EA201301353A1 - Композиции и способы получения пиримидиновых и пиридиновых соединений с втк ингибирующей активностью - Google Patents

Композиции и способы получения пиримидиновых и пиридиновых соединений с втк ингибирующей активностью

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Publication number
EA201301353A1
EA201301353A1 EA201301353A EA201301353A EA201301353A1 EA 201301353 A1 EA201301353 A1 EA 201301353A1 EA 201301353 A EA201301353 A EA 201301353A EA 201301353 A EA201301353 A EA 201301353A EA 201301353 A1 EA201301353 A1 EA 201301353A1
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EA
Eurasian Patent Office
Prior art keywords
formula
pyridine compounds
vtk
compositions
methods
Prior art date
Application number
EA201301353A
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English (en)
Other versions
EA027584B1 (ru
Inventor
Брайан Л. Ходоус
Лесли Лю-Буджалски
Рейнальдо Джонс
Доналд Банкстон
Тереза Л. Джонсон
Игорь Евгеньевич Мочалкин
Нган Нгуен
Сюй Цю
Андреас Гоутопоулос
Надиа Бруггер
Original Assignee
Мерк Патент Гмбх
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Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201301353A1 publication Critical patent/EA201301353A1/ru
Publication of EA027584B1 publication Critical patent/EA027584B1/ru

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

Настоящее изобретение обеспечивает новые пиримидиновые и пиридиновые соединения в соответствии с формулой (I), формулой (II), формулой (III), формулой (IV) и формулой (V), их получение и применение для лечения гиперпролиферативных заболеваний, включая, но не ограничиваясь перечисленным, рак, волчанку, аллергические расстройства, болезнь Шегрена и ревматоидный артрит. В предпочтительных вариантах осуществления настоящее изобретение описывает необратимо действующие ингибиторы киназ, включая, но не ограничиваясь перечисленным, ингибиторы тирозинкиназы Брутона.
EA201301353A 2011-06-10 2012-06-10 Композиции и способы получения пиримидиновых и пиридиновых соединений с btk ингибирующей активностью EA027584B1 (ru)

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