RS51026B - Derivati 3-(4-amidopirol-2-ilmetiliden)-2-indolinona kao inhibitori protein kinaze - Google Patents
Derivati 3-(4-amidopirol-2-ilmetiliden)-2-indolinona kao inhibitori protein kinazeInfo
- Publication number
- RS51026B RS51026B YUP-717/03A YUP71703A RS51026B RS 51026 B RS51026 B RS 51026B YU P71703 A YUP71703 A YU P71703A RS 51026 B RS51026 B RS 51026B
- Authority
- RS
- Serbia
- Prior art keywords
- alkyl
- group
- hydrogen
- aryl
- membered
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26868301P | 2001-02-15 | 2001-02-15 | |
US31236101P | 2001-08-15 | 2001-08-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
YU71703A YU71703A (sh) | 2006-05-25 |
RS51026B true RS51026B (sr) | 2010-10-31 |
Family
ID=26953263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-717/03A RS51026B (sr) | 2001-02-15 | 2002-02-15 | Derivati 3-(4-amidopirol-2-ilmetiliden)-2-indolinona kao inhibitori protein kinaze |
Country Status (41)
Country | Link |
---|---|
US (4) | US6653308B2 (sr) |
EP (1) | EP1370554B1 (sr) |
JP (1) | JP3677501B2 (sr) |
KR (1) | KR100884858B1 (sr) |
CN (1) | CN100338059C (sr) |
AP (1) | AP1718A (sr) |
AR (1) | AR042586A1 (sr) |
AT (1) | ATE307128T1 (sr) |
AU (1) | AU2002247133B2 (sr) |
BG (1) | BG108098A (sr) |
BR (1) | BR0207494A (sr) |
CA (1) | CA2438314C (sr) |
CR (1) | CR7056A (sr) |
CZ (1) | CZ20032414A3 (sr) |
DE (1) | DE60206736T2 (sr) |
DK (1) | DK1370554T3 (sr) |
EA (1) | EA007186B1 (sr) |
EE (1) | EE200300385A (sr) |
ES (1) | ES2251580T3 (sr) |
GE (1) | GEP20053600B (sr) |
HK (1) | HK1059621A1 (sr) |
HR (1) | HRP20030657B1 (sr) |
HU (1) | HUP0303146A3 (sr) |
IL (2) | IL157418A0 (sr) |
IS (1) | IS2411B (sr) |
MA (1) | MA26997A1 (sr) |
MX (1) | MXPA03007367A (sr) |
MY (1) | MY126235A (sr) |
NO (1) | NO326604B1 (sr) |
NZ (1) | NZ527572A (sr) |
OA (1) | OA12834A (sr) |
PE (1) | PE20021006A1 (sr) |
PL (1) | PL364176A1 (sr) |
RS (1) | RS51026B (sr) |
SI (1) | SI1370554T1 (sr) |
SK (1) | SK11332003A3 (sr) |
TN (1) | TNSN03055A1 (sr) |
TW (1) | TWI324155B (sr) |
UA (1) | UA75635C2 (sr) |
WO (1) | WO2002066463A1 (sr) |
ZA (2) | ZA200306335B (sr) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6861442B1 (en) * | 1998-12-30 | 2005-03-01 | Sugen, Inc. | PYK2 and inflammation |
AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
TWI259081B (en) * | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
JP2005528344A (ja) * | 2002-02-15 | 2005-09-22 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | インドリノン誘導体の製造法 |
WO2003097854A2 (en) * | 2002-05-17 | 2003-11-27 | Sugen, Inc. | Novel biomarkers of tyrosine kinase inhibitor exposure and activity in mammals |
AR042042A1 (es) * | 2002-11-15 | 2005-06-08 | Sugen Inc | Administracion combinada de una indolinona con un agente quimioterapeutico para trastornos de proliferacion celular |
US20040209937A1 (en) * | 2003-02-24 | 2004-10-21 | Sugen, Inc. | Treatment of excessive osteolysis with indolinone compounds |
DE10334582A1 (de) * | 2003-07-28 | 2005-02-24 | Basf Ag | Verfahren zur Herstellung von Maleinsäureanhydrid |
CA2540639C (en) * | 2003-10-02 | 2010-08-31 | Pharmacia & Upjohn Company Llc | Salts and polymorphs of a pyrrole-substituted indolinone compound |
JP2007509173A (ja) | 2003-10-24 | 2007-04-12 | シエーリング アクチエンゲゼルシャフト | インドリノン誘導体類及び疾病状態、例えば癌の処理へのそれらの使用 |
AU2004294981A1 (en) * | 2003-11-26 | 2005-06-16 | The Scripps Research Institute | Advanced indolinone based protein kinase inhibitors |
CA2566707A1 (en) | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
US20060009510A1 (en) * | 2004-07-09 | 2006-01-12 | Pharmacia & Upjohn Company Llc | Method of synthesizing indolinone compounds |
CN102886045A (zh) * | 2005-02-03 | 2013-01-23 | 综合医院公司 | 治疗吉非替尼耐药性癌症的方法 |
CN101146553A (zh) * | 2005-03-23 | 2008-03-19 | 辉瑞产品公司 | 用于治疗癌症的抗-ctla4抗体和吲哚酮组合治疗 |
EP2444419A1 (en) | 2005-04-26 | 2012-04-25 | Pfizer Inc. | P-Cadherin antibodies |
MX2007014810A (es) * | 2005-05-26 | 2008-02-21 | Scripps Research Inst | Inhibidores de la proteina quinasa mejoradas a base de indolinona. |
PE20080035A1 (es) | 2005-09-07 | 2008-01-30 | Amgen Fremont Inc | Anticuerpos monoclonales humanos para la quinasa-1 tipo receptor de activina |
US20090012085A1 (en) * | 2005-09-20 | 2009-01-08 | Charles Michael Baum | Dosage forms and methods of treatment using a tyrosine kinase inhibitor |
US7629339B2 (en) * | 2005-09-22 | 2009-12-08 | The Scripps Research Institute | Alkoxy indolinone based protein kinase inhibitors |
EP1971333A4 (en) * | 2005-12-29 | 2009-05-20 | Scripps Research Inst | AMINO ACID DERIVATIVES OF PROTEIN KINASE INHIBITORS ON INDOLINONE BASE |
AU2007251282A1 (en) | 2006-05-09 | 2007-11-22 | Pfizer Products Inc. | Cycloalkylamino acid derivatives and pharmaceutical compositions thereof |
US20070282318A1 (en) * | 2006-05-16 | 2007-12-06 | Spooner Gregory J | Subcutaneous thermolipolysis using radiofrequency energy |
US7928136B2 (en) | 2006-09-11 | 2011-04-19 | Curis, Inc. | Substituted 2-indolinone as PTK inhibitors containing a zinc binding moiety |
JP2010502743A (ja) * | 2006-09-11 | 2010-01-28 | キュリス,インコーポレイテッド | 抗増殖薬剤としての多機能性低分子 |
JP5568304B2 (ja) | 2006-09-15 | 2014-08-06 | タイロジェネクス,インコーポレイテッド | キナーゼ阻害剤化合物 |
US20100255004A1 (en) * | 2007-04-13 | 2010-10-07 | Dana Farber Cancer Institute | Receptor tyrosine kinase profiling |
WO2008145398A1 (en) * | 2007-06-01 | 2008-12-04 | Pfizer Italia S.R.L. | 4-arylpyrrole substituted 2-indoline derivatives active as protein kinase inhibitors |
WO2009014941A1 (en) * | 2007-07-24 | 2009-01-29 | Shenzen Chipscreen Bioscience, Ltd. | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
US20100256392A1 (en) * | 2007-11-21 | 2010-10-07 | Teva Pharmaceutical Industries Ltd. | Polymorphs of sunitinib base and processes for preparation thereof |
PL2274303T3 (pl) * | 2008-03-31 | 2013-03-29 | Teva Pharma | Sposoby otrzymywania sunitynibu i jego soli |
US8158656B2 (en) * | 2008-05-16 | 2012-04-17 | Shenzhen Chipscreen Biosciences Ltd. | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
EP2292613B1 (en) | 2008-05-23 | 2015-09-30 | Shanghai Institute of Pharmaceutical Industry | Dihydroindolinone derivatives |
AU2009267048A1 (en) * | 2008-06-30 | 2010-01-07 | Cylene Pharmaceuticals, Inc. | Oxindole compounds |
US20100029491A1 (en) * | 2008-07-11 | 2010-02-04 | Maike Schmidt | Methods and compositions for diagnostic use for tumor treatment |
EP2373642A2 (en) | 2008-07-24 | 2011-10-12 | Teva Pharmaceutical Industries Ltd | Process for the preparation of sunitinib malate via sunitinib acetate and their polymorphs |
US8211901B2 (en) | 2009-05-22 | 2012-07-03 | Shenzhen Chipscreen Biosciences Ltd. | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
CN101906076B (zh) | 2009-06-04 | 2013-03-13 | 深圳微芯生物科技有限责任公司 | 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用 |
US20110076271A1 (en) | 2009-07-13 | 2011-03-31 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
FR2948940B1 (fr) * | 2009-08-04 | 2011-07-22 | Servier Lab | Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2011027249A2 (en) | 2009-09-01 | 2011-03-10 | Pfizer Inc. | Benzimidazole derivatives |
JP2013504595A (ja) | 2009-09-11 | 2013-02-07 | ジェネンテック, インコーポレイテッド | 抗癌剤に対する応答の可能性が増加した患者を同定するための方法 |
ES2530732T3 (es) | 2009-09-17 | 2015-03-05 | Hoffmann La Roche | Procedimientos de diagnóstico para el cáncer de pulmón |
WO2011073521A1 (en) | 2009-12-15 | 2011-06-23 | Petri Salven | Methods for enriching adult-derived endothelial progenitor cells and uses thereof |
WO2011119777A2 (en) * | 2010-03-23 | 2011-09-29 | The Johns Hopkins University | Compositions and methods for treatment of neurodegenerative disease |
WO2011153224A2 (en) | 2010-06-02 | 2011-12-08 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
EP2848940A1 (en) | 2010-07-19 | 2015-03-18 | F. Hoffmann-La Roche AG | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
EP2596359A1 (en) | 2010-07-19 | 2013-05-29 | F.Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
EP2596026B1 (en) | 2010-07-23 | 2020-04-08 | Trustees of Boston University | Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery |
WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
EP2630134B9 (en) | 2010-10-20 | 2018-04-18 | Pfizer Inc | Pyridine-2- derivatives as smoothened receptor modulators |
CN103945696B (zh) * | 2011-04-08 | 2016-06-29 | 贝达医药公司 | 新颖吲哚啉酮蛋白激酶抑制剂 |
WO2012158810A1 (en) * | 2011-05-17 | 2012-11-22 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
AU2012311184A1 (en) | 2011-09-22 | 2014-03-06 | Pfizer Inc. | Pyrrolopyrimidine and purine derivatives |
LT3181567T (lt) | 2012-09-10 | 2019-07-25 | Principia Biopharma Inc. | Pirazolpirimidino junginiai kaip kinazės slopikliai |
CN103274986A (zh) * | 2013-06-20 | 2013-09-04 | 湖南欧亚生物有限公司 | 一种舒尼替尼中间体的合成和精制方法 |
FR3008411B1 (fr) * | 2013-07-12 | 2015-07-03 | Servier Lab | Nouveau sel de la 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, sa preparation, et les formulations qui le contiennent |
UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
ES2841248T3 (es) | 2014-02-21 | 2021-07-07 | Principia Biopharma Inc | Sales y forma sólida de un inhibidor de BTK |
WO2015155624A1 (en) | 2014-04-10 | 2015-10-15 | Pfizer Inc. | Dihydropyrrolopyrimidine derivatives |
NZ725496A (en) | 2014-04-30 | 2019-11-29 | Pfizer | Cycloalkyl-linked diheterocycle derivatives |
WO2016001789A1 (en) | 2014-06-30 | 2016-01-07 | Pfizer Inc. | Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer |
CA2970723C (en) | 2014-12-18 | 2023-09-05 | Principia Biopharma Inc. | Treatment of pemphigus |
CN104592143B (zh) * | 2015-01-23 | 2017-04-05 | 四川大学 | 一种噁唑烷酮类化合物的制备方法 |
TW201718572A (zh) | 2015-06-24 | 2017-06-01 | 普林斯匹亞生物製藥公司 | 酪胺酸激酶抑制劑 |
WO2017009751A1 (en) | 2015-07-15 | 2017-01-19 | Pfizer Inc. | Pyrimidine derivatives |
KR102663118B1 (ko) | 2015-08-31 | 2024-05-03 | 동아쏘시오홀딩스 주식회사 | 헤테로아릴 화합물 및 치료 약물로서의 이의 용도 |
CN106928114B (zh) * | 2015-12-31 | 2020-07-28 | 韶远科技(上海)有限公司 | 含有脲基的环状手性氨基类化合物及其可放大工艺和用途 |
EP3478273A1 (en) | 2016-06-29 | 2019-05-08 | Principia Biopharma Inc. | Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
KR20210068479A (ko) * | 2018-10-05 | 2021-06-09 | 아이크노스 사이언스 에스.에이. | Map4k1 억제제로서의 사용을 위한 인돌리논 화합물 |
WO2023081923A1 (en) | 2021-11-08 | 2023-05-11 | Frequency Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
Family Cites Families (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL104796C (sr) | 1957-08-19 | |||
DE878539C (de) | 1939-08-17 | 1953-06-05 | Hoechst Ag | Verfahren zur Herstellung von Methinfarbstoffen |
US2622960A (en) * | 1948-03-16 | 1952-12-23 | A P W Products Company Inc | Glyoxal treatment of absorbent paper to improve wet strength |
BE507136A (sr) | 1950-11-18 | |||
BE553661A (sr) | 1955-12-23 | |||
BE558210A (sr) | 1956-06-08 | |||
NL251055A (sr) | 1959-04-29 | |||
FR1398224A (fr) | 1964-05-06 | 1965-05-07 | Ici Ltd | Procédé de teinture de matières textiles de polyacrylonitrile |
US3308134A (en) | 1965-10-22 | 1967-03-07 | Mcneilab Inc | Spiro(indan-2, 3'-indoline)-1, 2'-diones |
US3551571A (en) | 1967-05-19 | 1970-12-29 | Endo Lab | Methods for reducing pain,reducing fever and alleviating inflammatory syndromes with heteroaromatic pyrrol-3-yl ketones |
US3564016A (en) | 1968-03-07 | 1971-02-16 | Endo Lab | Method of decarbonylation |
US4070366A (en) | 1968-06-12 | 1978-01-24 | Canadian Patents & Development Limited | Alkylation process |
FR1599772A (sr) | 1968-09-17 | 1970-07-20 | ||
US3922163A (en) | 1970-01-30 | 1975-11-25 | Upjohn Co | Organic compounds and process |
US3715364A (en) | 1970-12-28 | 1973-02-06 | Merck & Co Inc | Nitroimidazole carboxamides |
DE2159363A1 (de) | 1971-11-30 | 1973-06-14 | Bayer Ag | Antimikrobielle mittel |
DE2159362A1 (de) | 1971-11-30 | 1973-06-14 | Bayer Ag | Nitrofuranderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2159360A1 (de) | 1971-11-30 | 1973-06-14 | Bayer Ag | Nitrofuranderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2159361A1 (de) | 1971-11-30 | 1973-06-14 | Bayer Ag | Nitrofuranderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
GB1384599A (en) | 1972-05-04 | 1975-02-19 | Colgate Palmolive Co | Coloured detergent compositions |
JPS4918256A (sr) * | 1972-06-09 | 1974-02-18 | ||
US3880871A (en) | 1973-09-27 | 1975-04-29 | Squibb & Sons Inc | Isothiocyanophenyl substituted imidazoles |
US4002643A (en) | 1975-06-27 | 1977-01-11 | Mcneil Laboratories, Inc. | Preparation of β-acyl pyrroles |
US4002749A (en) | 1975-08-12 | 1977-01-11 | E. R. Squibb & Sons, Inc. | Substituted indolinones |
US4053613A (en) | 1975-09-17 | 1977-10-11 | E. R. Squibb & Sons, Inc. | 1,3,thiazolinyl and 1,3 thiazinyl substituted indolinones |
GR73560B (sr) | 1979-02-24 | 1984-03-15 | Pfizer | |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4343923A (en) | 1980-08-07 | 1982-08-10 | Armstrong World Industries, Inc. | Process for reducing the acid dye uptake of polyamide textile materials with N-acylimidazole compound |
CH646956A5 (de) | 1981-12-15 | 1984-12-28 | Ciba Geigy Ag | Imidazolide. |
EP0095285A1 (en) | 1982-05-21 | 1983-11-30 | Sumitomo Chemical Company, Limited | N-acylimidazoles, their production and use |
DE3310891A1 (de) | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
US4489089A (en) | 1983-04-06 | 1984-12-18 | American Cyanamid Company | Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides |
DE3480392D1 (en) | 1983-04-29 | 1989-12-14 | Ciba Geigy Ag | Imidazolides and their use as curing agents for polyepoxides |
DE3415138A1 (de) | 1984-04-21 | 1985-10-31 | Basf Ag, 6700 Ludwigshafen | N-(azolylcarbamoyl)-hydroxylamine und diese enthaltende fungizide |
DE3426419A1 (de) | 1984-07-18 | 1986-01-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
US4560700A (en) | 1985-02-08 | 1985-12-24 | Merrell Dow Pharmaceuticals Inc. | Pyrrole-3-carboxylate cardiotonic agents |
JPH078851B2 (ja) | 1985-07-29 | 1995-02-01 | 鐘淵化学工業株式会社 | 3−フエニルチオメチルスチレン誘導体 |
US4966849A (en) | 1985-09-20 | 1990-10-30 | President And Fellows Of Harvard College | CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression |
WO1993012786A1 (en) | 1986-07-10 | 1993-07-08 | Howard Harry R Jr | Indolinone derivatives |
US4853404A (en) | 1986-10-13 | 1989-08-01 | Tanabe Seiyaku Co., Ltd. | Phenoxyacetic acid derivatives composition and use |
EP0304493B1 (en) | 1987-03-11 | 1992-09-02 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Hydroxystyrene derivatives |
US5089516A (en) | 1987-03-11 | 1992-02-18 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | 1-phenyl-3,5-pyrazolidinedione hydroxystyrene compounds which have tyrosine kinase inhibiting activity |
US5202341A (en) | 1987-03-11 | 1993-04-13 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Hydroxystyrene compounds having tyrosine kinase inhibiting activity |
US5043348A (en) | 1987-04-24 | 1991-08-27 | Cassella Aktiengesellschaft | Pyrrolealdehydes, their preparation and their use |
US5217999A (en) | 1987-12-24 | 1993-06-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Styryl compounds which inhibit EGF receptor protein tyrosine kinase |
DE3808071A1 (de) | 1988-03-11 | 1989-09-21 | Basf Ag | Verfahren zur herstellung von acylierten imidazolen |
US4868304A (en) | 1988-05-27 | 1989-09-19 | Iowa State University Research Foundation, Inc. | Synthesis of nitrogen heterocycles |
JPH06104658B2 (ja) | 1988-06-23 | 1994-12-21 | 三菱化成株式会社 | ピロールカルボン酸誘導体 |
CA1339784C (en) | 1988-06-23 | 1998-03-31 | Shinya Inoue | Pyrrolecarboxylic acid derivatives |
DE3824658A1 (de) | 1988-07-15 | 1990-01-18 | Schering Ag | N-hetaryl-imidazolderivate |
GB8816944D0 (en) | 1988-07-15 | 1988-08-17 | Sobio Lab | Compounds |
US5084280A (en) | 1988-12-15 | 1992-01-28 | Chapman Chemical Company | Wood preservation composition and method |
DE3902439A1 (de) | 1989-01-27 | 1990-08-02 | Basf Ag | Pflanzenschuetzende mittel auf basis von 1-aryl- bzw. 1-hetarylimidazolcarbonsaeureestern |
US5047554A (en) | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
ATE159718T1 (de) | 1989-07-25 | 1997-11-15 | Taiho Pharmaceutical Co Ltd | Oxoindolderivate |
US5258357A (en) | 1989-10-07 | 1993-11-02 | Basf Aktiengesellschaft | Carboxamides, their preparation and their use as herbicides |
CA2032421A1 (en) | 1989-12-20 | 1991-06-21 | Mitsubishi Chemical Corporation | Pyrrolealdehyde derivative |
GB9004483D0 (en) | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
CA2012634A1 (en) | 1990-03-20 | 1991-09-20 | Hassan Salari | Tyrphostins for treatment of allergic, inflammatory and cardiovascular diseases |
US5196446A (en) | 1990-04-16 | 1993-03-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Certain indole compounds which inhibit EGF receptor tyrosine kinase |
US5302606A (en) | 1990-04-16 | 1994-04-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase |
CH680293A5 (sr) * | 1990-06-26 | 1992-07-31 | Lonza Ag | |
IT1247509B (it) | 1991-04-19 | 1994-12-17 | Univ Cagliari | Composti di sintesi atti all'impiego nella terapia delle infezioni da rhinovirus |
CA2102780C (en) | 1991-05-10 | 2007-01-09 | Alfred P. Spada | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
GB9115160D0 (en) | 1991-07-12 | 1991-08-28 | Erba Carlo Spa | Methylen-oxindole derivatives and process for their preparation |
US5124347A (en) | 1991-07-31 | 1992-06-23 | Warner-Lambert Co. | 3-5-ditertiarybutylphenyl-4-hydroxymethylidene derivatives of 1,3-dihydro-2H-indole-2-ones as antiinflammatory agents |
CZ290470B6 (cs) | 1991-10-18 | 2002-07-17 | Monsanto Technology Llc | 5 či 6 členné aromáty jako fungicidy pro kontrolu stéblolamu rostlin, způsob kontroly a fungicidní směs k provedení tohoto způsobu |
US5389661A (en) | 1991-12-05 | 1995-02-14 | Warner-Lambert Company | Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties |
US5322950A (en) | 1991-12-05 | 1994-06-21 | Warner-Lambert Company | Imidazole with angiotensin II antagonist properties |
GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
FR2689397A1 (fr) | 1992-04-01 | 1993-10-08 | Adir | Utilisation des dérivés de la 3-(3,5-Ditert-Butyl-4-Hydroxybenzylidenyl) Indoline-2-one pour l'obtention de médicaments. |
DE4211531A1 (de) | 1992-04-06 | 1993-10-07 | Cassella Ag | Verfahren zur Herstellung von Pyrrolderivaten |
FR2694004B1 (fr) | 1992-07-21 | 1994-08-26 | Adir | Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US5330992A (en) | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
GB9226855D0 (en) | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
JP3507124B2 (ja) | 1993-05-26 | 2004-03-15 | 塩野義製薬株式会社 | ベンジリデン誘導体の製造法 |
EP0632102B1 (de) | 1993-06-28 | 1997-04-02 | Bayer Ag | Massefärben von Kunststoffen |
US5332736A (en) | 1993-11-01 | 1994-07-26 | Ortho Pharmaceutical Corporation | Anti-convulsant aroyl aminoacylpyrroles |
US5610173A (en) | 1994-01-07 | 1997-03-11 | Sugen, Inc. | Formulations for lipophilic compounds |
GB9507298D0 (en) | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
US5786488A (en) | 1996-11-13 | 1998-07-28 | Sugen, Inc. | Synthetic methods for the preparation of indolyquinones |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
JP3246712B2 (ja) | 1995-11-15 | 2002-01-15 | 株式会社トクヤマ | エテニルアミド化合物の製造方法 |
DE19602525A1 (de) * | 1996-01-25 | 1997-08-07 | Starck H C Gmbh Co Kg | Sphärische Keramikformkörper, Verfahren zu ihrer Herstellung sowie deren Verwendung |
EP0788890A1 (en) | 1996-02-06 | 1997-08-13 | Agfa-Gevaert N.V. | Dyes and dye-donor elements for thermal dye transfer recording |
CA2206201A1 (en) | 1996-05-29 | 1997-11-29 | Yoshiaki Isobe | Pyrazole derivatives and their pharmaceutical use |
AU3767997A (en) | 1996-08-01 | 1998-02-25 | Merckle Gmbh | Acylpyrroldicarboxylic acids and acylindoldicarboxylic acids and their derivatives and inhibitors of the cytosolic phospholipase a2 |
US6133305A (en) | 1997-09-26 | 2000-10-17 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
EP2020408B1 (en) | 1998-05-29 | 2013-06-26 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitor |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
US6395736B1 (en) | 1998-12-14 | 2002-05-28 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
KR100685192B1 (ko) * | 1998-12-17 | 2007-02-22 | 에프. 호프만-라 로슈 아게 | 4,5-아졸로-옥신돌 |
CA2354873A1 (en) | 1998-12-17 | 2000-06-22 | F. Hoffmann-La Roche Ag | 4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular cdk2 |
US6284894B1 (en) | 1998-12-18 | 2001-09-04 | Nycomed Imaging As | Preparation of allylic aromatic compounds |
MXPA02008021A (es) * | 2000-02-15 | 2004-04-05 | Sugen Inc | Indolinonas sustituidas con pirroles inhibidoras de proteinquinasas. |
TWI270545B (en) | 2000-05-24 | 2007-01-11 | Sugen Inc | Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
JP2005528344A (ja) * | 2002-02-15 | 2005-09-22 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | インドリノン誘導体の製造法 |
-
2002
- 2002-02-14 AR ARP020100509A patent/AR042586A1/es unknown
- 2002-02-15 EA EA200300793A patent/EA007186B1/ru not_active IP Right Cessation
- 2002-02-15 DK DK02714897T patent/DK1370554T3/da active
- 2002-02-15 DE DE60206736T patent/DE60206736T2/de not_active Expired - Lifetime
- 2002-02-15 EP EP02714897A patent/EP1370554B1/en not_active Expired - Lifetime
- 2002-02-15 CZ CZ20032414A patent/CZ20032414A3/cs unknown
- 2002-02-15 SK SK1133-2003A patent/SK11332003A3/sk not_active Application Discontinuation
- 2002-02-15 EE EEP200300385A patent/EE200300385A/xx unknown
- 2002-02-15 MX MXPA03007367A patent/MXPA03007367A/es active IP Right Grant
- 2002-02-15 UA UA2003087745A patent/UA75635C2/uk unknown
- 2002-02-15 MY MYPI20020528A patent/MY126235A/en unknown
- 2002-02-15 AT AT02714897T patent/ATE307128T1/de not_active IP Right Cessation
- 2002-02-15 ES ES02714897T patent/ES2251580T3/es not_active Expired - Lifetime
- 2002-02-15 TW TW091102595A patent/TWI324155B/zh not_active IP Right Cessation
- 2002-02-15 IL IL15741802A patent/IL157418A0/xx active IP Right Grant
- 2002-02-15 OA OA1200300211A patent/OA12834A/en unknown
- 2002-02-15 JP JP2002565978A patent/JP3677501B2/ja not_active Expired - Fee Related
- 2002-02-15 RS YUP-717/03A patent/RS51026B/sr unknown
- 2002-02-15 WO PCT/US2002/004407 patent/WO2002066463A1/en active IP Right Grant
- 2002-02-15 PE PE2002000134A patent/PE20021006A1/es not_active Application Discontinuation
- 2002-02-15 BR BR0207494-0A patent/BR0207494A/pt not_active IP Right Cessation
- 2002-02-15 PL PL02364176A patent/PL364176A1/xx not_active IP Right Cessation
- 2002-02-15 US US10/076,140 patent/US6653308B2/en not_active Expired - Fee Related
- 2002-02-15 CN CNB028066804A patent/CN100338059C/zh not_active Expired - Fee Related
- 2002-02-15 AP APAP/P/2003/002836A patent/AP1718A/en active
- 2002-02-15 SI SI200230238T patent/SI1370554T1/sl unknown
- 2002-02-15 CA CA2438314A patent/CA2438314C/en not_active Expired - Fee Related
- 2002-02-15 GE GE5287A patent/GEP20053600B/en unknown
- 2002-02-15 HU HU0303146A patent/HUP0303146A3/hu unknown
- 2002-02-15 NZ NZ527572A patent/NZ527572A/en unknown
- 2002-02-15 KR KR1020037010772A patent/KR100884858B1/ko not_active IP Right Cessation
- 2002-02-15 AU AU2002247133A patent/AU2002247133B2/en not_active Ceased
-
2003
- 2003-07-08 TN TNPCT/US2002/004407A patent/TNSN03055A1/en unknown
- 2003-08-14 IL IL157418A patent/IL157418A/en not_active IP Right Cessation
- 2003-08-14 IS IS6913A patent/IS2411B/is unknown
- 2003-08-14 CR CR7056A patent/CR7056A/es unknown
- 2003-08-14 ZA ZA2003/06335A patent/ZA200306335B/en unknown
- 2003-08-14 HR HR20030657A patent/HRP20030657B1/xx not_active IP Right Cessation
- 2003-08-14 NO NO20033608A patent/NO326604B1/no not_active IP Right Cessation
- 2003-08-15 BG BG108098A patent/BG108098A/bg unknown
- 2003-08-15 MA MA27282A patent/MA26997A1/fr unknown
- 2003-09-08 US US10/656,907 patent/US7179910B2/en not_active Expired - Fee Related
-
2004
- 2004-03-25 HK HK04102229A patent/HK1059621A1/xx not_active IP Right Cessation
- 2004-07-14 ZA ZA200405615A patent/ZA200405615B/en unknown
-
2006
- 2006-08-28 US US11/511,981 patent/US7256189B2/en not_active Expired - Fee Related
-
2007
- 2007-07-18 US US11/779,807 patent/US7582756B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RS51026B (sr) | Derivati 3-(4-amidopirol-2-ilmetiliden)-2-indolinona kao inhibitori protein kinaze | |
TR200400185T4 (tr) | PDE 5 inhibitörleri olarak, 8-kuinolinkisantin ve 8-izokuinolinkisantin türevleri. | |
PE10399A1 (es) | Derivados de aminoacidos | |
ATE405271T1 (de) | Pyrazoloä3,4-düpyrimidinderivate und ihre verwendung als antagonisten des purinergen rezeptors | |
HUP0203228A2 (hu) | Szubsztituált indolszármazékok az NFKB-aktivitás módosítására, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
YU53298A (en) | Aryl pyrimidine derivatives | |
AR044543A1 (es) | Derivados de pirazolo-quinazolina, un procedimiento para su preparacion y su uso como inhibidor de quinasa | |
MXPA01004256A (es) | N-arilamidas del acido antranilico y del acido tioantranilico. | |
NZ512731A (en) | Tricyclic inhibitors of poly(ADP-ribose) polymerases | |
HUP0400963A2 (hu) | Antidiarrheás és perifériális analgetikus hatású helyettesített ciklohexán-1,4-diamin-származékok felhasználása gyógyszerkészítmények előállítására | |
NO894287D0 (no) | 1,4-diazepinderivater og fremgangsmaate for deres fremstilling. | |
AR035548A1 (es) | Compuestos organicos | |
RS51782B (sr) | Azetidini kao inhibitori mek za lečenje proliferativnih bolesti | |
AR032621A1 (es) | Compuestos derivados de tiofeno, metodo para su preparacion, composicion farmaceutica y uso en la fabricacion de medicamentos | |
HUP0201935A2 (hu) | A SYK tirozin-protein-kináz inhibitoraiként alkalmazható purinszármazékok | |
BRPI0418074A (pt) | derivado de amida e medicamento | |
AR034203A1 (es) | Derivados de 1-aril- o 1-alquilsulfonilbenzazol como ligandos de 5-hidroxitriptamina-6, un metodo para su preparacion, composicion farmaceutica y el uso de los mismos para la fabricacion de un medicamento | |
HUP0300527A2 (hu) | Pirrolopirimidinon-származékok, a vegyületek előállítása és alkalmazása | |
HUP0300413A2 (hu) | Amidcsoportot viselő benzolgyűrűs csoporttal helyettesített piperidint tartalmazó és rokonszerkezetű vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
MXPA05007671A (es) | Derivados de triazina como absorbedores de uv. | |
AR037907A1 (es) | Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6 | |
RS49906B (sr) | Benzociklohepteni, postupak za njihovo dobijanje, farmaceutski preparati koji ove sadrže kao i njihova primena za izradu lekova | |
WO2005094772A3 (en) | Use of benzophenone uv filters for preventing tanning | |
YU46890B (sh) | Postupak za dobijanje cikličnih sulfata | |
DK69790D0 (da) | Heterocykliske forbindelser, deres fremstilling af anvendelse |