GT201300255A - Pirazolo (4,3-d) pirimidinas utiles como inhibidores de cinasas - Google Patents

Pirazolo (4,3-d) pirimidinas utiles como inhibidores de cinasas

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Publication number
GT201300255A
GT201300255A GT201300255A GT201300255A GT201300255A GT 201300255 A GT201300255 A GT 201300255A GT 201300255 A GT201300255 A GT 201300255A GT 201300255 A GT201300255 A GT 201300255A GT 201300255 A GT201300255 A GT 201300255A
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GT
Guatemala
Prior art keywords
pirazolo
pyrimidins
useful
kinase inhibitors
lrkk2
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GT201300255A
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English (en)
Inventor
Almstetter Michael
Thormann Michael
Treml Andreas
Traube Nadine
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Application filed filed Critical
Publication of GT201300255A publication Critical patent/GT201300255A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A[4,3-D]PIRIMIDINAS QUE SON CAPASES DE INHIBIR UNA O MÁS CINASAS, ESPECIALMENTE SYK, LRKK2, MYLK O SUS MUTANTES. LOS COMPUESTOS ENCUENTRAN APLICACIONES EN EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNITARIAS, INFLAMATORIAS, METABÓLICAS, NEUROLÓGICAS, NEURODEGENERATIVAS Y CÁNCER, ENTRE OTRAS.
GT201300255A 2011-04-21 2013-10-18 Pirazolo (4,3-d) pirimidinas utiles como inhibidores de cinasas GT201300255A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161517582P 2011-04-21 2011-04-21

Publications (1)

Publication Number Publication Date
GT201300255A true GT201300255A (es) 2015-03-16

Family

ID=46017783

Family Applications (1)

Application Number Title Priority Date Filing Date
GT201300255A GT201300255A (es) 2011-04-21 2013-10-18 Pirazolo (4,3-d) pirimidinas utiles como inhibidores de cinasas

Country Status (26)

Country Link
US (1) US9802937B2 (es)
EP (1) EP2699579B1 (es)
JP (1) JP6222776B2 (es)
KR (1) KR101649611B1 (es)
CN (1) CN103492389B (es)
AP (1) AP2013007253A0 (es)
AU (1) AU2012244550C1 (es)
BR (1) BR112013026521A2 (es)
CA (1) CA2831634C (es)
CL (1) CL2013003051A1 (es)
CO (1) CO6831982A2 (es)
CR (1) CR20130536A (es)
CU (1) CU20130143A7 (es)
EA (1) EA029040B1 (es)
EC (1) ECSP13012982A (es)
GT (1) GT201300255A (es)
HK (1) HK1192248A1 (es)
IL (1) IL228968A (es)
MA (1) MA35124B1 (es)
MX (1) MX363696B (es)
PE (1) PE20140928A1 (es)
SG (1) SG194549A1 (es)
TN (1) TN2013000419A1 (es)
TW (1) TWI606049B (es)
WO (1) WO2012143144A1 (es)
ZA (1) ZA201307839B (es)

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