CO4700520A1 - Benzopiranos - Google Patents
BenzopiranosInfo
- Publication number
- CO4700520A1 CO4700520A1 CO96026387A CO96026387A CO4700520A1 CO 4700520 A1 CO4700520 A1 CO 4700520A1 CO 96026387 A CO96026387 A CO 96026387A CO 96026387 A CO96026387 A CO 96026387A CO 4700520 A1 CO4700520 A1 CO 4700520A1
- Authority
- CO
- Colombia
- Prior art keywords
- oxide
- alkyl
- carbon atoms
- ester
- benzopyran
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un 2,2-di(C1-5 alquil)-o trans-2,2-di(C1-5 -alquil)-3,4-dihidro-3-hidroxi-4-carboxamido-6-(N-arilsulfonamido)-3H-1-benzopirano o un N-óxido del mismo; o un éster fisiológicamente hidrolizable y aceptable de este benzopirano o N-óxido; o una sal de adición de ácido o de amonio cuaternario de este benzopirano, N-óxido o éster. Un compuesto de la fórmula I caracterizado porqueR1 es arilo,R2 es H o alquilo de 1 a 5 átomos de carbono, o es alquileno de 2 a 5 átomos de carbono unido a R1 ,R3 es un grupo de la fórmula -N(R9 )-COR10 en donde R9 es hidrógeno y R10 es fenilo o piridilo, o R9 y R10 conjuntamente son 1,3-butadienileno o representan un grupo de la fórmula -(CH2 )n - oen la cual n es un número entero desde 3 hasta 5 inclusive y m es 1 ó 2, R4 es hidrógeno y R5 es hidroxi en la posición trans con respecto a R3 , o R4 y,R5 representa conjuntamente un enlace adicional como se indica por la línea a rayas. R6 y R7 son independientemente, alquilo de 1 a 5 átomos de carbono, yR8 es hidrógeno o alquilo de 1 a 5 átomos de carbono; o el N-óxido del mismo;o el éster fisiológicamente hidrolizable y aceptable de este compuesto o N-óxido, o la sal de adición de ácido o de amonio cuaternario de este compuesto, N-óxido o éster.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9510477.4A GB9510477D0 (en) | 1995-05-24 | 1995-05-24 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4700520A1 true CO4700520A1 (es) | 1998-12-29 |
Family
ID=10774940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO96026387A CO4700520A1 (es) | 1995-05-24 | 1996-05-23 | Benzopiranos |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5905156A (es) |
| EP (1) | EP0828733B1 (es) |
| JP (1) | JPH11505820A (es) |
| KR (1) | KR100437981B1 (es) |
| CN (1) | CN1077888C (es) |
| AR (1) | AR004489A1 (es) |
| AT (1) | ATE205204T1 (es) |
| AU (1) | AU703276B2 (es) |
| BR (1) | BR9609048A (es) |
| CA (1) | CA2217821C (es) |
| CO (1) | CO4700520A1 (es) |
| CZ (1) | CZ294474B6 (es) |
| DE (1) | DE69615019T2 (es) |
| DK (1) | DK0828733T3 (es) |
| ES (1) | ES2163634T3 (es) |
| FI (1) | FI973992A (es) |
| GB (1) | GB9510477D0 (es) |
| HK (1) | HK1014137A1 (es) |
| HU (1) | HU222772B1 (es) |
| IL (1) | IL118382A (es) |
| MY (1) | MY114924A (es) |
| NO (1) | NO314846B1 (es) |
| NZ (1) | NZ309765A (es) |
| PL (1) | PL184144B1 (es) |
| PT (1) | PT828733E (es) |
| RU (1) | RU2160735C2 (es) |
| SK (1) | SK283215B6 (es) |
| TR (1) | TR199701417T1 (es) |
| TW (1) | TW421646B (es) |
| WO (1) | WO1996037490A1 (es) |
| ZA (1) | ZA964209B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5972894A (en) * | 1997-08-07 | 1999-10-26 | Cytran, Inc. | Peptides having potassium channel opener activity |
| GB9822024D0 (en) * | 1998-10-09 | 1998-12-02 | Novartis Ag | Organic compounds |
| GB9909792D0 (en) | 1998-12-04 | 1999-06-23 | Cambridge Bioclinical Limited | Potassium channel activators and their use |
| US6384244B2 (en) | 2000-05-18 | 2002-05-07 | Merck & Co., Inc. | Process for preparing cis- aminochromanols |
| US7098340B2 (en) | 2003-05-14 | 2006-08-29 | Warner Lambert Company Llc | Benzyl sulfonamide derivatives |
| KR100704009B1 (ko) * | 2005-08-30 | 2007-04-04 | 한국화학연구원 | 염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(ｎ-메틸치환술폰아미도)메틸-2ｈ-1-벤조피란 유도체 |
| KR20180067561A (ko) | 2015-09-28 | 2018-06-20 | 제넨테크, 인크. | 치료 화합물 및 그의 사용 방법 |
| CN106008288A (zh) * | 2016-06-15 | 2016-10-12 | 西北农林科技大学 | 一种苯磺酰胺类化合物及其用途 |
| JP2020511511A (ja) | 2017-03-24 | 2020-04-16 | ジェネンテック， インコーポレイテッド | ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2030627A6 (es) * | 1990-11-28 | 1992-11-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de compuestos benzopiranicos. |
| KR950009863B1 (ko) * | 1991-05-22 | 1995-08-29 | 재단법인한국화학연구소 | 벤조피란 유도체와 그의 제조방법 |
| TW244350B (es) * | 1991-12-14 | 1995-04-01 | Hoechst Ag | |
| US5236935A (en) * | 1992-05-21 | 1993-08-17 | Korea Research Institute Of Chemical Technology | Benzopyran derivatives and processes for the preparation thereof |
-
1995
- 1995-05-24 GB GBGB9510477.4A patent/GB9510477D0/en active Pending
-
1996
- 1996-05-22 MY MYPI96001911A patent/MY114924A/en unknown
- 1996-05-22 IL IL11838296A patent/IL118382A/xx not_active IP Right Cessation
- 1996-05-22 TW TW085106034A patent/TW421646B/zh not_active IP Right Cessation
- 1996-05-23 CO CO96026387A patent/CO4700520A1/es unknown
- 1996-05-24 DE DE69615019T patent/DE69615019T2/de not_active Expired - Lifetime
- 1996-05-24 CZ CZ19973688A patent/CZ294474B6/cs not_active IP Right Cessation
- 1996-05-24 RU RU97120993/04A patent/RU2160735C2/ru not_active IP Right Cessation
- 1996-05-24 HU HU9801751A patent/HU222772B1/hu not_active IP Right Cessation
- 1996-05-24 SK SK1577-97A patent/SK283215B6/sk not_active IP Right Cessation
- 1996-05-24 DK DK96917431T patent/DK0828733T3/da active
- 1996-05-24 EP EP96917431A patent/EP0828733B1/en not_active Expired - Lifetime
- 1996-05-24 ES ES96917431T patent/ES2163634T3/es not_active Expired - Lifetime
- 1996-05-24 ZA ZA9604209A patent/ZA964209B/xx unknown
- 1996-05-24 AU AU60008/96A patent/AU703276B2/en not_active Ceased
- 1996-05-24 BR BR9609048A patent/BR9609048A/pt not_active IP Right Cessation
- 1996-05-24 WO PCT/EP1996/002257 patent/WO1996037490A1/en active IP Right Grant
- 1996-05-24 NZ NZ309765A patent/NZ309765A/xx unknown
- 1996-05-24 CN CN96194146A patent/CN1077888C/zh not_active Expired - Fee Related
- 1996-05-24 PT PT96917431T patent/PT828733E/pt unknown
- 1996-05-24 CA CA002217821A patent/CA2217821C/en not_active Expired - Fee Related
- 1996-05-24 KR KR1019970708400A patent/KR100437981B1/ko not_active IP Right Cessation
- 1996-05-24 AR ARP960102708A patent/AR004489A1/es active IP Right Grant
- 1996-05-24 JP JP8535402A patent/JPH11505820A/ja not_active Ceased
- 1996-05-24 PL PL96324042A patent/PL184144B1/pl not_active IP Right Cessation
- 1996-05-24 US US08/952,549 patent/US5905156A/en not_active Expired - Lifetime
- 1996-05-24 AT AT96917431T patent/ATE205204T1/de active
- 1996-05-24 TR TR97/01417T patent/TR199701417T1/xx unknown
-
1997
- 1997-10-17 FI FI973992A patent/FI973992A/fi unknown
- 1997-11-21 NO NO19975365A patent/NO314846B1/no unknown
-
1998
- 1998-12-11 HK HK98113216A patent/HK1014137A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2159277T3 (es) | Un derivado del pirrolidiltiocarbapenemo. | |
| CO5590897A2 (es) | Compuestos heterociclicos que proporcionan agentes farmacologicos que son potentes agonistas de ppars y composiciones farmaceuticas que los contienen | |
| CO4700520A1 (es) | Benzopiranos | |
| DK1022277T3 (da) | Nye taxanderivater | |
| DE69033935D1 (de) | Bis(3,4-Dialkylbenzyliden)sorbitolacetale und diese enthaltende Zusammensetzungen | |
| AR034858A1 (es) | Compuestos elevadores de abca-1,composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento | |
| AR052915A1 (es) | Derivados de pirrolidin y piperidin acetileno | |
| ES2188556T3 (es) | Complejos metalicos de poliaminoacidos biciclicos, su procedimiento de preparacion y su aplicacion en formacion de imagenes medicas. | |
| AR049464A1 (es) | Antagonistas de receptores de acetilcolina muscarinicos. composiciones farmaceuticas | |
| AR006890A1 (es) | Compuestos alquil-4-silil-fenoles y esteres de los mismos como agentes antiateroscleroticos | |
| AR012032A1 (es) | Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacion | |
| KR880001583A (ko) | 광학적 활성 벤젠설폰아미드 유도체의 제조방법 | |
| ES2078324T3 (es) | Pteridina-4 (3h)-onas, procedimientos de preparacion y medicamentos que los contienen. | |
| ATE290526T1 (de) | Vitamin-d3?-derivate und aus diesen hergestellte heilmittel gegen entzündliche erkrankungen der atemwege | |
| KR880007552A (ko) | 암민-지환식아민-백금 착화합물 및 항 종양제 | |
| CO5580782A2 (es) | Antibioticos de glicopeptido-cefalosporina entrecruzados | |
| EA200000948A1 (ru) | Новые полициклические азаиндолы, способ их получения и фармацевтические композиции, содержащие их | |
| ATE168679T1 (de) | Neue tetracyclische verbindungen | |
| EA200300458A1 (ru) | Новые соединения аминотриазолона, способ их получения и фармацевтические композиции, содержащие их | |
| AR247737A1 (es) | Un procedimiento para la fabricacion de compuestos. | |
| FI914526A0 (fi) | Foerening, dess framstaellning och anvaendning. | |
| HK1028046A1 (en) | Intermediates and methods useful in the semisynthesis of paclitaxel and analogs | |
| CO4950517A1 (es) | Procedimiento para la preparacion de 4-sustituido-1h-indol - 3 - glioxamidas | |
| DE69008069T2 (de) | Antipsychotische Verbindungen. | |
| NO994931D0 (no) | Chelateringsmidler |