MX2013012983A - Composiciones y metodos para la produccion de compuestos de pirimidina con actividad inhibidora de tirosina cinasa de bruton. - Google Patents

Composiciones y metodos para la produccion de compuestos de pirimidina con actividad inhibidora de tirosina cinasa de bruton.

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Publication number
MX2013012983A
MX2013012983A MX2013012983A MX2013012983A MX2013012983A MX 2013012983 A MX2013012983 A MX 2013012983A MX 2013012983 A MX2013012983 A MX 2013012983A MX 2013012983 A MX2013012983 A MX 2013012983A MX 2013012983 A MX2013012983 A MX 2013012983A
Authority
MX
Mexico
Prior art keywords
formula
pyrimidine
pyridine compounds
compositions
production
Prior art date
Application number
MX2013012983A
Other languages
English (en)
Other versions
MX354412B (es
Inventor
Brian L Hodous
Lesley Liu-Bujalski
Reinaldo Jones
Donald Bankston
Theresa L Johnson
Igor Mochalkin
Ngan Nguyen
Hui Qiu
Andreas Goutopoulos
Nadia Brugger
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2013012983A publication Critical patent/MX2013012983A/es
Publication of MX354412B publication Critical patent/MX354412B/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

La presente invención proporciona nuevos compuestos de pirimidina y piridina de acuerdo con la Fórmula (I), Fórmula (II), Fórmula (III), Fórmula (IV) y Fórmula (V), su manufactura y uso para el tratamiento de enfermedades hiperproliferativas, incluyendo, pero no se limitan a, cáncer, lupus, enfermedades alérgicas, enfermedad de Sjogren y artritis reumatoide. En las modalidades preferidas, la presente invención describe inhibidores de cinasa irreversibles, que incluyen, pero no se limitan a, inhibidores de tirosina cinasa de Bruton.
MX2013012983A 2011-06-10 2012-06-10 Composiciones y metodos para la produccion de compuestos de pirimidina con actividad inhibidora de tirosina cinasa de bruton. MX354412B (es)

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