AR035564A1 - Moduladores selectivos de receptores de estrogenos en combinacion con estrogenos - Google Patents
Moduladores selectivos de receptores de estrogenos en combinacion con estrogenosInfo
- Publication number
- AR035564A1 AR035564A1 ARP010100372A ARP010100372A AR035564A1 AR 035564 A1 AR035564 A1 AR 035564A1 AR P010100372 A ARP010100372 A AR P010100372A AR P010100372 A ARP010100372 A AR P010100372A AR 035564 A1 AR035564 A1 AR 035564A1
- Authority
- AR
- Argentina
- Prior art keywords
- administration
- strogens
- strogen
- receivers
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Métodos novedosos para reducir o eliminar la incidencia de accesos de calor y síntomas menopáusicos, que al mismo tiempo disminuyen el riesgo de adquirir cáncer de mama o de endometrio y para tratar y/o inhibir además el desarrollo de osteoporosis, hipercolesterolemia, hiperlipidemia, ateroesclerosis, hipertensión, resistencia a insulina, diabetes, pérdida de masa muscular, obesidad, irregularidades menstruales, enfermedad de Alzheimer o sequedad vaginal en animales de sangre caliente susceptibles, inclusive seres humanos que comprende la administración de un modulador selectivo de receptores de estrógeno, en particular compuestos que presentan la estructura general (1) y una cantidad de un estrógeno o un compuesto estrogénico / androgénico mixto. Además, se describe específicamente la administración de bifosfonatos, progestágeno o un precursor de esteroides sexuales para el tratamiento médico y/o la inhibición de algunas de las enfermedades mencionadas anteriormente. También se describen composiciones farmacéuticas para la distribución del o de los ingredientes activos y uno o varios conjuntos de elementos (''kits'') de utilidad para la presente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17860100P | 2000-01-28 | 2000-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR035564A1 true AR035564A1 (es) | 2004-06-16 |
Family
ID=22653187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010100372A AR035564A1 (es) | 2000-01-28 | 2001-01-26 | Moduladores selectivos de receptores de estrogenos en combinacion con estrogenos |
Country Status (21)
Country | Link |
---|---|
US (3) | US20020198179A1 (es) |
EP (1) | EP1251855A1 (es) |
JP (1) | JP2003520817A (es) |
KR (1) | KR20020073566A (es) |
CN (1) | CN1400904A (es) |
AR (1) | AR035564A1 (es) |
AU (1) | AU2991301A (es) |
BR (1) | BR0108107A (es) |
CA (1) | CA2395730A1 (es) |
CZ (1) | CZ20022401A3 (es) |
HK (1) | HK1048761A1 (es) |
HU (1) | HUP0204211A3 (es) |
IL (1) | IL149990A0 (es) |
MX (1) | MXPA02007165A (es) |
NO (1) | NO20023484D0 (es) |
NZ (1) | NZ534348A (es) |
PL (1) | PL357163A1 (es) |
RU (1) | RU2342145C2 (es) |
SK (1) | SK9592002A3 (es) |
WO (1) | WO2001054699A1 (es) |
ZA (1) | ZA200205926B (es) |
Families Citing this family (70)
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WO1997012623A1 (en) * | 1995-10-06 | 1997-04-10 | Arch Development Corporation | Methods and compositions for viral enhancement of cell killing |
BR0112360A (pt) * | 2000-07-06 | 2003-05-06 | Wyeth Corp | Método para aumentar a atividade da sintase de óxido nìtrico |
WO2002003988A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for treating neuropeptide y-related conditions |
US6245819B1 (en) | 2000-07-21 | 2001-06-12 | Hormos Medical Oy, Ltd. | Method for the treatment of vaginal dryness and sexual dysfunction in women during or after the menopause |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
IL145838A (en) * | 2000-10-16 | 2008-11-03 | Pfizer Prod Inc | Use of an estrogen agonist / antagonist to produce a drug for the treatment of vaginitis |
US7276250B2 (en) * | 2001-07-06 | 2007-10-02 | Penwest Pharmaceuticals Company | Sustained release formulations of oxymorphone |
PL367094A1 (en) * | 2001-07-31 | 2005-02-21 | Pfizer Products Inc. | Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins |
US20040214898A1 (en) * | 2001-11-29 | 2004-10-28 | Steiner Mitchell S. | Methods for treating hot flashes |
US20080249183A1 (en) * | 2001-11-29 | 2008-10-09 | Steiner Mitchell S | Treatment of androgen-deprivation induced osteoporosis |
US20050080143A1 (en) * | 2001-11-29 | 2005-04-14 | Steiner Mitchell S. | Treatment of androgen-deprivation induced osteoporosis |
US20070197664A1 (en) * | 2001-11-29 | 2007-08-23 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
US20060269611A1 (en) * | 2001-11-29 | 2006-11-30 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
TW200307553A (en) * | 2002-05-24 | 2003-12-16 | Akzo Nobel Nv | Treatment of post-menopausal complaints in breast cancer patients |
ATE344025T1 (de) * | 2002-06-06 | 2006-11-15 | Hormos Medical Ltd | Behandlung oder prävention von urogenitaler atrophie und deren symptomen bei frauen |
MXPA05000824A (es) * | 2003-05-23 | 2005-04-28 | Akzo Nobel Nv | Forma de dosis farmaceutica de liberacion inmediata que contiene tibolona polimorfa. |
WO2005073190A1 (en) * | 2004-01-29 | 2005-08-11 | Eli Lilly And Company | Selective estrogen receptor modulators |
US8080675B2 (en) | 2004-09-21 | 2011-12-20 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
US7601855B2 (en) | 2004-09-21 | 2009-10-13 | Novogen Research Pty Ltd | Substituted chroman derivatives, medicaments and use in therapy |
MX2007004830A (es) * | 2004-10-20 | 2007-10-04 | Endorech Inc | Precursores esteroides sexuales solos o en combinacion con un modulador receptor de estrogeno selectivo y/o con estrogenos y/o con un inhibidor de fosfodiesterasa gmpc de tipo 5 para la prevencion y tratamiento de resequedad vaginal y disfuncion sexu |
AU2006214515A1 (en) * | 2005-02-16 | 2006-08-24 | Wyeth | Use of estrogen receptor-b selective agonists for radiation-or chemotherapy-induced mucosistis and radiation cystitis |
BRPI0711525A2 (pt) | 2006-06-02 | 2011-11-01 | Pear Tree Women S Health Care | composição farmacêutica e método para tratar sintomas de vaginite atrófica |
US8933130B2 (en) * | 2006-06-23 | 2015-01-13 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
WO2008101030A1 (en) * | 2007-02-13 | 2008-08-21 | The Regents Of The University Of California | Methods for amplifying steroid hormone effects |
WO2008099060A2 (en) | 2007-02-14 | 2008-08-21 | Hormos Medical Ltd | Methods for the preparation of fispemifene from ospemifene |
ES2524002T3 (es) | 2007-02-14 | 2014-12-03 | Forendo Pharma Ltd. | Método para la preparación de derivados de trifenilbuteno con valor terapéutico |
US8268806B2 (en) | 2007-08-10 | 2012-09-18 | Endorecherche, Inc. | Pharmaceutical compositions |
US20140040862A1 (en) * | 2008-04-03 | 2014-02-06 | Adobe Systems Incorporated | Copying Reusable Components from a Remote Source |
AU2014201406B2 (en) * | 2009-06-16 | 2016-08-11 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
AU2016235019B2 (en) * | 2009-06-16 | 2018-06-28 | Endorecherche, Inc. | Treatment of alzheimer's disease, loss of cognition, memory loss, and dementia with sex steroid precursors in combination with selective estrogen receptor modulators |
US20100317635A1 (en) * | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
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BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
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CN102631677A (zh) * | 2012-04-19 | 2012-08-15 | 中国农业大学 | 一种预防和/或治疗动脉粥样硬化的药物组合物 |
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US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
JP6174156B2 (ja) | 2012-10-19 | 2017-08-02 | フェルミオン オサケ ユキチュア | オスペミフェンの製造方法 |
JP2015535283A (ja) | 2012-11-02 | 2015-12-10 | レプロス セラピューティクス インコーポレイティド | 癌療法における使用のためのトランス−クロミフェン |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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EP3834824A1 (en) | 2014-03-28 | 2021-06-16 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
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HUE054998T2 (hu) | 2015-02-02 | 2021-10-28 | Mei Pharma Inc | Kombinációs terápiák emlõrák kezelésében való alkalmazásra |
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US10729650B2 (en) * | 2017-01-23 | 2020-08-04 | United States Of America As Represented By The Secretary Of The Air Force | Skin punch biopsy and wound-debridgement training model |
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US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
US5446061A (en) * | 1993-11-05 | 1995-08-29 | Eli Lilly And Company | Methods for lowering serum cholesterol |
US5446071A (en) * | 1994-11-18 | 1995-08-29 | Eli Lilly And Company | Methods for lowering serum cholesterol |
US5922349A (en) * | 1995-09-28 | 1999-07-13 | Schering Aktiengesellschaft | Hormone replacement therapy method and hormone dispenser |
ATE206701T1 (de) * | 1996-04-19 | 2001-10-15 | American Home Prod | Östrogene verbindungen |
AR017256A1 (es) * | 1997-08-21 | 2001-09-05 | American Home Prod | Compuestos de indol sustituidos, metodo para la sintesis en fase solida de los mismos, conjuntos de combinacion para ser empleados en dicho metodo, uso delos compuestos para preparar un medicamento y composiciones farmaceuticas que los comprenden |
US6465445B1 (en) * | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
US7005428B1 (en) * | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
DE19916419B4 (de) * | 1999-04-08 | 2005-06-16 | Schering Ag | Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose |
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-
2001
- 2001-01-26 AU AU29913/01A patent/AU2991301A/en not_active Abandoned
- 2001-01-26 HU HU0204211A patent/HUP0204211A3/hu unknown
- 2001-01-26 RU RU2002123047/14A patent/RU2342145C2/ru not_active IP Right Cessation
- 2001-01-26 CA CA002395730A patent/CA2395730A1/en not_active Abandoned
- 2001-01-26 SK SK959-2002A patent/SK9592002A3/sk not_active Application Discontinuation
- 2001-01-26 JP JP2001554683A patent/JP2003520817A/ja active Pending
- 2001-01-26 KR KR1020027009728A patent/KR20020073566A/ko not_active Application Discontinuation
- 2001-01-26 CZ CZ20022401A patent/CZ20022401A3/cs unknown
- 2001-01-26 BR BR0108107-1A patent/BR0108107A/pt not_active Application Discontinuation
- 2001-01-26 EP EP01902194A patent/EP1251855A1/en not_active Withdrawn
- 2001-01-26 IL IL14999001A patent/IL149990A0/xx unknown
- 2001-01-26 NZ NZ534348A patent/NZ534348A/en active IP Right Revival
- 2001-01-26 PL PL01357163A patent/PL357163A1/xx not_active Application Discontinuation
- 2001-01-26 WO PCT/CA2001/000086 patent/WO2001054699A1/en active Application Filing
- 2001-01-26 CN CN01804028A patent/CN1400904A/zh active Pending
- 2001-01-26 AR ARP010100372A patent/AR035564A1/es unknown
- 2001-01-26 MX MXPA02007165A patent/MXPA02007165A/es not_active Application Discontinuation
- 2001-11-07 US US10/052,803 patent/US20020198179A1/en not_active Abandoned
- 2001-11-07 US US10/052,824 patent/US20030040510A1/en not_active Abandoned
-
2002
- 2002-05-09 US US10/143,894 patent/US20030065008A1/en not_active Abandoned
- 2002-07-22 NO NO20023484A patent/NO20023484D0/no not_active Application Discontinuation
- 2002-07-24 ZA ZA200005926A patent/ZA200205926B/xx unknown
-
2003
- 2003-02-06 HK HK03100850.6A patent/HK1048761A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CZ20022401A3 (cs) | 2003-10-15 |
HUP0204211A3 (en) | 2005-06-28 |
AU2991301A (en) | 2001-08-07 |
SK9592002A3 (en) | 2003-12-02 |
US20020198179A1 (en) | 2002-12-26 |
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