EA201301184A1 - Пиразоло[4,3-d]пиримидины, пригодные в качестве ингибиторов киназ - Google Patents

Пиразоло[4,3-d]пиримидины, пригодные в качестве ингибиторов киназ

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Publication number
EA201301184A1
EA201301184A1 EA201301184A EA201301184A EA201301184A1 EA 201301184 A1 EA201301184 A1 EA 201301184A1 EA 201301184 A EA201301184 A EA 201301184A EA 201301184 A EA201301184 A EA 201301184A EA 201301184 A1 EA201301184 A1 EA 201301184A1
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Prior art keywords
diseases
disease
kinase
pyrazolo
compounds
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EA201301184A
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English (en)
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EA029040B1 (ru
Inventor
Михаэль Альмштеттер
Михаэль Торманн
Андреас Тремль
Надине Траубе
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Оригенис Гмбх
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Application filed by Оригенис Гмбх filed Critical Оригенис Гмбх
Publication of EA201301184A1 publication Critical patent/EA201301184A1/ru
Publication of EA029040B1 publication Critical patent/EA029040B1/ru

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

Настоящее изобретение относится к новым соединениям формулы (I)которые способны ингибировать одну или несколько киназ, в особенности SYK (селезеночная тирозинкиназа), LRRK2 (богатая лейцином повторная киназа 2) и/или MYLK (киназа легких цепей миозина) или их мутанты. Соединения находят применение при лечении различных заболеваний. Эти заболевания включают аутоиммунные заболевания, воспалительные заболевания, заболевания костей, заболевания обмена веществ, неврологические и нейродегенеративные заболевания, рак, сердечно-сосудистые заболевания, аллергии, астму, болезнь Альцгеймера, болезнь Паркинсона, нарушения кожи, заболевания глаз, инфекционные заболевания и гормоносвязанные заболевания.
EA201301184A 2011-04-21 2012-04-23 ПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПРИГОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗ EA029040B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161517582P 2011-04-21 2011-04-21
PCT/EP2012/001737 WO2012143144A1 (en) 2011-04-21 2012-04-23 Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors

Publications (2)

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EA201301184A1 true EA201301184A1 (ru) 2014-08-29
EA029040B1 EA029040B1 (ru) 2018-02-28

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EA201301184A EA029040B1 (ru) 2011-04-21 2012-04-23 ПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПРИГОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗ

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US (1) US9802937B2 (ru)
EP (1) EP2699579B1 (ru)
JP (1) JP6222776B2 (ru)
KR (1) KR101649611B1 (ru)
CN (1) CN103492389B (ru)
AP (1) AP2013007253A0 (ru)
AU (1) AU2012244550C1 (ru)
BR (1) BR112013026521A2 (ru)
CA (1) CA2831634C (ru)
CL (1) CL2013003051A1 (ru)
CO (1) CO6831982A2 (ru)
CR (1) CR20130536A (ru)
CU (1) CU20130143A7 (ru)
EA (1) EA029040B1 (ru)
EC (1) ECSP13012982A (ru)
GT (1) GT201300255A (ru)
HK (1) HK1192248A1 (ru)
IL (1) IL228968A (ru)
MA (1) MA35124B1 (ru)
MX (1) MX363696B (ru)
PE (1) PE20140928A1 (ru)
SG (1) SG194549A1 (ru)
TN (1) TN2013000419A1 (ru)
TW (1) TWI606049B (ru)
WO (1) WO2012143144A1 (ru)
ZA (1) ZA201307839B (ru)

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