UA99964C2 - SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS - Google Patents

SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS

Info

Publication number
UA99964C2
UA99964C2 UAA201014583A UAA201014583A UA99964C2 UA 99964 C2 UA99964 C2 UA 99964C2 UA A201014583 A UAA201014583 A UA A201014583A UA A201014583 A UAA201014583 A UA A201014583A UA 99964 C2 UA99964 C2 UA 99964C2
Authority
UA
Ukraine
Prior art keywords
diols
pyrimidine
dihydrothieno
synthesis
pyrimidine diols
Prior art date
Application number
UAA201014583A
Other languages
English (en)
Ukrainian (uk)
Inventor
Рохелио Перес Фрутос
Томас Дж. Темпоун
Джейсон Алан Малдер
Дхилеепкумар Кришнамурти
Крис Хью Сенанаяке
Original Assignee
Берингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41319263&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA99964(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Берингер Ингельхайм Интернациональ Гмбх filed Critical Берингер Ингельхайм Интернациональ Гмбх
Publication of UA99964C2 publication Critical patent/UA99964C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

В заявке описан способ получения дигидротиено[3,2-d]пиримидиндиолов и подобных пиримидиндиолов, который является эффективным и характеризуется высоким выходом, и для которого не нужны дорогие и потенциально нестабильные промежуточные продукты. Диолы используют как промежуточные продукты для синтеза пиримидинов, которые ингибируют PDE4 и поэтому применимы для лечения респираторных или желудочно-кишечных заболеваний и нарушений, и заболеваний и нарушений периферической или центральной нервной системы, воспалительных патологических состояний и раковых заболеваний.
UAA201014583A 2008-05-13 2009-07-05 SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS UA99964C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5281608P 2008-05-13 2008-05-13

Publications (1)

Publication Number Publication Date
UA99964C2 true UA99964C2 (en) 2012-10-25

Family

ID=41319263

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201014583A UA99964C2 (en) 2008-05-13 2009-07-05 SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS

Country Status (32)

Country Link
US (1) US8471010B2 (ru)
EP (1) EP2315755B1 (ru)
JP (1) JP5281153B2 (ru)
KR (1) KR20110021764A (ru)
CN (1) CN102026984B (ru)
AR (1) AR071720A1 (ru)
AU (1) AU2009246686B2 (ru)
BR (1) BRPI0912546A2 (ru)
CA (1) CA2722970A1 (ru)
CL (1) CL2009001149A1 (ru)
CO (1) CO6260135A2 (ru)
CY (1) CY1113577T1 (ru)
DK (1) DK2315755T3 (ru)
EA (1) EA019735B1 (ru)
EC (1) ECSP10010571A (ru)
ES (1) ES2392920T3 (ru)
HK (1) HK1151524A1 (ru)
HR (1) HRP20120860T1 (ru)
IL (1) IL208382A0 (ru)
MA (1) MA32312B1 (ru)
ME (1) ME01465B (ru)
MX (1) MX2010011025A (ru)
MY (1) MY152292A (ru)
NZ (1) NZ588484A (ru)
PL (1) PL2315755T3 (ru)
PT (1) PT2315755E (ru)
RS (1) RS52476B (ru)
SI (1) SI2315755T1 (ru)
TW (1) TWI421254B (ru)
UA (1) UA99964C2 (ru)
WO (1) WO2009140127A2 (ru)
ZA (1) ZA201006891B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
WO2013082275A1 (en) * 2011-11-30 2013-06-06 Trustees Of Boston College Inhibitors of phosphodiesterases 11 (pde11) and methods of use to elevate cortisol production

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470336A1 (de) * 1962-07-04 1969-03-20 Thomae Gmbh Dr K Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung
FR2029250A5 (ru) * 1969-01-21 1970-10-16 Roussel Uclaf
AR044743A1 (es) * 2002-09-26 2005-10-05 Nihon Nohyaku Co Ltd Herbicida, metodo de emplearlo, derivados de tienopirimidina sustituida,compuestos intermediarios, y procedimientos que se utilizan para producirlos,
WO2006111549A1 (de) * 2005-04-21 2006-10-26 Boehringer Ingelheim International Gmbh Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
US7851468B2 (en) * 2006-05-15 2010-12-14 Cephalon, Inc. Substituted pyrazolo[3,4-d]pyrimidines

Also Published As

Publication number Publication date
DK2315755T3 (da) 2012-10-15
IL208382A0 (en) 2010-12-30
EP2315755A2 (en) 2011-05-04
EA201001775A1 (ru) 2011-06-30
ZA201006891B (en) 2011-06-29
WO2009140127A2 (en) 2009-11-19
PL2315755T3 (pl) 2013-01-31
EP2315755B1 (en) 2012-08-08
JP5281153B2 (ja) 2013-09-04
SI2315755T1 (sl) 2012-10-30
HRP20120860T1 (hr) 2012-11-30
EA019735B1 (ru) 2014-05-30
TW201006841A (en) 2010-02-16
AR071720A1 (es) 2010-07-07
CA2722970A1 (en) 2009-11-19
ME01465B (me) 2014-04-20
US20110130563A1 (en) 2011-06-02
BRPI0912546A2 (pt) 2016-10-18
CN102026984B (zh) 2013-12-25
MY152292A (en) 2014-09-15
ES2392920T3 (es) 2012-12-17
CO6260135A2 (es) 2011-03-22
JP2011520886A (ja) 2011-07-21
AU2009246686A1 (en) 2009-11-19
CN102026984A (zh) 2011-04-20
MX2010011025A (es) 2010-11-05
AU2009246686B2 (en) 2014-02-13
TWI421254B (zh) 2014-01-01
MA32312B1 (fr) 2011-05-02
ECSP10010571A (es) 2010-11-30
RS52476B (en) 2013-02-28
KR20110021764A (ko) 2011-03-04
CY1113577T1 (el) 2016-06-22
WO2009140127A3 (en) 2010-01-28
NZ588484A (en) 2012-06-29
HK1151524A1 (en) 2012-02-03
US8471010B2 (en) 2013-06-25
CL2009001149A1 (es) 2010-07-23
PT2315755E (pt) 2012-10-03

Similar Documents

Publication Publication Date Title
PH12016502060A1 (en) Processes for preparing jak inhibitors and related intermediate compounds
MX2011012353A (es) Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus.
UA101493C2 (ru) Производные азетидина и циклобутана как ингибиторы jak
TW200631583A (en) Substituted pteridines for the treatment of inflammatory diseases
IN2014DN07384A (ru)
MY156434A (en) Alkylamino-substituted dicyanopyridines and their amino acid ester prodrugs
TW200635597A (en) Substituted pteridines for the treatment of inflammatory diseases
EA201290878A1 (ru) ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-a]ПИРАЗИНА И ИХ ПРИМЕНЕНИЕ ДЛЯ ПРОФИЛАКТИКИ ИЛИ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ, ПСИХИАТРИЧЕСКИХ И МЕТАБОЛИЧЕСКИХ РАССТРОЙСТВ И ЗАБОЛЕВАНИЙ
TW200800968A (en) Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs
UA109459C2 (xx) ПОХІДНІ 5,6-ДИГІДРОІМІДАЗО[1,2-a]ПІРАЗИН-8-ІЛАМІНУ, ПРИДАТНІ ЯК ІНГІБІТОРИ БЕТА-СЕКРЕТАЗИ (BACE)
EA020330B3 (ru) Хиназолиновые соединения
TN2013000325A1 (en) (1,2,4)triazolo[4,3-a]quinoxaline derivatives as inhibitors of phosphodiesterases
TW200633711A (en) Substituted pteridines for the treatment of inflammatory diseases
MX349550B (es) 1,7-diazacarbazoles y metodos de uso.
WO2007135026A3 (de) Substituierte pteridine als therapeutika
MX2010006331A (es) Hidantoinas sustituidas como inhibidores de cinasa mek.
UA99964C2 (en) SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS
TN2010000521A1 (en) Synthesis of dihydrothieno [3,2-d] pyrimidine diols and similar pyrimidine diols
EA201171030A1 (ru) 2-МОРФОЛИНОПИРИДО[3,2-d]ПИРИМИДИНЫ
UA106617C2 (uk) N-(ГЕТЕРО)АРИЛПІРОЛІДИНОВІ ПОХІДНІ ПІРАЗОЛ-4-ІЛПІРОЛО[2,3-d]ПІРИМІДИНІВ І ПІРОЛ-3-ІЛПІРОЛО[2,3-d]ПІРИМІДИНІВ ЯК ІНГІБІТОРИ ЯНУС-КІНАЗИ