PL2274303T3 - Sposoby otrzymywania sunitynibu i jego soli - Google Patents

Sposoby otrzymywania sunitynibu i jego soli

Info

Publication number
PL2274303T3
PL2274303T3 PL09728114T PL09728114T PL2274303T3 PL 2274303 T3 PL2274303 T3 PL 2274303T3 PL 09728114 T PL09728114 T PL 09728114T PL 09728114 T PL09728114 T PL 09728114T PL 2274303 T3 PL2274303 T3 PL 2274303T3
Authority
PL
Poland
Prior art keywords
salts
processes
preparing sunitinib
sunitinib
preparing
Prior art date
Application number
PL09728114T
Other languages
English (en)
Inventor
Ettore Bigatti
Augusto Canavesi
Peter Lindsay Macdonald
Francesca Scarpitta
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of PL2274303T3 publication Critical patent/PL2274303T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL09728114T 2008-03-31 2009-03-31 Sposoby otrzymywania sunitynibu i jego soli PL2274303T3 (pl)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US4110308P 2008-03-31 2008-03-31
US8240508P 2008-07-21 2008-07-21
US8268108P 2008-07-22 2008-07-22
US8899808P 2008-08-14 2008-08-14
US9434108P 2008-09-04 2008-09-04
US9759208P 2008-09-17 2008-09-17
US11304408P 2008-11-10 2008-11-10
PCT/US2009/038934 WO2009124037A1 (en) 2008-03-31 2009-03-31 Processes for preparing sunitinib and salts thereof
EP09728114A EP2274303B1 (en) 2008-03-31 2009-03-31 Processes for preparing sunitinib and salts thereof

Publications (1)

Publication Number Publication Date
PL2274303T3 true PL2274303T3 (pl) 2013-03-29

Family

ID=40791224

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09728114T PL2274303T3 (pl) 2008-03-31 2009-03-31 Sposoby otrzymywania sunitynibu i jego soli

Country Status (8)

Country Link
US (2) US20090247767A1 (pl)
EP (1) EP2274303B1 (pl)
JP (1) JP2011516488A (pl)
KR (1) KR20100119582A (pl)
CA (1) CA2720164A1 (pl)
ES (1) ES2391501T3 (pl)
PL (1) PL2274303T3 (pl)
WO (1) WO2009124037A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2280960A1 (en) * 2008-04-16 2011-02-09 Natco Pharma Limited Novel polymorphic forms of sunitinib base
US8846953B2 (en) 2010-11-01 2014-09-30 Scinopharm Taiwan, Ltd. Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles
WO2013140232A1 (en) 2012-03-23 2013-09-26 Laurus Labs Private Limited An improved process for the preparation of sunitinib and its acid addition salts thereof
PT3039424T (pt) 2013-08-28 2020-09-03 Crown Bioscience Inc Taicang Assinaturas de expressão genética que permitem prever a resposta de um sujeito a um inibidor multiquinase e métodos de utilização do mesmo
CN105622680B (zh) * 2015-12-22 2018-01-19 杭州卢普生物科技有限公司 一种舒尼替尼衍生物及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME00415B (me) * 2000-02-15 2011-10-10 Pharmacia & Upjohn Co Llc Pirol supstituisani 2-indol protein kinazni inhibitori
DE10023484A1 (de) * 2000-05-09 2001-11-22 Schering Ag Anthranylamide und deren Verwendung als Arzneimittel
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
EP3168218B1 (en) * 2001-08-15 2018-11-14 Pharmacia & Upjohn Company LLC A crystal comprising an l-malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide for use as a medicament
EP1434774A1 (en) * 2001-10-10 2004-07-07 Sugen, Inc. 3-(4-substituted heterocyclyl)-pyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
PL372302A1 (pl) * 2002-02-15 2005-07-11 Pharmacia & Upjohn Company Sposób wytwarzania pochodnych indolinonu
ES2197003B1 (es) * 2002-04-08 2005-03-16 J. URIACH & CIA S.A. Nuevos compuestos antagonistas de integrinas alfa.
ATE447560T1 (de) * 2002-06-28 2009-11-15 Nippon Shinyaku Co Ltd Amidderivat
US7427611B2 (en) * 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US20060009510A1 (en) * 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
PL1773768T3 (pl) * 2004-07-30 2019-03-29 Exelixis, Inc. Pochodne pirolu jako środki farmaceutyczne
AU2006205220B2 (en) * 2005-01-10 2012-09-13 Exelixis, Inc. Heterocyclic carboxamide compounds as steroid nuclear receptors ligands
KR20080083341A (ko) * 2005-12-29 2008-09-17 더 스크립스 리서치 인스티튜트 인돌리논의 아미노산 유도체 기재의 단백질 키나제 억제제
WO2009067686A2 (en) * 2007-11-21 2009-05-28 Teva Pharmaceutical Industries Ltd. Sunitinib hemi-l-malate, polymorphs and preparation thereof, polymorphs of racemic sunitinib malate, compositins containing sunitinib base and malic acid and preparation thereof

Also Published As

Publication number Publication date
JP2011516488A (ja) 2011-05-26
ES2391501T3 (es) 2012-11-27
US20090247767A1 (en) 2009-10-01
CA2720164A1 (en) 2009-10-08
KR20100119582A (ko) 2010-11-09
WO2009124037A1 (en) 2009-10-08
EP2274303B1 (en) 2012-08-29
EP2274303A1 (en) 2011-01-19
US20100160646A1 (en) 2010-06-24

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PL2274303T3 (pl) Sposoby otrzymywania sunitynibu i jego soli