ATE159718T1 - Oxoindolderivate - Google Patents
OxoindolderivateInfo
- Publication number
- ATE159718T1 ATE159718T1 AT90910878T AT90910878T ATE159718T1 AT E159718 T1 ATE159718 T1 AT E159718T1 AT 90910878 T AT90910878 T AT 90910878T AT 90910878 T AT90910878 T AT 90910878T AT E159718 T1 ATE159718 T1 AT E159718T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- halogen
- lower alkoxy
- alkyl
- benzyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19182289 | 1989-07-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE159718T1 true ATE159718T1 (de) | 1997-11-15 |
Family
ID=16281100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90910878T ATE159718T1 (de) | 1989-07-25 | 1990-07-23 | Oxoindolderivate |
Country Status (10)
Country | Link |
---|---|
US (1) | US5206261A (de) |
EP (1) | EP0429685B1 (de) |
JP (1) | JP2739188B2 (de) |
KR (1) | KR930011300B1 (de) |
AT (1) | ATE159718T1 (de) |
CA (1) | CA2037923C (de) |
DE (1) | DE69031649T2 (de) |
DK (1) | DK0429685T3 (de) |
ES (1) | ES2110965T3 (de) |
WO (1) | WO1991001306A1 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2100523T3 (es) * | 1992-01-16 | 1997-06-16 | Du Pont Merck Pharma | Nuevos liberadores de neurotransmisores utiles para la potenciacion de las facultades cognoscitivas. |
RU2051151C1 (ru) * | 1992-01-16 | 1995-12-27 | Дзе Дюпон Мерк Фармасьютикал Компани | Азотсодержащие гетероциклические производные флуорена |
US5849780A (en) * | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
FR2686878B1 (fr) * | 1992-01-30 | 1995-06-30 | Sanofi Elf | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
US5310935A (en) * | 1992-06-30 | 1994-05-10 | Pharmagroup International | Optically active 5-oxygenated (3S)-1,3-dimethyloxindole-3-acetic acids |
FR2694004B1 (fr) * | 1992-07-21 | 1994-08-26 | Adir | Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
US5296478A (en) * | 1992-10-07 | 1994-03-22 | The Dupont Merck Pharmaceutical Co. | 1-substituted oxindoles as cognition enhancers |
FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US6147106A (en) * | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
ATE243034T1 (de) * | 1996-01-17 | 2003-07-15 | Taiho Pharmaceutical Co Ltd | Intimale verdickungsinhibitoren |
US20040067531A1 (en) * | 1997-08-20 | 2004-04-08 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
ES2192877T3 (es) | 1998-12-17 | 2003-10-16 | Hoffmann La Roche | 4-alquenil (y alquinil) oxindoles como inhibidores de kinasas ciclina-dependientes, en particular cdk2. |
KR20010101266A (ko) | 1998-12-17 | 2001-11-14 | 프리돌린 클라우스너, 롤란드 비. 보레르 | Jnk 단백질 키나제의 억제제로서의 4-아릴옥신돌 |
TR200101756T2 (tr) | 1998-12-17 | 2001-10-22 | F.Hoffmann-La Roche Ag | Protein kinaz inhibitörleri olarak 4,5-pirazinoksindoller. |
US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
US6689806B1 (en) * | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
EP1251862B1 (de) * | 2000-01-18 | 2008-10-01 | Merck & Co., Inc. | Orhthalmologische zusammenstellungen zur behandlung von ocularer hypertension |
CZ303705B6 (cs) * | 2000-02-15 | 2013-03-27 | Sugen, Inc. | Pyrrolem substituovaná 2-indolinonová sloucenina pro pouzití jako inhibitor proteinkináz a farmaceutická kompozice s jejím obsahem |
FR2807038B1 (fr) * | 2000-04-03 | 2002-08-16 | Sanofi Synthelabo | Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant |
US6504034B2 (en) | 2001-01-23 | 2003-01-07 | Hoffmann-La Roche Inc. | Naphthostyrils |
AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
CA2462950A1 (en) | 2001-10-10 | 2003-04-17 | Sugen, Inc. | 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors |
DK1848694T3 (da) * | 2005-02-07 | 2010-01-25 | Hoffmann La Roche | Heterocykliske substituerede phenylmethanoner som inhibitorer af glycintransporter |
WO2006105795A1 (en) * | 2005-04-08 | 2006-10-12 | Leo Pharma A/S | Novel indolinone derivatives |
AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
MY158766A (en) | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
CL2007002950A1 (es) | 2006-10-12 | 2008-02-01 | Xenon Pharmaceuticals Inc | Uso de compuestos derivados de espiro-oxindol en el tratamiento de hipercolesterolemia, hiperplasia benigna de prostata, pruritis, cancer |
US8263606B2 (en) | 2008-10-17 | 2012-09-11 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
EP2350091B1 (de) | 2008-10-17 | 2015-06-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindol verbindungen und ihre verwendung als therapeutische wirkstoffe |
AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
EP2733145A1 (de) | 2009-10-14 | 2014-05-21 | Xenon Pharmaceuticals Inc. | Synthetische Verfahren für Spirooxindolverbindungen |
PE20121699A1 (es) | 2010-02-26 | 2012-12-22 | Xenon Pharmaceuticals Inc | Composiciones farmaceuticas del compuesto espiro-oxindol para administracion topica |
WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
CN106946759B (zh) * | 2017-03-22 | 2020-02-14 | 中南大学 | 2-吲哚酮衍生物及其开环衍生物及合成方法与用途 |
CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3428649A (en) * | 1968-01-23 | 1969-02-18 | Mcneilab Inc | Oxindole derivatives |
DE3114351A1 (de) * | 1981-04-09 | 1982-11-04 | Hoechst Ag, 6000 Frankfurt | "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung" |
-
1990
- 1990-07-23 US US07/663,960 patent/US5206261A/en not_active Expired - Lifetime
- 1990-07-23 EP EP90910878A patent/EP0429685B1/de not_active Expired - Lifetime
- 1990-07-23 ES ES90910878T patent/ES2110965T3/es not_active Expired - Lifetime
- 1990-07-23 CA CA002037923A patent/CA2037923C/en not_active Expired - Fee Related
- 1990-07-23 KR KR1019910700315A patent/KR930011300B1/ko not_active IP Right Cessation
- 1990-07-23 DK DK90910878.9T patent/DK0429685T3/da active
- 1990-07-23 AT AT90910878T patent/ATE159718T1/de not_active IP Right Cessation
- 1990-07-23 WO PCT/JP1990/000945 patent/WO1991001306A1/ja active IP Right Grant
- 1990-07-23 DE DE69031649T patent/DE69031649T2/de not_active Expired - Fee Related
- 1990-07-23 JP JP2510214A patent/JP2739188B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69031649D1 (de) | 1997-12-04 |
EP0429685A4 (en) | 1991-12-04 |
EP0429685A1 (de) | 1991-06-05 |
DK0429685T3 (da) | 1997-12-15 |
AU6032190A (en) | 1991-02-22 |
KR930011300B1 (ko) | 1993-11-29 |
CA2037923A1 (en) | 1991-01-26 |
EP0429685B1 (de) | 1997-10-29 |
ES2110965T3 (es) | 1998-03-01 |
WO1991001306A1 (fr) | 1991-02-07 |
US5206261A (en) | 1993-04-27 |
KR920701153A (ko) | 1992-08-11 |
JP2739188B2 (ja) | 1998-04-08 |
AU617621B2 (en) | 1991-11-28 |
CA2037923C (en) | 1996-08-06 |
DE69031649T2 (de) | 1998-02-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE159718T1 (de) | Oxoindolderivate | |
GB9423968D0 (en) | Resolution | |
DK0524495T3 (da) | Fremgangsmåde til fremstilling af pyranoner og pyrandioner | |
NO166589C (no) | Selv-tverrbindbar akrylpolymerer. | |
BR9200219A (pt) | Composto 1-(2-piridil)pirazois,processo para suas preparacoes,composicoes pesticidas e metodo para controlar artropodes,nematodes,helmintas ou protozoarios | |
PT95852A (pt) | Processo para a preparacao de agentes hipoglicemicos de oxazolidinediona | |
PT90623A (pt) | Processo para a preparacao de n-heterociclil-4-guanilalquil-benzamidas uteis como inibidores de protease | |
ZA905452B (en) | Novel 3-methoximinopropionic esters and fungicides containing them | |
DK199388A (da) | Sulfonyldecahydro-8h-isoquino-oe2,1-gaaoe1,6aa-naphthyridiner, optiske isomerer deraf og beslaegtede forbindelser | |
IT1215298B (it) | 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione. | |
GR3020488T3 (en) | Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system | |
ES2083568T3 (es) | Derivado de biciclolactama. | |
YU168491A (sh) | 8-azabiciklo/3,2,1/oktilalkiltiazolidinoli in postopek za njihovo pripravo | |
HU905000D0 (en) | Process for producing compounds suitable for treatment of gastric ulcer | |
FI923744A0 (fi) | Foerfarande och mellanprodukter foer framstaellning av 6-fluorbensisotiazoler. | |
EP0108322A3 (en) | Ketene-o,o-acetates and process for their preparation | |
DE68921470D1 (de) | Diazabicycloalkan-derivate. | |
ATE28876T1 (de) | Triorganozinnacetylsalicylate und diese enthaltende biozide mittel. | |
ATE143591T1 (de) | Verwendung von bis-(p- hydroxyphenylthio)methanderivaten zur hemmung der fortschreitenden entwicklung von insulinabhängingem diabetes mellitus | |
DK561389A (da) | Hukommelsesforbedrende midler indeholdende dioxopiperidinderivater | |
ATE108782T1 (de) | Neue benzoxazolon-verbindungen und ihre verwendung als mikrobizid. | |
TH5307EX (th) | สารฆ่าวัชพืชชนิดเฮเทอโรไซคลิค |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |