TWI455735B - 用於藥劑施配器之歧管 - Google Patents

用於藥劑施配器之歧管 Download PDF

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TWI455735B
TWI455735B TW095146307A TW95146307A TWI455735B TW I455735 B TWI455735 B TW I455735B TW 095146307 A TW095146307 A TW 095146307A TW 95146307 A TW95146307 A TW 95146307A TW I455735 B TWI455735 B TW I455735B
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chamber
outlet
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TW200730207A (en
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Michael Birsha Davies
Mark Andrew Hailey
Mark Gregory Palmer
Richard Ian Walker
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Glaxo Group Ltd
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Priority claimed from GB0525237A external-priority patent/GB0525237D0/en
Priority claimed from GB0623405A external-priority patent/GB0623405D0/en
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    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
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    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
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    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
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    • A61M16/10—Preparation of respiratory gases or vapours
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    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
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Claims (56)

  1. 一種在用於自複數個泡罩包裝之每一個之敞口泡罩藥囊遞送藥劑粉末之藥劑施配器裝置中使用的歧管，該歧管包括一本體，該本體界定一具僅一單一通氣管入口及複數個通氣管出口之通氣管，該通氣管用於自該通氣管入口向該通氣管出口引導空氣流；該本體進一步界定一具有複數個室入口及一室出口之室，其中該等通氣管出口及該等室入口經配置以形成複數個通氣管出口與室入口對，每一該等對在使用時皆與不同的該等複數個泡罩包裝之一的敞口泡罩藥囊相關聯；其中該等對之該通氣管出口及室入口位於相互並列位置，以便當該等相關聯泡罩包裝之該敞口泡罩藥囊位於與其相鄰處時，可經由該等相關聯敞口泡罩藥囊將該空氣流自通氣管出口引導至室入口，以夾帶該藥劑粉末並能夠在該空氣流中將其自該室入口運送至該室出口，且其中在該通氣管與該室之間提供一或多個放氣孔以便能將放出空氣流引導至該室中從而破壞式地衝擊運送該所夾帶藥劑粉末之空氣流。
  2. 如請求項1之歧管，其中該室僅具有一單一室出口。
  3. 如請求項1或2之歧管，其中該歧管係經設置以便在使用時有3至50%的穿過該通氣管入口進入該歧管之總空氣流 經由該或各通氣管出口被引向一敞口泡罩藥囊，且有97至50%的該總空氣流穿過該一或多個放氣孔被引導至該室中。
  4. 如請求項3之歧管，其中該歧管係經設置以便在使用時有5至25%的穿過該通氣管入口進入該歧管之總空氣流經由該或各通氣管出口被引向一敞口泡罩藥囊，且有95至75%的該總空氣流穿過該一或多個放氣孔被引導至該室中。
  5. 如請求項1或2之歧管，其中該歧管對於以60公升/分鐘之速率穿過該通氣管入口進入該歧管之總空氣流可提供一1至5kPa之空氣流阻力。
  6. 如請求項1或2之歧管，其中該或各通氣管出口及室入口可界定一基本上呈圓形的輪廓，其視情況具有一1至7毫米之直徑。
  7. 如請求項1或2之歧管，其中該或各通氣管出口或室入口可界定一基本上呈圓形的輪廓，其視情況具有一1至7毫米之直徑。
  8. 如請求項1或2之歧管，其中該或各通氣管出口及室入口上提供有一跨越其之過樑。
  9. 如請求項1或2之歧管，其中該或各通氣管出口或室入口上提供有一跨越其之過樑。
  10. 如請求項8之歧管，其中該過樑為十字形形狀。
  11. 如請求項9之歧管，其中該過樑為十字形形狀。
  12. 如請求項1或2之歧管，其中該通氣管及該室位於彼此並列的位置。
  13. 如請求項1或2之歧管，其中該通氣管及該室係一個位於另一個之頂部。
  14. 如請求項1或2之歧管，其中該通氣管及該室共用一公用壁且在該公用壁上提供有該一或多個放氣孔中之至少一個。
  15. 如請求項13之歧管，其中在該公用壁上提供有全部該一或多個放氣孔。
  16. 如請求項1或2之歧管，其中該一或多個放氣孔具有一自1至35毫米2 之總橫截面積。
  17. 如請求項1或2之歧管，其中該一或多個放氣孔具有一自10至30毫米2 之總橫截面積。
  18. 如請求項1或2之歧管，其中該一或多個放氣孔界定一選自由卵圓形、圓形、D形及細長狹縫形輪廓組成之群的輪廓。
  19. 如請求項18之歧管，其中該一或多個放氣孔界定一圓形或卵圓形輪廓，且各自具有一自1至7毫米之直徑。
  20. 如請求項18之歧管，其中該一或多個放氣孔界定一圓形或卵圓形輪廓，且各自具有一自2至5毫米之直徑。
  21. 如請求項18之歧管，其中該一或多個放氣孔界定一D形輪廓，且各自具有一自1至10毫米之最大直徑。
  22. 如請求項18之歧管，其中該一或多個放氣孔界定一D形輪廓，且各自具有一自3至7毫米之最大直徑。
  23. 如請求項18之歧管，其中該一或多個放氣孔界定一細長狹縫形輪廓，且各自具有一自1至20毫米之長度及一自0.5 至3毫米之寬度。
  24. 如請求項18之歧管，其中該一或多個放氣孔界定一細長狹縫形輪廓，且各自具有一自3至10毫米之長度及一自0.7至2毫米之寬度。
  25. 如請求項1或2之歧管，其包括兩個相互平行排列的細長狹縫形放氣孔。
  26. 如請求項25之歧管，其中該細長狹縫具有一傾斜形狀，其自靠近該室出口的一第一端向靠近該通氣管出口的一第二端漸縮。
  27. 如請求項25之歧管，其中該細長狹縫具有一傾斜形狀，其自靠近該室出口的一第一端向靠近該通氣管出口的一第二端漸縮，且其中該等放氣孔經構建及配置以使在使用中使得空氣流的第二部分額外圍繞該室之邊界表面流動，以形成一鄰近該邊界表面的鞘狀空氣毯。
  28. 如請求項1或2之歧管，其中該一或多個放氣孔係毗鄰該通氣管出口及室入口提供。
  29. 如請求項1或2之歧管，其中該一或多個放氣孔係毗鄰該通氣管出口或室入口提供。
  30. 如請求項1或2之歧管，其中該一或多個放氣孔係與該通氣管出口及室入口間隔開。
  31. 如請求項1或2之歧管，其中該一或多個放氣孔係與該通氣管出口或室入口間隔開。
  32. 如請求項30之歧管，其中該一或多個放氣孔與該室入口之間距等於該室之自該室入口至該室出口量測之長度的 介於10%至100%之間。
  33. 如請求項30之歧管，其中該一或多個放氣孔與該室入口之間距等於該室之自該室入口至該室出口量測之長度的介於20%至100%之間。
  34. 如請求項30之歧管，其中該一或多個放氣孔與該室入口之間距等於該室之自該室入口至該室出口量測之長度的介於30%至100%之間。
  35. 如請求項31之歧管，其中該一或多個放氣孔與該室入口之間距等於該室之自該室入口至該室出口量測之長度的介於10%至100%之間。
  36. 如請求項31之歧管，其中該一或多個放氣孔與該室入口之間距等於該室之自該室入口至該室出口量測之長度的介於20%至100%之間。
  37. 如請求項31之歧管，其中該一或多個放氣孔與該室入口之間距等於該室之自該室入口至該室出口量測之長度的介於30%至100%之間。
  38. 如請求項1或2之歧管，其中該一或多個放氣孔之至少一個係指向該室之一內側壁。
  39. 如請求項1或2之歧管，其中該歧管係由高密度聚乙烯製成。
  40. 如請求項1或2之歧管，其中該歧管係全部或部分地由一含氟聚合物材料構成及覆蓋。
  41. 如請求項1或2之歧管，其中該歧管係全部或部分地由一含氟聚合物材料構成或覆蓋。
  42. 如請求項40之歧管，其中該含氟聚合物材料包括複數個一或多個選自由下列組成之群的單體單元：四氟乙烯(PTFE)、氟化乙丙烯(FEP)、全氟化烷氧烴(PFA)、乙烯四氟乙烯(ETFE)、聚亞二氟乙烯(PVDF)、氯化乙烯四氟乙烯及任何其混合物。
  43. 如請求項41之歧管，其中該含氟聚合物材料包括複數個一或多個選自由下列組成之群的單體單元：四氟乙烯(PTFE)、氟化乙丙烯(FEP)、全氟化烷氧烴(PFA)、乙烯四氟乙烯(ETFE)、聚亞二氟乙烯(PVDF)、氯化乙烯四氟乙烯及任何其混合物。
  44. 如請求項1或2之歧管，其中該通氣管及該室經定向而彼此大體垂直。
  45. 如請求項1或2之歧管，其中該空氣流(夾帶空氣流)及該放出空氣流係當在該室出口處施加吸力時穿過該通氣管入口被吸進該歧管中之吸入空氣流的相應空氣流部分。
  46. 如請求項1或2之歧管，其係經修改以便當在該室出口施加吸力時該放出空氣流大於該夾帶空氣流。
  47. 如請求項1或2之歧管，其中進入該室內之僅有的空氣進入點為該一或多個室入口、該一或多個放氣孔及該室出口。
  48. 如請求項1或2之歧管，其中進入該通氣管之僅有的空氣進入點為該通氣管入口、該一或多個放氣孔及該一或多個通氣管出口。
  49. 如請求項1或2之歧管，其為單件式物件。
  50. 如請求項1或2之歧管，其為一模鑄物件。
  51. 如請求項1或2之歧管，其中該歧管包含一對曲壁，用以承納複數個泡罩包裝之每一個之該敞口泡罩藥囊。
  52. 如請求項51之歧管，其中每一曲壁界定該複數個通氣管出口與室入口對之其中之一。
  53. 一種歧管與管口之子總成，其包括如請求項1或2之歧管及一配合至其而與該室出口相連通以便在該管口處吸氣可穿過該通氣管入口將空氣流引導至該歧管的管口。
  54. 如請求項53之總成，其中該管口係以可釋放方式與該歧管配合。
  55. 如請求項53之總成，其中該歧管及管口以扣合方式嚙合。
  56. 一種適合自複數個泡罩包裝之每一個之一敞口泡罩藥囊同時遞送藥劑粉末之藥劑施配器裝置，包含一施配機構，其用於自位於一敞開操作臺之該複數個泡罩包裝施配藥劑，其中該施配器裝置包括一如請求項1至2中任一項之定位於該敞開操作臺之歧管。
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GB0525237A GB0525237D0 (en) 2005-12-12 2005-12-12 Manifold for use in medicament dispenser
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