UY25030A1 - Formulaciones farmaceuticas para la entrega sostenida de medicamentos - Google Patents
Formulaciones farmaceuticas para la entrega sostenida de medicamentosInfo
- Publication number
- UY25030A1 UY25030A1 UY25030A UY25030A UY25030A1 UY 25030 A1 UY25030 A1 UY 25030A1 UY 25030 A UY25030 A UY 25030A UY 25030 A UY25030 A UY 25030A UY 25030 A1 UY25030 A1 UY 25030A1
- Authority
- UY
- Uruguay
- Prior art keywords
- anionic
- peptide
- vehicle
- lhrh
- compounds
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Nanotechnology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se revelan formulaciones de entrega sostenida que comprenden un compuesto no soluble en agua de un péptido, en una proporción de la menos 57%, y un vehículo de macromolécula. Las formulaciones del invento permiten la carga de altas concentraciones del péptido en un pequeno volumen y para la entrega de un péptido farmacéuticamente activo, por períodos prolongados, por ejemplo, un mes, luego de la administración del compuesto. La formación del compuesto no soluble en agua es intervenida, por lo menos en parte, por interacciones iónicas entre el péptido farmacéuticamente activo y el vehículo macromolecular, dónde es péptido es catiónico y el vehículo es aniónico. El vehículo macromolecular es seleccionado de un grupo que consiste en algino, alginato, polímero de acetato aniónico, polímero de acrílico aniónico, gomas xantham, derivados caragénicos aniónicos, derivados ácidos poligalacturónicos aniónicos, glicolato de almidón de sodio y fragmentos, derivados y sales de los mismos, farmacéuticamente aceptables. Los compuestos del invento pueden ser molidos o triturados hasta llegar a un fino polvo. En forma de polvo, los compuestos forman suspensiones acuosas estables y dispersiones, adecuadas para la inyección. En una realización preferida, el péptido del compuesto es un LHRH análogo (hormona luteinizante liberadora de hormona), de preferencia un LHRH antagonista, y el vehículo de macromolécula es un polímero aniónico, de preferencia carboximetilcelulosa. El análogo de LHRH es puede ser administrado mediante fertilización in vitro o con propósitos contraceptivos. Los compuestos de esta invención son de uso en patologías tratables con análogos de LHRH como ser hipertrofia prostática benigna, pubertad precoz, endometriosis y fibroma uterino.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/762,747 US5968895A (en) | 1996-12-11 | 1996-12-11 | Pharmaceutical formulations for sustained drug delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25030A1 true UY25030A1 (es) | 2001-08-27 |
Family
ID=25065930
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY24806A UY24806A1 (es) | 1996-12-11 | 1997-12-11 | Procedimiento para la preparación de composiciones farmacéuticas para la entrega sostenida de péptidos |
UY25030A UY25030A1 (es) | 1996-12-11 | 1998-06-04 | Formulaciones farmaceuticas para la entrega sostenida de medicamentos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY24806A UY24806A1 (es) | 1996-12-11 | 1997-12-11 | Procedimiento para la preparación de composiciones farmacéuticas para la entrega sostenida de péptidos |
Country Status (35)
Country | Link |
---|---|
US (4) | US5968895A (es) |
EP (4) | EP1878437B1 (es) |
JP (3) | JP4033498B2 (es) |
KR (2) | KR20110122773A (es) |
CN (2) | CN101596306A (es) |
AR (1) | AR010351A1 (es) |
AT (3) | ATE378059T1 (es) |
AU (1) | AU735174B2 (es) |
BR (1) | BR9714015A (es) |
CA (1) | CA2274847A1 (es) |
CO (1) | CO4910114A1 (es) |
CZ (1) | CZ301119B6 (es) |
DE (2) | DE69738460D1 (es) |
DK (1) | DK1398037T3 (es) |
DZ (1) | DZ2371A1 (es) |
ES (1) | ES2299192T3 (es) |
HK (2) | HK1023282A1 (es) |
HR (1) | HRP970674A2 (es) |
HU (1) | HUP0000299A3 (es) |
IL (3) | IL130309A (es) |
JO (1) | JO1998B1 (es) |
MA (1) | MA26456A1 (es) |
NZ (4) | NZ537042A (es) |
PE (1) | PE20000008A1 (es) |
PL (2) | PL200675B1 (es) |
PT (1) | PT952843E (es) |
RU (1) | RU2202371C2 (es) |
SI (1) | SI0952843T1 (es) |
SK (1) | SK287305B6 (es) |
TN (1) | TNSN97205A1 (es) |
TR (1) | TR199901382T2 (es) |
UA (1) | UA68343C2 (es) |
UY (2) | UY24806A1 (es) |
WO (1) | WO1998025642A2 (es) |
ZA (1) | ZA9710994B (es) |
Families Citing this family (97)
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US6197337B1 (en) * | 1999-05-10 | 2001-03-06 | Kenneth Weisman | Therapeutic uses of abarelix |
US6864355B1 (en) | 2000-05-02 | 2005-03-08 | Yale University | Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain |
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