DK0429685T3 - Oxoindolderivat - Google Patents
OxoindolderivatInfo
- Publication number
- DK0429685T3 DK0429685T3 DK90910878.9T DK90910878T DK0429685T3 DK 0429685 T3 DK0429685 T3 DK 0429685T3 DK 90910878 T DK90910878 T DK 90910878T DK 0429685 T3 DK0429685 T3 DK 0429685T3
- Authority
- DK
- Denmark
- Prior art keywords
- lower alkyl
- halogen
- lower alkoxy
- alkyl
- benzyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19182289 | 1989-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0429685T3 true DK0429685T3 (da) | 1997-12-15 |
Family
ID=16281100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90910878.9T DK0429685T3 (da) | 1989-07-25 | 1990-07-23 | Oxoindolderivat |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5206261A (de) |
| EP (1) | EP0429685B1 (de) |
| JP (1) | JP2739188B2 (de) |
| KR (1) | KR930011300B1 (de) |
| AT (1) | ATE159718T1 (de) |
| CA (1) | CA2037923C (de) |
| DE (1) | DE69031649T2 (de) |
| DK (1) | DK0429685T3 (de) |
| ES (1) | ES2110965T3 (de) |
| WO (1) | WO1991001306A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2051151C1 (ru) * | 1992-01-16 | 1995-12-27 | Дзе Дюпон Мерк Фармасьютикал Компани | Азотсодержащие гетероциклические производные флуорена |
| EP0623127B1 (de) * | 1992-01-16 | 1997-04-02 | The Du Pont Merck Pharmaceutical Company | Verbindungen,die neurotransmitter freisetzen,um die lernfähigkeit zu erhöhen |
| US5849780A (en) * | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| FR2686878B1 (fr) * | 1992-01-30 | 1995-06-30 | Sanofi Elf | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
| US5310935A (en) * | 1992-06-30 | 1994-05-10 | Pharmagroup International | Optically active 5-oxygenated (3S)-1,3-dimethyloxindole-3-acetic acids |
| FR2694004B1 (fr) * | 1992-07-21 | 1994-08-26 | Adir | Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
| US5296478A (en) * | 1992-10-07 | 1994-03-22 | The Dupont Merck Pharmaceutical Co. | 1-substituted oxindoles as cognition enhancers |
| FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6147106A (en) * | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US5977130A (en) * | 1996-01-17 | 1999-11-02 | Taiho Pharmeutical Co., Ltd. | Intimal hypertrophy inhibitors |
| US20040067531A1 (en) * | 1997-08-20 | 2004-04-08 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
| US6531502B1 (en) * | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
| WO2000035908A1 (en) * | 1998-12-17 | 2000-06-22 | F. Hoffmann-La Roche Ag | 4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular cdk2 |
| US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| JP2002532503A (ja) | 1998-12-17 | 2002-10-02 | エフ．ホフマン−ラ ロシュ アーゲー | プロテインキナーゼ阻害剤としての４，５−ピラジノオキシンドール |
| KR20010101266A (ko) | 1998-12-17 | 2001-11-14 | 프리돌린 클라우스너, 롤란드 비. 보레르 | Ｊｎｋ 단백질 키나제의 억제제로서의 4-아릴옥신돌 |
| US6689806B1 (en) * | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| AU771130B2 (en) * | 2000-01-18 | 2004-03-11 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| WO2001060814A2 (en) * | 2000-02-15 | 2001-08-23 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| FR2807038B1 (fr) * | 2000-04-03 | 2002-08-16 | Sanofi Synthelabo | Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant |
| US6504034B2 (en) | 2001-01-23 | 2003-01-07 | Hoffmann-La Roche Inc. | Naphthostyrils |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| US6642232B2 (en) | 2001-10-10 | 2003-11-04 | Sugen, Inc. | 3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors |
| PL1848694T3 (pl) | 2005-02-07 | 2010-05-31 | Hoffmann La Roche | Fenylometanony podstawione grupą heterocykliczną jako inhibitory transportera 1 glicyny |
| WO2006105795A1 (en) * | 2005-04-08 | 2006-10-12 | Leo Pharma A/S | Novel indolinone derivatives |
| MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| MY158766A (en) | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| BRPI0719210A2 (pt) | 2006-10-12 | 2015-05-05 | Xenon Pharmaceuticals Inc | Uso de compostos espiro-oxindol como agentes terapêuticos |
| CA2741024A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| CN102256983B (zh) | 2008-10-17 | 2017-04-05 | 泽农医药公司 | 螺羟吲哚化合物及其作为治疗剂的用途 |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| AU2010306768B2 (en) | 2009-10-14 | 2016-08-04 | Xenon Pharmaceuticals Inc. | Synthetic methods for spiro-oxindole compounds |
| EP2538919B1 (de) | 2010-02-26 | 2017-07-12 | Xenon Pharmaceuticals Inc. | Pharmazeutische zusammensetzungen einer spirooxindolverbindung für die topische verabreichung und ihre verwendung als therapeutika |
| WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| CN106946759B (zh) * | 2017-03-22 | 2020-02-14 | 中南大学 | 2-吲哚酮衍生物及其开环衍生物及合成方法与用途 |
| CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3428649A (en) * | 1968-01-23 | 1969-02-18 | Mcneilab Inc | Oxindole derivatives |
| DE3114351A1 (de) * | 1981-04-09 | 1982-11-04 | Hoechst Ag, 6000 Frankfurt | "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung" |
-
1990
- 1990-07-23 JP JP2510214A patent/JP2739188B2/ja not_active Expired - Fee Related
- 1990-07-23 AT AT90910878T patent/ATE159718T1/de not_active IP Right Cessation
- 1990-07-23 DE DE69031649T patent/DE69031649T2/de not_active Expired - Fee Related
- 1990-07-23 WO PCT/JP1990/000945 patent/WO1991001306A1/ja active IP Right Grant
- 1990-07-23 EP EP90910878A patent/EP0429685B1/de not_active Expired - Lifetime
- 1990-07-23 KR KR1019910700315A patent/KR930011300B1/ko not_active IP Right Cessation
- 1990-07-23 ES ES90910878T patent/ES2110965T3/es not_active Expired - Lifetime
- 1990-07-23 US US07/663,960 patent/US5206261A/en not_active Expired - Lifetime
- 1990-07-23 DK DK90910878.9T patent/DK0429685T3/da active
- 1990-07-23 CA CA002037923A patent/CA2037923C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991001306A1 (fr) | 1991-02-07 |
| ATE159718T1 (de) | 1997-11-15 |
| EP0429685A4 (en) | 1991-12-04 |
| EP0429685A1 (de) | 1991-06-05 |
| EP0429685B1 (de) | 1997-10-29 |
| JP2739188B2 (ja) | 1998-04-08 |
| DE69031649T2 (de) | 1998-02-26 |
| CA2037923C (en) | 1996-08-06 |
| KR930011300B1 (ko) | 1993-11-29 |
| ES2110965T3 (es) | 1998-03-01 |
| AU617621B2 (en) | 1991-11-28 |
| AU6032190A (en) | 1991-02-22 |
| CA2037923A1 (en) | 1991-01-26 |
| DE69031649D1 (de) | 1997-12-04 |
| KR920701153A (ko) | 1992-08-11 |
| US5206261A (en) | 1993-04-27 |
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