WO2002066463A1 - 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors - Google Patents
3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors Download PDFInfo
- Publication number
- WO2002066463A1 WO2002066463A1 PCT/US2002/004407 US0204407W WO02066463A1 WO 2002066463 A1 WO2002066463 A1 WO 2002066463A1 US 0204407 W US0204407 W US 0204407W WO 02066463 A1 WO02066463 A1 WO 02066463A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oxo
- dihydro
- hydroxy
- pyrrole
- dimethyl
- Prior art date
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- 0 C**C(C1C(N2)=CC=C(C)C1)C2=O Chemical compound C**C(C1C(N2)=CC=C(C)C1)C2=O 0.000 description 3
- HCUXXPJOSVSWBJ-ZDLGFXPLSA-N Cc1c(/C=C(/c(cc(cc2)F)c2N2)\C2=O)[nH]c(C)c1C(NCC(CN(CC1)CCS1(O)=O)O)=O Chemical compound Cc1c(/C=C(/c(cc(cc2)F)c2N2)\C2=O)[nH]c(C)c1C(NCC(CN(CC1)CCS1(O)=O)O)=O HCUXXPJOSVSWBJ-ZDLGFXPLSA-N 0.000 description 1
- CTNPALGJUAXMMC-PMFHANACSA-N Cc1c(/C=C(/c(cc(cc2)F)c2N2)\C2=O)[nH]c(C)c1C(NC[C@@H](CN1CCOCC1)O)=O Chemical compound Cc1c(/C=C(/c(cc(cc2)F)c2N2)\C2=O)[nH]c(C)c1C(NC[C@@H](CN1CCOCC1)O)=O CTNPALGJUAXMMC-PMFHANACSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Priority Applications (42)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA200300793A EA007186B1 (ru) | 2001-02-15 | 2002-02-15 | Производные 3-(4-амидопиррол-2-илметилиден)-2-индолинона в качестве ингибиторов протеинкиназ |
MXPA03007367A MXPA03007367A (es) | 2001-02-15 | 2002-02-15 | Derivados de 3-(4-amidopirrol-2-ilmetilideno)-2-indolinona como inhibidores de proteina cinasa. |
EP02714897A EP1370554B1 (en) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors |
JP2002565978A JP3677501B2 (ja) | 2001-02-15 | 2002-02-15 | 蛋白質キナーゼ阻害剤としての3−(4−アミドピロール−2−イルメチリデン)−2−インドリノン誘導体 |
SI200230238T SI1370554T1 (sl) | 2001-02-15 | 2002-02-15 | 3-(4-amidopirol-2-ilmetiliden)-2-indolinonski derivati kot inhibitorji protein kinaze |
DE60206736T DE60206736T2 (de) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinon-derivative als protein-kinase inhibitoren |
CNB028066804A CN100338059C (zh) | 2001-02-15 | 2002-02-15 | 作为蛋白激酶抑制剂的3-(4-酰氨基吡咯-2-基亚甲基)-2-二氢吲哚酮衍生物 |
SK1133-2003A SK11332003A3 (sk) | 2001-02-15 | 2002-02-15 | Deriváty 3-(4-amidopyrol-2-ylmetylidén)-2-indolinónu ako inhibítory proteínkinázy |
AT02714897T ATE307128T1 (de) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinon- derivative als protein-kinase inhibitoren |
AU2002247133A AU2002247133B2 (en) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors |
UA2003087745A UA75635C2 (en) | 2001-02-15 | 2002-02-15 | Derivatives of 3-(4-amidopyrol-2-ylmethyliden)-2-indolinone as inhibitors of protein kinase |
PL02364176A PL364176A1 (en) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors |
APAP/P/2003/002836A AP1718A (en) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors |
NZ527572A NZ527572A (en) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors |
BR0207494-0A BR0207494A (pt) | 2001-02-15 | 2002-02-15 | Derivados de 3-(4-amidopirrol-2-ilmetilideno)-2-indolinona como inibidores de proteìna quinase |
KR1020037010772A KR100884858B1 (ko) | 2001-02-15 | 2002-02-15 | 단백질 키나제 억제제로서의3-(4-아미도피롤-2-일메틸리덴)-2-인돌리논 유도체 |
IL15741802A IL157418A0 (en) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors |
EEP200300385A EE200300385A (et) | 2001-02-15 | 2002-02-15 | 3-(4-amidopürrool-2-üülmetülideen)-2-indolinooni derivaadid kui proteiini kinaasi inhibiitorid |
HU0303146A HUP0303146A3 (en) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors and pharmaceutical compositions containing them |
CA2438314A CA2438314C (en) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors |
EP03742760A EP1476443A2 (en) | 2002-02-15 | 2003-02-14 | Process for preparing indolinone derivatives |
JP2003569632A JP2005528344A (ja) | 2002-02-15 | 2003-02-14 | インドリノン誘導体の製造法 |
MXPA04006992A MXPA04006992A (es) | 2002-02-15 | 2003-02-14 | Procedimiento para preparar derivados de indolinona. |
PCT/US2003/004520 WO2003070725A2 (en) | 2002-02-15 | 2003-02-14 | Process for preparing indolinone derivatives |
YU70904A RS70904A (en) | 2002-02-15 | 2003-02-14 | Process for preparing indolinone derivatives |
KR1020047012598A KR100657110B1 (ko) | 2002-02-15 | 2003-02-14 | 인돌리논 유도체의 제조방법 |
CNB038039885A CN1308326C (zh) | 2002-02-15 | 2003-02-14 | 吲哚满酮衍生物的制备方法 |
BR0307721-7A BR0307721A (pt) | 2002-02-15 | 2003-02-14 | Processo para preparação de derivados de indolinona |
PL03372302A PL372302A1 (en) | 2002-02-15 | 2003-02-14 | Process for preparing indolinone derivatives |
CA002475455A CA2475455A1 (en) | 2002-02-15 | 2003-02-14 | Process for preparing indolinone derivatives |
AU2003216282A AU2003216282A1 (en) | 2002-02-15 | 2003-02-14 | Process for preparing indolinone derivatives |
RU2004124711/04A RU2299209C2 (ru) | 2002-02-15 | 2003-02-14 | Способ получения производных индолинона |
US10/367,008 US7119209B2 (en) | 2002-02-15 | 2003-02-14 | Process for preparing indolinone derivatives |
IS6913A IS2411B (is) | 2001-02-15 | 2003-08-14 | 3-(4-amídópýrról-2-ýlmetýlíden)-2-indólínon afleiður sem prótein kínasa hindrar |
IL157418A IL157418A (en) | 2001-02-15 | 2003-08-14 | Derivatives of 3- (4-amidopyrol-2-ylmethylidene) -2-indolinone The pharmaceutical compositions containing them and their use in the preparation of medicinal preparations for preventive treatment or medical treatment of protein-related kinase diseases |
ZA2003/06335A ZA200306335B (en) | 2001-02-15 | 2003-08-14 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors |
NO20033608A NO326604B1 (no) | 2001-02-15 | 2003-08-14 | 3-(4-amidopyrrol-2-ylmetliden)-2-indolinonderivater, fremstilling av slike, farmasoytiske preparater inneholdende slike, metode for a modulere den katalytiske aktiviteten til en proteinkinase in vitro med slike forbindelser samt anvendelse av slike forbindelser for fremstilling av medikament for behandling av sykdommer hos pattedyr |
HR20030657A HRP20030657B1 (en) | 2001-02-15 | 2003-08-14 | 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors |
HK04102229A HK1059621A1 (en) | 2001-02-15 | 2004-03-25 | 3-(4-Amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors |
ZA200405615A ZA200405615B (en) | 2001-02-15 | 2004-07-14 | Process for preparing indoline derivatives. |
US11/095,433 US20050171357A1 (en) | 2002-02-15 | 2005-03-30 | Process for preparing indolinone derivatives |
HK05109991A HK1078075A1 (en) | 2002-02-15 | 2005-11-09 | Process for preparing indolinone derivatives |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26868301P | 2001-02-15 | 2001-02-15 | |
US60/268,683 | 2001-02-15 | ||
US31236101P | 2001-08-15 | 2001-08-15 | |
US60/312,361 | 2001-08-15 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/367,008 Continuation-In-Part US7119209B2 (en) | 2002-02-15 | 2003-02-14 | Process for preparing indolinone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002066463A1 true WO2002066463A1 (en) | 2002-08-29 |
Family
ID=26953263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/004407 WO2002066463A1 (en) | 2001-02-15 | 2002-02-15 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors |
Country Status (41)
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003070725A2 (en) * | 2002-02-15 | 2003-08-28 | Pharmacia & Upjohn Company | Process for preparing indolinone derivatives |
EP1446117A2 (en) * | 2001-10-26 | 2004-08-18 | Sugen, Inc. | Treatment of acute myeloid leukemia with indolinone compounds |
WO2005033098A1 (en) * | 2003-10-02 | 2005-04-14 | Pharmacia & Upjohn Company Llc | Salts and polymorphs of a pyrrole-substituted indolinone compound |
US7105563B2 (en) | 2003-10-24 | 2006-09-12 | Schering Aktiengesellschaft | Indolinone derivatives and their use in treating disease-states such as cancer |
JP2007500137A (ja) * | 2003-07-28 | 2007-01-11 | ビーエーエスエフ アクチェンゲゼルシャフト | 無水マレイン酸の製造方法 |
JP2007512353A (ja) * | 2003-11-26 | 2007-05-17 | ザ スクリプス リサーチ インスティテュート | 高機能インドリノン系プロテインキナーゼ阻害剤 |
EP1893194A1 (en) * | 2005-05-26 | 2008-03-05 | The Scripps Research Institute | Enhanced indolinone based protein kinase inhibitors |
CN100430060C (zh) * | 2002-11-15 | 2008-11-05 | 苏根公司 | 用于细胞增殖性障碍的二氢吲哚酮与化疗剂的联合的制药用途 |
WO2008145398A1 (en) * | 2007-06-01 | 2008-12-04 | Pfizer Italia S.R.L. | 4-arylpyrrole substituted 2-indoline derivatives active as protein kinase inhibitors |
US7683057B2 (en) | 2006-09-15 | 2010-03-23 | Tyrogenex, Inc. | Kinase inhibitor compounds |
JP2011516488A (ja) * | 2008-03-31 | 2011-05-26 | テバ ファーマシューティカル インダストリーズ リミティド | スニチニブ及びその塩の調製方法 |
WO2012158810A1 (en) * | 2011-05-17 | 2012-11-22 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
EA019481B1 (ru) * | 2009-08-04 | 2014-04-30 | Ле Лаборатуар Сервье | Новые дигидроиндолоновые соединения, способ их получения и фармацевтические композиции, содержащие их |
US8829039B2 (en) | 2008-05-23 | 2014-09-09 | Shanghai Institute Of Pharmaceutical Industry | Dihydroindolinone derivatives |
CN104592143A (zh) * | 2015-01-23 | 2015-05-06 | 四川大学 | 一种噁唑烷酮类化合物的制备方法 |
MD4507C1 (ro) * | 2013-07-12 | 2018-03-31 | Les Laboratoires Servier | Metansulfonat de 3-[((3Z)-3-{[4-(4-morfolinilmetil)-1H-pirol-2-il]metilen}-2-oxo-2,3-dihidro-1H-indol-5-il)metil]-1,3-tiazolidin-2,4-dionă, procedeu de obţinere a lui şi forme preparative care îl conţin |
US10456403B2 (en) | 2014-02-21 | 2019-10-29 | Principia Biopharma Inc. | Salts and solid form of a BTK inhibitor |
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