UY25889A1 - Procedimiento para la preparación de derivados bicíclicos sustituídos útiles como agentes contra el cáncer - Google Patents
Procedimiento para la preparación de derivados bicíclicos sustituídos útiles como agentes contra el cáncerInfo
- Publication number
- UY25889A1 UY25889A1 UY25889A UY25889A UY25889A1 UY 25889 A1 UY25889 A1 UY 25889A1 UY 25889 A UY25889 A UY 25889A UY 25889 A UY25889 A UY 25889A UY 25889 A1 UY25889 A1 UY 25889A1
- Authority
- UY
- Uruguay
- Prior art keywords
- formula
- compound
- represented
- group
- quinazolin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Procedimiento para preparar compuestos de la fórmula general (1) representada en la figura 1, y sus sales y solvatos farmacéuticamente aceptables, caracterizados porque: A representa un anillo condensado de 5, 6 o 7 miembros que contiene opcionalmente de 1 a 4 heteroátomos que pueden ser iguales o diferentes; X es N o CH; R1 y R2 son independientemente H o alquilo C1-C6; R3 es -(CR1R2)m-R8, donde m es 0 o 1; o R1 y R3 se toman conjuntamente para formar un grupo con su fórmula representada en la figura 2; donde el procedimiento comprende: hacer reaccionar un compuesto de fórmula (11) o (2) con un compuesto de fórmula 3 todos representados en la figura 3 donde Z es un grupo saliente, o hacer reaccionar un compuesto de fórmula (7) con un compuesto de fórmula (3) ambos representados en la figura 4, donde Z1 es un grupo activador, para proporcionar un intermediario, donde luego Z1 se convierte en un grupo R4. Ejemplos seleccionados de fórmula 1: 3-[4-(1-bencenosulfonil-1H-indol-5-ilamino)-quinazolin-6-il]-alil éster del ácido acético; (1-bencenosulfonil-1H-indol-5-il)-{6-[3-(4-metil-piperazin-1-il)-prop-1-inil]-quinazolin-4-il}-amina; N-{3-[4-(3-cloro-4-fenoxi-fenilamino)-quinazolin-6+-il]-prop-2-inil}-acetamida; entre otros. Los compuestos de fórmula 1 son útiles para el tratamiento del crecimiento anormal de las células en mamíferos, con la administración de y a composiciones farmáceuticas para el tratamiento de tales trastornos, que contienen los compuestos de fórmula (1), junto a un agente antitumoral y un vehículo farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11734699P | 1999-01-27 | 1999-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25889A1 true UY25889A1 (es) | 2000-08-21 |
Family
ID=22372402
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25887A UY25887A1 (es) | 1999-01-27 | 1999-12-29 | Derivados bicíclicos sustituidos útiles como agentes contra el cáncer |
| UY25889A UY25889A1 (es) | 1999-01-27 | 1999-12-30 | Procedimiento para la preparación de derivados bicíclicos sustituídos útiles como agentes contra el cáncer |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25887A UY25887A1 (es) | 1999-01-27 | 1999-12-29 | Derivados bicíclicos sustituidos útiles como agentes contra el cáncer |
Country Status (45)
Families Citing this family (171)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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2001
- 2001-04-12 US US09/834,259 patent/US6541481B2/en not_active Expired - Fee Related
- 2001-05-22 IS IS5949A patent/IS5949A/is unknown
- 2001-06-27 CR CR6404A patent/CR6404A/es not_active Application Discontinuation
- 2001-07-17 ZA ZA200105867A patent/ZA200105867B/en unknown
- 2001-07-18 HR HR20010542A patent/HRP20010542A2/hr not_active Application Discontinuation
- 2001-07-26 NO NO20013671A patent/NO322297B1/no unknown
- 2001-08-24 BG BG105842A patent/BG105842A/bg unknown
-
2002
- 2002-07-24 HK HK02105471.5A patent/HK1043795B/zh not_active IP Right Cessation
-
2003
- 2003-01-21 US US10/349,475 patent/US20030186995A1/en not_active Abandoned
-
2004
- 2004-07-23 JP JP2004216138A patent/JP2005002125A/ja active Pending
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| Date | Code | Title | Description |
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| ABAN | Application deemed to be withdrawn (no publication fee paid) |
Effective date: 20090417 |