UA77765C2 - N3 alkylated derivatives of benzimidazole as mek inhibitors - Google Patents
N3 alkylated derivatives of benzimidazole as mek inhibitors Download PDFInfo
- Publication number
- UA77765C2 UA77765C2 UA20040907722A UA20040907722A UA77765C2 UA 77765 C2 UA77765 C2 UA 77765C2 UA 20040907722 A UA20040907722 A UA 20040907722A UA 20040907722 A UA20040907722 A UA 20040907722A UA 77765 C2 UA77765 C2 UA 77765C2
- Authority
- UA
- Ukraine
- Prior art keywords
- heteroaryl
- aryl
- heterocyclyl
- group
- arylalkyl
- Prior art date
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- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 title abstract description 3
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 144
- 238000000034 method Methods 0.000 claims abstract description 47
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- 230000003463 hyperproliferative effect Effects 0.000 claims abstract description 14
- -1 difluoromethoxyl Chemical group 0.000 claims description 133
- 125000000623 heterocyclic group Chemical group 0.000 claims description 102
- 125000001072 heteroaryl group Chemical group 0.000 claims description 94
- 125000003118 aryl group Chemical group 0.000 claims description 90
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 62
- 125000000217 alkyl group Chemical group 0.000 claims description 60
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- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 53
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 52
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 50
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 49
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 45
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 27
- 125000003342 alkenyl group Chemical group 0.000 claims description 26
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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PCT/US2003/007864 WO2003077914A1 (en) | 2002-03-13 | 2003-03-13 | N3 alkylated benzimidazole derivatives as mek inhibitors |
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