TR200103454T2 - Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları. - Google Patents

Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları.

Info

Publication number
TR200103454T2
TR200103454T2 TR2001/03454T TR200103454T TR200103454T2 TR 200103454 T2 TR200103454 T2 TR 200103454T2 TR 2001/03454 T TR2001/03454 T TR 2001/03454T TR 200103454 T TR200103454 T TR 200103454T TR 200103454 T2 TR200103454 T2 TR 200103454T2
Authority
TR
Turkey
Prior art keywords
estrogen receptor
selective estrogen
sex steroid
combination
receptor modulator
Prior art date
Application number
TR2001/03454T
Other languages
English (en)
Inventor
Labrie Fernand
Original Assignee
Endorecherche, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endorecherche, Inc. filed Critical Endorecherche, Inc.
Publication of TR200103454T2 publication Critical patent/TR200103454T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Dehidroepiandrosteron, dehidroepiandrosteron sülfat, androst-5-en-3 , 17 -diol ve kendisinden birine in vivo olarak dönüstürülen bilesiklerden olusan gruptan seçilen bir cinsiyet steroidi öncünün bir miktari ve selektif östrojen reseptör modülatörü, bilhassa, genel yapi (I)'e sahip olan bilesiklerin verilmesini içeren, insanlar da dahil olmak üzere, hassas sicak kanli hayvanlardaki arteryoskleroz, hiperlipidemi, hiperkolesterolemi, gögüs kanseri veya osteoporozun tibbi tedavisi ve/veya bunlarin gelisiminin inhibisyonu için yeni metotlar. Selektif östrojen reseptör modülatörleri ve/veya cinsiyet steroidi öncüsü ile kombinasyon halindeki bifosfonatlarin ilave olarak verilmesi; osteoporozun tibbi tedavisi ve/veya bunlarin gelisiminin inhibisyonu için bildirilmektedir. Bulusa faydali aktif muhteviyat ve kitlerin dagitilmasi için farmasötik kompozisyonlar da bildirilmeketedir. (Formül I)
TR2001/03454T 1998-06-11 1999-06-10 Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları. TR200103454T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/096,284 US6465445B1 (en) 1998-06-11 1998-06-11 Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors

Publications (1)

Publication Number Publication Date
TR200103454T2 true TR200103454T2 (tr) 2002-06-21

Family

ID=22256661

Family Applications (5)

Application Number Title Priority Date Filing Date
TR2001/03456T TR200103456T2 (tr) 1998-06-11 1999-06-10 Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları.
TR2001/03455T TR200103455T2 (tr) 1998-06-11 1999-06-10 Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları
TR2001/03454T TR200103454T2 (tr) 1998-06-11 1999-06-10 Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları.
TR2001/03453T TR200103453T2 (tr) 1998-06-11 1999-06-10 Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları
TR2001/00551T TR200100551T2 (tr) 1998-06-11 1999-06-10 Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları

Family Applications Before (2)

Application Number Title Priority Date Filing Date
TR2001/03456T TR200103456T2 (tr) 1998-06-11 1999-06-10 Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları.
TR2001/03455T TR200103455T2 (tr) 1998-06-11 1999-06-10 Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları

Family Applications After (2)

Application Number Title Priority Date Filing Date
TR2001/03453T TR200103453T2 (tr) 1998-06-11 1999-06-10 Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları
TR2001/00551T TR200100551T2 (tr) 1998-06-11 1999-06-10 Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları

Country Status (29)

Country Link
US (6) US6465445B1 (tr)
EP (5) EP1083905B1 (tr)
JP (3) JP2002517433A (tr)
KR (6) KR20090018870A (tr)
CN (2) CN1240388C (tr)
AR (1) AR043075A1 (tr)
AT (1) ATE308326T1 (tr)
AU (1) AU4253099A (tr)
BR (1) BR9911116A (tr)
CA (7) CA2768882C (tr)
CY (4) CY1113712T1 (tr)
DE (1) DE69928104T2 (tr)
DK (5) DK1623712T3 (tr)
ES (5) ES2253922T3 (tr)
HK (1) HK1040367B (tr)
HU (2) HU230495B1 (tr)
ID (1) ID28696A (tr)
IL (3) IL140178A0 (tr)
MX (1) MXPA00012306A (tr)
MY (3) MY125047A (tr)
NO (2) NO331022B1 (tr)
NZ (1) NZ508801A (tr)
PL (4) PL203343B1 (tr)
PT (4) PT1623712E (tr)
RU (1) RU2246947C2 (tr)
TR (5) TR200103456T2 (tr)
TW (2) TWI371279B (tr)
WO (1) WO1999063974A2 (tr)
ZA (1) ZA200007297B (tr)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0862445B2 (en) * 1995-10-06 2017-03-22 Arch Development Corporation Combination of herpes simplex virus and chemotherapy for treating cancer
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) * 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
ATE232525T1 (de) * 1998-08-14 2003-02-15 Schering Corp Enanthioauswählende synthese
US20030060425A1 (en) * 1998-11-24 2003-03-27 Ahlem Clarence N. Immune modulation method using steroid compounds
AU2156800A (en) * 1998-12-18 2000-07-12 Schering Corporation Oral antiestrogen pharmaceutical composition
PE20010404A1 (es) 1999-06-11 2001-04-09 Watson Pharmaceuticals Inc Combinacion de esteroides androgenicos no orales y compuestos estrogenicos y su uso en mujeres
EP1196163B1 (en) * 1999-07-06 2009-11-11 Endorecherche Inc. Pharmaceutical compositions for the treatment of insulin resistance
WO2001026651A2 (en) * 1999-10-14 2001-04-19 Endorecherche, Inc. Selective estrogen receptor modulators in the treatment or reduction of the risk of acquiring hypertension, cardiovascular diseases, and insulin resistance
TW593256B (en) * 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
RU2342145C2 (ru) * 2000-01-28 2008-12-27 Андорешерш, Инк. Селективные модуляторы рецептора эстрогена в комбинации с эстрогенами
WO2001062259A1 (en) 2000-02-25 2001-08-30 Hollis Eden Pharmaceuticals Method of treatment of prostate cancer
JP4896335B2 (ja) * 2000-03-01 2012-03-14 ナームローゼ・フエンノートチヤツプ・オルガノン エストロゲン化合物としてのクロマン誘導体
AU2001273144A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating neuropeptide y-related conditions
JP2004502734A (ja) * 2000-07-06 2004-01-29 ワイス 一酸化窒素シンターゼ活性の増強方法
AU2001273125A1 (en) * 2000-07-06 2002-01-21 American Home Products Corporation Combinations of bisphosphonates, estrogenic agents and optionally estrogens
PT1318837E (pt) 2000-08-11 2004-12-31 Wyeth Corp Metodo de tratamenton de carcinoma positivo a receptor de estrogenio
EP1192945A3 (en) * 2000-09-21 2004-03-03 Pfizer Products Inc. Use of an estrogen agonist/antagonist for treating osteoarthritis
IL145876A0 (en) * 2000-10-17 2002-07-25 Pfizer Prod Inc Methods and kits for improving vascular health
AU781168B2 (en) * 2001-01-26 2005-05-12 Pfizer Products Inc. Method of treating certain cancers using an estrogen agonist/antagonist
FR2827764B1 (fr) * 2001-07-27 2005-08-19 Oreal Composition, notamment cosmetique, renfermant un steroide et un glycol
HUP0401268A2 (hu) 2001-07-31 2004-11-29 Pfizer Products Inc. Ösztrogén agonisták/antagonisták, ösztrogének és progesztinek kombinációját tartalmazó gyógyszerkészítmények, valamint eljárás ezek előállítására
US20040044226A1 (en) * 2001-10-15 2004-03-04 Dininno Frank P. Estrogen receptor modulators
JP4554219B2 (ja) * 2002-04-24 2010-09-29 メルク・シャープ・エンド・ドーム・コーポレイション エストロゲン受容体調節剤
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
US20050095241A1 (en) * 2003-08-26 2005-05-05 Vadlamudi Ratna K. Estrogen receptor modulators and uses thereof
ATE532777T1 (de) 2004-09-21 2011-11-15 Marshall Edwards Inc Substituierte chromanderivate, medikamente und anwendungen in der therapie
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
US8941594B2 (en) * 2004-10-01 2015-01-27 Nvidia Corporation Interface, circuit and method for interfacing with an electronic device
WO2006042409A1 (en) * 2004-10-20 2006-04-27 Endorecherche, Inc. Sex steroid precursors alone or in combination with a selective estrogen receptor modulator and/or with estrogens and/or a type 5 cgmp phosphodiesterase inhibitor for the prevention and treatment of vaginal dryness and sexual dysfunction in postmenopausal women
JP5042209B2 (ja) 2005-03-24 2012-10-03 ノーラブズ エービー 酸化窒素による美容治療、前記治療を実施する装置、及びその製造方法
WO2007135547A2 (en) 2006-05-22 2007-11-29 Hormos Medical Ltd. Selective estrogen receptor modulators or aromatase inhibitors for treating chronic nonbacterial prostatitis
WO2007143607A2 (en) 2006-06-02 2007-12-13 Pear Tree Women's Health Care Method of treating atrophic vaginitis
JP5363344B2 (ja) 2007-02-14 2013-12-11 ホルモス メディカル リミテッド 治療に有用なトリフェニルブテン誘導体の調製方法
US7504530B2 (en) 2007-02-14 2009-03-17 Hormos Medical Ltd. Methods for the preparation of fispemifene from ospemifene
US8268806B2 (en) * 2007-08-10 2012-09-18 Endorecherche, Inc. Pharmaceutical compositions
AU2012204083C1 (en) * 2007-08-10 2015-02-05 Myriel Pharmaceuticals, Llc DHEA compositions for treating menopause
US20100048914A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2010036822A1 (en) * 2008-09-24 2010-04-01 Hollis-Eden Pharmaceuticals, Inc. Patient populations and treatment methods
EP3023433A1 (en) * 2009-02-05 2016-05-25 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
US20120142645A1 (en) * 2009-03-17 2012-06-07 Marx Christine E Neuroactive steroid compositions and methods of use for lowering cholesterol
US20100317635A1 (en) * 2009-06-16 2010-12-16 Endorecherche, Inc. Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators
AU2014201406B2 (en) * 2009-06-16 2016-08-11 Endorecherche, Inc. Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators
ES2627692T3 (es) 2010-06-10 2017-07-31 Aragon Pharmaceuticals, Inc. Moduladores de receptores de estrógenos y usos de los mismos
KR20130031339A (ko) * 2010-06-16 2013-03-28 앙도르쉐르슈 인코포레이티드 에스트로겐-관련 질병의 치료 또는 예방 방법
JP6013349B2 (ja) 2010-11-01 2016-10-25 メイ ファーマ, インク.Mei Pharma, Inc. 癌の処置のためのイソフラボノイド化合物および方法
WO2013006608A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Topical compositions
WO2013006613A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Methods of manufacturing topical compositions and apparatus for same
ES2545337T3 (es) * 2011-07-19 2015-09-10 Pantarhei Bioscience B.V. Comprimido que contiene dehidroepiandrosterona (DHEA)
US9320744B2 (en) 2011-10-19 2016-04-26 Dhea Llc DHEA bioadhesive controlled release gel
LT2782584T (lt) 2011-11-23 2021-09-10 Therapeuticsmd, Inc. Natūralios kombinuotos pakaitinės hormonų terapijos kompozicijos ir gydymas
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2013090829A1 (en) 2011-12-14 2013-06-20 Aragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
PE20150099A1 (es) 2011-12-16 2015-01-30 Olema Pharmaceuticals Inc Compuestos novedosos de benzopirano, composiciones y usos de los mismos
CN102631677A (zh) * 2012-04-19 2012-08-15 中国农业大学 一种预防和/或治疗动脉粥样硬化的药物组合物
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
WO2014060639A1 (en) 2012-10-19 2014-04-24 Fermion Oy A process for the preparation of ospemifene
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US9855211B2 (en) 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
EP2968370A4 (en) 2013-03-14 2016-09-21 Univ Maryland AGENT FOR ANDROGEN RECEPTOR DOWNWARD CONTROL AND USES THEREOF
WO2014203132A1 (en) 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Substituted benzopyran compounds, compositions and uses thereof
WO2014203129A1 (en) 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Combinations of benzopyran compounds, compositions and uses thereof
JP6513667B2 (ja) 2013-08-08 2019-05-15 ノヴァン，インコーポレイテッド 局所用組成物およびそれを使用する方法
WO2016022170A1 (en) 2014-08-08 2016-02-11 Novan, Inc. Topical emulsions
BR112016002970A2 (pt) 2013-08-12 2017-09-12 Tokai Pharmaceuticals Inc biomarcadores para o tratamento de distúrbios neoplásicos que usa terapias direcionadas ao androgênio
US9744177B2 (en) 2014-03-10 2017-08-29 Endorecherche, Inc. Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
WO2016007834A1 (en) 2014-07-11 2016-01-14 Novan, Inc. Topical antiviral compositions and methods of using the same
AU2015296609A1 (en) 2014-07-29 2016-12-22 Therapeuticsmd, Inc. Transdermal cream
GB201416186D0 (en) 2014-09-12 2014-10-29 Redx Pharma Ltd Compounds
ES2877712T3 (es) 2015-02-02 2021-11-17 Mei Pharma Inc Terapias combinadas para su uso en el tratamiento del cáncer de mama
US10452661B2 (en) * 2015-06-18 2019-10-22 Microsoft Technology Licensing, Llc Automated database schema annotation
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR102319497B1 (ko) 2016-03-02 2021-11-01 노반, 인크. 염증 치료용 조성물 및 염증 치료 방법
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
KR102426006B1 (ko) 2016-04-13 2022-07-29 노반, 인크. 감염 치료용 조성물, 시스템, 키트, 및 방법
FR3052805B1 (fr) 2016-06-20 2020-06-26 Safran Aircraft Engines Disque aubage monobloc ameliore, partie tournante d'une turbomachine comprenant un tel disque et turbomachine associee
CN109224029A (zh) * 2018-09-30 2019-01-18 泓博元生命科技（深圳）有限公司 含有nmn的降血脂组合物、制剂及其制备方法与应用
US12083130B2 (en) * 2019-10-03 2024-09-10 Caren Pharmaceuticals, Inc. Combination hormone formulations and therapies
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
CA3187514A1 (en) 2020-07-28 2022-02-03 Andrew BELFIELD Fused bicyclic raf inhibitors and methods for use thereof
WO2023156803A1 (en) * 2022-02-17 2023-08-24 Debreceni Egyetem Dhea-derived steroids
CN115554403B (zh) * 2022-08-16 2024-03-08 山东大学 类固醇激素dhea作为受体adgrg2激动剂配体的应用

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US550107A (en) * 1895-11-19 Thirds to henry zervas and julius wegert
US536220A (en) * 1895-03-26 Puzzle
DK122125B (da) 1967-10-04 1972-01-24 Schering Ag Analogifremgangsmåde til fremstilling af terapeutisk aktive carboxylsyreestere af 3β-hydroxy-5-androstan-17-on(dehydroepiandrosteron) med 7-11 carbonatomer i esterresten.
US3797494A (en) 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3797444A (en) 1971-04-19 1974-03-19 H Stubbs Towing guide
US3742951A (en) 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
US4005200A (en) * 1975-07-17 1977-01-25 Kanebo, Ltd. Method for improving the maturity of the parturient canal and the sensitivity to oxytocin
US4496556A (en) 1982-08-16 1985-01-29 Norman Orentreich Topical applications for preventing dry skin
US4542129A (en) 1982-08-16 1985-09-17 Norman Orentreich DHEA Formulations and methods for treating dry skin
DE3333240A1 (de) 1983-09-12 1985-03-28 Schering AG, 1000 Berlin und 4709 Bergkamen Mittel zur transdermalen applikation von arzneimittelwirkstoffen
US4725439A (en) 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
IE58836B1 (en) 1984-08-02 1993-11-17 Labrie Fernand Pharmaceutical composition for combination therapy of hormone dependent cancers
US4624665A (en) 1984-10-01 1986-11-25 Biotek, Inc. Method of transdermal drug delivery
US4568343A (en) 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4666441A (en) 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
IE60941B1 (en) 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US4816258A (en) 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
JP2551590B2 (ja) * 1987-06-26 1996-11-06 株式会社リコー 複写機光学系の速度制御方法
JPS6440428A (en) 1987-08-07 1989-02-10 Daiichi Yakuhin Sangyo Kk Antihyperlipemia
US5064654A (en) 1989-01-11 1991-11-12 Ciba-Geigy Corporation Mixed solvent mutually enhanced transdermal therapeutic system
US5162037A (en) 1988-04-01 1992-11-10 Whitson Laboratories, Inc. Magnetically influenced homeopathic pharmaceutical formulations, methods of their preparation and methods of their administration
HU208150B (en) 1988-10-31 1993-08-30 Endorecherche Inc Process for producing new estrogen derivatives having steroid hormone inhibitor activity and pharmaceutical compositions comprising such derivatives
US5686465A (en) 1988-10-31 1997-11-11 Endorecherche Inc. Sex steroid activity inhibitors
US5393785A (en) 1988-10-31 1995-02-28 Endorecherche, Inc. Therapeutic antiestrogens
US5395842A (en) 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
WO1990006120A1 (en) 1988-12-01 1990-06-14 Schering Corporation Compositions for transdermal delivery of estradiol
US4920115A (en) * 1988-12-28 1990-04-24 Virginia Commonwealth University Method of lowering LDL cholesterol in blood
WO1990010462A1 (en) 1989-03-10 1990-09-20 Endorecherche Inc. Combination therapy for treatment of estrogen sensitive diseases
US5071644A (en) 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels
HU222501B1 (hu) 1991-06-28 2003-07-28 Endorecherche Inc. MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására
ZA924811B (en) 1991-06-28 1993-12-29 Endorecherche Inc Controlled release systems and low dose androgens
US6060503A (en) 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
HUT64815A (en) 1992-09-04 1994-03-28 Berki An external correcting and fixing apparatus for treatment of fractures and defomities of bones as well as correcting unit preferably for external correcting and fixing units
US5354861A (en) 1992-11-04 1994-10-11 National University Of Singapore 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
TW383306B (en) * 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
DE69433994T2 (de) 1993-01-19 2005-09-22 Endorecherche Inc., Ste-Foy Therapeutische verwendungen und verabreichungsysteme von dehydroepiandrosteron
US5776923A (en) 1993-01-19 1998-07-07 Endorecherche, Inc. Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone
DE4401554A1 (de) 1993-02-16 1994-08-18 Freund Andreas Präparat zur Therapie und Prophylaxe von Erkrankungen, die bei Imbalancen von Plasmalipiden auftreten
ES2105525T3 (es) 1993-06-24 1997-10-16 Lilly Co Eli 2-fenil-3-aroilbenzotiofenos antiestrogenicos como agentes hipoglicemicos.
US5441964A (en) 1993-10-15 1995-08-15 Eli Lilly And Company Methods for inhibiting bone loss using substituted benzothiophene
US5391557A (en) 1993-10-15 1995-02-21 Eli Lilly And Company Methods for the treatment of peri-menopausal syndrome
US5418252A (en) 1993-10-15 1995-05-23 Eli Lilly And Company Method for inhibiting cartilage degradation
US5482950A (en) 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
US5407947A (en) 1993-11-05 1995-04-18 Eli Lilly And Company Methods for inhibiting bone loss using pyrolidine and piperidine substituted benzopyrans
US5446061A (en) 1993-11-05 1995-08-29 Eli Lilly And Company Methods for lowering serum cholesterol
PT654267E (pt) 1993-11-19 2002-09-30 Jenapharm Gmbh Carcinoestaticos para terapia hormonal contendo dienogest como componente eficaz
US5389646A (en) 1993-12-30 1995-02-14 Zymogenetics, Inc. Methods for treatment and prevention of bone loss using 2,3-benzopyrans
US5591753A (en) 1994-01-28 1997-01-07 Eli Lilly And Company Combination treatment for osteoporosis
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
US5425429A (en) * 1994-06-16 1995-06-20 Thompson; Michael C. Method and apparatus for forming lateral boreholes
US5681308A (en) 1994-06-24 1997-10-28 Stuart D. Edwards Ablation apparatus for cardiac chambers
PL181304B1 (pl) 1994-07-22 2001-07-31 Lilly Co Eli Preparat farmaceutyczny do hamowania zmniejszania masy kosci PL PL PL PL PL PL PL PL PL PL
US5502074A (en) 1994-08-22 1996-03-26 Eli Lilly And Company Benzothiophenes for bone healing and fracture repair
US5550123A (en) 1994-08-22 1996-08-27 Eli Lilly And Company Methods for inhibiting bone prosthesis degeneration
IL115022A (en) 1994-08-22 2000-07-31 Lilly Co Eli Pharmaceutical compositions for inhibiting endometrial cancer
HUT76891A (en) 1994-08-22 1997-12-29 Lilly Co Eli Use of benzotiophene derivatives for producing pharmaceutical compositions useful for maintaining teeth and oral bone
GB9418067D0 (en) 1994-09-07 1994-10-26 Orion Yhtymae Oy Triphenylethylenes for the prevention and treatment of osteoporosis
US5492921A (en) 1994-09-20 1996-02-20 Eli Lilly And Company Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation
US6703407B1 (en) 1994-09-20 2004-03-09 Eli Lilly And Company Benzofuran compounds, compositions, and methods
US5637598A (en) 1994-11-18 1997-06-10 Eli Lilly And Company Methods of inhibiting bone loss
US5446071A (en) * 1994-11-18 1995-08-29 Eli Lilly And Company Methods for lowering serum cholesterol
JPH10509962A (ja) 1994-11-29 1998-09-29 ヘキスト・マリオン・ルセル・インコーポレイテツド 骨粗鬆症の治療および予防におけるトリアリール−エチレン誘導体の使用方法
WO1996021443A1 (en) * 1995-01-13 1996-07-18 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia or hypercholesterolaemia or arteriosclerosis or for anticoagulative treatment
US5489587A (en) 1995-01-20 1996-02-06 Eli Lilly And Company Benzofurans used to inhibit bone loss
US5571808A (en) 1995-01-31 1996-11-05 Eli Lilly And Company Method for treating smoking-related bone loss
US5552401A (en) 1995-02-28 1996-09-03 Eli Lilly And Company 2-benzyl-3-arylbenzothiophenes
US5523309A (en) 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds
ES2124064T3 (es) 1995-06-07 1999-01-16 Lilly Co Eli Compuestos y composiciones con cadenas laterales nitrogenadas no basicas.
US5567828A (en) 1995-06-07 1996-10-22 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side
US5747059A (en) 1996-01-11 1998-05-05 Novo Nordisk A/S Atrophy of skin/mucous membrane
AU1367297A (en) 1996-01-11 1997-08-01 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical comp osition for the treatment or prophylaxis of menopausal symptoms
US5726202A (en) 1996-01-11 1998-03-10 Novo Nordisk A/S Benign prostatic hypertrophy
US5883118A (en) 1996-01-11 1999-03-16 Nova Nordisk A/S Prostatic carcinoma
CZ217198A3 (cs) 1996-01-11 1998-11-11 Novo Nordisk A/S Použití L-enantiomeru centochromanu pro výrobu farmaceutického prostředku
CN1211256A (zh) * 1996-02-14 1999-03-17 赫彻斯特马里恩鲁斯公司 用作睾酮5α-还原酶和C17～20裂解酶活性抑制剂的17β－环丙基(氨基/氧基)－4－氮杂甾族化合物
US6432982B1 (en) 1996-02-21 2002-08-13 Eli Lilly And Company Benzothiophenes, and formulations and methods using same
JP2000505455A (ja) 1996-02-22 2000-05-09 イーライ・リリー・アンド・カンパニー ベンゾチオフエン類、それらを含む製剤、および方法
IL120262A (en) 1996-02-28 2001-01-28 Pfizer Droloxifene and derivatives thereof for use in increasing serum testosterone levels
WO1997032837A1 (fr) 1996-03-06 1997-09-12 Sumitomo Pharmaceuticals Co., Ltd. Derives estrogenes non steroidiens
EP0801066A1 (en) 1996-03-12 1997-10-15 Eli Lilly And Company Heterocyclic substituted benzothiophenes and pharmaceutical compositions
WO1997037662A1 (en) * 1996-04-11 1997-10-16 Loria Roger M 5-ANDROSTENE 3β,17α DIOL AS AN INHIBITOR OF TUMOR GROWTH
TW397821B (en) 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
DE122009000061I1 (de) 1996-04-19 2009-12-31 Wyeth N D Ges D Staates Delawa Östrogene Verbindungen
US5843984A (en) 1996-05-09 1998-12-01 Eli Lilly And Company Sulfated benzothiophene derivatives, methods of use and formulations containing same
GB9616700D0 (en) * 1996-08-09 1996-09-25 Carey Beverly J Hormone supplement
PL333356A1 (en) * 1996-08-28 1999-12-06 Lilly Co Eli Amorphous benzothiophenes, methods of obtaining them and ways of their application
US6511970B1 (en) * 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6069175A (en) * 1996-11-15 2000-05-30 Pfizer Inc. Estrogen agonist/antagonists treatment of atherosclerosis
US5855920A (en) * 1996-12-13 1999-01-05 Chein; Edmund Y. M. Total hormone replacement therapy
US5861391A (en) * 1997-01-29 1999-01-19 Research Development Foundation Use of dehydroepiandrosterone to treat primary adrenal insufficiency and Addison's disease
WO1998034621A1 (en) * 1997-02-07 1998-08-13 Theratech, Inc. Composition and method for supplementing testosterone in women with symptoms of testosterone deficiency
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
CO4940467A1 (es) * 1997-06-27 2000-07-24 Smithkline Beecham Corp Nuevos metodos
US5908859A (en) * 1997-08-11 1999-06-01 Eli Lilly And Company Benzothiophenes for inhibiting hyperlipidemia
EP1027057A4 (en) * 1997-10-28 2003-01-02 Vivus Inc TREATMENT OF FEMALE SEXUAL DISORDERS
KR100620772B1 (ko) 1998-05-15 2006-09-13 와이어쓰 에스트로겐과 2-페닐-1-[4-(2-아미노에톡시)-벤질]-인돌을 포함하는 약제학적 조성물
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
TR200102867T2 (tr) * 1998-06-11 2002-06-21 Endorecherchel@Inc
US7005428B1 (en) * 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
HUP9900284A2 (hu) 1999-02-09 2001-02-28 János Váradi Háromfázisú, hidraulikus rugózó elem közúti és vasúti járművek számára
EP1196163B1 (en) 1999-07-06 2009-11-11 Endorecherche Inc. Pharmaceutical compositions for the treatment of insulin resistance
WO2001026651A2 (en) * 1999-10-14 2001-04-19 Endorecherche, Inc. Selective estrogen receptor modulators in the treatment or reduction of the risk of acquiring hypertension, cardiovascular diseases, and insulin resistance
WO2006042409A1 (en) * 2004-10-20 2006-04-27 Endorecherche, Inc. Sex steroid precursors alone or in combination with a selective estrogen receptor modulator and/or with estrogens and/or a type 5 cgmp phosphodiesterase inhibitor for the prevention and treatment of vaginal dryness and sexual dysfunction in postmenopausal women
US8268806B2 (en) * 2007-08-10 2012-09-18 Endorecherche, Inc. Pharmaceutical compositions

Also Published As

Publication number Publication date
IL140178A0 (en) 2002-02-10
US7884092B2 (en) 2011-02-08
CA2768682A1 (en) 1999-12-16
DE69928104D1 (de) 2005-12-08
EP1623712A3 (en) 2009-12-16
KR20090018870A (ko) 2009-02-23
DE69928104T2 (de) 2006-08-24
EP2386304B1 (en) 2014-03-19
ES2458218T3 (es) 2014-04-30
HUP0103345A2 (hu) 2002-02-28
ES2463868T9 (es) 2014-06-24
EP2386305B9 (en) 2014-12-17
TR200103456T2 (tr) 2002-06-21
HU230495B1 (hu) 2016-09-28
EP2399582B9 (en) 2014-09-10
HK1040367B (zh) 2006-09-29
PT2386305E (pt) 2014-04-17
PT2386304E (pt) 2014-05-26
WO1999063974A2 (en) 1999-12-16
KR20010052763A (ko) 2001-06-25
MY157030A (en) 2016-04-15
PL199798B1 (pl) 2008-10-31
KR20090016771A (ko) 2009-02-17
EP2399582B1 (en) 2014-03-26
EP2386304B9 (en) 2014-11-05
EP2386305A3 (en) 2011-12-07
MY125047A (en) 2006-07-31
DK2399582T3 (da) 2014-07-07
DK2386305T3 (da) 2014-04-14
EP2386304A2 (en) 2011-11-16
NO20006254D0 (no) 2000-12-08
RU2246947C2 (ru) 2005-02-27
PL203343B1 (pl) 2009-09-30
EP2399582A1 (en) 2011-12-28
US6670346B1 (en) 2003-12-30
CY1115231T1 (el) 2017-01-04
DK1083905T3 (da) 2006-03-20
MY151187A (en) 2014-04-30
HK1040367A1 (en) 2002-06-07
HUP0103345A3 (en) 2002-11-28
CA2334577C (en) 2008-08-05
DK1623712T3 (da) 2013-01-21
EP1083905A2 (en) 2001-03-21
CA2334577A1 (en) 1999-12-16
KR100944261B1 (ko) 2010-02-24
ES2253922T3 (es) 2006-06-01
BR9911116A (pt) 2001-02-28
CA2768882A1 (en) 1999-12-16
CN1636566A (zh) 2005-07-13
US20070027124A1 (en) 2007-02-01
MXPA00012306A (es) 2003-07-28
NO20092730L (no) 2001-02-01
CA2768828A1 (en) 1999-12-16
TR200103455T2 (tr) 2002-06-21
EP1623712B1 (en) 2012-12-12
PL345887A1 (en) 2002-01-14
JP2007191484A (ja) 2007-08-02
CY1113712T1 (el) 2016-06-22
AU4253099A (en) 1999-12-30
PT2399582E (pt) 2014-06-25
CA2768828C (en) 2013-08-13
CA2768773C (en) 2013-08-13
PT1623712E (pt) 2013-02-13
US7429576B2 (en) 2008-09-30
NO332187B1 (no) 2012-07-23
ES2399051T3 (es) 2013-03-25
WO1999063974A3 (en) 2000-06-29
EP2386305B1 (en) 2014-02-12
PL195772B1 (pl) 2007-10-31
TR200100551T2 (tr) 2001-07-23
EP1083905B1 (en) 2005-11-02
JP2002517433A (ja) 2002-06-18
CA2768682C (en) 2014-03-18
NO20006254L (no) 2001-02-01
TWI371279B (en) 2012-09-01
HU1600307D0 (hu) 2002-02-28
CY1115317T1 (el) 2017-01-04
CN1240388C (zh) 2006-02-08
ID28696A (id) 2001-06-28
ATE308326T1 (de) 2005-11-15
AR043075A1 (es) 2005-07-20
CA2768773A1 (en) 1999-12-16
US20070027122A1 (en) 2007-02-01
US8188066B2 (en) 2012-05-29
TWI258369B (en) 2006-07-21
ZA200007297B (en) 2002-02-08
IL140178A (en) 2008-07-08
CA2768882C (en) 2015-01-27
JP2013049703A (ja) 2013-03-14
KR20090018227A (ko) 2009-02-19
CN1312718A (zh) 2001-09-12
CA2768841C (en) 2013-08-13
EP2386304A3 (en) 2011-12-07
KR20090018226A (ko) 2009-02-19
CA2768841A1 (en) 1999-12-16
EP1623712A2 (en) 2006-02-08
NO331022B1 (no) 2011-09-12
IL185087A0 (en) 2007-12-03
EP2386305A2 (en) 2011-11-16
NZ508801A (en) 2003-08-29
TR200103453T2 (tr) 2002-06-21
ES2463868T3 (es) 2014-05-29
US20040157812A1 (en) 2004-08-12
PL203704B1 (pl) 2009-11-30
CA2632567A1 (en) 1999-12-16
ES2458218T9 (es) 2014-06-24
DK2386304T3 (da) 2014-05-12
CY1115069T1 (el) 2016-12-14
US20070027123A1 (en) 2007-02-01
ES2473040T3 (es) 2014-07-03
TW200810763A (en) 2008-03-01
US7943603B2 (en) 2011-05-17
CA2632567C (en) 2012-04-10
KR20090018871A (ko) 2009-02-23
US6465445B1 (en) 2002-10-15

Similar Documents

Publication Publication Date Title
TR200103454T2 (tr) Cinsiyet steroidi öncüleri ile kombinasyon halindeki bir selektif östrojen reseptör modülatörünün tıbbi kullanımları.
Lee et al. Bisphosphonate treatment inhibits the growth of prostate cancer cells
KR100956912B1 (ko) 17α-알킬-17β-옥시-에스트라트리엔 및 그의 제조를 위한중간체, 및 약제 및 제약 제제의 제조를 위한 상기17α-알킬-17β-옥시-에스트라트리엔의 용도
AR035564A1 (es) Moduladores selectivos de receptores de estrogenos en combinacion con estrogenos
CA2334702C (en) Pharmaceutical compositions and uses for androst-5-ene-3.beta.,17.beta.-diol
CA2321427A1 (en) Combination preparation of estrogen and anti-estrogen
Senaratne et al. The role of bisphosphonates in breast cancer: Direct effects of bisphosphonates on breast cancer cells
HUP0104680A2 (hu) Háromfázisú orális fogamzásgátló
IE902459A1 (en) Combination therapy for the prophylaxis and/or treatment of¹benign prostatic hyperplasia
ATE347365T1 (de) Verwendung von öestrogen in kombination mit progestogen für die hormonsubstitutions-therapie
BRPI0617683A2 (pt) processo para a contracepção hormonal preventiva segundo a necessidade e uso de um emplastro transdérmico
RU97104120A (ru) Фармацевтические композиции, содержащие производные эстра-1,3,5(10)-триена
BR9912466A (pt) Utilização de sulfamatos de estrogênio biogênicos na terapia de reposição hormonal
CA2448278A1 (en) Drug delivery system comprising a tetrahidroxilated estrogen for use in hormonal contraception
Gordan et al. Calusterone (7β, 17α-DimethyItestosterone) as Primary and Secondary Therapy of Advanced Breast Cancer
DE69521125D1 (de) IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONDERIVATE UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN
AU2002215958C1 (en) Use of inhibitors of progesterone receptor for treating cancer
BR0213466A (pt) Uso de (11beta,17beta)-11-(1,3- benzodioxol-s-il)-17-hidróxi-17-(1-propinil) estra-4,9-dien-3-ona, preparação farmacêutica, e, método para o tratamento de um paciente sofrendo de distúrbio depressivo grave
RS107004A (en) 9-alpha-substituted estratrienes as selectively active estrogen
WO1999045886A3 (en) New contraceptive kit for monotherapy
BR0016737A (pt) 14,15-ciclopropano-androstanos insaturados, processos para a sua preparação e composições farmacêuticas contendo estes compostos
WO2004093852A3 (en) Use of steroid derivatives for the treatment of angiotensin ii related disease e.g. cardiovascular and proliferative disorders
BR9915009A (pt) Composto, composição farmacêutica, método de estimular a liberação do hormÈnio do crescimento da pituitária de um mamìfero, e, uso de um composto ou de um sal farmaceuticamente aceitável do mesmo
AU2006202187A1 (en) 17alpah-alkyl-17beta-oxy-estratrienes and intermediate products for their production, uses thereof and pharmaceutical preparations
TR200200429T2 (tr) Kilo alımını tedavi ve/veya önleme metodları.