HRP20140803T1 - Inhalator suhog praha - Google Patents
Inhalator suhog praha Download PDFInfo
- Publication number
- HRP20140803T1 HRP20140803T1 HRP20140803AT HRP20140803T HRP20140803T1 HR P20140803 T1 HRP20140803 T1 HR P20140803T1 HR P20140803A T HRP20140803A T HR P20140803AT HR P20140803 T HRP20140803 T HR P20140803T HR P20140803 T1 HRP20140803 T1 HR P20140803T1
- Authority
- HR
- Croatia
- Prior art keywords
- drug
- inhaler
- blister
- air
- pipeline
- Prior art date
Links
- 229940112141 dry powder inhaler Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 claims 24
- 229940079593 drug Drugs 0.000 claims 18
- -1 polyethylene Polymers 0.000 claims 3
- 229920001903 high density polyethylene Polymers 0.000 claims 2
- 239000004700 high-density polyethylene Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 229920000877 Melamine resin Polymers 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000004642 Polyimide Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 229920001807 Urea-formaldehyde Polymers 0.000 claims 1
- 230000004888 barrier function Effects 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 239000003822 epoxy resin Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims 1
- JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002991 molded plastic Substances 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920000647 polyepoxide Polymers 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920000139 polyethylene terephthalate Polymers 0.000 claims 1
- 239000005020 polyethylene terephthalate Substances 0.000 claims 1
- 229920001721 polyimide Polymers 0.000 claims 1
- ODGAOXROABLFNM-UHFFFAOYSA-N polynoxylin Chemical compound O=C.NC(N)=O ODGAOXROABLFNM-UHFFFAOYSA-N 0.000 claims 1
- 229920000098 polyolefin Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 229920001187 thermosetting polymer Polymers 0.000 claims 1
- 239000004634 thermosetting polymer Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0043—Non-destructive separation of the package, e.g. peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
- A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0075—Mechanical counters having a display or indicator on a disc
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (15)
1. Inhalator za dostavu lijeka u obliku suhog praha pacijentu iz otvorenog džepa blistera iz pakiranja blistera (1), pakiranje blistera (1) ima množinu džepova blistera (3) odvojenih u dužnom smjeru pakiranja (1) i svaki sadrži izmjerenu dozu lijeka, inhalator obuhvaća:
kućište (103, 105) za ulaganje korištenih i neiskorištenih dijelova pakiranja blistera (1) zajedno s mehanizmom za rasprišvanje lijeka za otvaranje džepova blistera (3) pakiranja blistera (1); i
cjevovod kroz koji se može uvući zrak pri uporabi inhalatora, cjevovod obuhvaća ulaz zraka (125) za prihvaćanje vanjskog zraka, barem jedan otvor za lijek (127a, 127b) za komuniciranje s otvorenim džepom pakiranja blistera (1) za omogućavanje povlačenja lijeka pomoću zraka uvučenog kroz cjevovod, i izlaz zraka (129) za dostavu povučenog lijeka pacijentu,
pri čemu je inhalator karakteriziran na način da su cjevovod i dio kućišta (103, 105) omogućeni kao jedinstveno modulirana plastična sastavnica, i pri čemu jedinstvena sastavnica određuje, u uporabi, barem dio vanjske površine inhalatora, na vanjskoj površini na kojoj je postavljen ulaz zraka (125).
2. Inhalator u skladu s patentnim zahtjevom 1, pri čemu je cjevovod postavljen tako da je, u uporabi, zrak uvučen u cjevovod jedino kroz ulaz zraka (125).
3. Inhalator u skladu s patentnim zahtjevom 1 ili 2, pri čemu ulaz zraka (125) cjevovoda određuje jedinu točku za ulaz za vanjski zrak u inhalator.
4. Inhalator u skladu s bilo kojim od prethodnih patentnih zahtjeva, pri čemu ulaz zraka (125) cjevovoda ima izraženo izduženi oblik poprečnog presjeka, i pri čemu se površina poprečnog presjeka cjevovoda smanjuje u smjeru protoka zraka.
5. Inhalator u skladu s bilo kojim od prethodnih patentnih zahtjeva, pri čemu cjevovod obuhvaća najmanje dva otvora za lijek (127a, 127b) postavljena jedan iza drugoga u smjeru strujanja zraka cjevovoda, prvi otvor za lijek (127a) za protok zraka iz cjevovoda u otvoreni džep blistera (3) i drugi otvor za lijek (127b) za protok unešenog lijeka iz otvorenog džepa blistera (3) u cjevovod.
6. Inhalator u skladu s patentnim zahtjevom 5, pri čemu je geometrija cjevovoda prilagođena za usmjeravanje zraka iz ulaza zraka (125) u otvoreni džep blistera (3) kroz prvi otvor za lijek (127a) i za usmjeravanje unešenog lijeka iz otvorenog džepa blistera (3) u cjevovod kroz drugi otvor za lijek (127b).
7. Inhalator u skladu s patentnim zahtjevom 6, pri čemu je geometrija cjevovoda tako prilagođena omogućavajući sredstvo za restrikciju protoka zraka između prvog i drugog otvora za lijek (127a, 127b), prema izboru gdje sredstvo za restrikciju protoka zraka obuhvaća lokaliziranu redukciju na površini poprečnog presjeka cjevovoda.
8. Inhalator u skladu s bilo kojim prethodnim patentnim zahtjevom, pri čemu jedinstvena sastavnica nadalje određuje dio za usta (133) postavljen da prihvaća, u uporabi, uneseni lijek iz izlaza zraka (129) cjevovoda.
9. Inhalator u skladu s patentnim zahtjevom 8, pri čemu su cjevovod i dio za usta (133) postavljeni tako da je smjer protoka zraka u dijelu za usta (133) sadržajno okomit na smjer protoka zraka u cjevovodu i luk cjevovoda je smješten pored barem jednog otvora za lijek (127a, 127b), tako da uneseni lijek može biti dostavljen pacijentu iz otvorenog džepa blistera (3) duž sadržajno ravne putanje.
10. Inhalator u skladu s patentnim zahtjevom 8 ili 9, pri čemu se područje poprečnog presjeka dijela za usta (133) povećava u smjeru protoka zraka.
11. Inhalator u skladu s patentnim zahtjevom 10, pri čemu su konične stijenke otvora za usta (133) opskrbljene množinom rupica za skretanje protoka zraka (135a, 135b) i pri čemu su rupice za skretanje protoka zraka (135a, 135b) u fluidnoj komunikaciji sa cjevovodom i postavljene tako da je, u uporabi, zrak iz cjevovoda uvučen kroz rupice za skretanje protoka zraka (135a, 135b) u smjeru sadržajno paralelnom središnjoj osi dijela za usta (133) za sprečavanje pretjeranog poprečnog širenja unesenog lijeka u dijelu za usta (133).
12. Inhalator u skladu s bilo kojim prethodnim patentnim zahtjevom, pri čemu je barem jedan otvor za lijek (127a, 127b) opskrbljen barem jednom preprekom za usitnjavanje unesenog lijeka.
13. Inhalator u skladu s bilo kojim prethodnim patentnim zahtjevom, pri čemu je jedinstvena sastavnica oblikovana iz lijevanog plastičnog materijala i poželjno je oblikovana iz materijala odabranog iz grupe koja se sastoji od poliolefina, uključujući polietilen, posebno polietilen visoke gustoće (HDPE), i polipropilen; poliestere, uključujući polietilen tereftalat; poliamide, uključujući najlone; termopodesive polimere, uključujući urea-formaldehid, melamin, epoksi smole i poliimide; i njihove smjese ili kopolimere.
14. Inhalator u skladu s bilo kojim prethodnim patentnim zahtjevom, pri čemu kućište (103, 105) obuhvaća par vanjskih pripadnika kućišta koje određuju vanjski oblik inhalatora, i pri čemu je jedan iz para vanjskih pripadnika kućišta jedinstvena sastavnica, pri čemu kućište na izbor nadalje obuhvaća unutrašnjeg pripadnika kućišta (137) postavljenog unutar para vanjskih pripadnika kućišta.
15. Inhalator u skladu s patentnim zahtjevom 14, za dostavu lijeka iz pakiranja blistera (3) u obliku fleksibilne izdužene trake obuhvaća plohu baze (5) koja ima množinu šupljina razmaknutih duž svoje duljine i pokrovnu plohu (7) odvojivo učvršćenu na baznu plohu (5) radi određivanja množine džepova blistera (3), pri čemu inhalator nadalje obuhvaća pakiranje blistera (1), pri čemu svaki džep blistera (3) sadrži izmjerenu dozu suhog praha lijeka, i pri čemu inhalator nadalje obuhvaća mehanizam raspršivanja lijeka za otvaranje džepova blistera (3) pakiranja blistera (1), pri čemu mehanizam raspršivanja lijeka obuhvaća sredstvo za odvajanje pokrovne plohe (7) od bazne plohe (5) pakiranja blistera (1).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17916709P | 2009-05-18 | 2009-05-18 | |
| PCT/EP2010/002993 WO2010136134A1 (en) | 2009-05-18 | 2010-05-17 | Dry-powder inhaler |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140803T1 true HRP20140803T1 (hr) | 2014-11-07 |
Family
ID=42670300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140803AT HRP20140803T1 (hr) | 2009-05-18 | 2014-08-25 | Inhalator suhog praha |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8931479B2 (hr) |
| EP (1) | EP2432530B1 (hr) |
| JP (1) | JP5667170B2 (hr) |
| CN (1) | CN102573969B (hr) |
| DK (1) | DK2432530T3 (hr) |
| EA (1) | EA021402B1 (hr) |
| ES (1) | ES2498166T3 (hr) |
| HK (1) | HK1171704A1 (hr) |
| HR (1) | HRP20140803T1 (hr) |
| IL (1) | IL216294A (hr) |
| PL (1) | PL2432530T3 (hr) |
| PT (1) | PT2432530E (hr) |
| SI (1) | SI2432530T1 (hr) |
| SM (1) | SMT201400131B (hr) |
| WO (1) | WO2010136134A1 (hr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009079078A1 (en) | 2007-12-14 | 2009-06-25 | Labogroup S.A.S. | Delivering aerosolizable food products |
| GB0910537D0 (en) | 2009-06-18 | 2009-07-29 | Ivax Pharmaceuticals Ireland | Inhaler |
| FR2979057B1 (fr) * | 2011-08-19 | 2013-08-30 | Valois Sas | Dispositif d'inhalation de poudre. |
| AU2013202919C1 (en) * | 2012-07-03 | 2016-02-04 | Advent Pharmaceuticals Pty Ltd | Blister Pack |
| GB201223008D0 (en) * | 2012-12-20 | 2013-01-30 | Euro Celtique Sa | Counter |
| USD745138S1 (en) * | 2013-01-30 | 2015-12-08 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Member of an inhaler device |
| USD774178S1 (en) * | 2015-03-10 | 2016-12-13 | Reciprocal Labs Corporation | Usage monitoring attachment for a dry powder inhaler |
| USD769439S1 (en) * | 2015-03-18 | 2016-10-18 | Amneal Pharmaceuticals Company Gmbh | Inhalation device |
| USD767114S1 (en) * | 2015-03-18 | 2016-09-20 | Amneal Pharmaceuticals Company Gmbh | Inhalation device |
| CN105343970B (zh) * | 2015-10-29 | 2018-10-30 | 上海朔茂网络科技有限公司 | 一种用药追踪装置及其追踪方法 |
| JP7043417B2 (ja) * | 2016-04-26 | 2022-03-29 | エルテーエス ローマン テラピー－ジステーメ アーゲー | 有効成分を含んだまたは有効成分を担持したストリップを分配する（ｄｉｓｐｅｎｓｅ）デバイスおよび方法 |
| US10441511B2 (en) * | 2017-07-10 | 2019-10-15 | Joseph Hamilton | Systems, devices, and/or methods for managing medicament dispenser |
| CN109793969B (zh) * | 2017-11-17 | 2022-02-01 | 捷普科技（上海）有限公司 | 药剂分配器 |
| GB201812671D0 (en) * | 2018-08-03 | 2018-09-19 | Coalesce Product Dev Ltd | An inhaler device |
| WO2020058823A1 (en) * | 2018-09-17 | 2020-03-26 | Lupin, Inc. | Dose indicator assembly for a medicament dispenser |
| WO2020058206A1 (en) * | 2018-09-17 | 2020-03-26 | Vectura Delivery Devices Limited | Dry powder inhaler |
| EP4061457A1 (en) | 2020-06-15 | 2022-09-28 | Norton (Waterford) Limited | Blister pack and inhaler comprising the same |
| PL244221B1 (pl) | 2020-09-24 | 2023-12-18 | Polfarmex Spolka Akcyjna | Inhalator do podawania leku |
| PL244222B1 (pl) | 2020-09-24 | 2023-12-18 | Polfarmex Spolka Akcyjna | Inhalator do podawania leku |
| CA3227858A1 (en) | 2021-09-29 | 2023-04-06 | Norton (Waterford) Limited | Dry powder medicament inhaler |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| GB0317374D0 (en) * | 2003-07-24 | 2003-08-27 | Glaxo Group Ltd | Medicament dispenser |
| EP1730676B1 (en) | 2004-02-16 | 2013-08-28 | Glaxo Group Limited | Counter for use with a medicament dispenser |
| GB0403394D0 (en) * | 2004-02-16 | 2004-03-17 | Glaxo Group Ltd | Counter for use with a medicament dispenser |
| GB0418278D0 (en) * | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Medicament dispenser |
| GB0427853D0 (en) * | 2004-12-20 | 2005-01-19 | Glaxo Group Ltd | Manifold for use in medicament dispenser |
| GB0427856D0 (en) * | 2004-12-20 | 2005-01-19 | Glaxo Group Ltd | Maniflod for use in medicament dispenser |
| GB0509952D0 (en) * | 2005-05-16 | 2005-06-22 | Glaxo Group Ltd | Fault indicator |
| GB0515584D0 (en) * | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
| AR058289A1 (es) | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | Colector para ser usado en dispensador de medicamento |
| CN105435343A (zh) * | 2009-05-18 | 2016-03-30 | 诺顿·希尔思凯尔有限公司 | 干燥粉末吸入器 |
| EA021160B1 (ru) * | 2009-05-18 | 2015-04-30 | Нортон Хэлткэа Лимитед | Сухопорошковый ингалятор |
-
2010
- 2010-05-17 PT PT107205486T patent/PT2432530E/pt unknown
- 2010-05-17 EA EA201171419A patent/EA021402B1/ru not_active IP Right Cessation
- 2010-05-17 PL PL10720548T patent/PL2432530T3/pl unknown
- 2010-05-17 DK DK10720548.6T patent/DK2432530T3/da active
- 2010-05-17 EP EP10720548.6A patent/EP2432530B1/en active Active
- 2010-05-17 CN CN201080028701.6A patent/CN102573969B/zh not_active Expired - Fee Related
- 2010-05-17 US US13/321,077 patent/US8931479B2/en active Active
- 2010-05-17 JP JP2012511180A patent/JP5667170B2/ja not_active Expired - Fee Related
- 2010-05-17 WO PCT/EP2010/002993 patent/WO2010136134A1/en active Application Filing
- 2010-05-17 SI SI201030716T patent/SI2432530T1/sl unknown
- 2010-05-17 ES ES10720548.6T patent/ES2498166T3/es active Active
-
2011
- 2011-11-10 IL IL216294A patent/IL216294A/en not_active IP Right Cessation
-
2012
- 2012-11-30 HK HK12112411.2A patent/HK1171704A1/xx not_active IP Right Cessation
-
2014
- 2014-08-25 HR HRP20140803AT patent/HRP20140803T1/hr unknown
- 2014-09-10 SM SM201400131T patent/SMT201400131B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI2432530T1 (sl) | 2015-02-27 |
| PT2432530E (pt) | 2014-09-05 |
| DK2432530T3 (da) | 2014-09-01 |
| SMT201400131B (it) | 2014-11-10 |
| PL2432530T3 (pl) | 2015-04-30 |
| US8931479B2 (en) | 2015-01-13 |
| IL216294A (en) | 2015-04-30 |
| CN102573969A (zh) | 2012-07-11 |
| EP2432530A1 (en) | 2012-03-28 |
| EP2432530B1 (en) | 2014-06-04 |
| JP2012527263A (ja) | 2012-11-08 |
| US20120097161A1 (en) | 2012-04-26 |
| JP5667170B2 (ja) | 2015-02-12 |
| CN102573969B (zh) | 2014-05-21 |
| ES2498166T3 (es) | 2014-09-24 |
| IL216294A0 (en) | 2012-01-31 |
| HK1171704A1 (en) | 2013-04-05 |
| WO2010136134A1 (en) | 2010-12-02 |
| EA201171419A1 (ru) | 2012-06-29 |
| EA021402B1 (ru) | 2015-06-30 |
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