TWI439455B - 新穎ｆｘｒ（ｎｒ１ｈ４）結合及活性調節化合物 - Google Patents
新穎ｆｘｒ（ｎｒ１ｈ４）結合及活性調節化合物 Download PDFInfo
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- TWI439455B TWI439455B TW101123785A TW101123785A TWI439455B TW I439455 B TWI439455 B TW I439455B TW 101123785 A TW101123785 A TW 101123785A TW 101123785 A TW101123785 A TW 101123785A TW I439455 B TWI439455 B TW I439455B
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Landscapes
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| TWI800914B (zh) * | 2019-02-19 | 2023-05-01 | 美商基利科學股份有限公司 | Fxr激動劑之固體形式 |
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| IL253437A0 (en) * | 2011-07-13 | 2017-09-28 | Gilead Sciences Inc | New compounds modulate fxr (nr1h4) activity and bind |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| PT3043865T (pt) | 2013-09-11 | 2021-01-14 | Univ Claude Bernard Lyon | Métodos e composições farmacêuticas para o tratamento da infeção por vírus da hepatite b |
| ES2731602T3 (es) | 2014-09-24 | 2019-11-18 | Gilead Sciences Inc | Métodos para tratar la enfermedad hepática |
| EP3006939A1 (en) | 2014-10-06 | 2016-04-13 | Gilead Sciences, Inc. | Histidine-rich Glycoprotein as a marker for hepatic Farnesoid X receptor activation |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| EP3034499A1 (en) * | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Novel FXR (NR1H4) modulating compounds |
| EP3034501A1 (en) * | 2014-12-17 | 2016-06-22 | Gilead Sciences, Inc. | Hydroxy containing FXR (NR1H4) modulating compounds |
| MX2017008057A (es) * | 2014-12-18 | 2017-09-28 | Novartis Ag | Derivados de azabiciclooctano como agonistas de fxr para el uso en el tratamiento de enfermedades hepaticas y gastrointestinales. |
| CA3100432C (en) | 2014-12-23 | 2023-08-08 | Gilead Sciences, Inc. | Processes for preparing ask1 inhibitors |
| MA41252A (fr) * | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| TWI698430B (zh) | 2015-02-13 | 2020-07-11 | 南北兄弟藥業投資有限公司 | 三環化合物及其在藥物中的應用 |
| WO2016161003A1 (en) | 2015-03-31 | 2016-10-06 | Enanta Phamraceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
| IL293770B2 (en) | 2015-07-06 | 2023-07-01 | Gilead Sciences Inc | Modulators of cot and methods of using them |
| CN106995416A (zh) * | 2016-01-26 | 2017-08-01 | 上海翰森生物医药科技有限公司 | Fxr激动剂及其制备方法和应用 |
| WO2017128896A1 (zh) * | 2016-01-26 | 2017-08-03 | 江苏豪森药业集团有限公司 | Fxr激动剂及其制备方法和应用 |
| TW201741307A (zh) * | 2016-02-22 | 2017-12-01 | 艾洛斯生物製藥公司 | Ｆｘｒ調節劑及其使用方法 |
| JP2019510752A (ja) | 2016-03-04 | 2019-04-18 | ギリアード サイエンシーズ， インコーポレイテッド | オートタキシン阻害剤の組成物及び合剤 |
| CA3019003A1 (en) | 2016-04-08 | 2017-10-12 | Gilead Sciences, Inc. | Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases |
| US10080743B2 (en) | 2016-04-26 | 2018-09-25 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
| WO2017189652A1 (en) * | 2016-04-26 | 2017-11-02 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
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- 2019-11-04 AU AU2019261667A patent/AU2019261667B2/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI800914B (zh) * | 2019-02-19 | 2023-05-01 | 美商基利科學股份有限公司 | Fxr激動劑之固體形式 |
| TWI824958B (zh) * | 2019-02-19 | 2023-12-01 | 美商基利科學股份有限公司 | Fxr激動劑之固體形式 |
| TWI857835B (zh) * | 2019-02-19 | 2024-10-01 | 美商基利科學股份有限公司 | Fxr激動劑之固體形式 |
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