 厚度为 1.1mm, 交 联后可在聚丙浠 (PP)无纺布上形成厚度约 1mm的海藻酸盐膜层 20， 即一层具有 网状结构的水胶型络合物膜层。 当该聚丙烯 (PP) 做成的无纺布以粗糙面无纺布 作为交联接触面时， 则所形成的海藻酸盐膜层 20 会和该无纺布即薄层载体 10 结合在一起； 而若该聚丙烯 (PP) 作成的无纺布以光滑面无纺布做为交联接触面 时， 则所形成的海藻酸盐膜层 20可以和该无纺布即薄层载体 10分离。 <实施例 2〉
利用厚度 0.42mm以聚丙烯 (PP)、 尼龙 (Nylon) 混合作成的不织布（无纺布） 当作可吸附液体的薄层载体 10, 以连续的浸泡方式浸入 2% (重量百分比）海藻 酸钠溶液； 在刮除不织布 （即薄层载体 10 ) 的表面 11上多余溶液后， 再于上、 下表面 11喷涂 4 %(重量百分比）乳酸钙溶液，即可连续产生含布厚度约 0.72mm 的含有海藻酸盐膜层 20的薄膜 1。 若希望获得较厚的海藻酸盐膜层 20， 则在乳 酸钙溶液作用完后， 再以海藻酸钠、 乳酸钙的顺序， 在所完成的薄膜 1 的一面 或两面上再接续喷涂并起交联作用， 藉以达到所需的薄膜 1的厚度为止。
<实施例 3 >
利用厚度 0.42mm以聚丙烯 (PP)、 尼龙 (Nylon) 混合作成的不织布 (无纺布） 当作该可吸附液体的薄层载体 10, 以连续的浸泡方式浸入 4 % (重量百分比） 乳酸钙溶液； 在刮除不织布（即薄层载体 10 )的表面 11上多余溶液后， 再亍上、 下表面 11 喷涂 2 % (重量百分比） 海藻酸钠溶液， 即可连续产生含布厚度约 0.72mm的含有海藻酸盐膜层 20的薄膜 1。 若希望获得较厚的海藻酸盐膜层 20， 则在海藻酸钠溶液作用完后， 再以乳酸钙、 海藻酸钠的顺序， 在所完成的薄膜 1 的一面或两面上再接续喷涂并起交联作用， 藉以达到所需的薄膜 1的厚度为止。
. 此外， 在实际制造本发明含有海藻酸盐膜层的薄膜时， 可视实际使用需要， 而进一步于该海藻酸盐水溶液 21 内再填加其它填加物， 该填加物可包含： 美容 用营养液、 美容用精华液、 美容用药液或有药效成分的物盾等或其它装饰用色 料等， 如： 动 /植物萃取物、 维生素、 生长因子、 胜肽、 蛋白质、 矿物质。
本发明含有海藻酸盐膜层的薄膜及其制造方法与现有技术比较具有下列优 点：
(1)可连续地、 快速地、 大量地生产， 有利于产量化生产海藻酸盐膜层及降 低其制作成本。
(2) 可利用一般的涂布作业的设备来进行生产， 有利于降低制作设备的成 本。
(3)当一次交联作用完成后， 更可再以该海藻酸盐水溶液及该盐类化合物水 溶液的顺序， 在该薄层载体的一面或两面上接续进行喷涂作业， 供在该薄层载 体的表面上再进行一次或一次以上的交联作用， 从而增加该海藻酸盐膜层的厚 度， 有利于控制该海藻酸盐膜层的厚度， 并提升本发明含有海藻酸盐膜层的薄 膜的使用效率及应用范围。 以上所述仅为本发明的较佳实施例， 对本发明而言仅仅是说明性的， 而非 限制性的。 本专业技术人员理解， 在本发明权利要求所限定的精神和范围内可 对其进行许多改变， 修改， 甚至等效， 但都将落入本发明的保护范围内。

Claims

1.一种含有海藻酸盐膜层的薄膜， 包含一薄层载体及至少一海藻酸盐膜层， 其特征在于，
该薄层载体为一可吸附液体的载体；
该海藻酸盐膜层为一具有网状结构的水胶型络合物膜层， 其制备方法包括 以下步骤： 利用一含适当重量百分比海藻酸钠或海藻酸钾的海藻酸盐水溶液及 一含适当重量百分比二价金属离子的盐类化合物水溶液； 再通过至少两个分开 且前后依序连续的作业程序， 以分别在该薄层载体的至少一表面上涂布一层该 海藻酸盐水溶液及一层该盐类化合物水溶液； 再使该海藻酸盐水溶液中的海藻 酸盐与该盐类化合物水溶液中的二价金属离子进行交联， 以在该薄层载体的表 面上或表面内层形成一具有网状结构的水胶型海藻酸盐膜层。
2.如权利要求 1所述的具海藻酸盐膜层的薄膜， 其特征在于， 由无纺布、 织 品、 多孔海绵状薄膜或塑料薄膜构成。
3.如权利要求 1所述的具海藻酸盐膜层的薄膜， 其特征在于， 所述薄层载体 的成分为合成纤维或天然纤维中的单一种或两种的任意组合。
4.如权利要求 3所述的具海藻酸盐膜层的薄膜， 其特征在于， 所述合成纤维 包含： 聚酯 (PET)、 尼龙 (Nylon)、 聚曱基丙烯酸甲酯 (Acrylics)、 聚丙烯 (PP)、 聚 乳酸 (PLA) 。
5.如权利要求 3所述的具海藻酸盐膜层的薄膜， 其特征在于， 所述天然纤维 包含： 棉、 麻、 毛或丝。
6.如权利要求 1所述的具海藻酸盐膜层的薄膜， 其特征在于， 所述海藻酸盐 水溶液中海藻酸钠或海藻酸钾的含量范围为 0.01-20% (重量百分比） 。
7.如权利要求 1所述的具海藻酸盐膜层的薄膜， 其特征在于， 所述海藻酸盐 水溶液中海藻酸钠或海藻酸钾的含量范围为 1-5% (重量百分比） 。
8.如权利要求 1所述的具海藻酸盐膜层的薄膜， 其特征在于， 所述含二价金 属离子的盐类化合物水溶液为乳酸钙水溶液、 氯化钙水溶液、 葡萄醣钙水溶液、 聚麸胺酸钙水溶液、 碳酸钙水溶液或 υ酸钙水溶液。
9.如权利要求 1所述的具海藻酸盐膜层的薄膜， 其特征在于， 所述盐类化合 物水溶液中二价金属离子的含量范围为 0.01-50% (重量百分比） 。
10.如权利要求 1所述的具海藻酸盐膜层的薄膜， 其特征在于， 所述盐类化 合物水溶液中二价金属离子的含量范围为 1-10% (重量百分比） 。
11.如权利要求 1所述的具海藻酸盐膜层的薄聘， 其特征在于， 当所述薄层 载体的表面为粗糙面时， 所形成的海藻酸盐膜层和薄层载体结合成一体。
12.如权利要求 1所述的具海藻酸盐膜层的薄膜， 其特征在于， 当所述薄层 载体的表面为光滑面时， 所形成的海藻酸盐膜层和薄层载体分离。
13.如权利要求 1所述的具海藻酸盐膜层的薄膜， 其特征在于， 所述海藻酸 盐水溶液还填加有其它填加物， 所述其它填加物包含： 美容用营养液、 美容用 精华液、 美容用药液、 有药效成分的物质或装饰用色料。
14.一种如权利要求 1_13任一项所述的具海藻酸盐膜层的薄膜的制造方法， 包含下列步骤：
( a )提供一可吸附液体的薄层载体、 一含海藻酸钠或海藻酸钾适当重量百 分比的海藻酸盐水溶液及一含二价金属离子适当重量百分比的盐类化合物水溶 液；
( b )利用至少两个分开但前后依序且连续的涂布作业程序， 以分别地在所 述薄层载体的至少一表面上涂布一层所述海藻酸盐水溶液及一层所述盐类化合 物水溶液； 以及
( c )使所述海藻酸盐水溶液中的海藻酸盐与所述盐类化合物水溶液中的二 价金属离子在所述薄层载体的表面上进行交联， 以在所述薄层载体的表面上或 表面内层形成一具有网状结构的水胶型海藻酸盐膜层。
15.如权利要求 14所述的制造方法， 其特征在于， 所述薄层载体由无纺布、 织品、 多孔海绵状薄膜或塑料薄膜构成。
16.如权利要求 14所述的制造方法， 其特征在于， 所述薄层载体的成分为合 成纤维或天然纤维中的单一种或两种的任意组合。
17.如权利要求 14所述的制造方法， 其特征在于， 所述合成纤维包含： 聚酯 (PET)、 尼龙 (Nylon)、 聚甲基丙烯酸曱酯 (Acrylics), 聚丙烯 (PP)、 聚乳酸 (PLA) 。
18.如权利要求 14所述的制造方法， 其特征在于， 所述天然纤维包含： 棉、 麻、 毛或丝。
19.如权利要求 14所述的制造方法，其中所述海藻酸盐水溶液中海藻酸钠或 海藻酸钾的含量范围为 0.01-20% (重量百分比） 。
20.如权利要求 14所述的制造方法，其中所述海藻酸盐水溶液中海藻酸钠或 海藻酸钾的含量范围为 1-5% (重量百分比） 。
21.如权利要求 14所述的制造方法，其中所述含二价金属离子的盐类化合物 水溶液为乳酸钙水溶液、 氯化钙水溶液、 葡萄醣钙水溶液、 聚麸胺酸钙水溶液、 碳酸钙水溶液或 υ酸钙水溶液。
22.如权利要求 14所述的制造方法，其中所述盐类化合物水溶液中二价金属 离子的含量范围为 0.01-50% (重量百分比） 。
23.如权利要求 14所述的制造方法，其中所述盐类化合物水溶液中二价金属 离子涉外含量范围为 1 -10% (重量百分比） 。
24.如权利要求 14 所述的制造方法， 其中当所述薄层载体的表面为粗糙面 时， 所形成的海藻酸盐膜层和薄层载体结合成一体。
25.如权利要求 14 所述的制造方法， 其中当所述薄层载体的表面为光滑面 时， 所形成的海藻酸盐膜层和薄层载体分离。
26.如权利要求 14所述的制造方法， 其中所述步骤 （b ) 中为先在所述薄层 载体的至少一表面上涂布一层所述海藻酸盐水溶液， 之后再于该层海藻酸盐水 溶液上再涂布一层所述盐类化合物水溶液。
27.如权利要求 14所述的制造方法， 其中所述步骤 （b ) 中为先在所述薄层 载体的至少一表面上涂布一层所述盐类化合物水溶液， 之后再于该层盐类化合 物水溶液上再涂布一层所述海藻酸盐水溶液。
28.如权利要求 14所述的制造方法， 其中所述步骤 （b ) 中， 进行在前的涂 布作业为采用浸泡方式， 而进行在后的涂布作业为采用喷涂方式。
29.如权利要求 14所述的制造方法， 其中所述步骤 （c ) 中在交联作用完成 后进一步再以所述海藻酸盐水溶液及所述盐类化合物水溶液的顺序， 在所述薄 层载体的表面上接续进行喷涂作业， 使该薄层载体的表面上再进行交联以增加 海藻酸盐膜层的厚度。
30.如权利要求 14所述的制造方法， 其中所述海藻酸盐水溶液还填加有其它 填加物， 所述其它填加物包含： 美容用营养液、 美容用精华液、 美容用药液、 有药效成分的物质或装饰用色料。
PCT/CN2012/000350 2011-05-11 2012-03-20 含有海藻酸盐膜层的薄膜及其制造方法 WO2012152054A1 (zh)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP12782257.5A EP2711028B1 (en) 2011-05-11 2012-03-20 Film containing alginate membrane layer and method for preparing same
RU2013148631/15A RU2597778C2 (ru) 2011-05-11 2012-03-20 Пленка, содержащая альгинатную мембрану, и способ ее получения
KR1020167012043A KR20160055973A (ko) 2011-05-11 2012-03-20 알지네이트막 층을 보유하는 필름 및 그 제조 방법
SG2013082284A SG194817A1 (en) 2011-05-11 2012-03-20 Film containing alginate membrane layer and method for preparing same
AU2012253120A AU2012253120B2 (en) 2011-05-11 2012-03-20 Film containing alginate membrane layer and method for preparing same
NZ616735A NZ616735B2 (en) 2011-05-11 2012-03-20 Film containing alginate membrane layer and method for preparing same
BR112013028076A BR112013028076A2 (pt) 2011-05-11 2012-03-20 filme contendo membrana de alginato e seu método de fabricação
KR1020167012044A KR20160055974A (ko) 2011-05-11 2012-03-20 알지네이트막 층을 보유하는 필름 및 그 제조 방법
JP2014509584A JP2014513188A (ja) 2011-05-11 2012-03-20 アルギン酸塩皮膜を有する薄膜及びその製造方法
ES12782257T ES2731930T3 (es) 2011-05-11 2012-03-20 Película que contiene una capa de membrana de alginato y método de preparación asociado
KR1020137029260A KR20140005322A (ko) 2011-05-11 2012-03-20 알지네이트막 층을 보유하는 필름 및 그 제조 방법
ZA2013/07801A ZA201307801B (en) 2011-05-11 2013-10-18 Film containing alginate membrane and manufacturing method of the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201110120855.4A CN102774063B (zh) 2011-05-11 2011-05-11 含有海藻酸盐膜层的薄膜及其制造方法
CN201110120855.4 2011-05-11

Publications (1)

Publication Number Publication Date
WO2012152054A1 true WO2012152054A1 (zh) 2012-11-15

Family

ID=47119268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2012/000350 WO2012152054A1 (zh) 2011-05-11 2012-03-20 含有海藻酸盐膜层的薄膜及其制造方法

Country Status (13)

Country Link
EP (1) EP2711028B1 (zh)
JP (2) JP2014513188A (zh)
KR (3) KR20140005322A (zh)
CN (1) CN102774063B (zh)
AU (1) AU2012253120B2 (zh)
BR (1) BR112013028076A2 (zh)
ES (1) ES2731930T3 (zh)
MY (1) MY168204A (zh)
RU (1) RU2597778C2 (zh)
SG (1) SG194817A1 (zh)
TR (1) TR201909035T4 (zh)
WO (1) WO2012152054A1 (zh)
ZA (1) ZA201307801B (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015039277A1 (en) * 2013-09-17 2015-03-26 Colgate-Palmolive Company Oral care composition
US10500147B2 (en) 2014-01-24 2019-12-10 Colgate-Palmolive Company Toothpaste with alginate based rheology modifier
CN112941926A (zh) * 2021-01-28 2021-06-11 美高怡生生物技术(北京)有限公司 海藻酸钙-聚丙烯酸钠改性复合膜及其制备方法
CN114053882A (zh) * 2021-12-09 2022-02-18 天津工业大学 一种酸和离子共同交联耐盐水凝胶过滤膜的制备方法

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI549703B (zh) * 2013-12-27 2016-09-21 瑞光股份有限公司 止血敷材
CN104972590B (zh) * 2014-04-09 2017-06-16 博鸿生物科技股份有限公司 湿式胶膜的连续成膜制造设备及其成膜方法
CN103977716B (zh) * 2014-05-22 2016-01-06 武汉工程大学 一种过滤重金属离子的分离膜及其制备方法
CN109382004B (zh) * 2017-08-04 2020-04-24 天津工业大学 一种利用海藻酸钙膜分离回收混合重金属的方法
US20200406200A1 (en) * 2018-03-05 2020-12-31 King Abdullah University Of Science And Technology Green membranes for organic solvent nanofiltration and pervaporation
WO2020000290A1 (en) * 2018-06-28 2020-01-02 L'oreal Composition for caring for skin and a kit thereof
CN109294001B (zh) * 2018-08-08 2020-09-18 佛山科学技术学院 一种均匀内交联海藻酸钠膜及其制备方法
KR102123508B1 (ko) * 2018-10-01 2020-06-16 한국원자력연구원 전기전도성 마이크로 니들 패치의 제조방법 및 이에 의해 제조된 전기전도성 마이크로 니들 패치
CN109260970B (zh) * 2018-11-19 2021-08-03 天津工业大学 一种高强度无机掺杂海藻酸钙水凝胶过滤膜的制备方法
JP7179270B2 (ja) * 2019-01-30 2022-11-29 雄一 金井 アルギン酸塩被膜を有する繊維およびその製造方法
CN110743399A (zh) * 2019-11-26 2020-02-04 天津工业大学 一种含羧化g-C3N4的海藻酸钙抗菌水凝胶过滤膜的制备方法
CN111297738B (zh) * 2020-04-24 2021-09-28 山东大学 一种海藻面膜及其制备方法和应用
KR102440885B1 (ko) * 2020-08-05 2022-09-06 서울대학교산학협력단 색변이 고분자를 이용한 온도 이력 측정용 알지네이트 필름 제조법
CN112221350B (zh) * 2020-09-25 2022-04-19 浙江工业大学 一种基于氢氧化锌纳米线的新型纳滤膜的制备方法
KR102615766B1 (ko) * 2020-12-14 2023-12-20 주식회사 넥스트바이오메디컬 키토산 및 젤라틴을 포함하는 조직 보강용 점착 조성물 및 이의 제조방법
CN113062120B (zh) * 2021-04-09 2022-12-06 南京信息工程大学 一种海藻酸钠改性的两亲性羽毛及其制备方法与应用
CN113385048B (zh) * 2021-05-12 2022-09-27 自然资源部第三海洋研究所 一种高性能复合纳滤膜及其制备方法
KR20240016031A (ko) 2022-07-28 2024-02-06 고려대학교 산학협력단 이온 가교결합을 통해 내수성이 개선된 알지네이트 필름
CN115337286B (zh) * 2022-08-10 2023-06-27 浙江汇能生物股份有限公司 一种高稳定性虫草多糖的微囊化方法及高稳定性虫草多糖
CN115554191A (zh) * 2022-09-29 2023-01-03 新生活化妆品科技(上海)有限公司 一种面膜材料组合物的使用方法
KR20240050017A (ko) 2022-10-11 2024-04-18 주식회사 더데이원랩 해양유래 바이오매스 필름의 제조방법

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243069A2 (en) * 1986-04-17 1987-10-28 JOHNSON &amp; JOHNSON MEDICAL, INC. Adhesive wound dressing
US5144016A (en) 1990-05-29 1992-09-01 Protan Biopolymer A/S Alginate gels
US5230853A (en) 1990-04-23 1993-07-27 Merck & Co., Inc. Process for making polysaccharide fibers
US5470576A (en) * 1992-06-08 1995-11-28 The Kendall Company Process for preparing the alginate-containing wound dressing
WO1996010106A1 (en) 1994-09-29 1996-04-04 Innovative Technologies Limited Fibres
WO1997003710A1 (en) 1995-07-19 1997-02-06 Innovative Technologies Limited Wound treatment composition
US5622666A (en) 1992-09-30 1997-04-22 Novasso Oy Modified viscose fibres and method for their manufacture
US5660857A (en) 1993-03-22 1997-08-26 Johnson & Johnson Medical Inc. Biopolymer composites
US5675957A (en) 1995-04-24 1997-10-14 Mirae Corporation Device loading/unloading apparatus for semiconductor device handler
WO1997039781A1 (en) 1996-04-20 1997-10-30 Innovative Technologies Limited Dehydrated hydrogels
WO1998002196A1 (en) 1996-07-11 1998-01-22 Coloplast A/S A hydrocolloid wound gel
US6326524B1 (en) 1999-03-02 2001-12-04 Bristol-Myers Squibb Company Hydrocolloid foam dressing
US6372248B1 (en) 1994-10-28 2002-04-16 Innovative Technologies Limited Dehydrated hydrogels
TWI265814B (en) 2005-09-20 2006-11-11 Taiwan Textile Res Inst Glucan film and applications thereof
CN1915440A (zh) * 2006-08-10 2007-02-21 原子高科股份有限公司 以海藻酸盐为载体的药物涂层支架的涂层制备方法
CN101033564A (zh) * 2007-04-16 2007-09-12 青岛大学 普通及功能性海藻酸钙纤维的制备方法与用途
WO2008072817A1 (en) 2006-12-14 2008-06-19 Fineco Ltd. Hydrogel mask pack, method of preparing the same, and related composition
TW201100119A (en) 2009-06-26 2011-01-01 Ji-Chun Liu Herb mask composition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948575A (en) * 1989-01-24 1990-08-14 Minnesota Mining And Manufacturing Company Alginate hydrogel foam wound dressing
JP2728299B2 (ja) * 1989-05-26 1998-03-18 積水化学工業株式会社 外用剤用含水アルギン酸フイルムの製造方法
JP2862275B2 (ja) * 1989-05-26 1999-03-03 積水化学工業株式会社 外用剤用不織布強化含水アルギン酸フィルムの製造方法
US5484604A (en) * 1990-07-21 1996-01-16 Chatfield Pharmaceuticals Limited Cross-linked alginate transdermal medicine delivery devices
JP4202526B2 (ja) * 1999-05-07 2008-12-24 リンテック株式会社 水性ゲル積層体ロールの製造方法
JP2002255726A (ja) * 2001-02-26 2002-09-11 Kakui Kk 保湿成分付わた体
GB0210216D0 (en) * 2002-05-03 2002-06-12 First Water Ltd Ionically crosslinked alginate hydrogels, process for their manufacture and their use in medical devices
TWI263501B (en) * 2004-06-29 2006-10-11 Taiwan Textile Res Inst Sponge wound dressing made from chitin and alginate and method for forming the same
JP5162134B2 (ja) * 2007-01-22 2013-03-13 愛媛県 機能性材料の製造方法、機能性材料、シート状構造体、及び衛生製品
EP2278069B8 (en) * 2008-05-16 2016-07-13 Japan Tobacco, Inc. Process for producing cigarette paper having low ignition propensity
JP5435723B2 (ja) * 2009-01-26 2014-03-05 公益財団法人北九州産業学術推進機構 アルギン酸成形体の製造方法

Patent Citations (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243069A2 (en) * 1986-04-17 1987-10-28 JOHNSON &amp; JOHNSON MEDICAL, INC. Adhesive wound dressing
US5230853A (en) 1990-04-23 1993-07-27 Merck & Co., Inc. Process for making polysaccharide fibers
US5144016A (en) 1990-05-29 1992-09-01 Protan Biopolymer A/S Alginate gels
US5470576A (en) * 1992-06-08 1995-11-28 The Kendall Company Process for preparing the alginate-containing wound dressing
US5622666A (en) 1992-09-30 1997-04-22 Novasso Oy Modified viscose fibres and method for their manufacture
US5660857A (en) 1993-03-22 1997-08-26 Johnson & Johnson Medical Inc. Biopolymer composites
WO1996010106A1 (en) 1994-09-29 1996-04-04 Innovative Technologies Limited Fibres
US6080420A (en) 1994-09-29 2000-06-27 Advanced Medical Solutions Limited Fibres of cospun alginates
US6372248B1 (en) 1994-10-28 2002-04-16 Innovative Technologies Limited Dehydrated hydrogels
US5675957A (en) 1995-04-24 1997-10-14 Mirae Corporation Device loading/unloading apparatus for semiconductor device handler
WO1997003710A1 (en) 1995-07-19 1997-02-06 Innovative Technologies Limited Wound treatment composition
US6258995B1 (en) 1995-07-19 2001-07-10 Advanced Medical Solutions Limited Wound treatment composition
WO1997039781A1 (en) 1996-04-20 1997-10-30 Innovative Technologies Limited Dehydrated hydrogels
US6203845B1 (en) 1996-04-20 2001-03-20 Advanced Medical Solutions Limited Dehydrated hydrogels
WO1998002196A1 (en) 1996-07-11 1998-01-22 Coloplast A/S A hydrocolloid wound gel
US6201164B1 (en) 1996-07-11 2001-03-13 Coloplast A/S Hydrocolloid wound gel
US6326524B1 (en) 1999-03-02 2001-12-04 Bristol-Myers Squibb Company Hydrocolloid foam dressing
TWI265814B (en) 2005-09-20 2006-11-11 Taiwan Textile Res Inst Glucan film and applications thereof
CN1915440A (zh) * 2006-08-10 2007-02-21 原子高科股份有限公司 以海藻酸盐为载体的药物涂层支架的涂层制备方法
WO2008072817A1 (en) 2006-12-14 2008-06-19 Fineco Ltd. Hydrogel mask pack, method of preparing the same, and related composition
CN101033564A (zh) * 2007-04-16 2007-09-12 青岛大学 普通及功能性海藻酸钙纤维的制备方法与用途
TW201100119A (en) 2009-06-26 2011-01-01 Ji-Chun Liu Herb mask composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2711028A4

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015039277A1 (en) * 2013-09-17 2015-03-26 Colgate-Palmolive Company Oral care composition
AU2013401106A1 (en) * 2013-09-17 2016-03-03 Colgate-Palmolive Company Oral care composition
AU2013401106B2 (en) * 2013-09-17 2016-06-30 Colgate-Palmolive Company Oral care composition
US9713586B2 (en) 2013-09-17 2017-07-25 Colgate-Palmolive Company Oral care composition
US10500147B2 (en) 2014-01-24 2019-12-10 Colgate-Palmolive Company Toothpaste with alginate based rheology modifier
CN112941926A (zh) * 2021-01-28 2021-06-11 美高怡生生物技术(北京)有限公司 海藻酸钙-聚丙烯酸钠改性复合膜及其制备方法
CN114053882A (zh) * 2021-12-09 2022-02-18 天津工业大学 一种酸和离子共同交联耐盐水凝胶过滤膜的制备方法

Also Published As

Publication number Publication date
CN102774063B (zh) 2015-08-12
AU2012253120A1 (en) 2013-10-31
JP3207025U (ja) 2016-10-20
RU2013148631A (ru) 2015-06-20
CN102774063A (zh) 2012-11-14
NZ616735A (en) 2016-02-26
SG194817A1 (en) 2013-12-30
BR112013028076A2 (pt) 2017-01-31
EP2711028A4 (en) 2014-11-05
KR20160055974A (ko) 2016-05-18
RU2597778C2 (ru) 2016-09-20
JP2014513188A (ja) 2014-05-29
AU2012253120B2 (en) 2016-07-21
EP2711028A1 (en) 2014-03-26
EP2711028B1 (en) 2019-03-20
TR201909035T4 (tr) 2019-07-22
ZA201307801B (en) 2015-01-28
MY168204A (en) 2018-10-15
KR20140005322A (ko) 2014-01-14
KR20160055973A (ko) 2016-05-18
ES2731930T3 (es) 2019-11-19

Similar Documents

Publication Publication Date Title
WO2012152054A1 (zh) 含有海藻酸盐膜层的薄膜及其制造方法
CN106084257B (zh) 一种复合水凝胶及其制备方法
TW201244759A (en) Film with alginate layer and manufacturing method thereof
CN107245122B (zh) 一种丙烯酸钠吸水膨胀树脂溶液、pet纤维吸水膨胀阻水带及其制备方法
CN104472646A (zh) 一种适用于高温烘焙食品的Nisin双层微胶囊的制备方法
CN108126231A (zh) 一种高强度抑菌医用纱布的制备方法
CN105239371A (zh) 一种保湿面料的制造方法、面料、服装及保湿泡沫整理剂
CN105088781A (zh) 一种蚕丝纤维无纺布及其生产方法
CN106693041A (zh) 一种不对称润湿性壳聚糖/淀粉复合海绵及其制备方法
JP2010515836A (ja) 電離放射線下での架橋により布基材を機能化する方法
KR101077268B1 (ko) 코팅장갑의 응고액 함수율 조절방법
WO2015054347A2 (en) Fragrance adhesive tape
CN105670030B (zh) 一种空气层面料用海绵层增韧处理方法
JP5111988B2 (ja) 伸縮性不織布及びその製造方法
US2121717A (en) Method of coating fabrics and product thereof
CN203089549U (zh) 胶贴敷料
JPH03223213A (ja) アルギン酸塩含水ゲルシートの製造方法
CN215350807U (zh) 一种具有提升成分稳定性或负载益生菌组分能力的中空纤维面膜
CN204898405U (zh) 一种蚕丝纤维无纺布
JPS5926693B2 (ja) 粗密構造不織布の製造方法
NZ616735B2 (en) Film containing alginate membrane layer and method for preparing same
CN204814922U (zh) 化妆膜
JPS5939941Y2 (ja) 化粧用塗布具
TWI458469B (zh) 繃帶及其製造方法
RU2319801C1 (ru) Способ получения наполненного нетканого материала

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12782257

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2012782257

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2012253120

Country of ref document: AU

Date of ref document: 20120320

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 20137029260

Country of ref document: KR

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2014509584

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2013148631

Country of ref document: RU

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 112013028076

Country of ref document: BR

Kind code of ref document: A2