US4309430A
(en)
|
1980-06-27 |
1982-01-05 |
Merck & Co., Inc. |
Pyrazinyl-1,2,4-oxadiazole-5-ones, for treatment of edema, and processes for preparing same
|
US5329012A
(en)
|
1987-10-29 |
1994-07-12 |
The Research Foundation Of State University Of New York |
Bis(acyloxmethyl)imidazole compounds
|
JP2597917B2
(ja)
|
1990-04-26 |
1997-04-09 |
富士写真フイルム株式会社 |
新規な色素形成カプラー及びそれを用いたハロゲン化銀カラー写真感光材料
|
BR9608100A
(pt)
|
1995-05-09 |
1999-02-23 |
Basf Ag |
Pirazolo[1,5a] pirimidina processos para a sua preparação e para o controle e fungos nocivos e pragas composição e utilização dos compostos
|
WO1997043267A1
(en)
|
1996-05-11 |
1997-11-20 |
Kings College London |
Pyrazines
|
ES2294800T3
(es)
|
1996-07-24 |
2008-04-01 |
Bristol-Myers Squibb Pharma Company |
Azolo triazinas y pirimidinas.
|
US6191131B1
(en)
|
1997-07-23 |
2001-02-20 |
Dupont Pharmaceuticals Company |
Azolo triazines and pyrimidines
|
US6060478A
(en)
|
1996-07-24 |
2000-05-09 |
Dupont Pharmaceuticals |
Azolo triazines and pyrimidines
|
JPH10218881A
(ja)
|
1997-02-03 |
1998-08-18 |
Pola Chem Ind Inc |
新規なピロロピラゾロピリミジン誘導体
|
GB2323861B
(en)
|
1997-02-05 |
2001-06-20 |
Sector Exhibiting Systems |
Artificial wall structure
|
JP2002241379A
(ja)
|
1997-03-21 |
2002-08-28 |
Dainippon Pharmaceut Co Ltd |
3−オキサジアゾリルキノキサリン誘導体
|
JP2002501532A
(ja)
|
1997-05-30 |
2002-01-15 |
メルク エンド カンパニー インコーポレーテッド |
新規血管形成阻害薬
|
US6235741B1
(en)
|
1997-05-30 |
2001-05-22 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
CN1146561C
(zh)
|
1998-07-16 |
2004-04-21 |
盐野义制药株式会社 |
具有抗肿瘤活性的嘧啶衍生物
|
US6245759B1
(en)
|
1999-03-11 |
2001-06-12 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
US6660753B2
(en)
|
1999-08-19 |
2003-12-09 |
Nps Pharmaceuticals, Inc. |
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
JP2001302666A
(ja)
|
1999-09-21 |
2001-10-31 |
Nissan Chem Ind Ltd |
アゾール縮合ヘテロ環アニライド化合物及び除草剤
|
MY125533A
(en)
|
1999-12-06 |
2006-08-30 |
Bristol Myers Squibb Co |
Heterocyclic dihydropyrimidine compounds
|
ES2296667T3
(es)
|
1999-12-17 |
2008-05-01 |
Novartis Vaccines And Diagnostics, Inc. |
Inhibidores basados en pirazina de glicogeno sintasa quinasa-3.
|
AU2001264932A1
(en)
|
2000-05-26 |
2001-12-11 |
Neurogen Corporation |
Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands
|
US20020041880A1
(en)
|
2000-07-05 |
2002-04-11 |
Defeo-Jones Deborah |
Method of treating cancer
|
US6849660B1
(en)
|
2000-08-01 |
2005-02-01 |
Isis Pharmaceuticals, Inc. |
Antimicrobial biaryl compounds
|
US7067520B2
(en)
|
2000-11-17 |
2006-06-27 |
Ishihara Sangyo Kaisha, Ltd. |
Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts
|
EP1217000A1
(en)
|
2000-12-23 |
2002-06-26 |
Aventis Pharma Deutschland GmbH |
Inhibitors of factor Xa and factor VIIa
|
US6420637B1
(en)
|
2001-01-29 |
2002-07-16 |
Asgrow Seed Company L.L.C. |
Plants and seeds of corn variety I389972
|
GB0103926D0
(en)
|
2001-02-17 |
2001-04-04 |
Astrazeneca Ab |
Chemical compounds
|
EP1408986B1
(en)
|
2001-05-08 |
2008-09-24 |
Yale University |
Proteomimetic compounds and methods
|
US20030114467A1
(en)
|
2001-06-21 |
2003-06-19 |
Shakespeare William C. |
Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof
|
SE0102439D0
(sv)
|
2001-07-05 |
2001-07-05 |
Astrazeneca Ab |
New compounds
|
SE0102438D0
(sv)
|
2001-07-05 |
2001-07-05 |
Astrazeneca Ab |
New compounds
|
US6833371B2
(en)
|
2001-11-01 |
2004-12-21 |
Icagen, Inc. |
Pyrazolopyrimidines
|
ES2333586T3
(es)
|
2001-11-21 |
2010-02-24 |
PHARMACIA & UPJOHN COMPANY LLC |
Derivados de aril 1,4-pirazina sustituidos.
|
US6992087B2
(en)
|
2001-11-21 |
2006-01-31 |
Pfizer Inc |
Substituted aryl 1,4-pyrazine derivatives
|
KR20040084896A
(ko)
|
2002-02-06 |
2004-10-06 |
버텍스 파마슈티칼스 인코포레이티드 |
Gsk-3의 억제제로서 유용한 헤테로아릴 화합물
|
EP1485365B1
(en)
|
2002-03-13 |
2008-05-14 |
Janssen Pharmaceutica N.V. |
Sulfonyl-derivatives as novel inhibitors of histone deacetylase
|
GB0206860D0
(en)
|
2002-03-22 |
2002-05-01 |
Glaxo Group Ltd |
Compounds
|
TWI319387B
(en)
|
2002-04-05 |
2010-01-11 |
Astrazeneca Ab |
Benzamide derivatives
|
US7662826B2
(en)
*
|
2002-04-23 |
2010-02-16 |
Shionogi & Co., Ltd. |
Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same
|
GB0209715D0
(en)
|
2002-04-27 |
2002-06-05 |
Astrazeneca Ab |
Chemical compounds
|
US7704995B2
(en)
|
2002-05-03 |
2010-04-27 |
Exelixis, Inc. |
Protein kinase modulators and methods of use
|
CA2484209C
(en)
|
2002-05-03 |
2013-06-11 |
Exelixis, Inc. |
Protein kinase modulators and methods of use
|
AU2003241925A1
(en)
|
2002-05-31 |
2003-12-19 |
Eisai R&D Management Co., Ltd. |
Pyrazole compound and medicinal composition containing the same
|
US7449488B2
(en)
|
2002-06-04 |
2008-11-11 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
ES2304511T3
(es)
|
2002-06-04 |
2008-10-16 |
Schering Corporation |
Compuestos de pirazolo(1,5-a)pirimidina como agentes antivirales.
|
US7015227B2
(en)
|
2002-06-21 |
2006-03-21 |
Cgi Pharmaceuticals, Inc. |
Certain amino-substituted monocycles as kinase modulators
|
US7563798B2
(en)
|
2002-09-04 |
2009-07-21 |
Schering Corporation |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
US7119200B2
(en)
|
2002-09-04 |
2006-10-10 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
KR20050057139A
(ko)
|
2002-09-04 |
2005-06-16 |
쉐링 코포레이션 |
사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘
|
US8580782B2
(en)
|
2002-09-04 |
2013-11-12 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
|
US7196078B2
(en)
|
2002-09-04 |
2007-03-27 |
Schering Corpoartion |
Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
US7196092B2
(en)
|
2002-09-04 |
2007-03-27 |
Schering Corporation |
N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
US7205308B2
(en)
|
2002-09-04 |
2007-04-17 |
Schering Corporation |
Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
|
US7601724B2
(en)
|
2002-09-04 |
2009-10-13 |
Schering Corporation |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
MXPA05002573A
(es)
|
2002-09-04 |
2005-09-08 |
Schering Corp |
Pirazolopirimidinas como inhibidores de cinasa dependientes de ciclina.
|
KR20050033659A
(ko)
|
2002-09-04 |
2005-04-12 |
쉐링 코포레이션 |
사이클린 의존성 키나제 억제제로서의 피라졸로[1,5-a]피리미딘 화합물
|
US8673924B2
(en)
|
2002-09-04 |
2014-03-18 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
|
MXPA05002571A
(es)
|
2002-09-04 |
2005-09-08 |
Schering Corp |
Pirazolopirimidinas como inhibidores de cinasa dependientes de ciclina.
|
AU2003282679A1
(en)
|
2002-10-04 |
2004-05-04 |
Arena Pharmaceuticals, Inc. |
Hydroxypyrazoles for use against metabolic-related disorders
|
WO2004052315A2
(en)
|
2002-12-11 |
2004-06-24 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
SE0203754D0
(sv)
|
2002-12-17 |
2002-12-17 |
Astrazeneca Ab |
New compounds
|
SE0203752D0
(sv)
|
2002-12-17 |
2002-12-17 |
Astrazeneca Ab |
New compounds
|
GEP20084341B
(en)
|
2003-02-26 |
2008-03-25 |
Sugen Inc |
Aminoheteroaryl compounds as protein kinase inhibitors
|
EP1599482A4
(en)
|
2003-02-28 |
2008-10-01 |
Teijin Pharma Ltd |
PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
|
EP1606267B1
(en)
|
2003-03-11 |
2008-07-30 |
Pfizer Products Inc. |
Pyrazine compounds as transforming growth factor (tgf) inhibitors
|
JP2006520794A
(ja)
|
2003-03-21 |
2006-09-14 |
スミスクライン ビーチャム コーポレーション |
化合物
|
EP1608622A4
(en)
|
2003-03-24 |
2009-04-01 |
Merck & Co Inc |
BIARYLSUBSTITUTED 6-LOW HETEROCYCLES AS SODIUM CHANNEL BLOCKERS
|
GB2400101A
(en)
|
2003-03-28 |
2004-10-06 |
Biofocus Discovery Ltd |
Compounds capable of binding to the active site of protein kinases
|
US20060252741A1
(en)
|
2003-05-15 |
2006-11-09 |
Colandrea Vincent J |
3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists
|
AR045595A1
(es)
|
2003-09-04 |
2005-11-02 |
Vertex Pharma |
Composiciones utiles como inhibidores de proteinas quinasas
|
BRPI0414533A
(pt)
|
2003-09-18 |
2006-11-07 |
Conforma Therapeutics Corp |
composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90
|
US7807696B2
(en)
|
2003-10-07 |
2010-10-05 |
The Feinstein Institute For Medical Research |
Isoxazole and isothiazole compounds useful in the treatment of inflammation
|
AU2004293019B2
(en)
|
2003-11-19 |
2010-10-28 |
Array Biopharma Inc. |
Bicyclic inhibitors of MEK and methods of use thereof
|
DE10356579A1
(de)
|
2003-12-04 |
2005-07-07 |
Merck Patent Gmbh |
Aminderivate
|
JP2007524682A
(ja)
|
2004-02-12 |
2007-08-30 |
メルク エンド カムパニー インコーポレーテッド |
代謝調節型グルタミン酸受容体−5の調節物質としてのビピリジルアミド
|
JP2007523939A
(ja)
|
2004-02-25 |
2007-08-23 |
ビーエーエスエフ アクチェンゲゼルシャフト |
アゾロピリミジン化合物及び寄生性菌類を駆除するためのその使用
|
WO2005117909A2
(en)
|
2004-04-23 |
2005-12-15 |
Exelixis, Inc. |
Kinase modulators and methods of use
|
WO2005123672A2
(en)
|
2004-06-14 |
2005-12-29 |
Takeda San Diego, Inc. |
Kinase inhibitors
|
CA2573573A1
(en)
|
2004-07-27 |
2006-02-09 |
Sgx Pharmaceuticals, Inc. |
Fused ring heterocycle kinase modulators
|
US7626021B2
(en)
|
2004-07-27 |
2009-12-01 |
Sgx Pharmaceuticals, Inc. |
Fused ring heterocycle kinase modulators
|
US7528138B2
(en)
|
2004-11-04 |
2009-05-05 |
Vertex Pharmaceuticals Incorporated |
Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
|
US8003806B2
(en)
|
2004-11-12 |
2011-08-23 |
OSI Pharmaceuticals, LLC |
Integrin antagonists useful as anticancer agents
|
WO2006058074A1
(en)
|
2004-11-22 |
2006-06-01 |
Vertex Pharmaceuticals Incorporated |
Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases
|
GB0428235D0
(en)
|
2004-12-23 |
2005-01-26 |
Glaxo Group Ltd |
Novel compounds
|
US20080269249A2
(en)
|
2004-12-27 |
2008-10-30 |
Alcon, Inc. |
Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases and conditions
|
US7635699B2
(en)
|
2004-12-29 |
2009-12-22 |
Bristol-Myers Squibb Company |
Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
|
GB0500492D0
(en)
|
2005-01-11 |
2005-02-16 |
Cyclacel Ltd |
Compound
|
US20060156482A1
(en)
|
2005-01-14 |
2006-07-20 |
The Procter & Gamble Company |
Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
|
US7622583B2
(en)
|
2005-01-14 |
2009-11-24 |
Chemocentryx, Inc. |
Heteroaryl sulfonamides and CCR2
|
GB0501999D0
(en)
|
2005-02-01 |
2005-03-09 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
CN101163692B
(zh)
|
2005-02-16 |
2012-01-18 |
先灵公司 |
具有cxcr3拮抗活性的杂环取代的哌嗪
|
DE102005007534A1
(de)
|
2005-02-17 |
2006-08-31 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
ATE524467T1
(de)
|
2005-04-25 |
2011-09-15 |
Merck Patent Gmbh |
Neuartige aza-heterozyklen als kinase-inhibitoren
|
US20070155737A1
(en)
|
2005-05-20 |
2007-07-05 |
Alantos Pharmaceuticals, Inc. |
Heterobicyclic metalloprotease inhibitors
|
US20070155738A1
(en)
|
2005-05-20 |
2007-07-05 |
Alantos Pharmaceuticals, Inc. |
Heterobicyclic metalloprotease inhibitors
|
BRPI0609802A2
(pt)
|
2005-05-20 |
2017-05-02 |
Alantos Pharmaceuticals Holding Inc |
composto, composição farmacêutica e uso de um composto
|
WO2007015632A1
(en)
|
2005-08-04 |
2007-02-08 |
Cgk Co., Ltd. |
Atm and atr inhibitor
|
EP1940847A2
(en)
|
2005-10-06 |
2008-07-09 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
EP1942900B1
(en)
|
2005-10-06 |
2015-06-03 |
Merck Sharp & Dohme Corp. |
Use of pyrazolo [1,5-a] pyrimidine derivatives for inhibiting kinases methods for inhibiting protein kinases
|
WO2007044407A2
(en)
|
2005-10-06 |
2007-04-19 |
Schering Corporation |
Pyrazolo (1 , 5a) pyrimidines as protein kinase inhibitors
|
ATE533770T1
(de)
|
2005-10-06 |
2011-12-15 |
Schering Corp |
Pyrazolopyrimidine als proteinkinaseinhibitoren
|
US8372851B2
(en)
|
2005-10-21 |
2013-02-12 |
Exelixis, Inc. |
Pyrazolo pyrimidines as casein kinase II (CK2) modulators
|
AR056876A1
(es)
|
2005-10-21 |
2007-10-31 |
Tanabe Seiyaku Co |
Compuestos de pirazolo[1-5-a]pirimidina, antagonistas de receptores canabinoides cb1, composiciones farmaceuticas que los contienen y usos en el tratamiento de enfermedades del sistema nervioso central, tales como trastornos psicoticos, neurologicos y similares
|
TW200736260A
(en)
|
2005-11-10 |
2007-10-01 |
Smithkline Beecham Corp |
Inhibitors of Akt activity
|
DE602006011363D1
(de)
|
2005-12-01 |
2010-02-04 |
Hoffmann La Roche |
Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmer
|
WO2007066805A1
(ja)
|
2005-12-09 |
2007-06-14 |
Meiji Seika Kaisha, Ltd. |
リンコマイシン誘導体およびこれを有効成分とする抗菌剤
|
US7655662B2
(en)
|
2005-12-22 |
2010-02-02 |
Alcon Research, Ltd. |
(Indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines for treating glaucoma and controlling intraocular pressure
|
ITMI20060311A1
(it)
|
2006-02-21 |
2007-08-22 |
Btsr Int Spa |
Dispositivo perfezionato di alimentazione di filo o filatio ad una macchina tessile e metodo per attuare tale alimentazione
|
GB0603684D0
(en)
|
2006-02-23 |
2006-04-05 |
Novartis Ag |
Organic compounds
|
WO2007096764A2
(en)
|
2006-02-27 |
2007-08-30 |
Glenmark Pharmaceuticals S.A. |
Bicyclic heteroaryl derivatives as cannabinoid receptor modulators
|
TW200800203A
(en)
|
2006-03-08 |
2008-01-01 |
Astrazeneca Ab |
New use
|
CN101479255B
(zh)
|
2006-03-22 |
2013-05-01 |
沃泰克斯药物股份有限公司 |
用于治疗增殖性病症的c-MET蛋白激酶抑制剂
|
BRPI0709699A2
(pt)
|
2006-03-29 |
2011-07-26 |
Foldrx Pharmaceuticals Inc |
inibiÇço da toxidez da alfa-sinucleina
|
EP2001870A2
(en)
|
2006-03-31 |
2008-12-17 |
Schering Corporation |
Kinase inhibitors
|
KR20090019796A
(ko)
|
2006-05-22 |
2009-02-25 |
쉐링 코포레이션 |
CDK 억제제로서의 피라졸로[1,5-a]피리미딘
|
ATE456565T1
(de)
|
2006-06-22 |
2010-02-15 |
Biovitrum Ab Publ |
Pyridin- und pyrazinderivate als mnk- kinaseinhibitoren
|
US9216963B2
(en)
|
2006-06-22 |
2015-12-22 |
Medibeacon Inc. |
Pyrazine derivatives with extended conjugation and methods of using the same in optical applications
|
AR061793A1
(es)
|
2006-07-05 |
2008-09-24 |
Mitsubishi Tanabe Pharma Corp |
Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
PE20121506A1
(es)
|
2006-07-14 |
2012-11-26 |
Amgen Inc |
Compuestos triazolopiridinas como inhibidores de c-met
|
US8198448B2
(en)
|
2006-07-14 |
2012-06-12 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
WO2008037477A1
(en)
|
2006-09-29 |
2008-04-03 |
Novartis Ag |
Pyrazolopyrimidines as p13k lipid kinase inhibitors
|
GB0619342D0
(en)
|
2006-09-30 |
2006-11-08 |
Vernalis R&D Ltd |
New chemical compounds
|
BRPI0717845A2
(pt)
|
2006-10-04 |
2015-06-16 |
Hoffmann La Roche |
Uso de compostos, composições farmacêuticas e métodos para o tratamento e/ou profilaxia de enfermidades que podem ser tratadas com agentes de elevação de colesterol-hdl e compostos
|
NZ576278A
(en)
|
2006-10-19 |
2011-12-22 |
Signal Pharm Llc |
Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
|
CN101600714B
(zh)
|
2006-11-10 |
2013-08-21 |
百时美施贵宝公司 |
吡咯并吡啶激酶抑制剂
|
AU2007321924A1
(en)
|
2006-11-20 |
2008-05-29 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic metalloprotease inhibitors
|
CL2007003627A1
(es)
|
2006-12-15 |
2008-07-25 |
Bayer Schering Pharma Ag |
Compuestos derivados de 3-h-pirazolopiridinas; metodo de preparacion; composicion farmaceutica; y uso para el tratamiento de enfermedades de crecimiento vascular desregulado tal como leucemia mielogena aguda, retinopatia, artritis reumatoide, psorias
|
AU2007338792B2
(en)
|
2006-12-20 |
2012-05-31 |
Amgen Inc. |
Substituted heterocycles and methods of use
|
PE20081581A1
(es)
|
2006-12-21 |
2008-11-12 |
Plexxikon Inc |
COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
|
GB0625659D0
(en)
|
2006-12-21 |
2007-01-31 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
WO2008103277A2
(en)
|
2007-02-16 |
2008-08-28 |
Amgen Inc. |
Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors
|
BRPI0808523A2
(pt)
|
2007-03-01 |
2014-08-19 |
Novartis Vaccines & Diagnostic |
Inibidores de pim cinase e métodos de seu uso
|
NZ580241A
(en)
|
2007-04-10 |
2011-02-25 |
Bayer Cropscience Ag |
Insecticidal aryl isoxazoline derivatives
|
PE20090288A1
(es)
|
2007-05-10 |
2009-04-03 |
Smithkline Beecham Corp |
Derivados de quinoxalina como inhibidores de la pi3 quinasa
|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
EP2014661A1
(de)
|
2007-06-13 |
2009-01-14 |
Bayer CropScience AG |
Heterocyclisch substituierte Heterocyclyl-carbonsäurederivate
|
UY31137A1
(es)
|
2007-06-14 |
2009-01-05 |
Smithkline Beecham Corp |
Derivados de quinazolina como inhibidores de la pi3 quinasa
|
WO2008156174A1
(ja)
|
2007-06-21 |
2008-12-24 |
Taisho Pharmaceutical Co., Ltd. |
ピラジンアミド化合物
|
CA2691003A1
(en)
|
2007-06-26 |
2008-12-31 |
Lexicon Pharmaceuticals, Inc. |
Methods of treating serotonin-mediated diseases and disorders
|
US20090012103A1
(en)
|
2007-07-05 |
2009-01-08 |
Matthew Abelman |
Substituted heterocyclic compounds
|
WO2009006580A1
(en)
|
2007-07-05 |
2009-01-08 |
Cv Therapeutics, Inc. |
Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers
|
GB0713259D0
(en)
|
2007-07-09 |
2007-08-15 |
Astrazeneca Ab |
Pyrazine derivatives 954
|
MY154668A
(en)
|
2007-07-19 |
2015-07-15 |
Lundbeck & Co As H |
5-membered heterocyclic amides and related compounds
|
JP5241834B2
(ja)
|
2007-07-19 |
2013-07-17 |
メルク・シャープ・アンド・ドーム・コーポレーション |
プロテインキナーゼ阻害剤としての複素環アミド化合物
|
AP2010005167A0
(en)
|
2007-08-01 |
2010-02-28 |
Pfizer |
Pyrazole compounds and their use as RAF inhibitors
|
WO2009017954A1
(en)
|
2007-08-01 |
2009-02-05 |
Phenomix Corporation |
Inhibitors of jak2 kinase
|
WO2009024825A1
(en)
|
2007-08-21 |
2009-02-26 |
Astrazeneca Ab |
2-pyrazinylbenzimidazole derivatives as receptor tyrosine kinase inhibitors
|
EP2203436A1
(en)
|
2007-09-17 |
2010-07-07 |
Neurosearch A/S |
Pyrazine derivatives and their use as potassium channel modulators
|
KR20100089090A
(ko)
|
2007-10-25 |
2010-08-11 |
아스트라제네카 아베 |
세포 증식 장애의 치료에 유용한 피리딘 및 피라진 유도체
|
EP2225247A1
(en)
|
2007-11-28 |
2010-09-08 |
Schering Corporation |
2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
WO2009075790A1
(en)
|
2007-12-07 |
2009-06-18 |
Alantos Pharmaceuticals Holding, Inc. |
Metalloprotease inhibitors for intra-articular application
|
AU2008343173A1
(en)
*
|
2007-12-19 |
2009-07-09 |
Aj Park |
Pyrazolo [1,5-a] pyrimidines useful as JAK2 inhibitors
|
US8703777B2
(en)
|
2008-01-04 |
2014-04-22 |
Intellikine Llc |
Certain chemical entities, compositions and methods
|
EP2085398A1
(en)
|
2008-02-01 |
2009-08-05 |
Merz Pharma GmbH & Co. KGaA |
Pyrazolopyrimidines, a process for their preparation and their use as medicine
|
KR101261514B1
(ko)
|
2008-02-25 |
2013-05-07 |
에프. 호프만-라 로슈 아게 |
피롤로피라진 키나아제 저해제
|
ATE522536T1
(de)
|
2008-02-25 |
2011-09-15 |
Hoffmann La Roche |
Pyrrolopyrazin-kinasehemmer
|
CN101952296B
(zh)
|
2008-02-25 |
2013-08-21 |
霍夫曼-拉罗奇有限公司 |
吡咯并吡嗪激酶抑制剂
|
WO2009106445A1
(en)
|
2008-02-25 |
2009-09-03 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazine kinase inhibitors
|
TW200940537A
(en)
|
2008-02-26 |
2009-10-01 |
Astrazeneca Ab |
Heterocyclic urea derivatives and methods of use thereof
|
JP2011515401A
(ja)
|
2008-03-20 |
2011-05-19 |
アムジエン・インコーポレーテツド |
オーロラキナーゼモジュレーターおよび使用方法
|
WO2009152087A1
(en)
|
2008-06-10 |
2009-12-17 |
Plexxikon, Inc. |
Bicyclic heteroaryl compounds and methods for kinase modulation, and indications therefor
|
WO2010006086A2
(en)
|
2008-07-08 |
2010-01-14 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
GB0814364D0
(en)
|
2008-08-05 |
2008-09-10 |
Eisai London Res Lab Ltd |
Diazaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase
|
JP2011530511A
(ja)
|
2008-08-05 |
2011-12-22 |
メルク・シャープ・エンド・ドーム・コーポレイション |
治療用化合物
|
US8853125B2
(en)
|
2008-09-24 |
2014-10-07 |
Basf Se |
Pyrazole compounds for controlling invertebrate pests
|
AU2009307770A1
(en)
|
2008-10-21 |
2010-04-29 |
Vertex Pharmaceuticals Incorporated |
C-Met protein kinase inhibitors
|
AU2009308675A1
(en)
|
2008-10-31 |
2010-05-06 |
Genentech, Inc. |
Pyrazolopyrimidine JAK inhibitor compounds and methods
|
JP5702293B2
(ja)
|
2008-11-10 |
2015-04-15 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atrキナーゼの阻害剤として有用な化合物
|
WO2010059836A1
(en)
|
2008-11-20 |
2010-05-27 |
Decode Genetics Ehf |
Substituted aza-bridged bicyclics for cardiovascular and cns disease
|
AU2009324894B2
(en)
|
2008-11-25 |
2015-04-09 |
University Of Rochester |
MLK inhibitors and methods of use
|
SG171956A1
(en)
|
2008-12-05 |
2011-07-28 |
Hoffmann La Roche |
Pyrrolopyrazinyl urea kinase inhibitors
|
SI3354650T1
(sl)
|
2008-12-19 |
2022-06-30 |
Vertex Pharmaceuticals Incorporated |
Spojine, uporabne kot zaviralci ATR kinaze
|
RU2505540C2
(ru)
|
2008-12-23 |
2014-01-27 |
Эббви Инк. |
Антивирусные соединения
|
WO2010086040A1
(en)
|
2009-01-29 |
2010-08-05 |
Biomarin Iga, Ltd. |
Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
|
US8492582B2
(en)
|
2009-01-30 |
2013-07-23 |
Toyama Chemical Co., Ltd. |
N-acyl anthranilic acid derivative or salt thereof
|
US20100204265A1
(en)
|
2009-02-09 |
2010-08-12 |
Genelabs Technologies, Inc. |
Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
|
SG173639A1
(en)
|
2009-02-11 |
2011-09-29 |
Sunovion Pharmaceuticals Inc |
Histamine h3 inverse agonists and antagonists and methods of use thereof
|
CN101537007A
(zh)
|
2009-03-18 |
2009-09-23 |
中国医学科学院血液病医院(血液学研究所) |
N-(噻吩-2)吡唑并[1,5-a]嘧啶-3-甲酰胺类化合物在制备抗恶性肿瘤药物方面的应用
|
WO2010111653A2
(en)
|
2009-03-27 |
2010-09-30 |
The Uab Research Foundation |
Modulating ires-mediated translation
|
UA110324C2
(en)
|
2009-07-02 |
2015-12-25 |
Genentech Inc |
Jak inhibitory compounds based on pyrazolo pyrimidine
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
CN102471345A
(zh)
|
2009-07-15 |
2012-05-23 |
雅培制药有限公司 |
激酶的吡咯并吡嗪抑制剂
|
JP5819831B2
(ja)
|
2009-08-17 |
2015-11-24 |
インテリカイン, エルエルシー |
複素環式化合物およびそれらの使用
|
US8669259B2
(en)
|
2009-08-26 |
2014-03-11 |
Merck Sharp & Dohme Corp. |
Heterocyclic amide compounds as protein kinase inhibitors
|
CN101671336B
(zh)
|
2009-09-23 |
2013-11-13 |
辽宁利锋科技开发有限公司 |
芳杂环并嘧啶衍生物和类似物及其制备方法和用途
|
PL2509602T3
(pl)
|
2009-12-04 |
2017-08-31 |
Senhwa Biosciences, Inc. |
Pirazolopirymidyny i podobne heterocykle jako inhibitory ck2
|
DE112009005466T5
(de)
|
2009-12-22 |
2012-10-31 |
Intel Corporation |
Verfahren und Vorrichtung zum Bereitstellen einer sicheren Anwendungsausführung
|
SG184073A1
(en)
|
2010-03-18 |
2012-10-30 |
Pasteur Institut Korea |
Anti-infective compounds
|
US8518945B2
(en)
|
2010-03-22 |
2013-08-27 |
Hoffmann-La Roche Inc. |
Pyrrolopyrazine kinase inhibitors
|
WO2011121096A1
(en)
|
2010-03-31 |
2011-10-06 |
Dkfz Deutsches Krebsforschungszentrum |
PYRAZOL[1,5-a]PYRIMIDINE DERIVATIVES AS WNT PATHWAY ANTAGONISTS
|
AU2011236510A1
(en)
|
2010-04-08 |
2012-10-11 |
Zoetis Llc |
Substituted 3,5- di phenyl - isoxazoline derivatives as insecticides and acaricides
|
EP2558866B1
(en)
|
2010-04-15 |
2016-08-17 |
Tracon Pharmaceuticals, Inc. |
Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
|
EP2569287B1
(en)
|
2010-05-12 |
2014-07-09 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
EP2569286B1
(en)
|
2010-05-12 |
2014-08-20 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
EP2568984A1
(en)
|
2010-05-12 |
2013-03-20 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
US8962631B2
(en)
|
2010-05-12 |
2015-02-24 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
RU2012153675A
(ru)
|
2010-05-12 |
2014-06-20 |
Вертекс Фармасьютикалз Инкорпорейтед |
Соединения, пригодные в качестве ингибиторов atr киназы
|
CN102947272A
(zh)
|
2010-05-12 |
2013-02-27 |
沃泰克斯药物股份有限公司 |
用作atr激酶抑制剂的2-氨基吡啶衍生物
|
BR112012029437A2
(pt)
|
2010-05-20 |
2017-03-07 |
F Hoffmann - La Roche Ag |
derivados de pirrolo[2,3-b]pirazina-7-carboxamida e seu uso como inibidores de jak e syk
|
MX2012013194A
(es)
|
2010-05-20 |
2013-01-22 |
Hoffmann La Roche |
Derivados pirrolopirazinas como inhibidores de cinasas tirocina-cinasa del baso (syk) y cinasa de janus (jak).
|
WO2011163527A1
(en)
|
2010-06-23 |
2011-12-29 |
Vertex Pharmaceuticals Incorporated |
Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
|
ES2571334T3
(es)
|
2010-06-24 |
2016-05-24 |
Gilead Sciences Inc |
Pirazolo[1,5-a]pirimidinas y -triazinas como agentes antivirales
|
CN102311396B
(zh)
|
2010-07-05 |
2015-01-07 |
暨南大学 |
一种吡嗪类衍生物和其制备方法及在制药中的应用
|
CN110003219A
(zh)
|
2010-07-13 |
2019-07-12 |
弗·哈夫曼-拉罗切有限公司 |
作为irak4调节剂的吡唑并[1,5a]嘧啶和噻吩并[3,2b]嘧啶衍生物
|
EP2407478A1
(en)
|
2010-07-14 |
2012-01-18 |
GENETADI Biotech, S.L. |
New cyclotetrapeptides with pro-angiogenic properties
|
WO2012022045A1
(en)
|
2010-08-20 |
2012-02-23 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
US8883801B2
(en)
|
2010-08-23 |
2014-11-11 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
|
WO2012067822A1
(en)
|
2010-11-16 |
2012-05-24 |
Abbott Laboratories |
Pyrazolo [1, 5 -a] pyrimidin potassium channel modulators
|
US9370567B2
(en)
|
2010-11-16 |
2016-06-21 |
Array Biopharma Inc. |
Combination of checkpoint kinase 1 inhibitors and WEE 1 kinase inhibitors
|
JP6154746B2
(ja)
|
2010-12-08 |
2017-06-28 |
ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ |
グルコセレブロシダーゼ活性剤としての置換ピラゾロピリミジン類
|
CA2825098C
(en)
|
2011-01-27 |
2020-03-10 |
Universite De Montreal |
Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
|
WO2012138938A1
(en)
*
|
2011-04-05 |
2012-10-11 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazine compounds useful as inhibitors of tra kinase
|
CA2833698A1
(en)
|
2011-04-21 |
2012-10-26 |
Bayer Intellectual Property Gmbh |
Fluoroalkyl-substituted pyrazolopyridines and use thereof
|
US9029389B2
(en)
|
2011-04-21 |
2015-05-12 |
Institut Pasteur Korea |
Anti-inflammation compounds
|
EP2710006A1
(en)
|
2011-05-17 |
2014-03-26 |
Principia Biopharma Inc. |
Azaindole derivatives as tyrosine kinase inhibitors
|
JP2014522818A
(ja)
|
2011-06-22 |
2014-09-08 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
JP2014517079A
(ja)
|
2011-06-22 |
2014-07-17 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
CA2840224C
(en)
|
2011-06-22 |
2019-08-13 |
The General Hospital Corporation |
Treatment of proteinopathies
|
WO2012178123A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
WO2013010136A2
(en)
|
2011-07-13 |
2013-01-17 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
WO2013052263A2
(en)
|
2011-09-16 |
2013-04-11 |
Microbiotix, Inc. |
Antifungal compounds
|
US8853217B2
(en)
|
2011-09-30 |
2014-10-07 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
IN2014KN00929A
(pt)
|
2011-09-30 |
2015-08-21 |
Vertex Pharma |
|
JP2014528419A
(ja)
|
2011-09-30 |
2014-10-27 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atrキナーゼ阻害剤として有用な化合物
|
EP2751088B1
(en)
|
2011-09-30 |
2016-04-13 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
CN108685922A
(zh)
|
2011-09-30 |
2018-10-23 |
沃泰克斯药物股份有限公司 |
用atr抑制剂治疗胰腺癌和非小细胞肺癌
|
KR20140077963A
(ko)
|
2011-10-20 |
2014-06-24 |
글락소스미스클라인 엘엘씨 |
시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체
|
EP2776420A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
JP2015502925A
(ja)
|
2011-11-09 |
2015-01-29 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atrキナーゼの阻害剤として有用なピラジン化合物
|
EP2776421A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
US8841337B2
(en)
|
2011-11-09 |
2014-09-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
WO2013071094A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
WO2013138436A1
(en)
|
2012-03-14 |
2013-09-19 |
Bristol-Myers Squibb Company |
Cyclolic hydrazine derivatives as hiv attachment inhibitors
|
AR090548A1
(es)
|
2012-04-02 |
2014-11-19 |
Incyte Corp |
Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
|
JP6345645B2
(ja)
|
2012-04-02 |
2018-06-20 |
サイトキネティックス, インコーポレイテッド |
横隔膜機能を向上させるための方法
|
PL2833973T3
(pl)
|
2012-04-05 |
2018-02-28 |
Vertex Pharmaceuticals Incorporated |
Związki użyteczne jako inhibitory kinazy ATR i ich terapie skojarzone
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
CN103373996A
(zh)
|
2012-04-20 |
2013-10-30 |
山东亨利医药科技有限责任公司 |
作为crth2受体拮抗剂的二并环衍生物
|
KR20240023685A
(ko)
|
2012-05-15 |
2024-02-22 |
캔써 리서치 테크놀로지 리미티드 |
5-[[4-[[모르폴린-2-일]메틸아미노]-5-(트리플루오로메틸)-2-피리딜]아미노]피라진-2-카보니트릴및 그의 치료적 용도
|
US20130317021A1
(en)
|
2012-05-23 |
2013-11-28 |
Savira Pharmaceuticals Gmbh |
Heterocyclic pyrimidine carbonic acid derivatives which are useful in the treatment, amelioration or prevention of a viral disease
|
JP2015517555A
(ja)
|
2012-05-23 |
2015-06-22 |
ザヴィラ ファーマシューティカルズ ゲーエムベーハー |
7−オキソ−チアゾロピリジン炭酸誘導体及びウイルス性疾患の治療、改善又は予防におけるその使用
|
WO2014011911A2
(en)
|
2012-07-11 |
2014-01-16 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
WO2014015523A1
(en)
|
2012-07-27 |
2014-01-30 |
Hutchison Medipharma Limited |
Novel heteroaryl and heterocycle compounds, compositions and methods
|
RU2015107803A
(ru)
|
2012-08-06 |
2016-09-27 |
Савира Фармасьютикалз Гмбх |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(zh)
|
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|
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|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(es)
|
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|
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(ja)
|
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|
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(en)
|
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|
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|
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|
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|
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|
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|
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|
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(pt)
|
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|
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|
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|