WO2006127756A2 - Rapid deployment prosthetic heart valve - Google Patents

Rapid deployment prosthetic heart valve Download PDF

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Publication number
WO2006127756A2
WO2006127756A2 PCT/US2006/019999 US2006019999W WO2006127756A2 WO 2006127756 A2 WO2006127756 A2 WO 2006127756A2 US 2006019999 W US2006019999 W US 2006019999W WO 2006127756 A2 WO2006127756 A2 WO 2006127756A2
Authority
WO
WIPO (PCT)
Prior art keywords
valve
stent
heart valve
anchoring member
valve member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/019999
Other languages
English (en)
French (fr)
Other versions
WO2006127756A3 (en
Inventor
Stanton J. Rowe
Larry Wood
Henry Bourang
George Bakis
Benjamin Spenser
Netanel Benichou
Yaron Keidar
Assaf Bash
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Edwards Lifesciences Corp
Original Assignee
Edwards Lifesciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edwards Lifesciences Corp filed Critical Edwards Lifesciences Corp
Priority to JP2008513640A priority Critical patent/JP4912395B2/ja
Priority to EP15156445.7A priority patent/EP2901967B1/en
Priority to CA2607744A priority patent/CA2607744C/en
Priority to EP06760323.3A priority patent/EP1883375B1/en
Priority to CN2006800178760A priority patent/CN101180010B/zh
Publication of WO2006127756A2 publication Critical patent/WO2006127756A2/en
Publication of WO2006127756A3 publication Critical patent/WO2006127756A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625—Vascular tissue, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0041—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using additional screws, bolts, dowels or rivets, e.g. connecting screws
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0066—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements stapled
    • A—HUMAN NECESSITIES
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    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • A—HUMAN NECESSITIES
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    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0083—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using hook and loop-type fasteners
    • A—HUMAN NECESSITIES
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    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped
    • A—HUMAN NECESSITIES
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    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0067—Three-dimensional shapes conical
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    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Definitions

  • the present invention generally relates to prosthetic valves for implantation in body channels. More particularly, the present invention relates to prosthetic heart valves configured to be surgically implanted in less time than current valves.
  • aortic stenosis and other heart valve diseases Due to aortic stenosis and other heart valve diseases, thousands of patients undergo surgery each year wherein the defective native heart valve is replaced by a prosthetic valve, either bioprosthetic or mechanical.
  • a prosthetic valve either bioprosthetic or mechanical.
  • surgical implantation of the prosthetic valve typically requires an open-chest surgery during which the heart is stopped and patient placed on cardiopulmonary bypass (a so-called "heart-lung machine").
  • cardiopulmonary bypass a so-called "heart-lung machine”
  • the diseased native valve leaflets are excised and a prosthetic valve is sutured to the surrounding tissue at the valve annulus. Because of the trauma associated with the procedure and the attendant duration of extracorporeal blood circulation, some patients do not survive the surgical procedure or die shortly thereafter.
  • a prosthetic valve is configured to be implanted in a much less invasive procedure by way of catheterization.
  • U.S. Patent No. 5,411,552 to Andersen et al. describes a collapsible valve percutaneously introduced in a compressed state through a catheter and expanded in the desired position by balloon inflation.
  • Various embodiments of the present invention provide prosthetic valves and methods of use for replacing a defective native valve in a human heart. Certain embodiments are particularly well adapted for use in a surgical procedure for quickly and easily replacing a heart valve while minimizing time using extracorporeal circulation (i.e., bypass pump).
  • a method for treating a native aortic valve in a human heart comprises: 1) accessing a native valve through an opening in a chest; 2) advancing an expandable support structure to the site of a native aortic valve, the support structure being radially compressed during the advancement; 3) radially expanding the support structure at the site of the native aortic valve; and 4) mechanically coupling a valve member to the expanded support structure, wherein the valve member replaces the function of the native aortic valve.
  • the support structure is a stent, which may comprise a metallic frame.
  • the metallic frame is made of stainless steel.
  • at least a portion of the metallic frame is made of a shape memory material.
  • the valve member may take a variety of forms.
  • the valve member comprises biological tissue.
  • the valve member further comprises a coupling portion configured to be connected to the support structure in a quick and efficient manner.
  • the metallic frame is viewed under fluoroscopy during advancement of the prosthetic valve toward the native aortic valve.
  • the native valve leaflets may be removed before delivering the prosthetic valve. Alternatively, the native leaflets may be left in place to - -
  • the native leaflets recoil inward to enhance the fixation of the metallic frame in the body channel.
  • a balloon or other expansion member may be used to push the valve leaflets out of the way and thereby dilate the native valve before implantation of the support structure.
  • a method for treating a native aortic valve in a human heart comprises accessing a native valve through an opening in a chest; advancing an expandable member to a position within the native aortic valve, the native aortic valve having at least two valvular leaflets; dilating the native aortic valve by expanding the expandable member to push aside the valvular leaflets of the native aortic valve; collapsing the expandable member and withdrawing the expandable member from the native aortic valve; advancing an expandable support structure to a position within the dilated native aortic valve, the support structure being radially compressed during the advancement; radially expanding the support structure within the dilated aortic valve, wherein the expanded support structure maintains the native aortic valve in the dilated condition; and coupling a valve member to the expanded support structure, wherein the valve member replaces the function of the native aortic valve.
  • an improved prosthetic valve comprises an expandable stent sized for implantation at the site of a native aortic valve, the stent having a coupling means (e.g., a plurality of tines extending from a first end thereof); and a valve member comprising three leaflets mounted on a base portion.
  • the coupling means is configured for attachment to the valve member.
  • the coupling means may be provided on the valve member or on both the stent and valve member.
  • a particularly useful configuration of the present invention is a two-stage prosthetic heart valve, comprising an expandable anchoring member sized to contact a heart valve annulus in an expanded state and a substantially non-expandable valve member configured for connection to the anchoring member.
  • the valve member includes a base ring surrounding an inflow end thereof, and the anchoring member comprises a tubular structure having connectors adapted to engage the base ring.
  • the connectors may comprise prongs that change shape and engage the base ring.
  • the base ring may be made of a suture-permeable material, and the prongs are configured to pierce the base ring, or the prongs are shaped to wrap around the base ring.
  • the valve member includes a plurality of discrete connectors spaced around a peripheral inflow end thereof
  • the anchoring member comprises a tubular structure having a plurality of mating connectors spaced around a peripheral outflow end thereof.
  • the connectors on the valve member and anchoring member engage one another by displacing the valve member toward the anchoring member.
  • the connectors on either the valve member or anchoring member comprise latches
  • the connectors on the other of the valve member or anchoring member comprise brackets, the latches configured to engage and lock to the brackets upon axial movement of the latches and brackets toward one another.
  • the anchoring member comprises a stent having a wider outflow end than an inflow end thereof, wherein the valve member comprises a base ring surrounding an inflow end thereof that fits within the outflow end of the stent.
  • the valve member includes a suture-permeable base ring surrounding an inflow end thereof, and the - -
  • anchoring member comprises a tubular structure having a suture-permeable fixation ring attached thereto, wherein the valve member connects to the anchoring member via sutures looped between the base ring and the fixation ring.
  • Another embodiment of the present invention comprises a two- stage prosthetic heart valve, having an expandable anchoring member sized to contact a heart valve annulus in an expanded state, a valve member, and an adapter sized to surround the valve member and engage the anchoring member, to connect the valve member and anchoring member.
  • the adapter may be an annular ring or a wireform-shaped member that closely surrounds and conforms to cusps and commissures of a flexible leaflet valve member.
  • the adapter desirably includes a plurality of discrete connectors
  • the anchoring member comprises a tubular structure having a plurality of mating connectors spaced around a peripheral outflow end thereof.
  • the connectors on the adapter and anchoring member are configured to engage one another by displacing the adapter toward the anchoring member.
  • the connectors on either the adapter or anchoring member comprise latches
  • the connectors on the other of the adapter or anchoring member comprise brackets, the latches being configured to engage and lock to the brackets upon axial movement of the latches and brackets toward one another.
  • valve member preferably has a base ring surrounding an inflow end thereof, and the adapter further includes a plurality of connectors adapted to engage and couple the adapter directly to the base ring.
  • adapter further includes a plurality of connectors adapted to engage and couple the adapter directly to the base ring.
  • FIG. 1 Another aspect of the present invention is a system for retrofitting a conventional prosthetic heart valve, comprising an off-the-shelf, non-expandable prosthetic heart valve having a sewing ring capable of being implanted using sutures through the sewing ring in an open-heart procedure.
  • An expandable anchoring member contacts and anchors to a heart valve annulus in an expanded state.
  • Coupling means connects the prosthetic heart valve to the anchoring member, the prosthetic heart valve thus being attached to the heart valve annulus via the anchoring member.
  • the anchoring member may comprise a tubular structure having a suture-permeable fixation ring attached thereto, wherein the coupling means comprises sutures looped between the base ring and the fixation ring.
  • An adapter sized to surround the heart valve engages the anchoring member, to connect the heart valve and anchoring member.
  • the adapter may be annular or wireform-shaped.
  • the adapter includes a plurality of discrete connectors
  • the anchoring member comprises a tubular structure having a plurality of mating connectors spaced around a peripheral outflow end thereof, the connectors on the adapter and anchoring member being configured to engage one another by displacing the adapter toward the anchoring member.
  • a surgical method of implanting a prosthetic heart valve of the present invention in a patient involves providing a two-stage prosthetic heart valve comprising an expandable anchoring member and a valve member, the anchoring member being sized to contact a heart valve annulus in an expanded state and the valve member being configured to connect to the anchoring member.
  • the patient is prepared for surgery by placing him/her on cardiopulmonary bypass.
  • the surgeon creates a direct access pathway to the heart valve annulus that preferably permits direct (i.e., naked eye) visualization of the heart valve annulus.
  • the anchoring member is delivered and expanded to contact the valve annulus, and the valve member is delivered and connected to the anchoring member.
  • the direct access pathway is created by performing open-heart surgery.
  • the method may include balloon-expanding the anchoring member.
  • the valve member may be expandable and the method includes delivering the valve member in a compressed state and expanding it prior to connecting it to the anchoring member.
  • the valve member and the anchoring member are provided with mating connectors, and the step of delivering and connecting the valve member to the anchoring member comprises axially displacing the valve member toward the anchoring member so that the mating connectors engage.
  • the anchoring member comprises a stent having an outflow end larger than an inflow end thereof, and the valve member comprises a non-expandable valve member having a base ring on an inflow end thereof sized to fit within the outflow end of the stent.
  • the anchoring member may be provided with bendable connectors on an outflow end thereof, and the method includes causing the connectors to bend inward and engage a peripheral base ring of the valve member.
  • a bending tool may be used to bend connectors inward.
  • Another surgical method of implanting a two-stage prosthetic heart valve in a patient of the present invention includes providing an expandable anchoring member sized to contact a heart valve annulus in an expanded state, delivering and attaching the anchoring member to the heart valve annulus, providing a non-expandable valve member, and delivering and connecting the valve member to the anchoring member.
  • the valve member and the anchoring member may be provided with mating connectors, and the step of delivering and connecting the valve member to the anchoring member comprises axially displacing the valve member toward the anchoring member so that the mating connectors engage.
  • the anchoring member comprises a stent having an outflow end larger than an inflow end thereof, and wherein the valve member comprises a base ring on an inflow end thereof sized to fit within the outflow end of the stent.
  • the anchoring member may be provided with bendable connectors on an outflow end thereof, and the method - -
  • the connectors includes causing the connectors to bend inward and engage a peripheral base ring of the valve member, such as by using a bending tool.
  • the valve member includes a base ring on an inflow end thereof, and the method further includes providing an adapter sized to surround the valve member and seat on the base ring.
  • the method therefore includes the step of delivering and connecting the valve member and coupling the adapter to the anchoring member.
  • the adapter includes a plurality of discrete connectors
  • the anchoring member comprises a tubular structure having a plurality of mating connectors spaced around a peripheral outflow end thereof.
  • the step of coupling the adapter to the anchoring member comprises displacing the adapter toward the anchoring member to engage the mating connectors thereon.
  • the adapter may further have a plurality of connectors adapted to engage and couple the adapter directly to the base ring, and the method includes causing the connectors to engage the base ring.
  • a prosthetic heart valve and a separate expandable anchoring member are provided.
  • the prosthetic heart valve and anchoring member are positioned within a valve dilator/delivery tube having an exterior diameter sized to dilate a heart valve annulus.
  • the valve dilator/delivery tube advances to the heart valve annulus, and the annulus is dilated using the valve dilator/delivery tube.
  • the anchoring member is expulsed from the tube and expanded to contact the heart valve annulus.
  • the prosthetic heart valve is then expulsed from the valve dilator/delivery tube, and connected to the anchoring member.
  • Another method of the present invention comprises retrofitting and rapidly implanting a conventional prosthetic heart valve in a patient.
  • the method includes providing an off-the-shelf non-expandable prosthetic heart valve having a sewing ring capable of being implanted using sutures through the sewing ring in an open-heart procedure.
  • An expandable tissue anchoring member sized to contact a heart valve annulus in an expanded state is delivered and expanded into contact with the heart valve annulus.
  • the prosthetic heart valve is delivered and connected to the tissue anchoring member.
  • Figure 1 is an exploded perspective view illustrating a preferred embodiment of a two-stage prosthetic valve comprising a stent portion and a valve member, wherein the valve member may be quickly and easily connected to the stent portion.
  • Figure 2 illustrates the valve embodiment of Figure 1 after the valve member has been attached to the stent portion by crimping portions of the stent over the commissural points of the valve member.
  • Figure 3 is an exploded perspective view of an alternative embodiment wherein the stent is provided with a plurality of tines configured to be crimped to a ring along the base of the valve member.
  • Figure 4 illustrates the valve embodiment of Figure 3 after the valve member has been attached to the stent portion by crimping the tines on to the valve member.
  • Figure 4A is a sectional view through one side of the prosthetic heart valve of Figure 4 taken along line 4A-4A and showing one configuration of tines connecting through a sewing ring portion of the valve member.
  • Figure 5 is an exploded perspective view of an alternative embodiment wherein slotted posts are provided on the stent for coupling to protruding members on the valve member.
  • Figure 5A is an enlarged view of one of the slotted posts provided on the stent of Figure 5.
  • Figures 6 and 6A illustrate another alternative embodiment similar to Figures 5 and 5A wherein the posts are configured with L-shaped slots for locking the valve member to the stent.
  • Figure 7 is a sectional view through a body channel that illustrates an alternative embodiment of prosthetic heart valves wherein first and second stents are provided for anchoring a valve member within the body channel.
  • Figure 8 is an exploded perspective view of an alternative embodiment wherein the stent has a small diameter and a large diameter and wherein an expandable valve member is deployed within the large diameter.
  • Figure 9A is an exploded perspective view of another alternative embodiment of a two part prosthetic valve wherein a ring portion along the base of the valve member snaps into a groove formed in the stent.
  • Figure 9B illustrates the embodiment of Figure 9A with the valve member connected to the stent.
  • Figure 10 is an exploded perspective view of another alternative embodiment wherein the valve member and the stent are provided with corresponding threaded portions for threadably engaging the valve member to the stent.
  • Figure 11 is an exploded perspective view of an alternative prosthetic heart valve of the present invention having a valve member, stent, and a threaded locking ring for coupling the two together.
  • Figures 12A and 12B are exploded and assembled perspective views of an alternative two-stage prosthetic heart valve having a valve member and tubular, expandable stent with tabs on an outflow end for coupling to the valve member.
  • Figures 12C and 12D are sectional views through one side of the prosthetic heart valve of Figure 12B schematically illustrating an exemplary tool that may be used to bend the tabs on the outflow end of the stent around a sewing ring of the valve member.
  • Figures 13A and 13B are exploded and assembled perspective views of an alternative prosthetic heart valve of the present invention wherein a valve member and stent with tabs are coupled together in conjunction with a locking ring.
  • Figures 14A and 14B are exploded and assembled perspective views of a still further prosthetic heart valve wherein a valve member and tubular, expandable stent are coupled together using a wireform-shaped adapter having tabs.
  • Figures 15A and 15B are exploded and assembled perspective views of a prosthetic heart valve having a valve member and stent with locking bands on an outflow end.
  • Figures 16A and 16B are exploded and assembled perspective views of an alternative prosthetic heart valve wherein a stent exhibits locking clips on an outflow end that are guided through mating slits on a locking ring to join the stent to a valve member.
  • Figures 17A and 17B are exploded and assembled perspective views of an alternative prosthetic heart valve wherein a stent has brackets on an outflow end that receive guided locking clips on a locking ring to join the stent to a valve member.
  • Figure 18 is a perspective view of an alternative stent for use in a prosthetic heart valve of the present invention.
  • Figure 19 is a detailed sectional view through an inflow side of a prosthetic heart valve utilizing the stent of Figure 18 and showing a valve member base ring captured between two sets of prongs. - -
  • Figure 20 is a perspective exploded view of a prosthetic heart valve having a tubular stent with upstanding tines and a valve member with an additional adapter ring arranged around a base ring.
  • Figure 21 is an exploded perspective view of an exemplary prosthetic heart valve having an expandable stent and non-expandable valve member connected by an array of parachute sutures being removed from a storage jar.
  • Figures 22A-22C are several views of the implantation of the prosthetic heart valve of Figure 21 assisted by a tubular valve dilator/delivery tube.
  • the present invention attempts to overcome drawbacks associated with conventional, open-heart surgery, while also adopting some of the techniques of newer technologies which decrease the duration of the treatment procedure.
  • the prosthetic heart valves of the present invention are primarily intended to be delivered and implanted using conventional surgical techniques, including the aforementioned open-heart surgery. There are a number of approaches in such surgeries, all of which result in the formation of a direct access pathway to the particular heart valve annulus.
  • a direct access pathway is one that permits direct (i.e., naked eye) visualization of the heart valve annulus.
  • embodiments of the two-stage prosthetic heart valves described herein may also be configured for delivery using percutaneous approaches, and those minimally- invasive surgical approaches that require remote implantation of the valve using indirect visualization.
  • One primary aspect of the present invention is a two-stage prosthetic heart valve wherein the tasks of implanting a tissue anchor and a valve member are somewhat separated and certain advantages result. For - -
  • a two-stage prosthetic heart valve of the present invention may have an expandable tissue anchoring member that is secured in the appropriate location using a balloon or other expansion technique. A valve member is then coupled to the tissue anchoring member in a separate or sequential operation.
  • an expandable anchoring member By utilizing an expandable anchoring member, the duration of the initial anchoring operation is greatly reduced as compared with a conventional sewing procedure utilizing an array of sutures.
  • the expandable anchoring member may simply be radially expanded outward into contact with the implantation site, or may be provided with additional anchoring means, such as barbs.
  • the operation may be carried out using a conventional open-heart approach and cardiopulmonary bypass. In one advantageous feature, the time on bypass is greatly reduced due to the relative speed of implanting the expandable anchoring member.
  • tissue anchoring member refers to a structural component of a heart valve that is capable of attaching to tissue of a heart valve annulus.
  • the anchoring members described herein are most typically tubular stents, or stents having varying diameters.
  • a stent is normally formed of a biocompatible metal wire frame, such as stainless steel or Nitinol.
  • Other anchoring members that could be used with valves of the present invention include rigid rings, spirally-wound tubes, and other such tubes that fit tightly within a valve annulus and define an orifice therethrough for the passage of blood, or within which a valve member is mounted. It is entirely conceivable, however, that the anchoring member could be separate clamps or hooks that do not define a continuous periphery. Although such devices sacrifice some dynamic stability, these devices can be configured to work well in conjunction with a particular valve member.
  • valve member refers to that component of a heart valve that possesses the fluid occluding surfaces to prevent blood flow in one direction while permitting it in another.
  • various constructions of valve numbers are available, including those with flexible leaflets and those with rigid leaflets or a ball and cage arrangement.
  • the leaflets may be bioprosthetic, synthetic, or metallic.
  • a primary focus of the present invention is the two-stage prosthetic heart valve having a first stage in which an anchoring member secures to a valve annulus, and a subsequent second stage in which a valve member connects to the anchoring member.
  • two-stage prosthetic heart valve including an anchoring member and a valve member
  • the valve member may be replaced after implantation without replacing the anchoring member. That is, an easily detachable means for coupling the valve member and anchoring member may be used that permits a new valve member to be implanted with relative ease.
  • Various configurations for coupling the valve member and anchoring member are described herein.
  • the term “expandable” is used herein to refer to a component of the heart valve capable of expanding from a first, delivery diameter to a second, implantation diameter.
  • An expandable structure therefore, does not mean one that might undergo slight expansion from a rise in temperature, or other such incidental cause.
  • “non- expandable” should not be interpreted to mean completely rigid or a dimensionally stable, as some slight expansion of conventional "non- expandable" heart valves, for example, may be observed.
  • body channel is used to define a blood conduit or vessel within the body.
  • prosthetic heart valve determines the body channel at issue.
  • An aortic valve replacement for example, would be implanted in, or adjacent to, the aortic annulus.
  • a mitral valve replacement will be implanted at the mitral annulus.
  • an improved prosthetic valve 10 generally includes an expandable anchoring member or stent 20 and a valve member 30.
  • the stent provides a support structure for anchoring the valve member within a body lumen.
  • a stent is described for purposes of illustration, any support structure capable of anchoring the valve member to the body lumen may be used.
  • the prosthetic valve is configured such that the valve member may be quickly and easily connected to the stent.
  • the anchoring members or stents described herein can be a variety of designs, including having the diamond-shaped openings shown or other configurations detailed below.
  • the material depends on the mode of delivery (i.e., balloon- or self-expanding), and the stent can be bare strut material or covered to promote in-growth and/or to reduce paravalvular leakage.
  • a suitable cover that is often used is a sleeve of fabric such as Dacron.
  • the stent may be securely deployed in the body channel using an expandable member, such as, for example, a balloon. Because the stent is expanded before the valve member is attached, the valve member will not be damaged or otherwise adversely affected during the stent deployment. After the stent has been deployed in the body channel, the valve member may be connected to the stent.
  • the two-stage prosthetic valve is well-suited for use in heart valve replacement.
  • the stent may be advantageously used to push the native leaflets aside such that the valve member can replace the function of the native valve.
  • the anchoring members or stents described herein could include barbs or other such tissue anchors to further secure the stent to the tissue. In one preferred embodiment, the barbs are deployable (e.g., configured to extend or be pushed radially outward) by the expansion of a balloon.
  • the two-stage prosthetic valve illustrated in Figure 1 provides a device and method for substantially reducing the time of the surgical procedure. This reduces the time required on extracorporeal circulation and thereby substantially reduces the risk to the patient.
  • the surgical time is reduced because the stent may be deployed quickly and the valve member may be attached to the stent quickly. This simplifies and reduces the surgical time as compared with replacement valves that are sutured to the tissue after removing the native leaflets.
  • the valve member 30 When used for aortic valve replacement, the valve member 30 preferably has three leaflets 36 which provide the valvular function for replacing the function of the native valve.
  • the valve leaflets may be taken from another human heart (cadaver), a cow (bovine), a pig (porcine valve) or a horse (equine).
  • the valve member may comprise mechanical components rather than biological tissue.
  • the valve is compressible in diameter. Accordingly, the valve may be reduced in diameter for delivery into the stent and then expanded.
  • the three leaflets are supported by three commissural posts 34.
  • a ring 32 is provided along the base portion of the valve member.
  • the stent 20 is provided with two diameters.
  • a lower portion 22 has a small diameter and an upper portion 24 has a large diameter.
  • the lower portion 22 is preferably sized to be deployed at the location of the native valve (e.g., along the aortic annulus).
  • the upper portion 24 expands outwardly into the perspective cavity adjacent the native valve.
  • the upper portion 24 expands into the area of the sinus cavities just downstream from the aortic annulus.
  • the stent body is preferably configured with sufficient radial strength for pushing aside the native leaflets and holding the native leaflets open in a dilated condition.
  • the native leaflets provide a stable base for holding the stent, thereby helping to securely anchor the stent in the body.
  • the lower portion may be configured with anchoring members, such as, for example, hooks or barbs (not shown).
  • the upper portion 24 of the stent 20 has a larger diameter sized for receiving the valve member 30.
  • a transition region 28 between the upper and lower portions of the stent body may be advantageously used to provide a seat for the bottom end of the valve member.
  • the stent may further comprise a ridge (not shown) along an inner wall for providing a more definite seat portion within the stent.
  • the prosthetic valve 10 is provided with a coupling mechanism for securing the valve member 30 to the stent 20.
  • the coupling mechanism may take a variety of different forms.
  • the stent body comprises three posts 26 which correspond to the three commissural points 34 on the valve member.
  • the three posts 26 are preferably formed of a malleable material such that the posts 26 may be crimped over the commissural points on the valve member.
  • a bending tool (not shown) may be provided for crimping the posts 26 over the commissures of the valve member, or the posts 26 may be hinged or made of the shape memory material so as to curl once implanted in the body.
  • the prosthetic valve 10 is illustrated in the assembled condition with the posts 26 crimped over the commissural points 34 of the valve member.
  • the three posts on the stent are formed with a recess for receiving the commissural points, such as in a snap-fit relationship.
  • the stent 20 is expandable, but the valve member 30 is a conventional, non-expandable prosthetic heart valve, such as the Carpentier-Edwards PERIMOUNT Magna® Aortic Heart Valve available from Edwards Lifesciences of Irvine, California.
  • a "conventional" prosthetic heart valve is an off-the-shelf (i.e., suitable for stand-alone sale and use) non-expandable prosthetic heart valve having a sewing ring capable of being implanted using sutures through the sewing ring in an open-heart procedure.
  • An implant procedure therefore involves first delivering and expanding the stent 20 and the aortic annulus, and then coupling the valve member 30 thereto.
  • valve member 30 is non- expandable, the entire procedure is typically done using the conventional open-heart technique. However, because the stent 20 is delivered and implanted by simple expansion, the entire operation takes less time. This hybrid approach will also be much more comfortable to surgeons familiar with the open-heart procedures and conventional heart valves. Moreover, the relatively small change in procedure coupled with the use of proven heart valves should create a much easier regulatory path than strictly expandable, remote procedures.
  • a variation of the embodiment described in Figures 1 and 2 may incorporate an expandable stent 20 and an expandable valve member 30.
  • the valve member 30 may be capable of expansion within the body, such as the Cribier-Edwards Aortic Percutaneous Heart Valve, also available from Edwards Lifesciences. Therefore, the valve 10 may be implanted without an open-heart procedure, and even without stopping heart.
  • the three posts 26 on the stent 20 may be made of a shape memory material having a temperature-induced shape change once implanted.
  • a tool for bending the posts 26 may be delivered along with the valve 10 and utilized when the valve member 30 seats within the stent 20.
  • an alternative prosthetic valve 1OA comprises a stent 40 provided with a bottom portion 42 and an upper flared portion 44.
  • a plurality of prongs or tines 46 is disposed along a top end of the flared portion 44.
  • the tines 46 are preferably bendable members configured to engage the ring portion 32 along the base of the valve member 30.
  • the tines 46 are crimped over the ring as shown in Figure 4.
  • the tines 46 may have pointed tips for passing through a fabric or other similar material along the ring portion of the valve member, such as seen in Figure 4A.
  • the stent 40 is desirably an expandable member that can be easily delivered and implanted at the body channel.
  • the valve member 30 may be conventional, or may also be expandable.
  • the illustrated embodiment shows a conventional valve 30 having the sewing ring portion 32 surrounding an inflow end. Sewing rings are typically made of suture- permeable material covered with cloth.
  • the tines 46 may be sharp enough to pierce the material of the sewing ring portion 32 ( Figure 4A).
  • a conventional valve member 30 may be utilized without modification.
  • the sewing ring portion 30 may be replaced with a more rigid peripheral band or ring, and the tines 46 are simply bent inward so as to fold over the ring and capture the valve member 31 on the top of the stent 40.
  • a seat or rim of some sort is provided within the interior of the stent 40 so that the valve member 30 can easily be positioned therein.
  • the tines 46 may be mechanically bent using a deployment tool (not shown), or they may be hinged or made of a shape memory material so as to curl inward upon reaching a certain temperature.
  • another alternative prosthetic valve 1OB comprises an anchoring member or stent 50 provided with a cylindrical portion 52 and three posts 54 extending upward from the cylindrical portion.
  • Each post 54 may be slotted, as illustrated in the enlarged view of Figure 5B, or formed with an orifice.
  • Radially protruding members 38 are provided along the ring portion 32 of the valve member 30 for mating with the posts on the stent.
  • the exemplary slot has a thin neck portion 58 wherein engagement members, such as angled teeth, are provided. The teeth are angled such that the slot widens as the protruding member 38 is pushed downward into the slot. After passing through the teeth into the capture portion 59, the protruding member 38 is securely captured. Because the teeth are angled in only one direction, an upward force will not cause the slot to widen, thereby capturing the protruding member.
  • FIG. 6 yet another alternative embodiment of a component prosthetic valve 1OC is illustrated.
  • the embodiment of Figure 6 is similar to the embodiment illustrated and described above with respect to Figure 5.
  • the posts or connecting members 55 are provided with L-shaped slots 57 for receiving the protruding member disposed along the valve member.
  • FIG. 6A 5 an enlarged view of one preferred connecting member 55 is shown.
  • the slot 57 of the connecting member 55 is shaped such that the protruding member 38 moves longitudinally into the slot and then rotationally to enter the capture portion.
  • One or more teeth 58 may be provided for holding the protruding member in the capture portion.
  • the protruding member 38 may be held in the slot 57 using friction or a mechanical locking member.
  • a key lock system or "bayonet" attachment mechanism may be provided for coupling the valve member to the stent.
  • FIG. 7 another alternative prosthetic valve 1OD is illustrated wherein the valve member 30 is captured and held between first and second stents 60, 62.
  • the first stent 60 is expanded within a body channel such that the outer surface of the stent is in contact with the vessel wall 64.
  • the valve member 30 is then advanced through the body channel and into contact with the first stent.
  • a ring 32 is preferably provided along the base portion of the valve member for contacting the outflow end of the first stent.
  • the second stent is then advanced through the body channel and is deployed such that an inflow end of the second stent contacts a top surface of the ring 32 of the valve member for anchoring the valve member between the first and second stents.
  • FIG. 7 The embodiment of Figure 7 employs a slightly different means for connecting the valve member 30 the anchoring member.
  • stents 60, 62 capture the ring 32 of the valve member 30 therebetween simply by providing upper and lower barriers to movement.
  • the valve member 30 is desirably a non-expandable type, therefore the ring 32 is not overly susceptible to compression.
  • the valve member 30 remains sandwiched therebetween.
  • the outflow end of the first stent 60 and the inflow end of the upper stent 62 are preferably flat or blunt so as not to dig into the ring 32.
  • the ring 32 may be made relatively firm or rigid.
  • the facing edges of the stents 60, 62 may be provided with barbs or other such piercing devices, and the ring 32 provided as a conventional suture-permeable sewing ring.
  • the anchoring members or stents described herein could include barbs or other anchors to further secure the stent to the tissue.
  • the barbs could be deployable (e.g., configured to extend or be pushed radially outward) by the expansion of a balloon.
  • the stent can be covered to promote in-growth and/or to reduce paravalvular leakage. The cover would be similar to those on other valves, e.g., a Dacron tube or the like.
  • the valve member may be constructed with a tubular frame or cage for engaging one or both stents 60, 62.
  • the stents may be self-expanding or balloon- expandable.
  • valve member 30 of this embodiment is not required to be mounted within a cylindrical frame or stent. Accordingly, the flow through area of the valve member may be maximized to improve valve function.
  • first and second stents may be integrated as a single unit forming a chamber therebetween. In this variation, the valve member may be expanded within the chamber for securely deploying the valve member in the body channel.
  • the anchoring member or stent 70 is provided with a varying diameter. More particularly, a lower portion 72 of the stent has a small diameter sized for implantation at a native valve annulus. In one preferred configuration, the small diameter is about 23 mm.
  • the stent also has an upper portion 74 with a larger diameter for receiving an expandable valve member 3OA.
  • the larger diameter is about 29 mm.
  • the valve member 3OA is provided as a tubular body that is radially expandable. The valve leaflets are disposed along the interior of the valve member.
  • the stent 70 preferably includes a circular ridge 76 formed along the transition region between the large and small diameters.
  • the ridge provides a seat for the base of the valve member 30A.
  • the ridge 76 incorporates a support wire 78 that extends at least partially through the ridge for strength and may be used to provide a radiopaque marker.
  • the remaining portion of the ridge may be formed of Dacron or any other suitable material.
  • the stent 70 may be comprised of a screen or mesh.
  • a cover 75 such as a polymer sheet, may be provided along at least a portion of the stent to help prevent leakage and enhance sealing, hi addition, a sponge or cloth may be provided along the exterior portion of the stent for further enhancing sealing.
  • the stent 70 of Figure 8 may be self-expanding or balloon- expandable.
  • a expandable tapered (i.e., two diameter) balloon may be provided for deploying the stent.
  • the balloon When configured for use with a stent having diameters of 23 mm and 29 mm, the balloon may have diameters of 22 mm and 28 mm, respectively.
  • a valve member 30 is configured for connection with an anchoring member or stent 90.
  • the stent 90 is provided with a groove 94 formed in an inwardly-directed circumferential member 92.
  • the groove extends at least partially around the inner portion of the stent and is sized to receive the ring portion 32 of the valve member 30.
  • the ring is configured to snap fit into the groove, as seen in Figure 9B.
  • the ring is made of a shape memory material configured to expand after deployment in the body. In this variation, the ring is configured to radially expand for securely anchoring itself within the groove.
  • valve member 30 is configured for threadable engagement with an anchoring member or stent 100.
  • the stent is provided on one end with a threaded region 102 along an inner wall configured for receiving a threaded flange portion 33 on the valve member 30.
  • the threaded flange portion is preferably provided along the ring 32 at the base of the valve member.
  • the stent is substantially non-expandable and is delivered into the lumen in its fully expanded condition. This can be achieved by first stretching or dilating the delivery site for receiving the stent, hi another embodiment, only the lower portion of the stent is expanded for engaging the tissue.
  • the valve member is threadably attached to the threaded flange on the stent after the stent has been firmly anchored in the body channel. This attachment means is configured such that the valve member advantageously connects to the stent through rotational movement. Accordingly, longitudinal forces applied to the valve member after implantation will have little or no effect on the integrity of the connection between the stent and valve.
  • an alternative prosthetic heart valve 1OH comprises a valve member 30, an anchoring member or stent 110, and a locking ring 112.
  • the stent 110 desirably expands first at the implantation site, after which a conventional valve member 30 couples to the stent through the use of the locking ring 112.
  • the valve member 30 may also be expandable, and the stent 110 can take a variety of forms.
  • the stent 110 comprises a latticework of balloon- expandable members adapted to be delivered to the implantation site in a collapsed or compressed state, and then expanded from within using a balloon.
  • a self-expanding stent 110 could also be used, and additional anchoring means of such as exterior barbs may be provided to help prevent the stent from migrating after implantation.
  • a series of tabs or flanges 114 project slightly inwardly from an outflow end of the stent 110.
  • the flanges 114 are configured to mate with exterior threading 116 on a downwardly-projecting shoulder of the locking ring 112.
  • the number and configuration of the flanges 114 is selected to avoid interfering with radial expansion of the stent 110, and also to mate with the threads 116 of the locking ring 112.
  • a series of space-apart flanges 114 for example eight, evenly spaced around the outflow rim of the stent 110 project inward therefrom a distance of between 1-3 mm.
  • An inner bore 118 of the locking ring 112 possesses a diameter large enough to pass over the entire valve member 30 except for the base ring 32, which could be a sewing ring of a conventional heart valve.
  • the locking ring 112 surrounds the valve member 30 and desirably includes an inner ledge that rests on the base ring 32 thereof.
  • the inner diameter of the shoulder having the exterior threading 116 is sized larger than the base ring 32 and extends downwardly into engagement with the flanges 114.
  • valve member 30 After implantation, removal and replacement of the valve member 30 merely requires releasing the locking ring 112 from any tissue ingrowth, unscrewing and removing it, and releasing the valve member 30 from the stent 110 by cutting away any tissue ingrowth therebetween. - -
  • FIGS 12A and 12B illustrate another prosthetic heart valve 101 of the present invention having an expandable anchoring member or stent 120 coupled to a valve member 30.
  • the outflow end of the stent 120 exhibits a series of spaced-apart tabs 122 that curl around the base ring 32 of the valve member 30.
  • the stent 120 is a straight tube, and there are fewer tabs 122 (e.g., eight) than there are tines 46 in the valve 1OA.
  • the tabs 122 may be bent using an auxiliary tool (not shown), or may possess a property permitting autonomous bending, such as temperature-induced movement.
  • Figures 12C and 12D are sectional views through one side of the prosthetic heart valve 101 of Figure 12B schematically illustrating an exemplary tool that may be used to bend the tabs 122 on the outflow end of the stent 120 around the base ring 32 of the valve member 30. It should be noted that the section is taken radially through one side of the system, and the tool will typically be annular or at least peripherally arranged to bend each one of the tabs 122.
  • the tool comprises a forming member 124 having a forming surface 125.
  • the forming member 124 slides within and relative to an outer anvil 126 having an inwardly angled portion 128 that directly surrounds and engages each of the tabs 122.
  • the forming surface 125 is curved such that axial displacement of the forming member 124 in the direction shown in Figure 12C curls each of the tabs 122 inward to the shape of Figure 12D.
  • the tabs 122 wrap over the top of and restrain the base ring 32.
  • the tool may be used to bend prongs so that they pierce the base ring 32.
  • the outer anvil 126 is primarily used for centering purposes to guide the forming member 124 toward the tabs 122.
  • FIGS 13A and 13B illustrate another embodiment of a prosthetic valve 10J having multiple components joined together.
  • An anchoring member or stent 130 includes a plurality of tangs or flanges 132 on an outflow end.
  • a valve member 30 seats adjacent the outflow end of the stent 130, and a fixation ring 134 extends therearound.
  • a plurality of tabs 136 project downward from the fixation ring 34.
  • the tabs 136 enable the fixation ring 34 to be coupled to the base ring 32 of the valve member 30 by mechanically bending the tabs, or configuring the tabs to curl upon reaching a certain temperature.
  • the flanges 132 extend around the outside of the fixation ring 134 and bend around the upper or outflow end thereof. Again, this can be accomplished using an auxiliary tool or through temperature-induced movement.
  • the flanges 132 may be formed of a resilient polymer or metal having the shape seen in Figure 13B such that they can be flexed outward around the fixation ring 134 and then snapped back into place to secure the ring around the valve member 30.
  • the interior of the fixation ring 134 is desirably contoured to mate with the base ring 32 of the valve member 30.
  • the fixation ring 134 can be made of any number of materials, including rigid, flexible, metallic, polymer, bioabsorbable, etc.
  • One preferred configuration is a Teflon ring coated with anti-thrombogenic or anti-microbial compositions.
  • FIG 14A illustrates a still further prosthetic heart valve 1OK having an expandable anchoring member or stent 140, a valve member 30, and a wireform-shaped adapter 142.
  • the stent 140 and valve member 30 have been previously described.
  • the adapter 142 has a shape similar to a so-called "wireform" used in the internal construction of many prior art bioprosthetic tissue valves.
  • the valve member 30 is desirably a Carpentier-Edwards PERIMOUNT Magna® Aortic Heart Valve made by Edwards Lifesciences, and including therewithin an Elgiloy wireform.
  • the adapter 142 may be formed of biocompatible polymers or metals, preferably an alloy such as Nitinol.
  • the adapter 142 carries a plurality of securing tabs 144, 146.
  • three lower securing tabs 144 are located at the apex of the three cusps of the wireform-shape, and two upper securing tabs 146 are located at each of the upstanding commissures of the wireform-shape, for a total of six at the commissures.
  • Figure 14B is a detailed illustration of the assembly of the stent 140, valve member 30, and adapter 142.
  • the base ring 32 of the valve member 30 seats on or just within the outflow end of the stent 140, and the adapter 142 fits over the valve member and couples to it, as well as to the stent.
  • the cusps of the adapter 142 seat on or slightly outside the base ring 32 with the commissures surrounding and conforming to the commissures of the valve member 30.
  • the cusp securing tabs 144 bend up over the base ring 32 and down into engagement with the stent 140.
  • the two securing tabs 146 at each commissure of the adapter 142 bend or wrap around the corresponding valve member commissure.
  • a supplemental tool may be used to accomplish the bending of the securing members 144, 146, or they may exhibit temperature- changing properties.
  • the securing tabs 144, 146 are malleable, though other configurations are within the scope of the invention.
  • the lower securing tabs 144 may be barbs or tangs which pierce the base ring 32 and hook around the stent 140, while the upper securing tabs 146 may be resilient straps that wrap around each one of the commissures of the valve member 30.
  • the stent includes a plurality of upstanding barbs 147 comprising spaced apart posts having teeth 140.
  • the adapter 142 possesses a plurality of outwardly projecting brackets 149 defining slots therethrough. As seen in Figure 14B, the barbs 147 pass through the base ring 32 and through the slots of the brackets 149 in the adapter 142.
  • the teeth 148 prevent removal of the barbs - -
  • the securing tabs 144, 146 are not initially carried by the adapter 142, but instead are added after the assembly of the three components. For instance, staples or even sutures may be used after the valve member 30 seats on the stent 140, and the adapter 142 is lowered around the valve member. Even if sutures are used, the time required relative to a conventional sewing operation is greatly reduced. Moreover, the structural support and anchoring properties of the wireform-shaped adapter 142 greatly enhances the overall integrity of the assembly. In this regard, securing tabs such as those shown may be placed more continuously around the adapter 142 so as to provide more uniform contact with the valve member 30.
  • One possible configuration is a series of small hooks or brackets extending along the undulating adapter 142 that loop over the corresponding undulating shape on the valve member 30.
  • the valve member 30 is therefore restrained from upward movement relative to the adapter simply by lowering the adapter 142 over the valve member.
  • only the lower securing members need be actively attached, such as by causing their shape to change and bend into engagement with the stent 140, as seen in Figure 14B.
  • a further prosthetic valve embodiment 1OL seen in Figure 15A includes an expandable anchoring member or stent 150 and a valve member 30.
  • a plurality of fixation straps 152 is disposed along the outflow end of the stent 150.
  • Four such straps 152 are shown; however, in other variations, more or less may be utilized. For example, three straps extending farther around the periphery of the outflow end of the stent 150 may be substituted. Conversely, four or more straps that overlap one another may be used.
  • FIG. 15B illustrates the valve member 30 seated on top of the stent 150 with one of the straps 152 securing the two components together.
  • Straps 152 may be attached at both of their ends to the stent 150, and may comprise a resilient biocompatible material that stretches over the base ring 32 of the valve member 30. Alternatively, the straps may be bent or folded over the base ring. In one variation, one end of each strap 152 may be initially free, and after the strap is looped over the base ring 32 is then attached to the stent 150, somewhat like a belt configuration.
  • the straps 152 may be formed of a variety of materials, typically cloth-covered so as to permit tissue ingrowth over a cloth-covered base ring 32 for enhanced long-term anchorage. One possible variation is to incorporate small barbs or Velcro-style hooks in each of the straps 152 so as to gain better purchase on the base ring 32.
  • FIGs 16A and 16B illustrate a still further embodiment, wherein the prosthetic heart valve 1OM comprises a valve member 30, expandable anchoring member or stent 160, and coupling ring 162.
  • the coupling ring 162 defines a series of circumferentially-spaced apertures or slots 164 that receive upstanding hooks or latches 166 on the stent 160.
  • the coupling ring 162 surrounds the commissures of the valve member 30 and seats on the base ring 32, and the latches 166 extend through the slots 164 and are secured therein by outwardly directed teeth 168.
  • the latches 166 each comprise a pair of parallel, spaced apart upstanding members, each with an outwardly directed tooth 168, which may be cammed inward toward one another as they pass through the slots 164. As the teeth 168 clear the slot 164, the parallel members resiliently spring outward thus latching the stent 160 to the coupling ring 162.
  • the coupling ring 162 may further include a plurality of outwardly projecting tabs 172 that are bent or curl around the base ring 32.
  • one or more guide members may be used to direct the coupling ring toward the stent such that the slots are aligned with the latch members.
  • a plurality of guide filaments 170 are attached to each one of the upstanding latch members and passed through the corresponding slots.
  • Figure 16A illustrates the pre-assembled valve 1OM with the guide filaments 170 extending up through each of the slots 164.
  • the implantation procedure comprises first delivering and expanding the stent 160, and then advancing the valve member 30 to the position shown in Figure 16B.
  • each two guide filaments 170 comprises a strand of a single looped passing through small holes in each of the latch members. Removal of the guide filaments 170 is thus a simple matter of just pulling one of the strands, or severing the loop in between the latch members.
  • guide filaments could be used on any of the embodiments described herein to facilitate coupling of the separate components of the prosthetic heart valves.
  • a wireform similar to the embodiment illustrated in Figure 14A may also be used with a guiding filament.
  • the exemplary embodiment shows the latches 166 extending around the outside of the base ring 32 of the valve member 30. It is entirely feasible, on the other hand, to design the latches 166 to pierce through the base ring 32. Inclusion of the coupling ring 162 is suggested, because of its washer-like function in holding the assembly together. However, the latches 166 may be designed to pierce through and securely fasten to stent 160 to the base ring 32 without the use of the coupling ring 162. In this regard, the latches 166 may be configured differently, or more than the number shown may be provided.
  • 4, 6, 8, or more single latch members having a configuration such as shown with a leading sharp point and rearwardly directed barb (much like a fish hook) could fight adequate anchorage through a conventional base ring 32 made of a silicone sponge covered with cloth.
  • a leading sharp point and rearwardly directed barb could fight adequate anchorage through a conventional base ring 32 made of a silicone sponge covered with cloth.
  • the stent 160 in Figures 16A and 16B has an outflow end that is preferably sized larger than its inflow end. More particularly, the outflow end is flared so as to receive therein the base ring 32 of the valve member 30. In this way, a larger orifice valve member can be utilized than with a straight tubular stent.
  • the reader is also reminded that at least the flared portion of the stent 160 is desirably provided with a sleeve of Dacron or other such fabric to help prevent paravalvular leaking between the base ring 32 and the surrounding native valve annulus.
  • an expandable anchoring member or stent 180 couples to a valve member 30 through the use of a coupling ring 182 in a manner similar to the last-described embodiment.
  • the coupling ring 182 carries a plurality of latches 184 which mate with brackets 186 provided on the stent 180.
  • the latches 184 again comprise a pair of spaced-apart latch members having outwardly directed teeth 188, and the brackets 186 are simply apertures or slots in material loops that extend outward from the stent 180 adjacent its outflow end.
  • the latches 184 extend through the brackets 186 as seen in Figure 17B.
  • a plurality of guide filaments 190 loop through the brackets 186 and through holes provided in the latches 184. Simply parachuting the coupling ring 182 down the filaments 190 aims the latches 184 through the brackets 186.
  • any of the fixation rings i.e., locking ring 112, fixation ring 134, adapter 142, coupling ring 162, or coupling ring 182
  • a tissue growth factor or fibrin glue or the like may be coated on the exterior of any of these fixation rings for a better seal.
  • the fixation rings might have an outer rim of fabric for encouraging tissue ingrowth.
  • the various fixation rings described and the base ring 32 of the valve member 32 may be constructed as a single component.
  • the base ring 32 could be configured to have slots (or any coupling member) in lieu of a separate fixation ring.
  • an alternative expandable anchoring member or stent 200 is illustrated wherein the anchoring member is configured to receive a valve member 30 to form a prosthetic heart valve.
  • a portion of the valve member is gripped between inwardly extending members located within the stent.
  • the stent 200 comprises a plurality of axial struts 202 connected by a number of rows of circumferential crown-shaped struts 204 to form a generally tubular structure.
  • a lower or inflow end of the stent 200 includes a circumferential row of crown-shaped struts 206 that is larger than the others such that the inflow end of the stent flares outward.
  • the upper rows 204 of circumferential struts define valleys (pointing downward) at the axial struts 202 and peaks (pointing upward) midway between each two adjacent axial struts.
  • the spaces defined between adjacent axial struts 202 and adjacent rows of circumferential struts 204 are preferably chevron-shaped, pointed upward.
  • the lower circumferential row of struts 206 has upper peaks at the axial struts 202 and lower valleys therebetween, resulting in elongated hexagon-shaped spaces between the lower two circumferential rows of struts.
  • the stent 200 possesses a plurality of prongs that extend inward therefrom to capture the valve member 30.
  • the base ring 32 of the valve member 30 seats on a plurality of lower prongs 208.
  • Figure 18 shows the lower prongs 208 extending inward from the lower row of struts 206 at the valleys between adjacent axial struts 202.
  • the lower prongs 208 terminate in enlarged heads 210 to prevent damage to the base ring 32.
  • the lower prongs 208 project inward farther than the expanded to defined by the upper portion of the stent 200.
  • a plurality of upper prongs 212 extend inward from one of the upper rows of circumferential struts 204.
  • the upper prongs 212 project inward from the second lowest row. As seen in Figure 19, the upper prongs 212 contact the base ring 32 of the valve member 30. In this manner, the valve member 30 is captured between the lower prongs 208 and upper prongs 212.
  • the stent 200 includes twelve axial struts 202, and one of each of the prongs 208, 212 between each adjacent pair of axial struts, resulting in twelve each of the lower and upper prongs.
  • the number of prongs could be more or less depending on the configuration of the stent 200.
  • the prongs 208, 212 may be initially flat within the profile of the surrounding struts to prevent interference with an expansion- balloon. After stent deployment they may be bent inward into the angles shown using a tool (not shown).
  • the balloon wall could be relatively thick and able to withstand puncture by the round heads of the prongs 208, 212 such that they are at all times biased inward and automatically assume the angles shown after balloon removal.
  • the user advances the stent 200 in a collapsed state through the vasculature or a chest port into the target implantation site. Through self-expansion or balloon- expansion, the stent 200 expands into contact with the surrounding valve annulus. The valve member 30 then advances into position adjacent the - Jo -
  • valve member 30 is a conventional non-expandable design, but could also be expandable, in which case it is then expanded prior to assembly with the stent 200.
  • the outer diameter of the base ring 32 of the valve member 30 is sized approximately the same as the inner diameter of the tubular upper portion of the stent 200.
  • the valve member 30 advances from the outflow end of the stent 200 toward the inflow end until the base ring 32 contacts the circular row of upper prongs 212.
  • the upper prongs 212 are flexible, hinged, or otherwise capable of being displaced outward by the base ring 32 as the valve member 30 passes.
  • the base ring 32 seats on the circular row of relatively non-flexible lower prongs 28 and the valve member 30 cannot be advanced farther.
  • the spacing between the lower prongs 208 and the upper prongs 212 is such that the upper prongs 212 spring inward at the point that the base ring 32 seats on the lower prongs 208.
  • the upper prongs 212 may be formed with blunt heads like the lower prongs 208, or may be straight or even sharp-pointed to pierce the base ring 32 and provided enhanced anchorage. In a preferred embodiment, both the lower prongs 208 and upper prongs 212 possess enlarged, blunt heads such that the base ring 32 is merely trapped between the two sets of prongs.
  • the design of the stent 200 of Figure 18 thus enables rapid deployment of a valve member therewithin, as well as positive tactile feedback to the user with valve member 30 is completely installed. Because the base ring 32 is sized closely within the stent 200, good peripheral sealing is provided. To better enhance sealing, a peripheral skirt or layer of graft material may be added on the interior or exterior of the stent 200.
  • the stent 222 and manner of connecting the stent to the valve member 30 is similar to embodiment of Figures 3 and 4, and also the embodiment of Figure 12, in that a plurality of tines 226 project upward from the stent 222. However, instead of the tines 226 piercing or curling around the base ring 32 of the valve member 30, the tines interact with the adapter ring 224.
  • the adapter ring 224 attaches around the lower periphery of the base ring 32, preferably via a secure stitch line formed during assembly of the valve member 30.
  • the tines 226 pierce or otherwise engage the adapter ring 224 instead of the base ring 32 to couple the valve member 30 to the stent 222.
  • the supplemental adapter ring 224 provides an added margin of safety that helps prevent damage to the valve member 30 by the tines 226. For instance, if the tines 226 are configured to pierce and curl inward, they are farther away from the inner flexible leaflets 36 of the valve member which are susceptible to puncture or tearing.
  • yet another embodiment of a prosthetic heart valve 230 comprises an anchoring member or stent 232 coupled to a valve member 30 via a plurality of sutures 234.
  • the components of the valve 230 are shown exploded above a container or jar 236 used to store the components.
  • the entire assembly, including the attachment sutures 234, may be stored together in the jar 236 so as to be ready for deployment.
  • only the stent 232 and valve member 30 may be stored in the jar 236, and the sutures 234 added just prior to deployment but before the actual operation.
  • the stent 232 can be stored dry in a sterile container, while the valve member 30 having bioprosthetic leaflets may be stored separately in a suitable preservative fluid such as glutaraldehyde.
  • a suitable preservative fluid such as glutaraldehyde.
  • FIGS 22 A through 22C show the components of the prosthetic heart valve 230 in conjunction with a valve dilator/delivery tube 240.
  • the usage of the delivery tube 240 will be described below.
  • 232 comprises an expandable, tubular structure formed of a plurality of axial struts 242 joined by a plurality of angled circumferential struts 244.
  • the result is a series of both diamond-shaped and chevron-shaped openings.
  • Three axial bars 246 substitute for the more narrow struts 242 at three evenly-spaced positions around the stent 232. As seen in the view of Figure 22B, the commissures 34 of the valve member 30 align with the axial bars 246.
  • the stent 232 additionally comprises an inner fixation ring 250 and an outer sealing ring 252. Both these rings 250, 252 attach to the struts of the stent 232 independently, or to each other through the struts.
  • a series of sutures can be used to join the inner ring 250 and outer ring 252 in a relatively continuous circumferential line around the stent 232.
  • These rings are desirably made of suture-permeable, typically compressible material such as silicone rubber, or may be rolled up fabric cuffs.
  • the inner fixation ring 250 couples to the valve member 30, while the outer sealing ring 252 help prevent leakage around the stent 232.
  • the attachment sutures 234 extend upward within the stent 232 from the inner fixation ring 250.
  • each two strands of the attachment sutures 234 may be defined by looping a single length of suture downward and back upward through the fixation ring 250.
  • the circular array of sutures 234 then passes through corresponding sectors of the base ring 32 of the valve member 30. Again, this can be done at the time of valve assembly, just prior to the valve replacement procedure, or after the stent 232 has been implanted.
  • Those of skill in the art will understand the process of lining up the circular array of attachment sutures 234 into the appropriate locations around the base ring 32 to permit the valve - -
  • valve dilator/delivery tube 240 The entire procedure will now be described in conjunction with use of the valve dilator/delivery tube 240.
  • the valve replacement procedures described herein are sometimes done without removing the existing native valve.
  • the annulus and valve leaflets are often heavily calcified, and sometimes provide a serious impediment to passage and implant of a replacement valve, even a valve that is initially quite small and balloon expanded.
  • the delivery tube 240 receives all of the valve components therein and acts as a protective sleeve and dilator.
  • just the sealing ring 252 extends out of the delivery tube 240 at an inflow or leading end thereof.
  • the attachment sutures 234 are preinstalled within the fixation ring 250 and, while maintaining a non-crossing circular array, are passed through the delivery tube 240 to be accessible out the upper end.
  • the sutures 234 are then passed through the appropriate locations within the base ring 32 of the valve member 30.
  • this can be done during fabrication of the prosthetic heart valve 230, though some structure for maintaining the relative position and orientation of two components is required.
  • a holder (not shown) attached to the valve member 30 is used to advance the valve member along the array of sutures 234 and within the delivery tube 240, into the approximate position seen in Figure 22A.
  • the assembly of the prosthetic heart valve 230 within the delivery tube 240 advances into the body.
  • the leading end comprises the sealing ring 252 and an outwardly bulged portion 254 in the delivery tube 240.
  • the delivery tube 240 advances down the ascending aorta until the stent 232 lines up with the annulus (with the help of radiopaque markers or the like).
  • the outwardly bulged portion 254 in the delivery tube 240 helps open up the calcified annulus. Even if the native valve is resected, sometimes the annulus will shrink a little prior to implant of the valve.
  • the valve dilator/delivery tube 240 thus helps open up the annulus to permit implant of a desired diameter valve.
  • the contour of the bulged portion 254 is relatively smooth, and the material may be Teflon or other such highly lubricated surface so that the tube easily slips through the annulus. A slight back-and-forth movement may be required to fully open the annulus. [0116] At this stage, the delivery tube 250 retracts relative to the stent
  • stent 232 through the use of a pusher (not shown) for example, such that the stent 232 may fully expand into the annulus.
  • the stent 232 may be self-expanding and thus be only partially expanded within the delivery tube 240. When the delivery tube 240 is removed, the stent 232 springs outward into firm engagement with the annulus.
  • a balloon (not shown) may be used to accomplish the final expansion of the stent 232, which configuration would require a catheter passing through the center of the valve leaflets 34. If the stent 232 is balloon expandable, consideration must be taken of the continual attachment of the valve to the guide sutures 234. On the other hand, if the stent 232 is self-expanding, then typically an auxiliary sheath would be provided to hold the stent in the contracted condition.
  • valve member 30 When the user is satisfied that the stent 232 is properly positioned, the valve member 30 is advanced using the aforementioned holder (not shown). As the valve member 30 advances, care is taken to ensure that the attachment sutures 234 remain untangled and taut. Ultimately, the valve member 30 seats on the fixation ring 250 as seen in Figures 22B and 22C. At this point, the user ties and severs the attachment sutures 234 in a conventional manner. The provision of the sealing ring 252 directly adjacent and - -
  • preferred embodiments of the component based prosthetic valves described herein may be used with existing technology.
  • certain stent embodiments may be configured for attachment to sewing rings provided on existing prosthetic valves.
  • valve member require only small variations in order to be used with the component based system. Not only will this contribute to a lower price for the final valve, but also learned familiarity to the system for surgeons who might be hesitant to adopt a completely new system.
  • embodiments of the present invention provide important new devices and methods wherein a valve may be securely anchored to a body lumen in a quick and efficient manner.
  • Embodiments of the present invention provide a means for implanting a prosthetic valve in a surgical procedure without requiring the surgeon to suture the valve to the tissue. Accordingly, the surgical procedure time is substantially decreased.
  • the stent may be used to maintain the native valve in a dilated condition. As a result, it is not necessary for the surgeon to remove the native leaflets, thereby further reducing the procedure time.
  • the present invention provides an improved system wherein a valve member may be replaced in a more quick and efficient manner. More particularly, it is not necessary to cut any sutures in order to remove the valve. Rather, the valve member may be disconnected from the stent (or other support structure) and a new valve member may be connected in its place. This is an important advantage when using biological tissue valves or other valves having limited design lives. Still further, it will be appreciated that the devices and methods of the present invention may be configured for use in a minimally invasive approach (e.g., through a small - -

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PCT/US2006/019999 2005-05-24 2006-05-24 Rapid deployment prosthetic heart valve Ceased WO2006127756A2 (en)

Priority Applications (5)

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JP2008513640A JP4912395B2 (ja) 2005-05-24 2006-05-24 迅速配置式補綴用心臓弁
EP15156445.7A EP2901967B1 (en) 2005-05-24 2006-05-24 Rapid deployment prosthetic heart valve
CA2607744A CA2607744C (en) 2005-05-24 2006-05-24 Rapid deployment prosthetic heart valve
EP06760323.3A EP1883375B1 (en) 2005-05-24 2006-05-24 Rapid deployment prosthetic heart valve
CN2006800178760A CN101180010B (zh) 2005-05-24 2006-05-24 快速展开假体心脏瓣膜

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US20190201195A1 (en) 2019-07-04
US20200054450A1 (en) 2020-02-20
US20130317598A1 (en) 2013-11-28
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US8500798B2 (en) 2013-08-06
US20060287719A1 (en) 2006-12-21
US20170119525A1 (en) 2017-05-04
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US7708775B2 (en) 2010-05-04
US11284998B2 (en) 2022-03-29
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US20060287717A1 (en) 2006-12-21
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US10226338B1 (en) 2019-03-12
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US8911493B2 (en) 2014-12-16
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US20150105856A1 (en) 2015-04-16
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US10456251B2 (en) 2019-10-29
US20220211497A1 (en) 2022-07-07

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