TR201807740T4 - ATR kinaz inhibitörü olarak 2-amino-6-fluoro-n-(5-fluoro-4-(4-(4-(oksetan-3-il)piperazin-1-karbonil)piperidin-1-il)piridin-3-il)pirazolo[1,5alfa]pirimidin-3-karboksamid. - Google Patents

ATR kinaz inhibitörü olarak 2-amino-6-fluoro-n-(5-fluoro-4-(4-(4-(oksetan-3-il)piperazin-1-karbonil)piperidin-1-il)piridin-3-il)pirazolo[1,5alfa]pirimidin-3-karboksamid. Download PDF

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Publication number
TR201807740T4
TR201807740T4 TR2018/07740T TR201807740T TR201807740T4 TR 201807740 T4 TR201807740 T4 TR 201807740T4 TR 2018/07740 T TR2018/07740 T TR 2018/07740T TR 201807740 T TR201807740 T TR 201807740T TR 201807740 T4 TR201807740 T4 TR 201807740T4
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Turkey
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compounds
fluoro
5alf
oxetan
pyrazolo
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TR2018/07740T
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English (en)
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Ahmad Nadia
Boyall Dean
Charrier Jean-Damien
Davis Chris
Davis Rebecca
Durrant Steven
Etxebarria I Jardi Gorka
Fraysse Damien
Jimenez Juan-Miguel
Kay David
Knegtel Ronald
Middleton Donald
Odonnell Michael
Panesar Maninder
Pierard Francoise
Pinder Joanne
Shaw David
Storck Pierre-Henri
Studley John
Twin Heather
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Vertex Pharma
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Publication of TR201807740T4 publication Critical patent/TR201807740T4/tr

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Mevcut buluş, ATR proteini kinazını inhibitörleri olarak faydalı olan bileşikler ile ilgilidir. Buluş aynı zamanda buluşun bileşiklerini içeren farmasötik olarak kabul edilebilir bileşimler; bu buluşun bileşikleri kullanılarak çeşitli hastalıklar, bozukluklar ve durumların tedavi edilmesine yönelik yöntemler; bu buluşun bileşiklerinin hazırlanmasına yönelik prosesler; bu buluşun bileşiklerinin hazırlanmasına yönelik ara ürünler; ve in vitro uygulamalar içinde örneğin biyolojik ve patolojik fenomenlerde kinazların çalışması; bu tür kinazlar ile aracı olunan hücre içi sinyal transdüksiyon yollarının çalışması; ve yeni kinaz inhibitörlerinin karşılaştırmalı değerlendirmesinde bileşiklerin kullanımına yönelik yöntemler ile ilgilidir. Bu buluşun bileşikleri formüle (I) veya farmasötik olarak kabul edilebilir bir tuza sahiptir, burada değişkenler burada tanımlandığı gibidir. Ek olarak bu buluşun bileşikleri formüle (I-A) veya farmasötik olarak kabul edilebilir bir tuza sahiptir, burada değişkenler burada tanımlandığı gibidir.
TR2018/07740T 2012-12-07 2013-12-06 ATR kinaz inhibitörü olarak 2-amino-6-fluoro-n-(5-fluoro-4-(4-(4-(oksetan-3-il)piperazin-1-karbonil)piperidin-1-il)piridin-3-il)pirazolo[1,5alfa]pirimidin-3-karboksamid. TR201807740T4 (tr)

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US201261734726P 2012-12-07 2012-12-07
US201361787568P 2013-03-15 2013-03-15
US201361868132P 2013-08-21 2013-08-21

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TR201807740T4 true TR201807740T4 (tr) 2018-06-21

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