TW200936131A - Macrocyclic serine protease inhibitors - Google Patents

Macrocyclic serine protease inhibitors Download PDF

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Publication number
TW200936131A
TW200936131A TW098103395A TW98103395A TW200936131A TW 200936131 A TW200936131 A TW 200936131A TW 098103395 A TW098103395 A TW 098103395A TW 98103395 A TW98103395 A TW 98103395A TW 200936131 A TW200936131 A TW 200936131A
Authority
TW
Taiwan
Prior art keywords
compound
group
alkyl
substituents
aryl
Prior art date
Application number
TW098103395A
Other languages
English (en)
Chinese (zh)
Inventor
Christophe Claude Parsy
Francois-Rene Alexandre
Dominique Surleraux
Michel Derock
Frederic Leroy
Original Assignee
Idenix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix Pharmaceuticals Inc filed Critical Idenix Pharmaceuticals Inc
Publication of TW200936131A publication Critical patent/TW200936131A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
TW098103395A 2008-02-04 2009-02-03 Macrocyclic serine protease inhibitors TW200936131A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2608608P 2008-02-04 2008-02-04
US8386708P 2008-07-25 2008-07-25

Publications (1)

Publication Number Publication Date
TW200936131A true TW200936131A (en) 2009-09-01

Family

ID=40568607

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098103395A TW200936131A (en) 2008-02-04 2009-02-03 Macrocyclic serine protease inhibitors

Country Status (21)

Country Link
US (2) US8003659B2 (enExample)
EP (1) EP2250174B1 (enExample)
JP (1) JP5574982B2 (enExample)
KR (1) KR20100118991A (enExample)
CN (1) CN101977915B (enExample)
AR (1) AR070413A1 (enExample)
AU (1) AU2009210789B2 (enExample)
BR (1) BRPI0908021A2 (enExample)
CA (1) CA2712971A1 (enExample)
CO (1) CO6501153A2 (enExample)
CR (1) CR11618A (enExample)
EC (1) ECSP10010413A (enExample)
ES (1) ES2437147T3 (enExample)
IL (1) IL207333A0 (enExample)
MX (1) MX2010008523A (enExample)
NI (1) NI201000136A (enExample)
NZ (1) NZ587133A (enExample)
RU (1) RU2490272C2 (enExample)
TW (1) TW200936131A (enExample)
WO (1) WO2009099596A2 (enExample)
ZA (1) ZA201005318B (enExample)

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US20090202480A1 (en) 2009-08-13
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