UA117518C2 - 6-конденсовані гетероарилдигідропіримідини для лікування та профілактики зараження вірусом гепатиту b - Google Patents

6-конденсовані гетероарилдигідропіримідини для лікування та профілактики зараження вірусом гепатиту b

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Publication number
UA117518C2
UA117518C2 UAA201610076A UAA201610076A UA117518C2 UA 117518 C2 UA117518 C2 UA 117518C2 UA A201610076 A UAA201610076 A UA A201610076A UA A201610076 A UAA201610076 A UA A201610076A UA 117518 C2 UA117518 C2 UA 117518C2
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UA
Ukraine
Prior art keywords
prophylaxis
hepatitis
treatment
novel
virus infection
Prior art date
Application number
UAA201610076A
Other languages
English (en)
Inventor
Лє Го
Тайшань Ху
Буюй Коу
Сяньфен Лінь
Хун Шень
Хоугуан Ші
Шисян ЯНЬ
Вейсін Чжан
Чжисень Чжан
Мінвей Чжоу
Вей ЧЖУ
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of UA117518C2 publication Critical patent/UA117518C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Abstract

В даному винаході запропоновані нові сполуки, що мають загальну формулу: EMBED ISISServer , де R1, R2, R3, R4, R5, R6, X, Y, W та n є такими, як тут описано, композиції, що містять зазначені сполуки, та способи застосування зазначених сполук.
UAA201610076A 2014-03-07 2015-03-04 6-конденсовані гетероарилдигідропіримідини для лікування та профілактики зараження вірусом гепатиту b UA117518C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNPCT/CN2014/073068 2014-03-07
CNPCT/CN2014/083027 2014-07-25
CN2015070895 2015-01-16
PCT/EP2015/054454 WO2015132276A1 (en) 2014-03-07 2015-03-04 Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection

Publications (1)

Publication Number Publication Date
UA117518C2 true UA117518C2 (uk) 2018-08-10

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Family Applications (1)

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UAA201610076A UA117518C2 (uk) 2014-03-07 2015-03-04 6-конденсовані гетероарилдигідропіримідини для лікування та профілактики зараження вірусом гепатиту b

Country Status (32)

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US (4) US9233978B2 (uk)
EP (1) EP3114128B1 (uk)
JP (1) JP6306750B2 (uk)
KR (2) KR101933844B1 (uk)
CN (3) CN107513073A (uk)
AU (1) AU2015226206B2 (uk)
BR (1) BR112016020566B1 (uk)
CA (1) CA2935811C (uk)
CL (1) CL2016002179A1 (uk)
CR (1) CR20160337A (uk)
DK (1) DK3114128T3 (uk)
EA (1) EA030115B9 (uk)
ES (1) ES2714110T3 (uk)
HK (1) HK1245784A1 (uk)
HR (1) HRP20190352T1 (uk)
HU (1) HUE041734T2 (uk)
IL (1) IL246449B (uk)
LT (1) LT3114128T (uk)
MA (1) MA39721A (uk)
MX (1) MX350439B (uk)
MY (1) MY188114A (uk)
NZ (1) NZ721520A (uk)
PE (1) PE20161338A1 (uk)
PH (1) PH12016501631A1 (uk)
PL (1) PL3114128T3 (uk)
PT (1) PT3114128T (uk)
RS (1) RS58384B1 (uk)
SG (1) SG11201607332UA (uk)
SI (1) SI3114128T1 (uk)
TW (2) TWI606050B (uk)
UA (1) UA117518C2 (uk)
WO (1) WO2015132276A1 (uk)

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US20150252057A1 (en) 2015-09-10
BR112016020566A2 (uk) 2017-08-15
CN107513073A (zh) 2017-12-26
SI3114128T1 (sl) 2019-04-30
PL3114128T3 (pl) 2019-06-28
US10081627B2 (en) 2018-09-25
EA030115B9 (ru) 2018-09-28
JP6306750B2 (ja) 2018-04-04
JP2017507186A (ja) 2017-03-16
DK3114128T3 (en) 2019-03-25
TWI606050B (zh) 2017-11-21
PT3114128T (pt) 2019-02-27
MY188114A (en) 2021-11-21
PE20161338A1 (es) 2016-12-12
CL2016002179A1 (es) 2017-02-17
US20200062753A1 (en) 2020-02-27
RS58384B1 (sr) 2019-04-30
US10428069B2 (en) 2019-10-01
US20160083383A1 (en) 2016-03-24
CN106061978A (zh) 2016-10-26
KR20160105978A (ko) 2016-09-08
LT3114128T (lt) 2019-03-25
MX350439B (es) 2017-09-06
CA2935811A1 (en) 2015-09-11

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