WO1997048440A1 - Device for enhancing transdermal agent delivery or sampling - Google Patents

Device for enhancing transdermal agent delivery or sampling Download PDF

Info

Publication number
WO1997048440A1
WO1997048440A1 PCT/US1997/010516 US9710516W WO9748440A1 WO 1997048440 A1 WO1997048440 A1 WO 1997048440A1 US 9710516 W US9710516 W US 9710516W WO 9748440 A1 WO9748440 A1 WO 9748440A1
Authority
WO
WIPO (PCT)
Prior art keywords
blades
sheet
agent
openings
blade
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/010516
Other languages
English (en)
French (fr)
Inventor
Michel J. N. Cormier
Armand P. Neukermans
Barry Block
Felix T. Theeuwes
Alfred A. Amkraut
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Priority to AT97930077T priority Critical patent/ATE234129T1/de
Priority to EP97930077A priority patent/EP0914178B1/en
Priority to AU33991/97A priority patent/AU3399197A/en
Priority to CA002253549A priority patent/CA2253549C/en
Priority to JP50326698A priority patent/JP4012252B2/ja
Priority to DE69719761T priority patent/DE69719761T2/de
Priority to DK97930077T priority patent/DK0914178T3/da
Publication of WO1997048440A1 publication Critical patent/WO1997048440A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A61B5/150427—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15105—Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism
    • A61B5/15113—Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Definitions

  • the present invention relates to transdermal agent delivery and sampling.
  • this invention relates to the transdermal delivery of agents, such as e peptides and proteins, as well as the transdermal sampling of agents, such as glucose,
  • Dresent invention uses skin-piercing microblades to enhance the 1 transdermal flux of the agents during transdermal delivery or sampling and ancho ⁇ ng 2 elements to assist in retaining the delivery or sampling device in the skin. 3 4 Background of the Invention 5
  • polypeptides and proteins are easily degraded during and after penetration
  • Electrotransport refers generally to the passage of a beneficial agent, e.g., a drug or 2 ⁇ drug precursor, through a body surface such as skin, mucous membranes, nails, and
  • the electrotransport of agents through a body surface 1 may be attained in various manners.
  • Electroosmosis another type of electrotransport process, involves the movement of a
  • Electroporation still another type of electrotransport, involves the passage of an agent e through pores formed by applying a high voltage electrical pulse to a membrane
  • Electrotransport delivery generally increases agent delivery, 9 particularly large molecular weight species (e g , polypeptides) delivery rates, relative 0 to passive or non-elect ⁇ cally assisted transdermal delivery
  • agent delivery 9 particularly large molecular weight species (e g , polypeptides) delivery rates
  • e g polypeptides
  • 3 One method of increasing the agent transdermal delivery rate involves pre-
  • permeation enhancer is broadly used herein to
  • the mechanism may involve a reduction ie of the electrical resistance of the body surface to the passage of the agent
  • the agent e.g., degradation by skin enzymes
  • Gerstel does disclose the use of other shapes, to pierce the outer layer of the
  • the present invention provides a reproducible, high volume production, low-cost device suitable for increasing transdermal flux and improving attachment to the skin with minimal to no skin irritation
  • the device generally comprises a structure that attaches to the skin more effectively than the prior art devices
  • the invention comprises a plurality of microblades for piercing and anchoring to the skin
  • the blades typically have a length of less than about 04 mm and a width and thickness which is even smaller In spite of their small size, the blades can be made with an extremely reproducible size and shape so that the microslits formed by the blades puncturing the skin also have a very reproducible size and depth Because the blades have a small thickness (i e , small relative to the width and length of the blades), the blades produce less tissue damage for a given cross-section than a skin piercing microneedle having a circular cross-section
  • the device of the present invention pierces the stratum corneum of a body surface to form pathways through which a substance (e g ,
  • the device is anchored to the body surface in any of plurality of ways, including but not limited to, having an extension such as a prong or barb extending from at least some of the microblades, having an opening extending perpendicular through at least some of the microblades, covering essentially the entire surface area of the skin contacting surface of the device with adhesive except 1 for one side ol the microblades, orienting at least some of the plurality of microblades at
  • the device of the present invention can be used in connection with drug
  • Delivery devices for use with the B present invention include, but are not limited to, electrotransport devices, passive 9 devices, osmotic devices and pressure-driven devices.
  • Sampling devices for use with o the present invention include, but are not limited to, "reverse" electrotransport devices 1 as disclosed in Glikfeld et al., U.S. Patent No 5,279,543, passive devices, osmotic 2 devices and negative pressure driven devices 3
  • the present invention also provides a high yield, low-cost method for producing,
  • Figure 1 is a perspective exploded view of one embodiment of an
  • Figure 2 is an enlarged perspective view of the skin proximal side of the blade
  • Figure 3 is a partial top plan view of a blade array pattern in accordance with
  • FIG. 25 Figure 4 is partial top plan view of yet another embodiment of the blade array
  • FIG. 27 Figure 5 is an enlarged view of a portion of the blades of the blade array pattern
  • FIG. 29 Figure 6 is an enlarged view of a blade tip in accordance with one embodiment
  • FIG. 30 of the present invention 1 Figure 7 is an enlarged view of a blade tip in accordance with another
  • FIG. 3 Figure 8 is a diagrammatic representation of a method for producing blades of
  • Figure 9 is an enlarged cross-sectional view of angled blades in accordance
  • Figures 10, 11 and 12 are yet other embodiments of the blades with anchoring ⁇ elements of the present invention.
  • Figure 27 is a diagrammatic cross-sectional view of another embodiment of a
  • Figure 28 is a diagrammatic cross-sectional view of a sampling system in
  • Figure 29 is a diagrammatic cross-sectional view of another embodiment of the ⁇ blades of the present invention.
  • Device 2 is used for the percutaneous administration or sampling of an
  • mice such as mice, rats, guinea pigs, and the like.
  • epidermis generally comprises three layers commonly identified as stratum
  • 1 Device 2 comprises a plurality of microblades 4 (i.e., a blade array) extending
  • body surface refers generally to the skin, mucous membranes, and 7 nails of an animal or human, and to the outer surface of a plant.
  • the device 2 of the present invention improves the attachment of
  • Barbs 50 can be on any number of the blades from one blade to all blades.
  • the microblades 4 are generally formed from a single piece of material and are
  • the microblades 4 and the sheet 6 are essentially impermeable or are
  • the sheet 6 is formed with an opening 8
  • agent e.g., body analyte
  • the opening 8 corresponds to the portion of the
  • 30 per opening can be any number, preferably however between 1 and about 30 blades
  • the device may have only one opening and one
  • the agent can be administered at a controlled rate of release from the
  • the microblades 4 have a thickness which is much e smaller than the width of the blades near their base, i e , near the point where the 7 blades are attached to the plate 6
  • This blade geometry provides maximum drug ⁇ percolation area with a minimum blade penetration area, and hence less tissue 9 damage
  • the drug percolation area is the skin area in contact with the blades which 0 provides for drug penetration in the skin
  • the microblades are shaped with the largest 1 possible surface area with a minimal cross-sectional area so as to give the largest
  • blade can be any of a range of widths
  • the widths can be different from blade to blade ⁇ in the array pattern Likewise, the width can be variable along the length of the blade,
  • the blade and the body surface after the blade array has been inserted is preferably in
  • microblades 4 ( Figure 5) are also provided with slanted
  • the angle of the leading edge is designated as ⁇ .
  • each blade can all be the same angle or can be at
  • each leading edge can be any 1 angle between about 10° to 90°, preferably between about 10° to 60°, more preferably
  • leading edge can also be segmented into two sections at
  • the first segment can have an angle ⁇ between about
  • each blade can be arcuate (i.e., curved) in e shape, having, for example, a convex or concave shape.
  • the 7 leading edge is a curved tip across the entire width of the blade.
  • microblades 4 are provided with barbs 50 ( Figures 2, 3 and 5) in some fashion so
  • 15 size of the barbs is such as to retain the delivery or sampling device during the normal
  • each microblade cuts ie through and pushes aside the skin tissue. After the microblades have come to rest in
  • the skin for an extended period of time (e.g., 24 hours), the skin tissue begins to heal
  • each blade can have a plurality of barbs extending therefrom.
  • microblades in one embodiment, have a cross-section that is wider in the area of
  • the blades can have an
  • the resulting curved cross-section of the blade can be, but is not limited to, angular,
  • the plurality of blades 4 for puncturing the stratum corneum are present on one ⁇ face surface 48 of the device 2 in any predetermined arrangement, for example, as a 9 cluster of blades spaced in rows having any desired number, or in any spaced apart 0 relation of one blade to each other.
  • the device 2 of the embodiment shown in Figures 1 1 and 2 is produced by the pattern shown in Figure 3.
  • Each blade has a width and 2 thickness that facilitates penetration of the stratum corneum without bending.
  • each blade is between about 137.5 ⁇ m to about 175 ⁇ m and the length is
  • the blades will be about 25
  • a thin sheet or plate 6 of metal such as
  • 26 sheet about 7 ⁇ m to about 100 ⁇ m thick, preferably about 25 ⁇ m to about 50 ⁇ m thick.
  • a punch 54 having a plurality of
  • the finished structure provides blades 4 with
  • Rectangular openings 8 are shown in the figures but the 9 invention encompasses the use of any shape openings including, but not limited to, 0 square, triangular, circular and elliptical.
  • the sheet 6 in some areas can have additional etched openings 80 ( Figure 4) to
  • the openings can be any of a variety of shapes (e.g., rectangular, circular,
  • the openings also allow the sheet to be more easily curved to
  • the present invention maximizes the openings through the ie sheet but with a sufficient number of horizontal and vertical continuous portions in the
  • the sheet will bend (i.e., crinkle).
  • the sheet will bend (i.e., crinkle).
  • concave surface can be shaped to match the convex pattern of the body.
  • the blades 4 can be patterned with resist on both sides 48,49 and subsequently
  • 29 blades 4 can be patterned and etched from one side (i.e., side 49) only ( Figure 6).
  • the etching process can be controlled to etch
  • the lithography process produces a
  • the lithography process also can produce very small dimensioned
  • each of the blades in 0 the blade array pattern is thinner than the surrounding sheet 6.
  • the sheet 6 1 forms a strong base and as the punch 54 deforms the blades 4 downward, each of the
  • a dry resist e.g., "Dynachem FL"
  • a wet resist e.g., "Shipley 111 S"
  • a suitable etchant e.g., ferric chloride
  • the blades 4 are at an angle of about 90° to the surface 48 of the
  • the blades are all
  • the angled blades have two principal advantages. First, penetration of
  • the blades is not opposed by the elasticity of the skin because the blades are slid
  • anchoring of the device is achieved by coating
  • One 0 method of producing this embodiment comprises spraying the adhesive on the device 2
  • the agent is free to
  • the sheet and blades can be made from materials that have sufficient strength
  • blades such as, glasses, ceramics, rigid polymers
  • metals and metal alloys examples include but are not
  • nickel, zirconium, titanium and titanium alloys consisting of nickel, molybdenum and
  • glasses include a devitrified glass such as "Photoceram" available
  • rigid polymers examples include but are not limited to 2 ⁇ polystyrene, polymethylmethacrylate, polypropylene, polyethylene, "Bakelite", cellulose
  • ABS acrylonitrile/butadiene/styrene
  • acryiic acid polymers including polyacrylates and polymethacrylates. 1 Very dense patterns can be created with unit cells wherein a unit cell has a
  • 3 pattern has the following characteristics: a unit cell area of 0.63 mm by 3.8 mm; the
  • 5 length per square centimeter is 625 mm.
  • microblades of the present invention make an elongated, thin microcut (i.e.,
  • the geometry of the microblades 4 results in minimal blade 0 volume in the skin with maximal blade surface area in the skin.
  • the advantages of the 1 present invention include, but are not limited to: (1 ) the thin blade geometry produces
  • prong 68 is etched in
  • the blades may be repunched to regain their substantially
  • Hinges 72 ( Figure 13) can be used to control the retention force of
  • the hinges allow for the retention force to be tailored
  • the force can be tailored by the amount of attachment of the prong to the
  • each prong can be any of a variety of shapes such as triangular, square, etc.
  • Tne prongs and curved protrusions act to anchor the device in the skin
  • the blade 4 has additional openings 74 extending through the blade 9 to enhance anchoring.
  • the edges forming the holes or other linear openings are 0 etched through the blade.
  • numerous small pits i.e.,
  • the elastic nature of the skin tissue causes the skin to move into the openings or
  • the skin tissue may heal and reconnect
  • the blades associated with each opening 8 can be oriented at any angle with
  • each opening can be along perpendicular sides of the openings.
  • the blades within each opening can be formed in a serrated pattern as illustrated in
  • 29 delivery or sampling device used i.e., electrotransport, passive, osmotic,
  • the present invention has a
  • the present invention produces a percolation area 0 of about 0.005 to .05 cm 2 /cm 2 of body surface, preferably about 0.01 cm 2 /cm 2 of body 1 surface.
  • Electrotransport refers generally
  • a beneficial agent e.g., a drug or drug precursor
  • Electroosmosis another type of electrotransport
  • Electroporation still another type of electrotransport, involves the passage of an agent
  • Electrotransport devices generally use at least two electrodes which are in 0 electrical contact with some portion of the skin, nails, mucous membranes, or other 1 body surface.
  • one of the two electrodes is 2 commonly referred to as the "donor” or “active” electrode, and is the one from which the 3 agent is delivered into the body.
  • one of the 4 two electrodes is referred to as the "receptor” electrode, and is the one into which the 5 agent (e.g., body electrolyte) is collected upon being withdrawn from the body.
  • the 6 second electrode is, typically termed the “counter” or “return” electrode, and serves to 7 close the electrical circuit through the body.
  • the agent to be s delivered is a cation, i.e., a positively charged ion
  • the anode becomes the active or 9 donor electrode, while the cathode serves to complete the circuit.
  • the cathode is the 1 donor electrode.
  • the agent to be sampled is a cation
  • the cathode becomes the 2 receptor electrode while the anode serves to complete the circuit.
  • the agent to 3 be sampled is an anion
  • the anode becomes the receptor electrode while the cathode 4 serves to complete the circuit.
  • Electrotransport delivery ⁇ systems generally require at least one reservoir or source of the agent to be delivered 9 to the body. Electrotransport sampling systems likewise require at least one reservoir so in which to collect the agent being sampled. Examples of such reservoirs include a 31 pouch or cavity as described in U.S. Patent No. 4,250,878 to Jacobsen et al., a porous 1 sponge or pad as described in U.S. Patent No. 4,141 ,359 to Jacobsen et al., and a
  • Such reservoirs are electrically connected to, and positioned between, the
  • an electrical power source e.g., one or more batteries
  • Optional electrotransport device components include a counter reservoir,
  • Device 10 comprises an upper housing 16, a circuit board assembly 18, a lower
  • Upper housing 16 has lateral wings 15 17 which assist in holding device 10 on a patient's skin.
  • Printed circuit board assembly 18 ie comprises an integrated circuit 19 coupled to discrete components 40 and battery 32.
  • Circuit board assembly 18 is attached to housing 16 by posts (not shown in Figure 1)
  • 25 board assembly 18 is a button cell battery 32.
  • Other types of batteries may also be
  • the device 10 is generally comprised of battery 32, electronic circuitry 19,40,
  • circuit board assembly 18 make electrical contact with the electrodes 24 and 22
  • formulation of reservoir 26 is preferably a viscous gel that fills the openings 8 such that
  • the reservoir 26 is in direct contact with the skin when the blades have penetrated the ⁇ stratum corneum.
  • the contact between the reservoir and skin provides a path for the 9 agent to be transported along. If the reservoir 26 is not in direct contact with the skin 0 initially typically sweat accumulates in the confined area and provides an agent- 1 transmitting pathway between reservoir 26 and the skin.
  • 2 Device 10 optionally has a feature which allows the patient to self-administer
  • the push button switch 12 is conveniently located
  • the device transmits to the user a visual and/or audible
  • Anodic electrode 22 is preferably comprised of silver and cathodic electrode 24 is
  • Both reservoirs 26 and 28 are preferably
  • Electrodes 22,24 and reservoirs 26,28 are comprised of polymeric gel materials. Electrodes 22,24 and reservoirs 26,28 are
  • Upper housing 16 is preferably composed of rubber or other elastomeric
  • Lower housing 20 is preferably
  • the 7 assembled device 10 is preferably water resistant (i.e., splash proof) and is most e preferably waterproof.
  • the system has a low profile that easily conforms to the body, g thereby allowing freedom of movement at, and around, the wearing site.
  • the reservoirs 0 26 and 28 are located on the skin-contacting side of the device 10 and are sufficiently 1 separated to prevent accidental electrical shorting during normal handling and use.
  • the device 10 adheres to the patient's body surface (e.g., skin) by means of an 3 adhesive layer 30 (which has upper adhesive side 34 and body contacting adhesive 4 side 36) and the anchoring elements on the device 2 of any of the embodiments 5 discussed above.
  • the adhesive side 36 covers the entire underneath side of the 6 device 10 except where the device 2 and reservoir 28 are located.
  • the adhesive side 7 36 has adhesive properties which assures that the device 10 remains in place on the 8 body during normal user activity, and yet permits reasonable removal after the 9 predetermined (e.g., 24-hour) wear period.
  • Upper adhesive side 34 adheres to lower 0 housing 20 and retains the electrodes and reservoirs within housing depression 25,25' 1 as well as retains device 2 to lower housing 20 and lower housing 20 to upper housing 2 16.
  • the bandage cover is stripped from the device before the device is
  • transdermal delivery device 88 comprises a reservoir 90 containing agent. Reservoir
  • 31 90 is preferably in the form of a matrix containing the agent dispersed therein. 1 Reservoir 90 is sandwiched between a backing layer 92, which is preferably
  • 3 reservoir 90 is formed of a material, such as a rubbery polymer, that is sufficiently
  • the reservoir 90 would initially not contain the agent.
  • ⁇ microblade array device 2 Located below membrane 94 is ⁇ microblade array device 2.
  • the device 88 adheres to a body surface by means of 9 contact adhesive layer 96 around the periphery of the device 2 and by the anchoring
  • the adhesive layer 96 may
  • a strippable release liner (not shown) is normally provided
  • transdermal therapeutic device 98 may be
  • Device 98 is comprised of an agent-containing
  • reservoir 90 (for a delivery configuration) which is preferably in the form of a matrix i ⁇ containing the agent dispersed therein.
  • the reservoir 90 In a sampling configuration, the reservoir 90
  • An impermeable backing layer 102 is provided
  • Adhesive overlay 100 maintains the device 98 on
  • Adhesive overlay 100 can be any material
  • the adhesive overlay 100 may be preferable to
  • 26 reservoir contains a material (such as, for example, an oily surfactant permeation
  • Impermeable backing layer 102 is preferably slightly larger than reservoir 90,
  • the formulation for the passive transdermal devices may be aqueous or non-
  • Aqueous formulations typically comprise water and about 1 to 2 weight percent 7 of a hydrophilic polymer as a gelling agent, such as hydroxyethylcellulose or ⁇ hydroxypropylcellulose.
  • Typical non-aqueous gels are comprised of silicone fluid or 9 mineral oil.
  • Mineral oil-based gels also typically contain 1 to 2 weight percent of a
  • gelling agent such as colloidal silicon dioxide.
  • the reservoir matrix is preferably a
  • hydrophilic polymer e.g., a hydrogel.
  • 15 reservoir matrix is preferably composed of a hydrophobic polymer.
  • Suitable polymeric ie matrices are well known in the transdermal drug delivery art.
  • the drug is present in the matrix i ⁇ or carrier at a concentration in excess of saturation, the amount of excess being a
  • the drug may,
  • the matrix or carrier may also contain dyes, pigments,
  • the agent is preferably delivered in
  • drugs should preferably be ionized and the drug salt should be soluble in water. It is e generally believed that the pathways for passive and electrotransported transdermal 7 drug delivery through intact skin are different, with passive delivery occurring through ⁇ lipid regions (i.e., hydrophobic regions) of the skin and electrotransport delivery 9 occurring through hydrophilic pathways or pores such as those associated with hair
  • the drug for passive delivery is generally hydrophobic, e.g., free base form, whereas
  • hydrophilic e.g., water
  • the drug preferably has sufficient ie solubility in the carrier solvent. It will be appreciated by those working in the field that 17 the present invention can be used in conjunction with a wide variety of osmotic delivery i ⁇ or sampling systems, as the invention is not limited to a particular device in this regard.
  • anti-infectives such as antibiotics and antiviral agents
  • analgesics including fentanyl, sufentanil, buprenorphine and analgesic combinations
  • anticonvulsants 28 anticonvulsants, antidepressants, antidiabetic agents, antidiarrheals, antihistamines,
  • antiparkinsonism drugs including antiparkinsonism drugs, antipruritics, antipsychotics, antipyretics, antispasmodics, 1 including gastrointestinal and urinary anticholinergics, sympathomimetrics, xanthine
  • cardiovascular preparations including calcium channel blockers such as
  • betablockers beta-agonists such as dobutamine and ritodrine
  • antiarrythmics such as atenolol
  • ACE inhibitors such as ranitidine
  • vasodilators including general, coronary, peripheral and cerebral, central e nervous system stimulants, cough and cold preparations, decongestants, diagnostics, 7 hormones such as parathyroid hormone, bisphosphoriates, hypnotics, ⁇ immunosuppressives, muscle relaxants, parasympatholytics, parasympathomimetrics, 9 prostaglandins, psychostimulants, sedatives and tranquilizers.
  • the invention is also
  • nucleotidic drugs including
  • the present invention has particular utility in the delivery of peptides
  • 17 surfaces such as skin. These substances typically have a molecular weight of at least ⁇ about 300 daltons, and more typically have a molecular weight of at least about 300 to
  • LHRH LHRH, LHRH analogs such as goserelin, buserelin, gonadorelin,
  • hormones e.g., HGH, HMG, desmopressin acetate, etc.
  • follicle luteoids e.g., follicle luteoids, ⁇ ANF,
  • growth factors such as growth factor releasing factor (GFRF), ⁇ MSH, GH, somatostatin,
  • bradykinin bradykinin, somatotropin, platelet-derived growth factor, asparaginase, bleomycin
  • CGRP calcitonin gene related peptide
  • IGF-1 insulin growth factor-1
  • neurotrophic factors neurotrophic factors
  • colony stimulating factors parathyroid hormone 3
  • the device 2 of the present invention can also be used
  • FIG. 11 Figure 28 illustrates an osmotic sampling device 104 in combination with any of the
  • Osmotic sampling devices can be
  • a body surface including, but not limited to glucose, body electrolytes, alcohol,
  • the osmotic sampling i6 device 104 is attached to a body surface by means of a flexible adhesive overlay 100 17 and the anchoring elements of device 2.
  • Device 104 is comprised of a salt layer 106 is located between a semi-permeable or osmotic membrane 94 and an optional agent
  • the optional agent sensing element can be any of a variety of
  • the adhesive overlay 100 can have a cut-out or
  • the agent sensing element can be located
  • the device 10 in the hairless guinea pig.
  • I I consisted of a sheet having a plurality of rectangular openings having six blades, three
  • Each device was a two cm 2 piece of stainless steel 25 ⁇ m thick etched and i ⁇ punched with eight pairs of offset rows or 160 groups of six blades for a total of 960

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Manufacturing & Machinery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Prostheses (AREA)
PCT/US1997/010516 1996-06-18 1997-06-17 Device for enhancing transdermal agent delivery or sampling Ceased WO1997048440A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AT97930077T ATE234129T1 (de) 1996-06-18 1997-06-17 Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
EP97930077A EP0914178B1 (en) 1996-06-18 1997-06-17 Device for enhancing transdermal agent delivery or sampling
AU33991/97A AU3399197A (en) 1996-06-18 1997-06-17 Device for enhancing transdermal agent delivery or sampling
CA002253549A CA2253549C (en) 1996-06-18 1997-06-17 Device for enhancing transdermal agent delivery or sampling
JP50326698A JP4012252B2 (ja) 1996-06-18 1997-06-17 薬剤の経皮放出又はサンプリングを高めるための装置
DE69719761T DE69719761T2 (de) 1996-06-18 1997-06-17 Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
DK97930077T DK0914178T3 (da) 1996-06-18 1997-06-17 Anordning til forøgelse af transdermal afgivelse eller prøveudtagning af et middel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1999096P 1996-06-18 1996-06-18
US60/019,990 1996-06-18

Publications (1)

Publication Number Publication Date
WO1997048440A1 true WO1997048440A1 (en) 1997-12-24

Family

ID=21796163

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US1997/010516 Ceased WO1997048440A1 (en) 1996-06-18 1997-06-17 Device for enhancing transdermal agent delivery or sampling
PCT/US1997/010596 Ceased WO1997048442A1 (en) 1996-06-18 1997-06-18 Device for enhancing transdermal agent delivery or sampling
PCT/US1997/010595 Ceased WO1997048441A1 (en) 1996-06-18 1997-06-18 Device for enhancing transdermal sampling

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US1997/010596 Ceased WO1997048442A1 (en) 1996-06-18 1997-06-18 Device for enhancing transdermal agent delivery or sampling
PCT/US1997/010595 Ceased WO1997048441A1 (en) 1996-06-18 1997-06-18 Device for enhancing transdermal sampling

Country Status (14)

Country Link
US (5) US6230051B1 (https=)
EP (3) EP0914178B1 (https=)
JP (4) JP4012252B2 (https=)
AR (2) AR008242A1 (https=)
AT (3) ATE234129T1 (https=)
AU (3) AU3399197A (https=)
CA (3) CA2253549C (https=)
DE (3) DE69719761T2 (https=)
DK (3) DK0914178T3 (https=)
ES (3) ES2195151T3 (https=)
PT (2) PT917483E (https=)
TW (1) TW349872B (https=)
WO (3) WO1997048440A1 (https=)
ZA (1) ZA975326B (https=)

Cited By (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029298A2 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
WO1999029365A1 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
WO1999029364A1 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
WO2000012173A1 (en) * 1998-08-31 2000-03-09 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
WO2001013989A1 (en) 1999-08-25 2001-03-01 Johnson And Johnson Consumer Companies, Inc. Tissue electroperforation for drug delivery and diagnostic sampling
EP1086719A1 (en) 1999-09-24 2001-03-28 Becton Dickinson and Company Method and device for abrading skin
EP1086718A1 (en) 1999-09-22 2001-03-28 Becton Dickinson and Company Method and apparatus for the transdermal administration of a substance
WO2001043643A1 (en) * 1999-12-16 2001-06-21 Alza Corporation Device for enhancing transdermal flux of sampled agents
US6251083B1 (en) 1999-09-07 2001-06-26 Amira Medical Interstitial fluid methods and devices for determination of an analyte in the body
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
WO2001093931A1 (en) 2000-06-06 2001-12-13 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a puncturing member into the intradermal space
WO2001093946A1 (en) 2000-06-08 2001-12-13 Becton, Dickson And Company Skin permeability enhancing device to withdraw or administer a substance and method of manufacturing the device
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
WO2002002180A2 (en) 2000-06-29 2002-01-10 Becton, Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
WO2002005890A2 (en) 2000-07-14 2002-01-24 Becton, Dickinson And Company Microdevice and method of manufacturing a microdevice
WO2002005889A1 (en) 2000-07-17 2002-01-24 Becton, Dickinson And Company Delivery device with microneedles for the transdermal administration of a substance
WO2002007813A1 (en) 2000-07-21 2002-01-31 Smithkline Beecham Biologicals S.A. Vaccines
WO2002015800A1 (en) 2000-08-24 2002-02-28 Alza Corporation Method for transdermal nucleic acid sampling
WO2002030506A2 (en) 2000-10-12 2002-04-18 Ink Jet Technology Ltd. Transdermal method
WO2002030301A1 (en) * 2000-10-13 2002-04-18 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
WO2002068044A2 (en) 2001-02-28 2002-09-06 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and sampling
WO2002019985A3 (en) * 2000-09-08 2002-09-06 Alza Corp Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
JP2002529159A (ja) * 1998-11-09 2002-09-10 エレクシス リミティド 経皮的な薬物の放出および分析物の抽出
WO2002072189A2 (en) 2001-03-14 2002-09-19 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6465709B1 (en) 1999-07-08 2002-10-15 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
WO2003053258A1 (en) * 2001-12-20 2003-07-03 Alza Corporation Skin-piercing microprojections having piercing depth control
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
WO2003066126A2 (en) 2002-02-04 2003-08-14 Becton, Dickinson And Company Dermal access member
WO2003084595A1 (en) 2002-04-02 2003-10-16 Becton, Dickinson And Company Valved intradermal delivery device
EP1383571A2 (en) 2001-04-20 2004-01-28 Alza Corporation Microprojection array immunization patch and method
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US6690959B2 (en) 2000-09-01 2004-02-10 Medtronic, Inc. Skin-mounted electrodes with nano spikes
WO2004020034A2 (en) 2002-08-29 2004-03-11 Becton Dickinson And Company Microabrader with controlled abrasion features
WO2003048031A3 (en) * 2001-11-30 2004-04-01 Alza Corp Methods and apparatuses for forming microprojection arrays
WO2004033021A1 (en) 2002-10-07 2004-04-22 Biovalve Technologies, Inc. Microneedle array patch
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
WO2005004842A2 (en) 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
US6855131B2 (en) 2000-10-13 2005-02-15 Alza Corporation Microprotrusion member retainer for impact applicator
US6855372B2 (en) 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
WO2005042054A2 (en) 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
WO2005049128A1 (de) * 2003-11-17 2005-06-02 Lts Lohmann Therapie-Systeme Ag Vorrichtung zur transdermalen verabreichung von wirkstoffen
WO2005051476A1 (en) * 2003-11-28 2005-06-09 Acrux Dds Pty Ltd Method and system for rapid transdermal administration
WO2005094260A2 (en) 2004-03-24 2005-10-13 Kevin Marchitto Microsurgical tissue treatment system
WO2006029279A1 (en) * 2004-09-08 2006-03-16 Alza Corporation Microprojection array with improved skin adhesion and compliance
US7060059B2 (en) 2002-10-11 2006-06-13 Becton, Dickinson And Company System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or multi-needle intradermal (ID) delivery device
US7066922B2 (en) 2001-10-26 2006-06-27 Massachusetts Institute Of Technology Transdermal transport device with suction
US7087035B2 (en) 1999-12-10 2006-08-08 Alza Corporation Device and method for enhancing skin piercing by microprotrusions
WO2006089285A1 (en) * 2005-02-16 2006-08-24 Alza Corporation Microprojection arrays with improved biocompatibility
US7097631B2 (en) 2003-10-31 2006-08-29 Alza Corporation Self-actuating applicator for microprojection array
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7186235B2 (en) 2001-06-08 2007-03-06 Becton, Dickinson And Company Device for manipulating a needle or abrader array and method of use
WO2007071711A2 (en) 2005-12-22 2007-06-28 Glaxosmithkline Biologicals Sa Vaccine
JP2007244875A (ja) * 1999-02-01 2007-09-27 Orthogen Ag 体液から治療上有効なタンパク質であるインターロイキン−１受容体拮抗薬を産生するための方法
WO2007116028A2 (en) 2006-04-07 2007-10-18 Glaxosmithkline Biologicals S.A. Conjugate vaccines
US7315758B2 (en) 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
EP1911488A2 (en) 1997-12-11 2008-04-16 Alza Corporation Device for enhancing transdermal agent flux
WO2008043774A1 (en) 2006-10-12 2008-04-17 Glaxosmithkline Biologicals S.A. Vaccine comprising an oil in water emulsion adjuvant
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
WO2008137747A1 (en) 2007-05-02 2008-11-13 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
US7455654B2 (en) 2003-10-28 2008-11-25 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
WO2009000826A1 (en) 2007-06-26 2008-12-31 Glaxosmithkline Biologicals S.A. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
US7537795B2 (en) 2000-10-26 2009-05-26 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US7556821B2 (en) 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US7556615B2 (en) 2001-09-12 2009-07-07 Becton, Dickinson And Company Microneedle-based pen device for drug delivery and method for using same
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
EP1450876A4 (en) * 2001-11-07 2009-12-30 Transpharma Medical Ltd INTEGRATED TRANSDERMAL DRUG DELIVERY SYSTEM
EP2140878A1 (en) 2000-09-15 2010-01-06 GlaxoSmithKline Biologicals S.A. Vaccine against streptococcus pneumoniae
WO2010057197A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7842008B2 (en) 2005-11-21 2010-11-30 Becton, Dickinson And Company Intradermal delivery device
EP2266603A1 (en) 2000-10-18 2010-12-29 GlaxoSmithKline Biologicals S.A. Tumour vaccines
WO2011015591A1 (en) 2009-08-05 2011-02-10 Glaxosmithkline Biologicals S.A. Immunogenic composition comprising antigenic s. aureus proteins
EP2298340A1 (en) 2004-09-22 2011-03-23 GlaxoSmithKline Biologicals S.A. Immunogenic composition for use in vaccination against staphylococcei
US7963935B2 (en) 2001-04-20 2011-06-21 Alza Corporation Microprojection array having a beneficial agent containing coating
WO2011110570A1 (en) 2010-03-09 2011-09-15 Glaxosmithkline Biologicals S.A. Treatment of streptococcal infections
WO2011110531A2 (en) 2010-03-09 2011-09-15 Glaxosmithkline Biologicals S.A. Conjugation process
EP2433648A2 (en) 2006-10-12 2012-03-28 GlaxoSmithKline Biologicals S.A. Vaccine comprising an oil in water emulsion adjuvant
EP2476433A1 (en) 2006-03-30 2012-07-18 GlaxoSmithKline Biologicals S.A. Immunogenic composition
WO2012119972A1 (en) 2011-03-07 2012-09-13 Glaxosmithkline Biologicals S.A. Conjugation process
WO2012156391A1 (en) 2011-05-17 2012-11-22 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
US8419708B2 (en) 2006-02-10 2013-04-16 Hisamitsu Pharmaceuticals Co., Inc. Transdermal drug administration apparatus having microneedles
EP2612680A1 (en) 2008-04-16 2013-07-10 GlaxoSmithKline Biologicals SA Vaccine
US8632801B2 (en) 2005-12-28 2014-01-21 Alza Corporation Stable therapeutic formulations
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
WO2014066663A1 (en) 2012-10-24 2014-05-01 Platelet Targeted Therapeutics, Llc Platelet targeted treatment
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
WO2015017561A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-profile microneedle patch applicator
US8962026B2 (en) 2008-09-26 2015-02-24 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
WO2015063611A2 (en) 2013-11-01 2015-05-07 University Of Oslo Albumin variants and uses thereof
WO2015071763A2 (en) 2013-11-15 2015-05-21 Oslo Universitetssykehus Hf Ctl peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof
WO2015071769A2 (en) 2013-11-13 2015-05-21 University Of Oslo Outer membrane vesicles and uses thereof
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9192749B2 (en) 2000-10-13 2015-11-24 Alza Corporation Microblade array impact applicator
WO2016057921A1 (en) 2014-10-10 2016-04-14 Baker Jr James R Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
US9314368B2 (en) 2010-01-25 2016-04-19 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods
EP3020412A1 (en) 2009-06-16 2016-05-18 The Regents of the University of Michigan An immunogenic composition comprising nanoemulsion inactivated rsv
US9375345B2 (en) 2006-09-26 2016-06-28 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US9408745B2 (en) 2007-08-21 2016-08-09 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
CN106061546A (zh) * 2014-02-10 2016-10-26 Lts勒曼治疗系统股份公司 微针系统及其制造方法
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
USD777338S1 (en) 2014-03-20 2017-01-24 Zeltiq Aesthetics, Inc. Cryotherapy applicator for cooling tissue
WO2017067962A1 (en) 2015-10-21 2017-04-27 Glaxosmithkline Biologicals S.A. Vaccine
US9655770B2 (en) 2007-07-13 2017-05-23 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US9717451B2 (en) 2000-06-08 2017-08-01 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US9737434B2 (en) 2008-12-17 2017-08-22 Zeltiq Aestehtics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
EP3251722A1 (en) 2001-04-20 2017-12-06 ALZA Corporation Microprojection array having a beneficial agent containing coating and method of forming the coating thereon
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
WO2017216286A1 (en) 2016-06-17 2017-12-21 Glaxosmithkline Biologicals S.A. Immunogenic composition
US9861421B2 (en) 2014-01-31 2018-01-09 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
US9861520B2 (en) 2009-04-30 2018-01-09 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
US9962534B2 (en) 2013-03-15 2018-05-08 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
US10022436B2 (en) 2016-01-11 2018-07-17 Verndari, Inc. Microneedle compositions and methods of using same
EP3375463A1 (en) 2002-05-06 2018-09-19 Becton, Dickinson and Company Method and device for controlling drug pharmacokinetics
EP3381370A1 (en) * 2017-03-31 2018-10-03 RichHealth Technology Corporation Transdermal microneedle array patch
US10092346B2 (en) 2010-07-20 2018-10-09 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
WO2018237221A1 (en) 2017-06-23 2018-12-27 Nosocomial Vaccine Corporation IMMUNOGENIC COMPOSITIONS
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
WO2019048936A1 (en) 2017-09-07 2019-03-14 University Of Oslo VACCINE MOLECULES
WO2019048928A1 (en) 2017-09-07 2019-03-14 University Of Oslo VACCINE MOLECULES
US10233429B2 (en) 2014-11-07 2019-03-19 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
WO2019090238A1 (en) 2017-11-03 2019-05-09 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
WO2019121926A1 (en) 2017-12-21 2019-06-27 Glaxosmithkline Biologicals Sa Immunogenic composition
WO2019121924A1 (en) 2017-12-21 2019-06-27 Glaxosmithkline Biologicals Sa Immunogenic composition
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10383787B2 (en) 2007-05-18 2019-08-20 Zeltiq Aesthetics, Inc. Treatment apparatus for removing heat from subcutaneous lipid-rich cells and massaging tissue
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10524956B2 (en) 2016-01-07 2020-01-07 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
US10555831B2 (en) 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
US10675176B1 (en) 2014-03-19 2020-06-09 Zeltiq Aesthetics, Inc. Treatment systems, devices, and methods for cooling targeted tissue
US10682297B2 (en) 2016-05-10 2020-06-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US10722395B2 (en) 2011-01-25 2020-07-28 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
US10765552B2 (en) 2016-02-18 2020-09-08 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US10806782B2 (en) 2014-11-07 2020-10-20 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
US10952891B1 (en) 2014-05-13 2021-03-23 Zeltiq Aesthetics, Inc. Treatment systems with adjustable gap applicators and methods for cooling tissue
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology
US11154418B2 (en) 2015-10-19 2021-10-26 Zeltiq Aesthetics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
US11173207B2 (en) 2016-05-19 2021-11-16 The Regents Of The University Of Michigan Adjuvant compositions
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
US11395760B2 (en) 2006-09-26 2022-07-26 Zeltiq Aesthetics, Inc. Tissue treatment methods
US11446175B2 (en) 2018-07-31 2022-09-20 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine
EP4226936A2 (en) 2015-03-05 2023-08-16 Northwestern University Non-neuroinvasive viruses and uses thereof
US11986421B2 (en) 2006-09-26 2024-05-21 Zeltiq Aesthetics, Inc. Cooling devices with flexible sensors
US12070411B2 (en) 2006-04-28 2024-08-27 Zeltiq Aesthetics, Inc. Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
US12076397B2 (en) 2016-05-10 2024-09-03 The Regents Of The University Of Michigan Emulsion adjuvant for intramuscular, intradermal and subcutaneous administration
WO2024229176A1 (en) 2023-05-04 2024-11-07 Affinivax, Inc. Rhizavidin variants
WO2025193903A1 (en) 2024-03-15 2025-09-18 Affinivax, Inc. Pneumococcal polysaccharide compositions and uses thereof
EP4717778A2 (en) 2017-07-19 2026-04-01 GlaxoSmithKline Biologicals SA Immunogenic composition

Families Citing this family (601)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2050057A1 (en) 1991-03-04 1992-09-05 Adam Heller Interferant eliminating biosensors
US5593852A (en) 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
AU5869796A (en) * 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
CA2253549C (en) * 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US6607509B2 (en) * 1997-12-31 2003-08-19 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
EP1056396B1 (en) * 1998-02-17 2005-11-09 Abbott Laboratories Interstitial fluid collection and monitoring device
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6757560B1 (en) * 1999-04-09 2004-06-29 Novosis Pharma Ag Transdermal delivery system (TDS) with electrode network
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
PT1077634E (pt) * 1998-05-13 2003-12-31 Cygnus Therapeutic Systems Monitorizacao de substancias fisiologicas a analisar
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6355021B1 (en) * 1998-07-14 2002-03-12 Maersk Medical A/S Medical puncturing device
USD526409S1 (en) 1998-07-14 2006-08-08 Unomedical A/S Medical puncturing device
WO2000004832A1 (en) * 1998-07-21 2000-02-03 Spectrx, Inc. System and method for continuous analyte monitoring
EP1163024B1 (en) * 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6792306B2 (en) * 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US6856821B2 (en) * 2000-05-26 2005-02-15 Kci Licensing, Inc. System for combined transcutaneous blood gas monitoring and vacuum assisted wound closure
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US20080033492A1 (en) * 2000-01-07 2008-02-07 Biowave Corporation Electro-therapy method
US7013179B2 (en) 2000-01-07 2006-03-14 Biowave Corporation Percutaneous electrode array
ATE296575T1 (de) * 2000-01-21 2005-06-15 Instrumentarium Corp Herstellungsverfahren für eine medizinische elektrode
US6622035B1 (en) * 2000-01-21 2003-09-16 Instrumentarium Corp. Electrode for measurement of weak bioelectrical signals
EP1225831A2 (en) * 2000-03-17 2002-07-31 Sontra Medical, Inc. Non-invasive body fluid sampling and analysis
US7141034B2 (en) * 2000-06-08 2006-11-28 Altea Therapeutics Corporation Transdermal drug delivery device, method of making same and method of using same
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
DE10057832C1 (de) * 2000-11-21 2002-02-21 Hartmann Paul Ag Blutanalysegerät
US6591133B1 (en) * 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
EP1345646A2 (en) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US6932933B2 (en) * 2001-03-30 2005-08-23 The Aerospace Corporation Ultraviolet method of embedding structures in photocerams
AU2002309528A1 (en) 2001-04-02 2002-10-15 Therasense, Inc. Blood glucose tracking apparatus and methods
ES2336081T3 (es) 2001-06-12 2010-04-08 Pelikan Technologies Inc. Dispositivo de puncion de auto-optimizacion con medios de adaptacion a variaciones temporales en las propiedades cutaneas.
ATE485766T1 (de) 2001-06-12 2010-11-15 Pelikan Technologies Inc Elektrisches betätigungselement für eine lanzette
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
WO2002102273A2 (en) * 2001-06-20 2002-12-27 Power Paper Ltd. Adhesive bandage with display
EP1407712B1 (en) * 2001-07-19 2013-07-10 ARKRAY, Inc. Piercing device
US20030028087A1 (en) * 2001-08-01 2003-02-06 Yuzhakov Vadim Vladimirovich Devices for analyte concentration determination and methods of using the same
SE0102736D0 (sv) * 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US8361037B2 (en) * 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20070179717A1 (en) * 2001-09-21 2007-08-02 Milliken Gordon L System and method for management of specimens
US6830562B2 (en) * 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
AU2002343457A1 (en) * 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
EP1469903A2 (en) * 2001-09-28 2004-10-27 BioValve Technologies, Inc. Microneedle with membrane
US20030069482A1 (en) * 2001-10-09 2003-04-10 Workman Jerome James Sampling article for determining quantitative and qualitative drug transfer to skin
US6966880B2 (en) * 2001-10-16 2005-11-22 Agilent Technologies, Inc. Universal diagnostic platform
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
AU2002367965A1 (en) * 2001-11-06 2003-12-31 Dermal Systems International Inc. High throughput methods and devices for assaying analytes in a fluid sample
ITTO20011228A1 (it) * 2001-12-28 2003-06-28 Cane Srl Contenitore per ago monouso.
US20040073175A1 (en) * 2002-01-07 2004-04-15 Jacobson James D. Infusion system
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
AU2003208296A1 (en) * 2002-02-12 2003-09-04 Unomedial A/S Infusion device with needle shield
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US8116860B2 (en) 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7232451B2 (en) * 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
US20030211619A1 (en) * 2002-05-09 2003-11-13 Lorin Olson Continuous strip of fluid sampling and testing devices and methods of making, packaging and using the same
US7060192B2 (en) * 2002-05-09 2006-06-13 Lifescan, Inc. Methods of fabricating physiological sample collection devices
US20030143113A2 (en) * 2002-05-09 2003-07-31 Lifescan, Inc. Physiological sample collection devices and methods of using the same
US20030212344A1 (en) * 2002-05-09 2003-11-13 Vadim Yuzhakov Physiological sample collection devices and methods of using the same
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
CN102872526A (zh) 2002-07-19 2013-01-16 3M创新有限公司 微针装置和微针施用设备
AR040819A1 (es) * 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
DK1556124T3 (da) * 2002-09-02 2008-02-18 Unomedical As Apparatur og fremgangsmåde til justering af en infusionsslanges længde
US7115112B2 (en) * 2002-09-02 2006-10-03 Unomedical A/S Device for subcutaneous administration of a medicament to a patient and tubing for same
US7258680B2 (en) * 2002-09-02 2007-08-21 Unomedical A/S Device for subcutaneous administration of a medicament to a patient
US20040051019A1 (en) * 2002-09-02 2004-03-18 Mogensen Lasse Wesseltoft Apparatus for and a method of adjusting the length of an infusion tube
US20120296233A9 (en) * 2002-09-05 2012-11-22 Freeman Dominique M Methods and apparatus for an analyte detecting device
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
EP1590033A2 (en) * 2002-09-30 2005-11-02 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
US7244394B2 (en) * 2002-10-03 2007-07-17 Novartis Ag Methods and kits for assays of analytes of interest in tears
US7381184B2 (en) 2002-11-05 2008-06-03 Abbott Diabetes Care Inc. Sensor inserter assembly
US7045069B2 (en) * 2002-11-14 2006-05-16 Gennady Ozeryansky Microfabrication method based on metal matrix composite technology
DK200201823A (da) 2002-11-26 2004-05-27 Maersk Medical As Forbindelsesstykke for en slangeforbindelse
US7018345B2 (en) * 2002-12-06 2006-03-28 Hisamitsu Pharmaceutical Co., Inc. Iontophoresis system
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
US8771183B2 (en) 2004-02-17 2014-07-08 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
US20040158202A1 (en) * 2003-02-12 2004-08-12 Soren Jensen Cover
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US20050070819A1 (en) * 2003-03-31 2005-03-31 Rosedale Medical, Inc. Body fluid sampling constructions and techniques
US7070580B2 (en) * 2003-04-01 2006-07-04 Unomedical A/S Infusion device and an adhesive sheet material and a release liner
US20040265351A1 (en) * 2003-04-10 2004-12-30 Miller Richard L. Methods and compositions for enhancing immune response
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
JP2004343275A (ja) * 2003-05-14 2004-12-02 Murata Mach Ltd 画像処理システム及びスキャナ装置
EP1628567B1 (en) 2003-05-30 2010-08-04 Pelikan Technologies Inc. Method and apparatus for fluid injection
EP1633235B1 (en) 2003-06-06 2014-05-21 Sanofi-Aventis Deutschland GmbH Apparatus for body fluid sampling and analyte sensing
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CN1845708A (zh) * 2003-07-02 2006-10-11 阿尔扎公司 微突出物阵列免疫贴剂和方法
EP1648363B1 (en) * 2003-07-03 2019-03-06 Corium International, Inc. Wound dressing, ingredient delivery device and iv hold-down, and method relating to same
US7695239B2 (en) * 2003-07-14 2010-04-13 Fortrend Engineering Corporation End effector gripper arms having corner grippers which reorient reticle during transfer
WO2005007223A2 (en) * 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US7761130B2 (en) * 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7467003B2 (en) * 2003-12-05 2008-12-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7460898B2 (en) * 2003-12-05 2008-12-02 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7424318B2 (en) 2003-12-05 2008-09-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7366556B2 (en) 2003-12-05 2008-04-29 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
JP2007501071A (ja) * 2003-08-04 2007-01-25 アルザ・コーポレーシヨン 経皮作用剤流率を向上させる方法および装置
US7223248B2 (en) * 2003-08-13 2007-05-29 Lifescan, Inc. Packaged medical device with a deployable dermal tissue penetration member
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
CA2536443A1 (en) * 2003-08-26 2005-03-03 Alza Corporation Device and method for intradermal cell implantation
US7099968B2 (en) * 2003-09-02 2006-08-29 Intel Corporation System and method for generating bus requests in advance based on speculation states
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
EP1671096A4 (en) 2003-09-29 2009-09-16 Pelikan Technologies Inc METHOD AND APPARATUS FOR PROVIDING IMPROVED SAMPLE CAPTURING DEVICE
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
USD579541S1 (en) 2003-10-15 2008-10-28 Unomedical A/S Medical insertion device
USD554253S1 (en) 2003-10-15 2007-10-30 Unomedical A/S Medical infusion device
USD576267S1 (en) 2003-10-15 2008-09-02 Unomedical A/S Medical infusion device
US8016811B2 (en) * 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
AU2004285481A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
USD914881S1 (en) 2003-11-05 2021-03-30 Abbott Diabetes Care Inc. Analyte sensor electronic mount
AU2004291040A1 (en) * 2003-11-13 2005-06-02 Alza Corporation System and method for transdermal delivery
EP1699524A4 (en) * 2003-11-18 2009-07-15 Nanopass Technologies Ltd Enhanced penetration system and method for sliding microneedles
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
EP1713533A4 (en) * 2003-11-21 2008-01-23 Univ California METHOD AND APPARATUS FOR PERFORATING A SURFACE TO EXTRACT, ANALYZE AND / OR DELIVER SUBSTANCE USING MICRO-NEEDLES
AU2004292953A1 (en) * 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8532730B2 (en) 2006-10-04 2013-09-10 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
WO2005057168A2 (en) 2003-12-05 2005-06-23 Dexcom, Inc. Calibration techniques for a continuous analyte sensor
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US20080312555A1 (en) * 2004-02-06 2008-12-18 Dirk Boecker Devices and methods for glucose measurement using rechargeable battery energy sources
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
WO2009048462A1 (en) 2007-10-09 2009-04-16 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
WO2005094526A2 (en) * 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
ATE424228T1 (de) 2004-03-26 2009-03-15 Unomedical As Infusionsset
CN101120101A (zh) * 2004-04-13 2008-02-06 阿尔扎公司 多联疫苗透皮释放的装置和方法
US20070184222A1 (en) * 2004-04-20 2007-08-09 University Of Rochester Hydrogel-supported porous semiconductor devices
CN100566669C (zh) * 2004-05-13 2009-12-09 阿尔扎公司 甲状旁腺激素药物的透皮释放装置
MXPA06013490A (es) * 2004-05-19 2007-06-12 Johnson & Johnson Metodo y formulacion para el suministro transdermico de agentes inmunologicamente activos.
WO2006011062A2 (en) 2004-05-20 2006-02-02 Albatros Technologies Gmbh & Co. Kg Printable hydrogel for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
WO2005119524A2 (en) 2004-06-04 2005-12-15 Therasense, Inc. Diabetes care host-client architecture and data management system
US20050273075A1 (en) * 2004-06-08 2005-12-08 Peter Krulevitch Method for delivering drugs to the adventitia using device having microprojections
US20050273049A1 (en) * 2004-06-08 2005-12-08 Peter Krulevitch Drug delivery device using microprojections
US8886272B2 (en) 2004-07-13 2014-11-11 Dexcom, Inc. Analyte sensor
US7905833B2 (en) 2004-07-13 2011-03-15 Dexcom, Inc. Transcutaneous analyte sensor
US20070045902A1 (en) 2004-07-13 2007-03-01 Brauker James H Analyte sensor
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US8989833B2 (en) 2004-07-13 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060030788A1 (en) * 2004-08-04 2006-02-09 Daniel Wong Apparatus and method for extracting bodily fluid utilizing a flat lancet
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
US20060058602A1 (en) * 2004-08-17 2006-03-16 Kwiatkowski Krzysztof C Interstitial fluid analyzer
US7798153B2 (en) * 2004-08-23 2010-09-21 Us Smokeless Tobacco Co. Nicotiana Kawakamii smokeless tobacco
TW200626177A (en) * 2004-09-28 2006-08-01 Alza Corp Method and formulation for stabilizing alum-adsorbed vaccines
ITPD20040252A1 (it) * 2004-10-14 2005-01-14 Bidoia Sas Di Gianfranco Bidoi Irrigatore chirurgico
JP4416625B2 (ja) * 2004-10-29 2010-02-17 シスメックス株式会社 組織切断器具、組織切断補助器具および収納容器
WO2006055799A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Masking method for coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
WO2006055844A2 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Method of contact coating a microneedle array
CN101060883B (zh) 2004-11-18 2010-06-23 3M创新有限公司 低轮廓微针阵列施放器
JP4927752B2 (ja) * 2004-11-18 2012-05-09 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイアプリケーターおよび保持装置
CN100367906C (zh) * 2004-12-08 2008-02-13 圣美迪诺医疗科技(湖州)有限公司 皮下植入式生物传感器
US7867199B2 (en) * 2004-12-10 2011-01-11 Unomedical A/S Inserter
US7588705B2 (en) * 2004-12-28 2009-09-15 Nabtesco Corporation Skin needle manufacturing apparatus and skin needle manufacturing method
US8571624B2 (en) 2004-12-29 2013-10-29 Abbott Diabetes Care Inc. Method and apparatus for mounting a data transmission device in a communication system
US9743862B2 (en) 2011-03-31 2017-08-29 Abbott Diabetes Care Inc. Systems and methods for transcutaneously implanting medical devices
US7883464B2 (en) 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US7731657B2 (en) * 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US7697967B2 (en) * 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US9259175B2 (en) 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US9351669B2 (en) 2009-09-30 2016-05-31 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US9636450B2 (en) 2007-02-19 2017-05-02 Udo Hoss Pump system modular components for delivering medication and analyte sensing at seperate insertion sites
US9398882B2 (en) 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US8613703B2 (en) * 2007-05-31 2013-12-24 Abbott Diabetes Care Inc. Insertion devices and methods
US20090082693A1 (en) * 2004-12-29 2009-03-26 Therasense, Inc. Method and apparatus for providing temperature sensor module in a data communication system
US10226207B2 (en) 2004-12-29 2019-03-12 Abbott Diabetes Care Inc. Sensor inserter having introducer
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US9572534B2 (en) 2010-06-29 2017-02-21 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US20090105569A1 (en) 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
WO2006078924A2 (en) * 2005-01-20 2006-07-27 Epley Medical Llc Minimally invasive, sustained, intra-tympanic drug delivery system
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
CA2602169A1 (en) * 2005-03-21 2006-09-28 Unomedical A/S A mounting pad, an adhesive device comprising such mounting pad, and methods of applying such devices to a patient
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
EP1869414A4 (en) * 2005-03-29 2010-07-28 Arkal Medical Inc DEVICES, SYSTEMS, METHODS, AND TOOLS FOR CONTINUOUS GLUCOSE MONITORING
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
MX2007016062A (es) * 2005-06-28 2008-03-10 Unomedical As Empaquetamiento para juego de infusion y metodo para aplicar un juego de infusion.
US20070004989A1 (en) * 2005-06-29 2007-01-04 Parvinder Dhillon Device for transdermal sampling
US20070025869A1 (en) * 2005-07-15 2007-02-01 Gordon John H Fluid Delivery Device
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
US8386030B2 (en) * 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
CA2620586A1 (en) 2005-08-31 2007-03-08 Boris P. Kovatchev Improving the accuracy of continuous glucose sensors
CN101687094B (zh) * 2005-09-06 2012-09-26 谢拉杰克特股份有限公司 含有药物颗粒和/或药物吸附颗粒的固体溶液穿孔器
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
AU2006291157A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Coatable transdermal delivery microprojection assembly
ATE480278T1 (de) 2005-09-12 2010-09-15 Unomedical As Einfürungssystem für ein infusionsset mit einem ersten und zweiten federeinheit
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
WO2007034438A2 (en) * 2005-09-26 2007-03-29 Koninklijke Philips Electronics N.V. Substance sampling and/or substance delivery via skin
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
WO2007041355A2 (en) 2005-09-30 2007-04-12 Intuity Medical, Inc. Catalysts for body fluid sample extraction
US20070078376A1 (en) * 2005-09-30 2007-04-05 Smith Gregory A Functionalized microneedles transdermal drug delivery systems, devices, and methods
US8880138B2 (en) 2005-09-30 2014-11-04 Abbott Diabetes Care Inc. Device for channeling fluid and methods of use
WO2007041526A2 (en) * 2005-09-30 2007-04-12 Transcutaneous Technologies Inc. Iontophoresis apparatus and method to deliver antibiotics to biological interfaces
US9521968B2 (en) 2005-09-30 2016-12-20 Abbott Diabetes Care Inc. Analyte sensor retention mechanism and methods of use
JP2009509659A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 生体界面への活性物質の送達のイオントフォレーシス装置及び方法
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
WO2007076458A1 (en) * 2005-12-21 2007-07-05 Primegen Biotech Llc Microinjector chip
US20080319404A1 (en) * 2005-12-21 2008-12-25 Pekurovsky Mikhail L Microneedle Devices
DE602006006477D1 (de) 2005-12-23 2009-06-04 Unomedical As Verabreichungsgerät
EP1968432A4 (en) 2005-12-28 2009-10-21 Abbott Diabetes Care Inc INTRODUCTION OF A MEDICAL DEVICE
US11298058B2 (en) 2005-12-28 2022-04-12 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US7736310B2 (en) 2006-01-30 2010-06-15 Abbott Diabetes Care Inc. On-body medical device securement
US7826879B2 (en) 2006-02-28 2010-11-02 Abbott Diabetes Care Inc. Analyte sensors and methods of use
US7885698B2 (en) * 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
AU2007219546B8 (en) 2006-02-28 2012-07-05 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
WO2007102842A2 (en) * 2006-03-09 2007-09-13 Dexcom, Inc. Systems and methods for processing analyte sensor data
AU2007225056A1 (en) * 2006-03-15 2007-09-20 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US9392969B2 (en) 2008-08-31 2016-07-19 Abbott Diabetes Care Inc. Closed loop control and signal attenuation detection
US8473022B2 (en) 2008-01-31 2013-06-25 Abbott Diabetes Care Inc. Analyte sensor with time lag compensation
US8478557B2 (en) 2009-07-31 2013-07-02 Abbott Diabetes Care Inc. Method and apparatus for providing analyte monitoring system calibration accuracy
US7801582B2 (en) 2006-03-31 2010-09-21 Abbott Diabetes Care Inc. Analyte monitoring and management system and methods therefor
US7630748B2 (en) 2006-10-25 2009-12-08 Abbott Diabetes Care Inc. Method and system for providing analyte monitoring
US7618369B2 (en) 2006-10-02 2009-11-17 Abbott Diabetes Care Inc. Method and system for dynamically updating calibration parameters for an analyte sensor
US8374668B1 (en) 2007-10-23 2013-02-12 Abbott Diabetes Care Inc. Analyte sensor with lag compensation
US8140312B2 (en) 2007-05-14 2012-03-20 Abbott Diabetes Care Inc. Method and system for determining analyte levels
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US8346335B2 (en) 2008-03-28 2013-01-01 Abbott Diabetes Care Inc. Analyte sensor calibration management
US7653425B2 (en) 2006-08-09 2010-01-26 Abbott Diabetes Care Inc. Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US9675290B2 (en) 2012-10-30 2017-06-13 Abbott Diabetes Care Inc. Sensitivity calibration of in vivo sensors used to measure analyte concentration
US8219173B2 (en) 2008-09-30 2012-07-10 Abbott Diabetes Care Inc. Optimizing analyte sensor calibration
US8224415B2 (en) 2009-01-29 2012-07-17 Abbott Diabetes Care Inc. Method and device for providing offset model based calibration for analyte sensor
WO2007116959A1 (ja) 2006-04-07 2007-10-18 Hisamitsu Pharmaceutical Co., Inc. マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
AU2007244831A1 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with sculptured microprojections for high drug loading
US20070293816A1 (en) * 2006-04-25 2007-12-20 Alza Corporation Microprojection Array Application with Grouped Microprojections for High Drug Loading
US20070299388A1 (en) * 2006-04-25 2007-12-27 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
WO2007143225A2 (en) 2006-06-07 2007-12-13 Abbott Diabetes Care, Inc. Analyte monitoring system and method
WO2007140783A2 (en) 2006-06-07 2007-12-13 Unomedical A/S Inserter for transcutaneous sensor
KR20090028701A (ko) 2006-06-09 2009-03-19 우노메디컬 에이/에스 장착 패드
US20080015494A1 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
RU2443436C2 (ru) 2006-08-02 2012-02-27 Уномедикал А/С Канюльное и доставочное устройство
EP2073888A4 (en) * 2006-08-28 2011-01-19 Agency Science Tech & Res MICRONED NEEDLES AND METHOD FOR PRODUCING MICRONED NEEDLES
WO2008027218A2 (en) * 2006-08-29 2008-03-06 Alza Corporation Drug electrotransport with hydration measurement of hydratable reservoir
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US7831287B2 (en) * 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
AU2007308804A1 (en) 2006-10-26 2008-05-02 Abbott Diabetes Care, Inc. Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors
EP1917990A1 (en) 2006-10-31 2008-05-07 Unomedical A/S Infusion set
US8332028B2 (en) * 2006-11-28 2012-12-11 Polyplus Battery Company Protected lithium electrodes for electro-transport drug delivery
US7785301B2 (en) * 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
US20080147186A1 (en) * 2006-12-14 2008-06-19 Joshi Ashok V Electrochemical Implant For Delivering Beneficial Agents
US8821446B2 (en) * 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
AU2008208009B2 (en) * 2007-01-22 2013-08-15 Passport Technologies, Inc. Transdermal porator and patch system and method for using same
US20080199894A1 (en) 2007-02-15 2008-08-21 Abbott Diabetes Care, Inc. Device and method for automatic data acquisition and/or detection
US8121857B2 (en) 2007-02-15 2012-02-21 Abbott Diabetes Care Inc. Device and method for automatic data acquisition and/or detection
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
CA2683959C (en) 2007-04-14 2017-08-29 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
WO2009096992A1 (en) 2007-04-14 2009-08-06 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in medical communication system
WO2008130898A1 (en) 2007-04-14 2008-10-30 Abbott Diabetes Care, Inc. Method and apparatus for providing data processing and control in medical communication system
CA2683930A1 (en) 2007-04-14 2008-10-23 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
EP2146622B1 (en) 2007-04-14 2016-05-11 Abbott Diabetes Care Inc. Method and apparatus for providing dynamic multi-stage signal amplification in a medical device
ES2461090T3 (es) 2007-04-14 2014-05-16 Abbott Diabetes Care Inc. Procedimiento y aparato para proporcionar tratamiento y control de datos en un sistema de comunicación médica
US8439861B2 (en) 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US9125548B2 (en) 2007-05-14 2015-09-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US10002233B2 (en) 2007-05-14 2018-06-19 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8444560B2 (en) 2007-05-14 2013-05-21 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8600681B2 (en) 2007-05-14 2013-12-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8260558B2 (en) 2007-05-14 2012-09-04 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8239166B2 (en) 2007-05-14 2012-08-07 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8103471B2 (en) 2007-05-14 2012-01-24 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US7996158B2 (en) 2007-05-14 2011-08-09 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8560038B2 (en) 2007-05-14 2013-10-15 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US20080306444A1 (en) 2007-06-08 2008-12-11 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
EP2155311B1 (en) 2007-06-20 2013-01-02 Unomedical A/S A method and an apparatus for making a catheter
CN103251414B (zh) 2007-06-21 2017-05-24 雅培糖尿病护理公司 用于分析物水平的检测的设备
EP2171031B1 (en) 2007-06-21 2018-12-05 Abbott Diabetes Care Inc. Health management devices and methods
WO2009006349A2 (en) * 2007-06-29 2009-01-08 Polyplus Battery Company Electrotransport devices, methods and drug electrode assemblies
US8160900B2 (en) 2007-06-29 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring and management device and method to analyze the frequency of user interaction with the device
EP2185224A1 (en) 2007-07-03 2010-05-19 Unomedical A/S Inserter having bistable equilibrium states
RU2010104457A (ru) 2007-07-10 2011-08-20 Уномедикал А/С (Dk) Устройство ввода с двумя пружинами
NZ582226A (en) 2007-07-18 2011-12-22 Unomedical As Insertion device with a pivoting action from a first to a second position and longitudinal action to a third position in the direction of insertion.
US8834366B2 (en) 2007-07-31 2014-09-16 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor calibration
US7768386B2 (en) * 2007-07-31 2010-08-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
JP2010535591A (ja) 2007-08-06 2010-11-25 トランスダーム， インコーポレイテッド ポリマー膜から形成される微小針アレイ
AU2008283929B2 (en) * 2007-08-06 2013-10-10 Serenity Pharmaceuticals, Llc Methods and devices for desmopressin drug delivery
US20090069740A1 (en) * 2007-09-07 2009-03-12 Polyplus Battery Company Protected donor electrodes for electro-transport drug delivery
US9549746B2 (en) * 2007-09-28 2017-01-24 The Queen's University Of Belfast Delivery device and method
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US8409093B2 (en) 2007-10-23 2013-04-02 Abbott Diabetes Care Inc. Assessing measures of glycemic variability
US8377031B2 (en) 2007-10-23 2013-02-19 Abbott Diabetes Care Inc. Closed loop control system with safety parameters and methods
US8216138B1 (en) 2007-10-23 2012-07-10 Abbott Diabetes Care Inc. Correlation of alternative site blood and interstitial fluid glucose concentrations to venous glucose concentration
US20090164239A1 (en) 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Dynamic Display Of Glucose Information
CA2745339C (en) 2007-12-24 2016-06-28 The University Of Queensland Coating method
US7766846B2 (en) 2008-01-28 2010-08-03 Roche Diagnostics Operations, Inc. Rapid blood expression and sampling
AU2009212106B9 (en) 2008-02-07 2014-05-22 Vaxxas Pty Limited Patch production
RU2010137844A (ru) 2008-02-13 2012-03-20 Уномедикал А/С (Dk) Уплотнение между канюльной частью и путем прохождения текучей среды
US8157747B2 (en) * 2008-02-15 2012-04-17 Lary Research & Development, Llc Single-use indicator for a surgical instrument and a surgical instrument incorporating same
CA2715667A1 (en) 2008-02-20 2009-08-27 Unomedical A/S Insertion device with horizontally moving part
WO2009146072A1 (en) 2008-04-01 2009-12-03 The General Hospital Corporation Method and apparatus for tissue expansion
US20090259176A1 (en) * 2008-04-09 2009-10-15 Los Gatos Research, Inc. Transdermal patch system
US8252229B2 (en) 2008-04-10 2012-08-28 Abbott Diabetes Care Inc. Method and system for sterilizing an analyte sensor
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
USD610690S1 (en) * 2008-04-16 2010-02-23 Hisamitsu Pharmaceutical Co., Inc. Combined medical patch and package
USD617463S1 (en) * 2008-04-16 2010-06-08 Hisamitsu Pharmaceutical Co., Inc. Combined medical patch and package
PL2712622T3 (pl) * 2008-05-21 2017-01-31 Ferring B.V. Ulegająca rozpadowi w ustach desmopresyna do zwiększania początkowego okresu snu niezakłócanego przez nokturię
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
JP5584202B2 (ja) * 2008-05-21 2014-09-03 セラジェクト， インコーポレイテッド 固溶体穿孔器パッチの製造方法及びその使用
WO2009140735A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents.
US9833183B2 (en) 2008-05-30 2017-12-05 Intuity Medical, Inc. Body fluid sampling device—sampling site interface
US8924159B2 (en) 2008-05-30 2014-12-30 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
US7826382B2 (en) 2008-05-30 2010-11-02 Abbott Diabetes Care Inc. Close proximity communication device and methods
US8591410B2 (en) 2008-05-30 2013-11-26 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
JP2011522616A (ja) * 2008-06-04 2011-08-04 セブンス センス バイオシステムズ，インコーポレーテッド シングルステップ診断のための組成物および方法
EP3639744B1 (en) 2008-06-06 2021-11-24 Intuity Medical, Inc. Blood glucose meter and method of operating
WO2009148624A1 (en) 2008-06-06 2009-12-10 Intuity Medical, Inc. Detection meter and mode of operation
WO2009158032A1 (en) * 2008-06-25 2009-12-30 Fe2, Inc. Patches and methods for the transdermal delivery of a therapeutically effective amount of iron
US8876755B2 (en) 2008-07-14 2014-11-04 Abbott Diabetes Care Inc. Closed loop control system interface and methods
US8202531B2 (en) * 2008-07-23 2012-06-19 Warsaw Orthopedic, Inc. Drug depots having one or more anchoring members
EP2149957B1 (en) * 2008-07-30 2017-06-14 Harman Becker Automotive Systems GmbH Priority based power distribution arrangement
US9943644B2 (en) 2008-08-31 2018-04-17 Abbott Diabetes Care Inc. Closed loop control with reference measurement and methods thereof
US20100057040A1 (en) 2008-08-31 2010-03-04 Abbott Diabetes Care, Inc. Robust Closed Loop Control And Methods
US8734422B2 (en) 2008-08-31 2014-05-27 Abbott Diabetes Care Inc. Closed loop control with improved alarm functions
US8622988B2 (en) 2008-08-31 2014-01-07 Abbott Diabetes Care Inc. Variable rate closed loop control and methods
US10383985B2 (en) * 2008-09-09 2019-08-20 Oxyband Technologies, Inc. Methods and apparatus for charging and evacuating a diffusion dressing
US8986208B2 (en) 2008-09-30 2015-03-24 Abbott Diabetes Care Inc. Analyte sensor sensitivity attenuation mitigation
US9326707B2 (en) 2008-11-10 2016-05-03 Abbott Diabetes Care Inc. Alarm characterization for analyte monitoring devices and systems
CN102256657A (zh) 2008-12-22 2011-11-23 犹诺医药有限公司 包括粘合垫的医疗器械
WO2010078313A1 (en) * 2008-12-30 2010-07-08 Nupathe, Inc. Electronic control of drug delivery system
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US20110105951A1 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin
WO2010101626A1 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Techniques and devices associated with blood sampling
US8781576B2 (en) * 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
US8615295B2 (en) 2009-03-17 2013-12-24 Cardiothrive, Inc. External defibrillator
US8617487B2 (en) 2009-03-25 2013-12-31 Venture Lending & Leasing Vi, Inc. Saliva sample collection systems
CN101829396B (zh) * 2009-03-27 2013-01-30 清华大学 微针阵列芯片及利用其的经皮给药贴剂及其制备方法
US8497777B2 (en) 2009-04-15 2013-07-30 Abbott Diabetes Care Inc. Analyte monitoring system having an alert
EP2419015A4 (en) 2009-04-16 2014-08-20 Abbott Diabetes Care Inc ANALYTE SENSOR CALIBRATION MANAGEMENT
EP2429627B1 (en) * 2009-04-24 2017-06-14 Corium International, Inc. Methods for manufacturing microprojection arrays
US8821945B2 (en) * 2009-04-25 2014-09-02 Fe3 Medical, Inc. Method for transdermal iontophoretic delivery of chelated agents
WO2010127050A1 (en) 2009-04-28 2010-11-04 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
GB2469839B (en) * 2009-04-29 2014-09-10 Cook Medical Technologies Llc Medical instrument
US8483967B2 (en) 2009-04-29 2013-07-09 Abbott Diabetes Care Inc. Method and system for providing real time analyte sensor calibration with retrospective backfill
WO2010127187A1 (en) 2009-04-29 2010-11-04 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
US8597274B2 (en) 2009-05-22 2013-12-03 Abbott Diabetes Care Inc. Usability features for integrated insulin delivery system
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
US8666466B2 (en) * 2009-06-10 2014-03-04 Medtronic, Inc. Device and method for monitoring of absolute oxygen saturation and tissue hemoglobin concentration
US8613892B2 (en) 2009-06-30 2013-12-24 Abbott Diabetes Care Inc. Analyte meter with a moveable head and methods of using the same
EP3689237B1 (en) 2009-07-23 2021-05-19 Abbott Diabetes Care, Inc. Method of manufacturing and system for continuous analyte measurement
JP2013500099A (ja) 2009-07-30 2013-01-07 ウノメディカル・アー／エス 水平方向の可動部材を備えた挿入デバイス
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
CN102548598B (zh) 2009-08-07 2014-09-17 犹诺医药有限公司 具有传感器和一个或多个插管的传送装置
EP4070727B1 (en) 2009-08-31 2023-07-05 Abbott Diabetes Care, Inc. Displays for a medical device
EP2473099A4 (en) 2009-08-31 2015-01-14 Abbott Diabetes Care Inc ANALYTICAL MONITORING SYSTEM AND METHOD FOR POWERFUL AND NOISE MANAGEMENT
WO2011026147A1 (en) 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Analyte signal processing device and methods
JP5795584B2 (ja) 2009-08-31 2015-10-14 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． 医療用装置
US20130018279A1 (en) * 2009-09-01 2013-01-17 Pathway Genomics "blood sample collection apparatus and kits"
US9320461B2 (en) 2009-09-29 2016-04-26 Abbott Diabetes Care Inc. Method and apparatus for providing notification function in analyte monitoring systems
WO2011053787A2 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for application to skin and control of actuation, delivery and/or perception thereof
WO2011053881A1 (en) 2009-10-30 2011-05-05 Abbott Diabetes Care Inc. Method and apparatus for detecting false hypoglycemic conditions
WO2011065972A2 (en) * 2009-11-24 2011-06-03 Seventh Sense Biosystems, Inc. Patient-enacted sampling technique
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
CN102811754B (zh) * 2010-01-13 2017-05-17 第七感生物系统有限公司 流体的快速输送和/或抽出
CN102791197B (zh) * 2010-01-13 2016-03-23 第七感生物系统有限公司 取样装置接口
USD924406S1 (en) 2010-02-01 2021-07-06 Abbott Diabetes Care Inc. Analyte sensor inserter
WO2011112753A1 (en) 2010-03-10 2011-09-15 Abbott Diabetes Care Inc. Systems, devices and methods for managing glucose levels
ES2881798T3 (es) 2010-03-24 2021-11-30 Abbott Diabetes Care Inc Insertadores de dispositivos médicos y procedimientos de inserción y uso de dispositivos médicos
CA2792138A1 (en) 2010-03-30 2011-10-06 Unomedical A/S Medical device
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
KR102341551B1 (ko) * 2010-04-28 2021-12-21 이노비오 파마수티컬즈, 인크. 구강 점막 전기천공 장치 및 그 용도
US8635046B2 (en) 2010-06-23 2014-01-21 Abbott Diabetes Care Inc. Method and system for evaluating analyte sensor response characteristics
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
US10092229B2 (en) 2010-06-29 2018-10-09 Abbott Diabetes Care Inc. Calibration of analyte measurement system
US11064921B2 (en) 2010-06-29 2021-07-20 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
US20120016308A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure packaging for fluid devices
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120041338A1 (en) * 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Clinical and/or consumer techniques and devices
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
EP2433663A1 (en) 2010-09-27 2012-03-28 Unomedical A/S Insertion system
EP2436412A1 (en) 2010-10-04 2012-04-04 Unomedical A/S A sprinkler cannula
WO2012048168A2 (en) 2010-10-07 2012-04-12 Abbott Diabetes Care Inc. Analyte monitoring devices and methods
US10024510B2 (en) * 2010-10-26 2018-07-17 Steven G. Hammond Flexible light emitting diode lighting process and assembly
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
CN103619255B (zh) 2011-02-28 2016-11-02 雅培糖尿病护理公司 与分析物监测装置关联的装置、系统和方法以及结合了它们的装置
US10136845B2 (en) 2011-02-28 2018-11-27 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
EP3575796B1 (en) 2011-04-15 2020-11-11 DexCom, Inc. Advanced analyte sensor calibration and error detection
EP3236259A1 (en) 2011-04-29 2017-10-25 Seventh Sense Biosystems, Inc. Plasma or serum production and removal of fluids under reduced pressure
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
JP6121400B2 (ja) 2011-04-29 2017-04-26 セブンス センス バイオシステムズ，インコーポレーテッド 流体の送達および／または受け取り
USD687551S1 (en) 2011-06-09 2013-08-06 3M Innovative Properties Company Micro-needle applicator device
USD687550S1 (en) 2011-06-09 2013-08-06 3M Innovative Properties Company Handle for a micro-needle device
EP4122384A1 (en) 2011-06-16 2023-01-25 Abbott Diabetes Care, Inc. Temperature-compensated analyte monitoring devices, systems, and methods thereof
WO2013020103A1 (en) 2011-08-03 2013-02-07 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
EP2763723B1 (en) 2011-10-05 2016-04-13 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
CN103874518A (zh) 2011-10-12 2014-06-18 3M创新有限公司 一体化微针阵列递送系统
US8585721B2 (en) * 2011-10-12 2013-11-19 Covidien Lp Mesh fixation system
AU2012323782B2 (en) * 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
US9069536B2 (en) 2011-10-31 2015-06-30 Abbott Diabetes Care Inc. Electronic devices having integrated reset systems and methods thereof
US9622691B2 (en) 2011-10-31 2017-04-18 Abbott Diabetes Care Inc. Model based variable risk false glucose threshold alarm prevention mechanism
CA2840640C (en) 2011-11-07 2020-03-24 Abbott Diabetes Care Inc. Analyte monitoring device and methods
US8710993B2 (en) 2011-11-23 2014-04-29 Abbott Diabetes Care Inc. Mitigating single point failure of devices in an analyte monitoring system and methods thereof
US9317656B2 (en) 2011-11-23 2016-04-19 Abbott Diabetes Care Inc. Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof
WO2013078426A2 (en) 2011-11-25 2013-05-30 Abbott Diabetes Care Inc. Analyte monitoring system and methods of use
AU2012352560B2 (en) 2011-12-11 2017-01-19 Abbott Diabetes Care Inc. Analyte sensor devices, connections, and methods
US20150157840A1 (en) * 2012-06-12 2015-06-11 Hisamitsu Pharmaceutical Co., Inc. Microneedle Sheet
US10132793B2 (en) 2012-08-30 2018-11-20 Abbott Diabetes Care Inc. Dropout detection in continuous analyte monitoring data during data excursions
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
EP2901153A4 (en) 2012-09-26 2016-04-27 Abbott Diabetes Care Inc METHOD AND DEVICE FOR IMPROVING DELAY CORRECTION FUNCTION DURING IN VIVO MEASUREMENT OF ANALYZ CONCENTRATION WITH ANALYZ CONCENTRATION VARIABILITY AND RANGE DATA
US20160128947A1 (en) * 2012-10-22 2016-05-12 Stc. Unm Bioadhesive films for local and/or systemic delivery
WO2014130359A1 (en) 2013-02-20 2014-08-28 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
CN105188569B (zh) 2013-03-15 2020-11-20 考里安公司 用于递送活性剂的微结构阵列
US10433773B1 (en) 2013-03-15 2019-10-08 Abbott Diabetes Care Inc. Noise rejection methods and apparatus for sparsely sampled analyte sensor data
US9474475B1 (en) 2013-03-15 2016-10-25 Abbott Diabetes Care Inc. Multi-rate analyte sensor data collection with sample rate configurable signal processing
US10076285B2 (en) 2013-03-15 2018-09-18 Abbott Diabetes Care Inc. Sensor fault detection using analyte sensor data pattern comparison
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback
BR112016002695B1 (pt) 2013-08-09 2022-09-20 Cytrellis Biosystems, Inc Dispositivo com um aparelho ablativo, um aparelho de remoção e um aparelho de posicionamento
US9486618B2 (en) * 2013-08-27 2016-11-08 Halo Neuro, Inc. Electrode system for electrical stimulation
CN105492067B (zh) 2013-08-27 2017-07-25 哈洛纽罗公司 用于电刺激的电极系统
EP3038700B1 (en) 2013-08-27 2020-03-11 Halo Neuro, Inc. Method and system for providing electrical stimulation to a user
US9782585B2 (en) 2013-08-27 2017-10-10 Halo Neuro, Inc. Method and system for providing electrical stimulation to a user
JP6272333B2 (ja) * 2013-09-06 2018-01-31 久光製薬株式会社 マイクロニードル・シート
DE102013219432A1 (de) * 2013-09-26 2015-03-26 Peter Röhr Blutentnahmevorrichtung und Verfahren zum Entnehmen von Blut
US10953143B2 (en) 2013-12-19 2021-03-23 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
AU2014374361B9 (en) 2013-12-31 2019-07-04 Abbott Diabetes Care Inc. Self-powered analyte sensor and devices using the same
TWI548395B (zh) * 2014-01-28 2016-09-11 微凸科技股份有限公司 連續經皮微針監測系統
WO2015117089A1 (en) * 2014-02-01 2015-08-06 Axion Biosystems, Inc. Neural interfacing device
EP2905047A1 (de) * 2014-02-10 2015-08-12 LTS LOHMANN Therapie-Systeme AG Mikronadelsystem und Verfahren seiner Herstellung
EP3111987B1 (en) * 2014-02-27 2022-04-20 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
US20170185748A1 (en) 2014-03-30 2017-06-29 Abbott Diabetes Care Inc. Method and Apparatus for Determining Meal Start and Peak Events in Analyte Monitoring Systems
CA2959506C (en) 2014-08-29 2022-10-18 Corium International, Inc. Microstructure array for delivery of active agents
CN105455855B (zh) * 2014-09-04 2018-05-25 微凸科技股份有限公司 乳酸量测装置及运动训练调整的方法
JP5967595B2 (ja) * 2014-09-08 2016-08-10 株式会社かいわ 穿刺器具
WO2016039333A1 (ja) * 2014-09-08 2016-03-17 株式会社かいわ 穿刺器具
KR102670286B1 (ko) 2014-11-14 2024-05-30 사이트렐리스 바이오시스템즈, 인크. 피부 절제를 위한 디바이스 및 방법
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
JP6571680B2 (ja) 2014-12-05 2019-09-04 久光製薬株式会社 マイクロニードルデバイスシステム
WO2016123665A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
CA2984939A1 (en) 2015-05-14 2016-11-17 Abbott Diabetes Care Inc. Compact medical device inserters and related systems and methods
US11553883B2 (en) 2015-07-10 2023-01-17 Abbott Diabetes Care Inc. System, device and method of dynamic glucose profile response to physiological parameters
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
CA2999538A1 (en) 2015-09-28 2017-04-06 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
EP3368146B1 (en) 2015-10-26 2021-04-07 Halo Neuro, Inc. Electrode positioning system
AU2017212738A1 (en) * 2016-01-27 2018-08-02 Undercover Colors, Inc. Apparatus, system, and method for detecting a target substance
EP3413966A4 (en) 2016-02-08 2019-11-27 Halo Neuro, Inc. METHOD AND SYSTEM FOR IMPROVING THE PROVISION OF ELECTRICAL STIMULATION
WO2017143345A1 (en) 2016-02-19 2017-08-24 Zp Opco, Inc. Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
US10939912B2 (en) * 2016-03-01 2021-03-09 Kitotech Medical, Inc. Microstructure-based systems, apparatus, and methods for wound closure
WO2017172920A1 (en) 2016-03-29 2017-10-05 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
US10485443B2 (en) 2016-06-20 2019-11-26 Halo Neuro, Inc. Electrical interface system
EP3493872A4 (en) * 2016-08-03 2020-04-08 Verndari, Inc. Microarrays and methods
EP3515323A4 (en) 2016-09-21 2020-06-10 Cytrellis Biosystems, Inc. COSMETIC RESTRUCTURING DEVICES AND METHODS
US11071478B2 (en) 2017-01-23 2021-07-27 Abbott Diabetes Care Inc. Systems, devices and methods for analyte sensor insertion
AU2018222745B2 (en) 2017-02-17 2021-02-18 Allergan, Inc. Microneedle array with active ingredient
EP3592218B1 (en) 2017-03-08 2024-01-17 Halo Neuro, Inc. System for electrical stimulation
EP3595515A4 (en) 2017-03-14 2020-12-30 University of Connecticut BIODEGRADABLE PRESSURE SENSOR
US11596330B2 (en) 2017-03-21 2023-03-07 Abbott Diabetes Care Inc. Methods, devices and system for providing diabetic condition diagnosis and therapy
ES2960937T3 (es) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Dispositivo y método para recubrir superficies
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
EP4473998A3 (en) 2017-08-04 2025-02-26 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
EP3672570A1 (en) 2017-08-23 2020-07-01 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches
US10524730B2 (en) * 2017-09-28 2020-01-07 Medtronic Minimed, Inc. Medical devices with microneedle arrays and methods for operating such medical devices
CN107874767B (zh) * 2017-10-12 2020-11-24 杭州博拓生物科技股份有限公司 一种检测样本中被分析物质的装置
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
US11382540B2 (en) 2017-10-24 2022-07-12 Dexcom, Inc. Pre-connected analyte sensors
JP6920179B2 (ja) 2017-11-15 2021-08-18 新光電気工業株式会社 生体用電極部品及びその製造方法
US10507324B2 (en) 2017-11-17 2019-12-17 Halo Neuro, Inc. System and method for individualizing modulation
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
JP7305311B2 (ja) 2018-05-30 2023-07-10 ロレアル マイクロニードルシート
CN112399908B (zh) 2018-06-25 2023-04-07 考里安公司 形成主模、铸模的方法以及制备微结构阵列的方法
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
JP7335061B2 (ja) 2018-06-29 2023-08-29 ロレアル マイクロニードルシートを使用する美容方法
JP2020002084A (ja) 2018-06-29 2020-01-09 ロレアル マイクロニードルシートを使用する美容方法
JP2020018327A (ja) 2018-07-17 2020-02-06 ロレアル マイクロニードルシート
EP3603737B1 (en) 2018-07-31 2020-08-26 Flow Neuroscience AB Positioning of electrodes for transcranial brain stimulation
JP7340601B2 (ja) * 2018-10-04 2023-09-07 オニオ アーエス 生体温度を継続的に無線で監視及び分析する通知機能付きセンサシステム及び方法
EP3890636A1 (en) * 2018-12-06 2021-10-13 Bausch Health Ireland Limited Microblade structure and method of treating tissue
MX2021007294A (es) 2018-12-21 2021-07-15 Abbott Diabetes Care Inc Sistemas, dispositivos y metodos para la insercion de sensores de analito.
JP7666887B2 (ja) 2018-12-21 2025-04-22 ロレアル マイクロニードルシートを使用するキット及び美容方法
US11826495B2 (en) 2019-03-01 2023-11-28 University Of Connecticut Biodegradable piezoelectric ultrasonic transducer system
USD1002852S1 (en) 2019-06-06 2023-10-24 Abbott Diabetes Care Inc. Analyte sensor device
CN114375181B (zh) * 2019-06-28 2025-10-31 帕斯帕特技术有限公司 用于控制向细丝装置递送能量的方法和系统
JP2021094146A (ja) 2019-12-16 2021-06-24 ロレアル マイクロニードルシートを使用する美容方法
WO2021168330A1 (en) * 2020-02-19 2021-08-26 Kitotech Medical, Inc. Microstructures to attach appliances to tissues
US11986613B2 (en) 2020-02-19 2024-05-21 Kitotech Medical, Inc. Microstructure systems and methods for pain treatment
US11745001B2 (en) 2020-03-10 2023-09-05 University Of Connecticut Therapeutic bandage
US12491290B2 (en) 2020-06-08 2025-12-09 University Of Connecticut Biodegradable piezoelectric composite materials
US20230226332A1 (en) 2020-06-17 2023-07-20 L'oreal Kit and cosmetic process using microneedle sheet
FR3113843B1 (fr) 2020-09-07 2024-03-15 Oreal Kit et traitement cosmetique utilisant une feuille de micro-aiguilles
TWI757205B (zh) * 2020-06-30 2022-03-01 財團法人工業技術研究院 微針電轉染裝置
EP4203819B1 (en) 2020-08-31 2024-07-31 Abbott Diabetes Care Inc. Systems, devices, and methods for analyte sensor insertion
ES3000715T3 (en) 2020-09-15 2025-03-03 Abbott Diabetes Care Inc Device for analyte monitoring
USD999913S1 (en) 2020-12-21 2023-09-26 Abbott Diabetes Care Inc Analyte sensor inserter
JP2024527596A (ja) 2021-07-16 2024-07-25 アボット ダイアベティス ケア インコーポレイテッド 検体監視のためのシステム、装置、及び方法
WO2023159181A1 (en) 2022-02-18 2023-08-24 Kitotech Medical, Inc. Force modulating deep skin staples and instruments
FR3135206A1 (fr) 2022-05-05 2023-11-10 L'oreal Processus cosmétique utilisant une feuille de micro-aiguilles
FR3139007B1 (fr) 2022-08-23 2026-01-02 Oreal Composition convenant pour des traitements cosmétiques de substance kératineuse
FR3160326B3 (fr) 2024-03-20 2026-04-17 Oreal Processus cosmétique mettant en œuvre des micro-aiguilles
WO2025173801A1 (en) 2024-02-14 2025-08-21 L'oreal Cosmetic process using microneedles

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US5250023A (en) * 1989-10-27 1993-10-05 Korean Research Institute on Chemical Technology Transdermal administration method of protein or peptide drug and its administration device thereof
US5279543A (en) * 1988-01-29 1994-01-18 The Regents Of The University Of California Device for iontophoretic non-invasive sampling or delivery of substances
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
WO1996017648A1 (de) * 1994-12-09 1996-06-13 Novartis Ag Transdermales system

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US946837A (en) * 1908-11-05 1910-01-18 Cordelia L Common Fountain tonic-applicator.
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
FR1133709A (fr) 1955-10-17 1957-04-01 Dispositif destiné à l'application de nouveaux traitements médicaux
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US2974787A (en) * 1960-05-10 1961-03-14 American Cyanamid Co Single use, prepackaged vaccinator
US3322121A (en) * 1965-11-26 1967-05-30 Oscar H Banker Skin-puncturing unit with a collapsible protective cover
CH522395A (fr) * 1968-07-26 1972-05-15 Micromedic Systems Inc Eprouvette destinée à la prise de sang percutanée et digitale
US3675766A (en) * 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
JPS5029096U (https=) * 1973-07-06 1975-04-02
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4014334A (en) 1976-02-02 1977-03-29 Alza Corporation Laminated osmotic system for dispensing beneficial agent
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4127118B1 (en) * 1977-03-16 1995-12-19 Alvaro Latorre Method of effecting and enhancing an erection
GB2008200B (en) 1977-11-09 1982-10-20 Emerit Andre A C Source of vacuum and device for creating and maintaining anegative pressure in an enclosure
US4250878A (en) 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4383529A (en) * 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4340048A (en) 1981-03-28 1982-07-20 Alza Corporation Self-driven hypodermic injector
US5370675A (en) * 1992-08-12 1994-12-06 Vidamed, Inc. Medical probe device and method
US4753651A (en) 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
USH356H (en) * 1985-02-27 1987-11-03 Medtronic, Inc. Epicardial lead having low threshold, low polarization myocardial electrode
SU1296174A1 (ru) * 1985-06-20 1987-03-15 Устиновский Государственный Медицинский Институт Устройство дл электрофореза лекарственных веществ
US4655766A (en) 1985-08-01 1987-04-07 Alza Corporation Fluid imbibing pump with self-regulating skin patch
US4756314A (en) 1985-10-28 1988-07-12 Alza Corporation Sweat collection patch
US4711247A (en) * 1986-04-18 1987-12-08 Henry Fishman Allergy testing method and apparatus
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
DE3735137A1 (de) * 1987-10-16 1989-05-03 Siemens Ag Anordnung zum abgeben von medikamenten bei einem implantierbaren medizinischen geraet
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5438984A (en) 1988-09-08 1995-08-08 Sudor Partners Apparatus and method for the collection of analytes on a dermal patch
US5147296A (en) 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US4941517A (en) * 1988-10-20 1990-07-17 Galloway Trust Aseptic fluid transfer apparatus and methods
US5054499A (en) 1989-03-27 1991-10-08 Swierczek Remi D Disposable skin perforator and blood testing device
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US5036861A (en) 1990-01-11 1991-08-06 Sembrowich Walter L Method and apparatus for non-invasively monitoring plasma glucose levels
US5161532A (en) 1990-04-19 1992-11-10 Teknekron Sensor Development Corporation Integral interstitial fluid sensor
US5300100A (en) * 1990-08-22 1994-04-05 Advanced Warming Systems, Inc. Body warmer
US5158537A (en) * 1990-10-29 1992-10-27 Alza Corporation Iontophoretic delivery device and method of hydrating same
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
SE9101022D0 (sv) 1991-01-09 1991-04-08 Paal Svedman Medicinsk suganordning
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5122114A (en) * 1991-02-01 1992-06-16 Board Of Regents, University Of Texas System Method of using intramedullary catheter
US5231993A (en) 1991-11-20 1993-08-03 Habley Medical Technology Corporation Blood sampler and component tester with guide member
JP2572823Y2 (ja) 1992-02-13 1998-05-25 株式会社アドバンス 簡易採血器
US5484399A (en) * 1992-02-27 1996-01-16 Sloan-Kettering Institute For Cancer Research Process and device to reduce interstitial fluid pressure in tissue
US5309909A (en) * 1992-05-22 1994-05-10 Physio-Control Corporation Combined skin preparation and monitoring electrode
JPH0670987A (ja) 1992-08-28 1994-03-15 Katsuro Tachibana 薬物投与・体液採取ユニット及び装置
US5300110A (en) * 1992-10-15 1994-04-05 Angeion Corporation Dirk-based epicardial defibrillation electrode
JPH0824680B2 (ja) 1992-10-26 1996-03-13 日本電気株式会社 吸引浸出液採取装置
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
JP2630197B2 (ja) 1993-04-28 1997-07-16 株式会社ニッショー 血液吸出器具
US5582184A (en) 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5885211A (en) 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
JPH084182A (ja) * 1994-06-17 1996-01-09 Nippon Steel Metal Prod Co Ltd フラットデッキプレート用のアンカー部材
DE69519023T2 (de) 1994-06-24 2001-06-13 Cygnus, Inc. Einrichtung zur iontophoretischen probennahme
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
US5571162A (en) * 1995-06-07 1996-11-05 Intermedics, Inc. Transvenous defibrillation lead with side hooks
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
ES2536459T3 (es) 1995-08-29 2015-05-25 Nitto Denko Corporation Microporación de piel humana para administración de fármacos y aplicaciones de supervisión
US5682233A (en) 1995-09-08 1997-10-28 Integ, Inc. Interstitial fluid sampler
CA2253549C (en) * 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
ATE241405T1 (de) 1996-07-03 2003-06-15 Altea Therapeutics Corp Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US5983136A (en) * 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
DE69806963T2 (de) * 1997-12-11 2002-11-21 Alza Corp., Mountain View Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
CA2313698C (en) * 1997-12-11 2008-04-15 Alza Corporation Device for enhancing transdermal agent flux
ES2314995T3 (es) * 1997-12-11 2009-03-16 Alza Corporation Dispositivo para mejorar el flujo de agentes tansdermicos.
US6022316A (en) * 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
ATE416692T1 (de) * 2000-10-13 2008-12-15 Alza Corp Mikronadelelementhalter für schlagapplikator
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
PL360978A1 (en) * 2000-10-13 2004-09-20 Alza Corporation Microblade array impact applicator
DE60138411D1 (de) * 2000-10-13 2009-05-28 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
NZ525551A (en) * 2000-10-26 2005-09-30 Alza Corp Transdermal drug delivery devices having coated microprotrusions
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
ATE444773T1 (de) * 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
US20030199810A1 (en) * 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
WO2003053258A1 (en) * 2001-12-20 2003-07-03 Alza Corporation Skin-piercing microprojections having piercing depth control
KR101087199B1 (ko) * 2002-06-14 2011-11-29 오가와코료 가부시키가이샤 향미열화 억제제 및 시트랄의 열화악취 생성 억제제
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
JP2007535337A (ja) * 2003-10-28 2007-12-06 アルザ・コーポレーシヨン 被覆された微小突起による治療用ペプチドおよびタンパクのポリマー接合体の送達
ES2377647T3 (es) * 2003-10-31 2012-03-29 Alza Corporation Aplicador auto-actuado para ordenamiento de microproyecciones
KR20070010115A (ko) * 2003-11-13 2007-01-22 알자 코포레이션 경피전달용 조성물 및 장치
US7556821B2 (en) * 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
CA2593112A1 (en) * 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion
TW200700094A (en) * 2005-01-31 2007-01-01 Alza Corp Coated microprojections having reduced variability and method for producing same
CA2596120A1 (en) * 2005-02-16 2006-08-24 Alza Corporation Microprojection arrays with improved biocompatibility
US8374997B2 (en) * 2005-05-20 2013-02-12 Teradota Us, Inc. Application code generation and execution with bypass, logging, user restartability and status functionality
US20060275170A1 (en) * 2005-06-02 2006-12-07 Mahmoud Ameri Method for terminal sterilization of transdermal delivery devices
EP1898989A2 (en) * 2005-06-21 2008-03-19 Alza Corporation Method and device for coating a continuous strip of microprojection members

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US5279543A (en) * 1988-01-29 1994-01-18 The Regents Of The University Of California Device for iontophoretic non-invasive sampling or delivery of substances
US5250023A (en) * 1989-10-27 1993-10-05 Korean Research Institute on Chemical Technology Transdermal administration method of protein or peptide drug and its administration device thereof
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
WO1996017648A1 (de) * 1994-12-09 1996-06-13 Novartis Ag Transdermales system

Cited By (279)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU739616B2 (en) * 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
WO1999029365A1 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
WO1999029364A1 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
US6083196A (en) * 1997-12-11 2000-07-04 Alza Corporation Device for enhancing transdermal agent flux
WO1999029298A2 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
US6953589B1 (en) 1997-12-11 2005-10-11 Alza Corporation Device for enhancing transdermal agent flux
EP1911488A2 (en) 1997-12-11 2008-04-16 Alza Corporation Device for enhancing transdermal agent flux
US6322808B1 (en) 1997-12-11 2001-11-27 Alza Corporation Device for enhancing transdermal agent flux
WO2000012173A1 (en) * 1998-08-31 2000-03-09 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
JP2002529159A (ja) * 1998-11-09 2002-09-10 エレクシス リミティド 経皮的な薬物の放出および分析物の抽出
JP2007244875A (ja) * 1999-02-01 2007-09-27 Orthogen Ag 体液から治療上有効なタンパク質であるインターロイキン−１受容体拮抗薬を産生するための方法
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6931277B1 (en) 1999-06-09 2005-08-16 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6471903B2 (en) 1999-06-09 2002-10-29 The Procter & Gamble Company Method for manufacturing an intracutaneous microneedle array
US7416541B2 (en) 1999-06-09 2008-08-26 Corium International, Inc. Intracutaneous microneedle array apparatus
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6652478B1 (en) 1999-06-09 2003-11-25 The Procter & Gamble Company Intracutaneous edged microneedle apparatus
US6451240B1 (en) 1999-06-09 2002-09-17 The Procter & Gamble Company Method of manufacturing an intracutaneous microneedle array
US6465709B1 (en) 1999-07-08 2002-10-15 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
WO2001013989A1 (en) 1999-08-25 2001-03-01 Johnson And Johnson Consumer Companies, Inc. Tissue electroperforation for drug delivery and diagnostic sampling
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US6251083B1 (en) 1999-09-07 2001-06-26 Amira Medical Interstitial fluid methods and devices for determination of an analyte in the body
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
EP1086718A1 (en) 1999-09-22 2001-03-28 Becton Dickinson and Company Method and apparatus for the transdermal administration of a substance
SG92728A1 (en) * 1999-09-22 2002-11-19 Becton Dickinson Co Method and apparatus for the transdermal administration of a substrate
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
EP1086719A1 (en) 1999-09-24 2001-03-28 Becton Dickinson and Company Method and device for abrading skin
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US7087035B2 (en) 1999-12-10 2006-08-08 Alza Corporation Device and method for enhancing skin piercing by microprotrusions
KR100750841B1 (ko) * 1999-12-16 2007-08-22 알자 코포레이션 채취되는 약물의 경피 유동을 강화하기 위한 장치 및 방법
US6562014B2 (en) 1999-12-16 2003-05-13 Alza Corporation Device and method for enhancing transdermal flux of agents being sampled
WO2001043643A1 (en) * 1999-12-16 2001-06-21 Alza Corporation Device for enhancing transdermal flux of sampled agents
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US7731968B2 (en) 2000-05-22 2010-06-08 Becton, Dickinson And Company Topical delivery of vaccines
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
WO2001093931A1 (en) 2000-06-06 2001-12-13 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a puncturing member into the intradermal space
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US9717451B2 (en) 2000-06-08 2017-08-01 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
WO2001093946A1 (en) 2000-06-08 2001-12-13 Becton, Dickson And Company Skin permeability enhancing device to withdraw or administer a substance and method of manufacturing the device
US6607513B1 (en) 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
WO2002002180A2 (en) 2000-06-29 2002-01-10 Becton, Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
WO2002005890A2 (en) 2000-07-14 2002-01-24 Becton, Dickinson And Company Microdevice and method of manufacturing a microdevice
WO2002005889A1 (en) 2000-07-17 2002-01-24 Becton, Dickinson And Company Delivery device with microneedles for the transdermal administration of a substance
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
WO2002007813A1 (en) 2000-07-21 2002-01-31 Smithkline Beecham Biologicals S.A. Vaccines
WO2002015800A1 (en) 2000-08-24 2002-02-28 Alza Corporation Method for transdermal nucleic acid sampling
US6690959B2 (en) 2000-09-01 2004-02-10 Medtronic, Inc. Skin-mounted electrodes with nano spikes
CN100421653C (zh) * 2000-09-08 2008-10-01 阿尔扎公司 通过抑制通道关闭来抑制药物透皮通量减少的方法
JP2004508319A (ja) * 2000-09-08 2004-03-18 アルザ・コーポレーシヨン 経路閉鎖を阻害することによる経皮的薬物流動の減少の抑制方法
RU2272618C2 (ru) * 2000-09-08 2006-03-27 Алза Корпорейшн Способы ингибирования уменьшения трансдермального движения лекарственного средства посредством ингибирования закрытия путей
WO2002019985A3 (en) * 2000-09-08 2002-09-06 Alza Corp Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
US7438926B2 (en) 2000-09-08 2008-10-21 Alza Corporation Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
KR100764699B1 (ko) * 2000-09-08 2007-10-08 알자 코포레이션 경로 폐쇄 저해에 의한 경피 약물 플럭스 감소 저해방법
EP2305298A1 (en) 2000-09-15 2011-04-06 GlaxoSmithKline Biologicals s.a. Vaccine against streptococcus pneumoniae
EP2314313A1 (en) 2000-09-15 2011-04-27 GlaxoSmithKline Biologicals S.A. Vaccine against streptococcus pneumoniae
EP2140878A1 (en) 2000-09-15 2010-01-06 GlaxoSmithKline Biologicals S.A. Vaccine against streptococcus pneumoniae
EP2305297A1 (en) 2000-09-15 2011-04-06 GlaxoSmithKline Biologicals s.a. Vaccine against streptococcus pneumoniae
WO2002030506A2 (en) 2000-10-12 2002-04-18 Ink Jet Technology Ltd. Transdermal method
AU2001296828B2 (en) * 2000-10-13 2005-11-24 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US6855131B2 (en) 2000-10-13 2005-02-15 Alza Corporation Microprotrusion member retainer for impact applicator
WO2002030301A1 (en) * 2000-10-13 2002-04-18 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US7798987B2 (en) 2000-10-13 2010-09-21 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US7131960B2 (en) 2000-10-13 2006-11-07 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US9192749B2 (en) 2000-10-13 2015-11-24 Alza Corporation Microblade array impact applicator
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
EP2266603A1 (en) 2000-10-18 2010-12-29 GlaxoSmithKline Biologicals S.A. Tumour vaccines
EP2085109A2 (en) 2000-10-26 2009-08-05 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US7537795B2 (en) 2000-10-26 2009-05-26 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US8663155B2 (en) 2000-10-26 2014-03-04 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
WO2002068044A2 (en) 2001-02-28 2002-09-06 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and sampling
US7763203B2 (en) 2001-03-14 2010-07-27 Corium International, Inc. Method of manufacturing microneedle structures using photolithography
WO2002072189A2 (en) 2001-03-14 2002-09-19 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US7435299B2 (en) 2001-03-16 2008-10-14 Alza Corporation Method and apparatus for coating skin piercing microprojections
US6855372B2 (en) 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
EP3251722A1 (en) 2001-04-20 2017-12-06 ALZA Corporation Microprojection array having a beneficial agent containing coating and method of forming the coating thereon
EP1383571A2 (en) 2001-04-20 2004-01-28 Alza Corporation Microprojection array immunization patch and method
US7963935B2 (en) 2001-04-20 2011-06-21 Alza Corporation Microprojection array having a beneficial agent containing coating
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US7186235B2 (en) 2001-06-08 2007-03-06 Becton, Dickinson And Company Device for manipulating a needle or abrader array and method of use
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US8900186B2 (en) 2001-09-12 2014-12-02 Becton, Dickinson And Company Microneedle-based pen device for drug delivery and method for using same
US10661066B2 (en) 2001-09-12 2020-05-26 Becton, Dickinson And Company Microneedle-based pen device for drug delivery and method for using same
US7556615B2 (en) 2001-09-12 2009-07-07 Becton, Dickinson And Company Microneedle-based pen device for drug delivery and method for using same
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7364568B2 (en) 2001-10-26 2008-04-29 Massachusetts Institute Of Technology Microneedle transdermal transport device
US7066922B2 (en) 2001-10-26 2006-06-27 Massachusetts Institute Of Technology Transdermal transport device with suction
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
EP1450876A4 (en) * 2001-11-07 2009-12-30 Transpharma Medical Ltd INTEGRATED TRANSDERMAL DRUG DELIVERY SYSTEM
WO2003048031A3 (en) * 2001-11-30 2004-04-01 Alza Corp Methods and apparatuses for forming microprojection arrays
WO2003053258A1 (en) * 2001-12-20 2003-07-03 Alza Corporation Skin-piercing microprojections having piercing depth control
EP2111885A2 (en) 2002-02-04 2009-10-28 Becton, Dickinson and Company, Wagner, Jaconda Device and method for delivering or withdrawing a substance through the skin
US7083592B2 (en) * 2002-02-04 2006-08-01 Becton Dickinson And Company Device and method for delivering withdrawing a substance through the skin
WO2003066126A2 (en) 2002-02-04 2003-08-14 Becton, Dickinson And Company Dermal access member
US6808506B2 (en) 2002-02-04 2004-10-26 Becton, Dickinson And Company Device and method for delivering or withdrawing a substance through the skin
US7047070B2 (en) 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
WO2003084595A1 (en) 2002-04-02 2003-10-16 Becton, Dickinson And Company Valved intradermal delivery device
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
EP3167929A1 (en) 2002-04-02 2017-05-17 Becton, Dickinson and Company Device for intradermally delivering a substance
EP1757240A1 (en) 2002-04-02 2007-02-28 Becton, Dickinson and Company Valved intradermal delivery device
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
EP3375463A1 (en) 2002-05-06 2018-09-19 Becton, Dickinson and Company Method and device for controlling drug pharmacokinetics
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7316671B2 (en) 2002-08-29 2008-01-08 Becton, Dickinson And Company Microprotrusion arrays and methods for using same to deliver substances into tissue
US7166086B2 (en) 2002-08-29 2007-01-23 Becton, Dickinson And Company Substance delivery via a rotating microabrading surface
WO2004020034A2 (en) 2002-08-29 2004-03-11 Becton Dickinson And Company Microabrader with controlled abrasion features
US8075826B2 (en) 2002-08-29 2011-12-13 Becton, Dickinson And Company Microprotrusion arrays and methods for using same to deliver substances into tissue
US7422567B2 (en) 2002-08-29 2008-09-09 Becton, Dickinson And Company Microabrader with controlled abrasion features
WO2004033021A1 (en) 2002-10-07 2004-04-22 Biovalve Technologies, Inc. Microneedle array patch
US8162901B2 (en) 2002-10-07 2012-04-24 Valeritas, Inc. Microneedle array patch
US7060059B2 (en) 2002-10-11 2006-06-13 Becton, Dickinson And Company System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or multi-needle intradermal (ID) delivery device
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7579013B2 (en) 2003-06-30 2009-08-25 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
WO2005004842A2 (en) 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
WO2005042054A2 (en) 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
US7455654B2 (en) 2003-10-28 2008-11-25 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
US9421351B2 (en) 2003-10-31 2016-08-23 Alza Corporation Self-actuating applicator for microprojection array
US7097631B2 (en) 2003-10-31 2006-08-29 Alza Corporation Self-actuating applicator for microprojection array
WO2005049128A1 (de) * 2003-11-17 2005-06-02 Lts Lohmann Therapie-Systeme Ag Vorrichtung zur transdermalen verabreichung von wirkstoffen
WO2005051476A1 (en) * 2003-11-28 2005-06-09 Acrux Dds Pty Ltd Method and system for rapid transdermal administration
WO2005094260A2 (en) 2004-03-24 2005-10-13 Kevin Marchitto Microsurgical tissue treatment system
US7556821B2 (en) 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US7315758B2 (en) 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
WO2006029279A1 (en) * 2004-09-08 2006-03-16 Alza Corporation Microprojection array with improved skin adhesion and compliance
EP2893938A1 (en) 2004-09-22 2015-07-15 GlaxoSmithKline Biologicals SA Immunogenic composition for use in vaccination against Staphylococcei
EP2298340A1 (en) 2004-09-22 2011-03-23 GlaxoSmithKline Biologicals S.A. Immunogenic composition for use in vaccination against staphylococcei
EP2305294A1 (en) 2004-09-22 2011-04-06 GlaxoSmithKline Biologicals SA Immunogenic composition for use in vaccination against staphylococcei
EP2305295A1 (en) 2004-09-22 2011-04-06 GlaxoSmithKline Biologicals SA Immunogenic composition for use in vaccination against staphylococcei
EP2305296A1 (en) 2004-09-22 2011-04-06 GlaxoSmithKline Biologicals SA Immunogenic composition for use in vaccination against staphylococcei
WO2006089285A1 (en) * 2005-02-16 2006-08-24 Alza Corporation Microprojection arrays with improved biocompatibility
US9452257B2 (en) 2005-11-21 2016-09-27 Becton, Dickinson And Company Intradermal delivery device
US7842008B2 (en) 2005-11-21 2010-11-30 Becton, Dickinson And Company Intradermal delivery device
EP2384765A2 (en) 2005-12-22 2011-11-09 GlaxoSmithKline Biologicals S.A. Streptococcus pneumoniae vaccine
WO2007071707A2 (en) 2005-12-22 2007-06-28 Glaxosmithkline Biologicals Sa Pneumococcal polysaccharide conjugate vaccine
EP2382986A2 (en) 2005-12-22 2011-11-02 GlaxoSmithKline Biologicals s.a. Vaccine against streptococcus pneumoniae
EP2402025A2 (en) 2005-12-22 2012-01-04 GlaxoSmithKline Biologicals S.A. Vaccine
WO2007071711A2 (en) 2005-12-22 2007-06-28 Glaxosmithkline Biologicals Sa Vaccine
WO2007071710A2 (en) 2005-12-22 2007-06-28 Glaxosmithkline Biologicals Sa Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
EP3020411A1 (en) 2005-12-22 2016-05-18 GlaxoSmithKline Biologicals s.a. Vaccine
US8632801B2 (en) 2005-12-28 2014-01-21 Alza Corporation Stable therapeutic formulations
US8419708B2 (en) 2006-02-10 2013-04-16 Hisamitsu Pharmaceuticals Co., Inc. Transdermal drug administration apparatus having microneedles
EP3141261A1 (en) 2006-03-30 2017-03-15 GlaxoSmithKline Biologicals S.A. Immunogenic composition
EP2476433A1 (en) 2006-03-30 2012-07-18 GlaxoSmithKline Biologicals S.A. Immunogenic composition
EP2476434A1 (en) 2006-03-30 2012-07-18 GlaxoSmithKline Biologicals S.A. Immunogenic composition
WO2007116028A2 (en) 2006-04-07 2007-10-18 Glaxosmithkline Biologicals S.A. Conjugate vaccines
EP2392346A1 (en) 2006-04-07 2011-12-07 GlaxoSmithKline Biologicals SA Streptococcus pneumoniae vaccine
US12070411B2 (en) 2006-04-28 2024-08-27 Zeltiq Aesthetics, Inc. Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
US11986421B2 (en) 2006-09-26 2024-05-21 Zeltiq Aesthetics, Inc. Cooling devices with flexible sensors
US11395760B2 (en) 2006-09-26 2022-07-26 Zeltiq Aesthetics, Inc. Tissue treatment methods
US9375345B2 (en) 2006-09-26 2016-06-28 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US11179269B2 (en) 2006-09-26 2021-11-23 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US11219549B2 (en) 2006-09-26 2022-01-11 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US10292859B2 (en) 2006-09-26 2019-05-21 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
WO2008043774A1 (en) 2006-10-12 2008-04-17 Glaxosmithkline Biologicals S.A. Vaccine comprising an oil in water emulsion adjuvant
EP2433648A2 (en) 2006-10-12 2012-03-28 GlaxoSmithKline Biologicals S.A. Vaccine comprising an oil in water emulsion adjuvant
US9498524B2 (en) 2007-04-16 2016-11-22 Corium International, Inc. Method of vaccine delivery via microneedle arrays
US10238848B2 (en) 2007-04-16 2019-03-26 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9452280B2 (en) 2007-04-16 2016-09-27 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
WO2008137747A1 (en) 2007-05-02 2008-11-13 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
US8747872B2 (en) 2007-05-02 2014-06-10 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
US9801842B2 (en) 2007-05-02 2017-10-31 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
US11291606B2 (en) 2007-05-18 2022-04-05 Zeltiq Aesthetics, Inc. Treatment apparatus for removing heat from subcutaneous lipid-rich cells and massaging tissue
US10383787B2 (en) 2007-05-18 2019-08-20 Zeltiq Aesthetics, Inc. Treatment apparatus for removing heat from subcutaneous lipid-rich cells and massaging tissue
EP2687228A2 (en) 2007-06-26 2014-01-22 GlaxoSmithKline Biologicals S.A. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
WO2009000826A1 (en) 2007-06-26 2008-12-31 Glaxosmithkline Biologicals S.A. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
US9655770B2 (en) 2007-07-13 2017-05-23 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US9408745B2 (en) 2007-08-21 2016-08-09 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
US11583438B1 (en) 2007-08-21 2023-02-21 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
US10675178B2 (en) 2007-08-21 2020-06-09 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
EP2612680A1 (en) 2008-04-16 2013-07-10 GlaxoSmithKline Biologicals SA Vaccine
US8962026B2 (en) 2008-09-26 2015-02-24 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
US9259407B2 (en) 2008-09-26 2016-02-16 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
WO2010057197A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
US11116825B2 (en) 2008-11-17 2021-09-14 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
US9974844B2 (en) 2008-11-17 2018-05-22 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
US9737434B2 (en) 2008-12-17 2017-08-22 Zeltiq Aestehtics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
US11224536B2 (en) 2009-04-30 2022-01-18 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
US11452634B2 (en) 2009-04-30 2022-09-27 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
US9861520B2 (en) 2009-04-30 2018-01-09 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
EP3020412A1 (en) 2009-06-16 2016-05-18 The Regents of the University of Michigan An immunogenic composition comprising nanoemulsion inactivated rsv
WO2011015591A1 (en) 2009-08-05 2011-02-10 Glaxosmithkline Biologicals S.A. Immunogenic composition comprising antigenic s. aureus proteins
US9844461B2 (en) 2010-01-25 2017-12-19 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants
US9314368B2 (en) 2010-01-25 2016-04-19 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods
WO2011110531A2 (en) 2010-03-09 2011-09-15 Glaxosmithkline Biologicals S.A. Conjugation process
WO2011110570A1 (en) 2010-03-09 2011-09-15 Glaxosmithkline Biologicals S.A. Treatment of streptococcal infections
EP2815762A2 (en) 2010-03-09 2014-12-24 GlaxoSmithKline Biologicals S.A. Conjugation process of bacterial polysaccharides to carrier proteins
US12377044B2 (en) 2010-05-04 2025-08-05 Panther Life Sciences Corporation Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US11419816B2 (en) 2010-05-04 2022-08-23 Corium, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US9687641B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US9555086B2 (en) 2010-06-16 2017-01-31 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
US10092346B2 (en) 2010-07-20 2018-10-09 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
US10722395B2 (en) 2011-01-25 2020-07-28 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
WO2012119972A1 (en) 2011-03-07 2012-09-13 Glaxosmithkline Biologicals S.A. Conjugation process
WO2012156391A1 (en) 2011-05-17 2012-11-22 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
WO2014066663A1 (en) 2012-10-24 2014-05-01 Platelet Targeted Therapeutics, Llc Platelet targeted treatment
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
US11110259B2 (en) 2013-03-12 2021-09-07 Corium, Inc. Microprojection applicators and methods of use
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
US11565097B2 (en) 2013-03-15 2023-01-31 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent and methods of use
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US9962534B2 (en) 2013-03-15 2018-05-08 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
WO2015017561A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-profile microneedle patch applicator
WO2015063611A2 (en) 2013-11-01 2015-05-07 University Of Oslo Albumin variants and uses thereof
WO2015071769A2 (en) 2013-11-13 2015-05-21 University Of Oslo Outer membrane vesicles and uses thereof
WO2015071763A2 (en) 2013-11-15 2015-05-21 Oslo Universitetssykehus Hf Ctl peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof
US10806500B2 (en) 2014-01-31 2020-10-20 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments
US11819257B2 (en) 2014-01-31 2023-11-21 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
US10912599B2 (en) 2014-01-31 2021-02-09 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
US10575890B2 (en) 2014-01-31 2020-03-03 Zeltiq Aesthetics, Inc. Treatment systems and methods for affecting glands and other targeted structures
US10201380B2 (en) 2014-01-31 2019-02-12 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments
US9861421B2 (en) 2014-01-31 2018-01-09 Zeltiq Aesthetics, Inc. Compositions, treatment systems and methods for improved cooling of lipid-rich tissue
CN106061546A (zh) * 2014-02-10 2016-10-26 Lts勒曼治疗系统股份公司 微针系统及其制造方法
US10675176B1 (en) 2014-03-19 2020-06-09 Zeltiq Aesthetics, Inc. Treatment systems, devices, and methods for cooling targeted tissue
USD777338S1 (en) 2014-03-20 2017-01-24 Zeltiq Aesthetics, Inc. Cryotherapy applicator for cooling tissue
US10952891B1 (en) 2014-05-13 2021-03-23 Zeltiq Aesthetics, Inc. Treatment systems with adjustable gap applicators and methods for cooling tissue
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
WO2016057921A1 (en) 2014-10-10 2016-04-14 Baker Jr James R Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
US11806318B2 (en) 2014-10-10 2023-11-07 The Regents Of The University Of Michigan Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
US12403192B2 (en) 2014-10-10 2025-09-02 The Regents Of The University Of Michigan Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
US11083788B2 (en) 2014-10-10 2021-08-10 The Regents Of The University Of Michigan Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
EP4112076A1 (en) 2014-10-10 2023-01-04 The Regents of The University of Michigan Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
US10806782B2 (en) 2014-11-07 2020-10-20 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
US10233429B2 (en) 2014-11-07 2019-03-19 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
EP4226937A2 (en) 2015-03-05 2023-08-16 Northwestern University Non-neuroinvasive viruses and uses thereof
EP4226936A2 (en) 2015-03-05 2023-08-16 Northwestern University Non-neuroinvasive viruses and uses thereof
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11154418B2 (en) 2015-10-19 2021-10-26 Zeltiq Aesthetics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
WO2017067962A1 (en) 2015-10-21 2017-04-27 Glaxosmithkline Biologicals S.A. Vaccine
US10524956B2 (en) 2016-01-07 2020-01-07 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
US10363303B2 (en) 2016-01-11 2019-07-30 Verndari, Inc. Microneedle compositions and methods of using same
US10022436B2 (en) 2016-01-11 2018-07-17 Verndari, Inc. Microneedle compositions and methods of using same
US10765552B2 (en) 2016-02-18 2020-09-08 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
US10682297B2 (en) 2016-05-10 2020-06-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US12076397B2 (en) 2016-05-10 2024-09-03 The Regents Of The University Of Michigan Emulsion adjuvant for intramuscular, intradermal and subcutaneous administration
US10555831B2 (en) 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
US11173207B2 (en) 2016-05-19 2021-11-16 The Regents Of The University Of Michigan Adjuvant compositions
WO2017216286A1 (en) 2016-06-17 2017-12-21 Glaxosmithkline Biologicals S.A. Immunogenic composition
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
EP3381370A1 (en) * 2017-03-31 2018-10-03 RichHealth Technology Corporation Transdermal microneedle array patch
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology
WO2018237221A1 (en) 2017-06-23 2018-12-27 Nosocomial Vaccine Corporation IMMUNOGENIC COMPOSITIONS
EP4327876A2 (en) 2017-06-23 2024-02-28 Affinivax, Inc. Immunogenic compositions
EP4717778A2 (en) 2017-07-19 2026-04-01 GlaxoSmithKline Biologicals SA Immunogenic composition
US12268736B2 (en) 2017-09-07 2025-04-08 University Of Oslo Vaccine molecules
US12447205B2 (en) 2017-09-07 2025-10-21 University Of Oslo Vaccine molecules
WO2019048936A1 (en) 2017-09-07 2019-03-14 University Of Oslo VACCINE MOLECULES
WO2019048928A1 (en) 2017-09-07 2019-03-14 University Of Oslo VACCINE MOLECULES
US12005112B2 (en) 2017-09-07 2024-06-11 University Of Oslo Vaccine molecules
WO2019090228A2 (en) 2017-11-03 2019-05-09 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
WO2019090238A1 (en) 2017-11-03 2019-05-09 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
WO2019121926A1 (en) 2017-12-21 2019-06-27 Glaxosmithkline Biologicals Sa Immunogenic composition
WO2019121924A1 (en) 2017-12-21 2019-06-27 Glaxosmithkline Biologicals Sa Immunogenic composition
US12102557B2 (en) 2018-07-31 2024-10-01 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics
US11446175B2 (en) 2018-07-31 2022-09-20 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine
WO2024229176A1 (en) 2023-05-04 2024-11-07 Affinivax, Inc. Rhizavidin variants
WO2025193903A1 (en) 2024-03-15 2025-09-18 Affinivax, Inc. Pneumococcal polysaccharide compositions and uses thereof

Also Published As

Publication number Publication date
AU3493397A (en) 1998-01-07
DE69730973D1 (de) 2004-11-04
JP2001505444A (ja) 2001-04-24
WO1997048442A1 (en) 1997-12-24
JP4012252B2 (ja) 2007-11-21
ATE277671T1 (de) 2004-10-15
CA2253549C (en) 2005-10-25
EP0917483B1 (en) 2004-09-29
TW349872B (en) 1999-01-11
DE69719761T2 (de) 2003-12-18
US7184826B2 (en) 2007-02-27
ATE234129T1 (de) 2003-03-15
DK0917484T3 (da) 2005-02-07
PT917484E (pt) 2004-12-31
JP3847790B2 (ja) 2006-11-22
ES2230611T3 (es) 2005-05-01
US6219574B1 (en) 2001-04-17
CA2253471C (en) 2007-10-30
EP0917483A1 (en) 1999-05-26
JP2000512529A (ja) 2000-09-26
CA2257217A1 (en) 1997-12-24
ZA975326B (en) 1998-01-14
DE69730973T2 (de) 2005-11-17
CA2253549A1 (en) 1997-12-24
EP0917484A1 (en) 1999-05-26
ES2195151T3 (es) 2003-12-01
EP0914178A1 (en) 1999-05-12
AU3399197A (en) 1998-01-07
CA2253471A1 (en) 1997-12-24
JP2007260436A (ja) 2007-10-11
EP0914178B1 (en) 2003-03-12
DE69730971D1 (de) 2004-11-04
US6537264B1 (en) 2003-03-25
DK0914178T3 (da) 2003-04-22
JP2001507947A (ja) 2001-06-19
EP0917484B1 (en) 2004-09-29
DE69719761D1 (de) 2003-04-17
US20020016562A1 (en) 2002-02-07
US20070118070A1 (en) 2007-05-24
PT917483E (pt) 2005-01-31
AU3572597A (en) 1998-01-07
ES2230614T3 (es) 2005-05-01
AR012859A2 (es) 2000-11-22
CA2257217C (en) 2006-03-07
US6230051B1 (en) 2001-05-08
WO1997048441A1 (en) 1997-12-24
AR008242A1 (es) 1999-12-29
ATE277670T1 (de) 2004-10-15
DE69730971T2 (de) 2005-11-17
DK0917483T3 (da) 2005-02-07

Similar Documents

Publication Publication Date Title
EP0914178B1 (en) Device for enhancing transdermal agent delivery or sampling
EP0957972B1 (en) Device and method for enhancing transdermal agent flux
US6918901B1 (en) Device and method for enhancing transdermal agent flux
CN1170603C (zh) 增强透皮物剂流量的装置
AU739616B2 (en) Device for enhancing transdermal agent flux
EP1037687B1 (en) Device for enhancing transdermal agent flux
KR100500202B1 (ko) 경피제제투여또는샘플링을향상시키기위한장치
KR100500203B1 (ko) 경피제제의투여또는샘플링을향상시키는장치
EP1911488A2 (en) Device for enhancing transdermal agent flux
MXPA00005725A (es) Dispositivo para aumentar el flujo transdermico de agentes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2253549

Country of ref document: CA

Ref country code: CA

Ref document number: 2253549

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1019980710299

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 1997930077

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1997930077

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1019980710299

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 1997930077

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1019980710299

Country of ref document: KR