TW421646B - Benzopyran derivatives having K<+>-channel opening activity - Google Patents

Benzopyran derivatives having K<+>-channel opening activity Download PDF

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Publication number
TW421646B
TW421646B TW085106034A TW85106034A TW421646B TW 421646 B TW421646 B TW 421646B TW 085106034 A TW085106034 A TW 085106034A TW 85106034 A TW85106034 A TW 85106034A TW 421646 B TW421646 B TW 421646B
Authority
TW
Taiwan
Prior art keywords
trans
dimethyl
phenyl
ministry
hydroxy
Prior art date
Application number
TW085106034A
Other languages
English (en)
Chinese (zh)
Inventor
Paul W Manley
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10774940&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW421646(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of TW421646B publication Critical patent/TW421646B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW085106034A 1995-05-24 1996-05-22 Benzopyran derivatives having K<+>-channel opening activity TW421646B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9510477.4A GB9510477D0 (en) 1995-05-24 1995-05-24 Organic compounds

Publications (1)

Publication Number Publication Date
TW421646B true TW421646B (en) 2001-02-11

Family

ID=10774940

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085106034A TW421646B (en) 1995-05-24 1996-05-22 Benzopyran derivatives having K<+>-channel opening activity

Country Status (30)

Country Link
US (1) US5905156A (enExample)
EP (1) EP0828733B1 (enExample)
JP (1) JPH11505820A (enExample)
KR (1) KR100437981B1 (enExample)
CN (1) CN1077888C (enExample)
AR (1) AR004489A1 (enExample)
AT (1) ATE205204T1 (enExample)
AU (1) AU703276B2 (enExample)
BR (1) BR9609048A (enExample)
CA (1) CA2217821C (enExample)
CO (1) CO4700520A1 (enExample)
CZ (1) CZ294474B6 (enExample)
DE (1) DE69615019T2 (enExample)
DK (1) DK0828733T3 (enExample)
ES (1) ES2163634T3 (enExample)
FI (1) FI973992L (enExample)
GB (1) GB9510477D0 (enExample)
HU (1) HU222772B1 (enExample)
IL (1) IL118382A (enExample)
MY (1) MY114924A (enExample)
NO (1) NO314846B1 (enExample)
NZ (1) NZ309765A (enExample)
PL (1) PL184144B1 (enExample)
PT (1) PT828733E (enExample)
RU (1) RU2160735C2 (enExample)
SK (1) SK283215B6 (enExample)
TR (1) TR199701417T1 (enExample)
TW (1) TW421646B (enExample)
WO (1) WO1996037490A1 (enExample)
ZA (1) ZA964209B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972894A (en) * 1997-08-07 1999-10-26 Cytran, Inc. Peptides having potassium channel opener activity
GB9822024D0 (en) * 1998-10-09 1998-12-02 Novartis Ag Organic compounds
GB9909792D0 (en) 1998-12-04 1999-06-23 Cambridge Bioclinical Limited Potassium channel activators and their use
US6384244B2 (en) 2000-05-18 2002-05-07 Merck & Co., Inc. Process for preparing cis- aminochromanols
ZA200501510B (en) * 2002-08-29 2006-10-25 Nissan Chemical Ind Ltd Process for producing aminobenzopyran compound
US7098340B2 (en) * 2003-05-14 2006-08-29 Warner Lambert Company Llc Benzyl sulfonamide derivatives
KR100704009B1 (ko) * 2005-08-30 2007-04-04 한국화학연구원 염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(ｎ-메틸치환술폰아미도)메틸-2ｈ-1-벤조피란 유도체
BR112018006189A2 (pt) 2015-09-28 2018-10-09 Genentech Inc compostos da fórmula, composição farmacêutica, métodos de tratamento de uma doença, de diminuição do fluxo de íons e de tratamento de prurido em um mamífero, método para tratamento de dores em um mamífero e uso de um composto
CN106008288A (zh) * 2016-06-15 2016-10-12 西北农林科技大学 一种苯磺酰胺类化合物及其用途
JP2020511511A (ja) * 2017-03-24 2020-04-16 ジェネンテック， インコーポレイテッド ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体
TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
ES2030627A6 (es) * 1990-11-28 1992-11-01 Uriach & Cia Sa J Procedimiento para la obtencion de compuestos benzopiranicos.
GB9102803D0 (en) * 1991-02-11 1991-03-27 Ici Plc Pyridine compounds
KR950009863B1 (ko) * 1991-05-22 1995-08-29 재단법인한국화학연구소 벤조피란 유도체와 그의 제조방법
TW244350B (enExample) * 1991-12-14 1995-04-01 Hoechst Ag
US5236935A (en) * 1992-05-21 1993-08-17 Korea Research Institute Of Chemical Technology Benzopyran derivatives and processes for the preparation thereof

Also Published As

Publication number Publication date
EP0828733B1 (en) 2001-09-05
CA2217821A1 (en) 1996-11-28
JPH11505820A (ja) 1999-05-25
NO975365D0 (no) 1997-11-21
HU222772B1 (hu) 2003-10-28
CO4700520A1 (es) 1998-12-29
AU703276B2 (en) 1999-03-25
NO314846B1 (no) 2003-06-02
EP0828733A1 (en) 1998-03-18
SK157797A3 (en) 1998-05-06
KR19990021925A (ko) 1999-03-25
BR9609048A (pt) 1999-02-23
CN1185153A (zh) 1998-06-17
MY114924A (en) 2003-02-28
FI973992A0 (fi) 1997-10-17
CA2217821C (en) 2008-05-06
AU6000896A (en) 1996-12-11
TR199701417T1 (xx) 1998-02-21
CN1077888C (zh) 2002-01-16
HK1014137A1 (en) 1999-09-24
FI973992A7 (fi) 1997-12-09
CZ294474B6 (cs) 2005-01-12
GB9510477D0 (en) 1995-07-19
WO1996037490A1 (en) 1996-11-28
CZ368897A3 (cs) 1998-02-18
SK283215B6 (sk) 2003-03-04
ES2163634T3 (es) 2002-02-01
NZ309765A (en) 2000-01-28
IL118382A (en) 2000-01-31
HUP9801751A2 (hu) 1999-06-28
NO975365L (no) 1998-01-15
KR100437981B1 (ko) 2004-07-16
ZA964209B (en) 1997-11-24
DK0828733T3 (da) 2001-12-17
DE69615019D1 (de) 2001-10-11
MX9709004A (es) 1998-03-31
DE69615019T2 (de) 2002-06-06
IL118382A0 (en) 1996-09-12
PL184144B1 (pl) 2002-09-30
RU2160735C2 (ru) 2000-12-20
US5905156A (en) 1999-05-18
HUP9801751A3 (en) 1999-08-30
AR004489A1 (es) 1998-12-16
FI973992L (fi) 1997-12-09
PL324042A1 (en) 1998-05-11
ATE205204T1 (de) 2001-09-15
PT828733E (pt) 2002-02-28

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MM4A Annulment or lapse of patent due to non-payment of fees