MA32312B1 - Synthese de diols dihydrothieno [3,2-d] pyrimidiniques et de diols pyrimidiniques analogues. - Google Patents
Synthese de diols dihydrothieno [3,2-d] pyrimidiniques et de diols pyrimidiniques analogues.Info
- Publication number
- MA32312B1 MA32312B1 MA33361A MA33361A MA32312B1 MA 32312 B1 MA32312 B1 MA 32312B1 MA 33361 A MA33361 A MA 33361A MA 33361 A MA33361 A MA 33361A MA 32312 B1 MA32312 B1 MA 32312B1
- Authority
- MA
- Morocco
- Prior art keywords
- pyrimidine
- dihydrothino
- diphenylated
- diploid
- isotopes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La présente invention concerne un procédé amélioré de préparation de diols dihydrothiénol[3,2-d]pyrimidiniques et de diols pyrimidiniques analogues. Ce procédé est efficace, présente un rendement élevé et ne requiert pas de produits intermédiaires coûteux et potentiellement instables. Les diols sont utilisés comme produits intermédiaires dans la synthèse de composés pyrimidiniques inhibant la pde4, et sont donc utiles dans le traitement de maladies et de plaintes respiratoires ou gastro-intestinales, de maladies et de troubles du système nerveux central ou périphérique, d'affections inflammatoires et de cancers.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5281608P | 2008-05-13 | 2008-05-13 | |
PCT/US2009/043068 WO2009140127A2 (fr) | 2008-05-13 | 2009-05-07 | SYNTHÈSE DE DIOLS DIHYDROTHIÉNO[3,2-d]PYRIMIDINIQUES ET DE DIOLS PYRIMIDINIQUES ANALOGUES |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32312B1 true MA32312B1 (fr) | 2011-05-02 |
Family
ID=41319263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33361A MA32312B1 (fr) | 2008-05-13 | 2010-11-12 | Synthese de diols dihydrothieno [3,2-d] pyrimidiniques et de diols pyrimidiniques analogues. |
Country Status (32)
Country | Link |
---|---|
US (1) | US8471010B2 (fr) |
EP (1) | EP2315755B1 (fr) |
JP (1) | JP5281153B2 (fr) |
KR (1) | KR20110021764A (fr) |
CN (1) | CN102026984B (fr) |
AR (1) | AR071720A1 (fr) |
AU (1) | AU2009246686B2 (fr) |
BR (1) | BRPI0912546A2 (fr) |
CA (1) | CA2722970A1 (fr) |
CL (1) | CL2009001149A1 (fr) |
CO (1) | CO6260135A2 (fr) |
CY (1) | CY1113577T1 (fr) |
DK (1) | DK2315755T3 (fr) |
EA (1) | EA019735B1 (fr) |
EC (1) | ECSP10010571A (fr) |
ES (1) | ES2392920T3 (fr) |
HK (1) | HK1151524A1 (fr) |
HR (1) | HRP20120860T1 (fr) |
IL (1) | IL208382A0 (fr) |
MA (1) | MA32312B1 (fr) |
ME (1) | ME01465B (fr) |
MX (1) | MX2010011025A (fr) |
MY (1) | MY152292A (fr) |
NZ (1) | NZ588484A (fr) |
PL (1) | PL2315755T3 (fr) |
PT (1) | PT2315755E (fr) |
RS (1) | RS52476B (fr) |
SI (1) | SI2315755T1 (fr) |
TW (1) | TWI421254B (fr) |
UA (1) | UA99964C2 (fr) |
WO (1) | WO2009140127A2 (fr) |
ZA (1) | ZA201006891B (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SA08280783B1 (ar) * | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
WO2013082275A1 (fr) * | 2011-11-30 | 2013-06-06 | Trustees Of Boston College | Inhibiteurs de phosphodiestérases 11 (pde11) et procédés d'utilisation pour augmenter la production de cortisol |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1470336A1 (de) * | 1962-07-04 | 1969-03-20 | Thomae Gmbh Dr K | Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung |
FR2029250A5 (fr) * | 1969-01-21 | 1970-10-16 | Roussel Uclaf | |
AR044743A1 (es) * | 2002-09-26 | 2005-10-05 | Nihon Nohyaku Co Ltd | Herbicida, metodo de emplearlo, derivados de tienopirimidina sustituida,compuestos intermediarios, y procedimientos que se utilizan para producirlos, |
BRPI0608387A2 (pt) * | 2006-04-19 | 2009-12-29 | Boehringer Ingelheim Int | compostos para o tratamento de doenças inflamatórias |
US7851468B2 (en) * | 2006-05-15 | 2010-12-14 | Cephalon, Inc. | Substituted pyrazolo[3,4-d]pyrimidines |
-
2009
- 2009-05-07 RS RS20120445A patent/RS52476B/en unknown
- 2009-05-07 SI SI200930337T patent/SI2315755T1/sl unknown
- 2009-05-07 ES ES09736709T patent/ES2392920T3/es active Active
- 2009-05-07 EA EA201001775A patent/EA019735B1/ru not_active IP Right Cessation
- 2009-05-07 EP EP09736709A patent/EP2315755B1/fr active Active
- 2009-05-07 KR KR1020107025268A patent/KR20110021764A/ko not_active Application Discontinuation
- 2009-05-07 PT PT09736709T patent/PT2315755E/pt unknown
- 2009-05-07 ME MEP-2012-113A patent/ME01465B/me unknown
- 2009-05-07 CA CA2722970A patent/CA2722970A1/fr not_active Abandoned
- 2009-05-07 MX MX2010011025A patent/MX2010011025A/es active IP Right Grant
- 2009-05-07 JP JP2011509563A patent/JP5281153B2/ja active Active
- 2009-05-07 BR BRPI0912546A patent/BRPI0912546A2/pt not_active IP Right Cessation
- 2009-05-07 AU AU2009246686A patent/AU2009246686B2/en not_active Ceased
- 2009-05-07 MY MYPI20105081 patent/MY152292A/en unknown
- 2009-05-07 PL PL09736709T patent/PL2315755T3/pl unknown
- 2009-05-07 NZ NZ588484A patent/NZ588484A/en not_active IP Right Cessation
- 2009-05-07 CN CN2009801169809A patent/CN102026984B/zh not_active Expired - Fee Related
- 2009-05-07 WO PCT/US2009/043068 patent/WO2009140127A2/fr active Application Filing
- 2009-05-07 US US12/989,575 patent/US8471010B2/en active Active
- 2009-05-07 DK DK09736709.8T patent/DK2315755T3/da active
- 2009-05-12 TW TW098115740A patent/TWI421254B/zh not_active IP Right Cessation
- 2009-05-12 AR ARP090101712A patent/AR071720A1/es unknown
- 2009-05-12 CL CL2009001149A patent/CL2009001149A1/es unknown
- 2009-07-05 UA UAA201014583A patent/UA99964C2/ru unknown
-
2010
- 2010-09-28 ZA ZA2010/06891A patent/ZA201006891B/en unknown
- 2010-10-03 IL IL208382A patent/IL208382A0/en unknown
- 2010-10-26 EC EC2010010571A patent/ECSP10010571A/es unknown
- 2010-11-10 CO CO10140646A patent/CO6260135A2/es active IP Right Grant
- 2010-11-12 MA MA33361A patent/MA32312B1/fr unknown
-
2011
- 2011-06-01 HK HK11105484.9A patent/HK1151524A1/xx not_active IP Right Cessation
-
2012
- 2012-10-23 HR HRP20120860AT patent/HRP20120860T1/hr unknown
- 2012-10-31 CY CY20121101046T patent/CY1113577T1/el unknown
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