EA201301183A1 - Гетероциклические соединения в качестве ингибиторов киназ - Google Patents
Гетероциклические соединения в качестве ингибиторов киназInfo
- Publication number
- EA201301183A1 EA201301183A1 EA201301183A EA201301183A EA201301183A1 EA 201301183 A1 EA201301183 A1 EA 201301183A1 EA 201301183 A EA201301183 A EA 201301183A EA 201301183 A EA201301183 A EA 201301183A EA 201301183 A1 EA201301183 A1 EA 201301183A1
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- Prior art keywords
- diseases
- kinase
- disease
- heterocyclic compounds
- compounds
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
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- Cardiology (AREA)
- Urology & Nephrology (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Изобретение относится к новым соединениям формулы (I)которые способны ингибировать одну или несколько киназ, в особенности SYK (селезеночная тирозинкиназа), LRRK2 (богатая лейцином повторная киназа 2) и/или MYLK (киназа легких цепей миозина), или их мутанты. Соединения находят применение при лечении различных заболеваний. Эти заболевания включают аутоиммунные заболевания, воспалительные заболевания, заболевания костей, заболевания обмена веществ, неврологические и нейродегенеративные заболевания, рак, сердечно-сосудистые заболевания, аллергии, астму, болезнь Альцгеймера, болезнь Паркинсона, нарушения кожи, заболевания глаз, инфекционные заболевания и гормоносвязанные заболевания.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161517581P | 2011-04-21 | 2011-04-21 | |
PCT/EP2012/001736 WO2012143143A1 (en) | 2011-04-21 | 2012-04-23 | Heterocyclic compounds as kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
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EA201301183A1 true EA201301183A1 (ru) | 2014-04-30 |
EA034193B1 EA034193B1 (ru) | 2020-01-15 |
Family
ID=46001141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201301183A EA034193B1 (ru) | 2011-04-21 | 2012-04-23 | Гетероциклические соединения в качестве ингибиторов киназ |
Country Status (25)
Country | Link |
---|---|
US (1) | US9499535B2 (ru) |
EP (1) | EP2699572B1 (ru) |
JP (1) | JP6278406B2 (ru) |
KR (1) | KR101649610B1 (ru) |
CN (1) | CN103717597B (ru) |
AP (1) | AP2013007252A0 (ru) |
AU (1) | AU2012244549B2 (ru) |
BR (1) | BR112013026744B1 (ru) |
CA (1) | CA2831680C (ru) |
CL (1) | CL2013003052A1 (ru) |
CO (1) | CO6831983A2 (ru) |
CR (1) | CR20130537A (ru) |
CU (1) | CU20130144A7 (ru) |
EA (1) | EA034193B1 (ru) |
EC (1) | ECSP13012984A (ru) |
GT (1) | GT201300259A (ru) |
HK (1) | HK1192247A1 (ru) |
IL (1) | IL228967B (ru) |
MA (1) | MA35123B1 (ru) |
MX (1) | MX365784B (ru) |
PE (1) | PE20140927A1 (ru) |
SG (1) | SG194216A1 (ru) |
TN (1) | TN2013000422A1 (ru) |
TW (1) | TWI557121B (ru) |
WO (1) | WO2012143143A1 (ru) |
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