JP5042209B2 - 酸化窒素による美容治療、前記治療を実施する装置、及びその製造方法 - Google Patents
酸化窒素による美容治療、前記治療を実施する装置、及びその製造方法 Download PDFInfo
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Description
以下の記載は、例えば、暦年齢、環境要因、ざ瘡、乾癬、皮膚炎、セルライトのような皮膚の生理的機能の変化、ウイルス及び/又は細菌攻撃、例えば、単純ヘルペスウイルス1型(HSV−1)、単純ヘルペスウイルス2型(HSV−2)、エプスタイン・バーウイルス(EBV)、サイトメガロウイルス(CMV)、水痘・帯状疱疹ウイルス(VZV)、ヒトヘルペスウイルス6型(exanthum subitum及びroseola infantum)、ヒトヘルペスウイルス8型(HHV−8)のようなヘルペス、おそらくHHV−8により生じたカポジ肉腫、ウイルスにより引き起こされたverruca vulgaris、verruca planae、verruca seborroica、糸状いぼ、モザイクいぼなどのようないぼ、及びポックスウイルスにより生じた軟体物によりひき起こされる美容上の障害の標的治療を可能にする装置に適用可能な本発明の実施態様に焦点を当てる。
Claims (40)
- 体の部位に美容的に適用されるように構成された装置であって、前記装置がプロトン供与体と接触したときに酸化窒素(NO)の用量を溶出するように構成された酸化窒素(NO)溶出ポリマーを含み、且つ前記装置は、前記ポリマーが使用時に酸化窒素(NO)を溶出するとき、前記部位を前記酸化窒素(NO)に暴露するように構成され、
前記酸化窒素(NO)溶出ポリマーが担体材料と一体化し、これにより、前記担体材料が使用時に酸化窒素(NO)の前記用量の溶出を調節及び制御し、
前記プロトン供与体が、プロトン供与体担体部材の中の前記装置内に保存されており、前記プロトン供与体担体部材が開放又は破壊されたときに、前記プロトン供与体が前記酸化窒素(NO)溶出ポリマーに接触することを特徴とする装置。 - 前記装置の使用時の酸化窒素(NO)の前記溶出が、前記暴露のために前記部位へ向けられている、請求項1記載の装置。
- 使用時に前記部位に向くように配置されている、装置の第1の側面にある、酸化窒素に透過性の第1の膜と、及び使用時に前記部位から離れるように配置されている、装置の第2の側面にある、酸化窒素に低い透過性を有するか又は透過性を有さない第2の膜とを含み、使用時の前記装置からの酸化窒素(NO)の前記実質的な方向が、使用時の前記装置からの酸化窒素の溶出が前記第2の側面で妨げられるように提供される、請求項2記載の装置。
- 前記酸化窒素(NO)溶出ポリマーが、ジアゼニウムジオレート基、S−ニトロシル化基及びO−ニトロシル化基、又はこれらの任意の組み合わせを含む、請求項1〜3のいずれか1項記載の装置。
- 前記酸化窒素(NO)溶出ポリマーが、前記体の前記部位で酸化窒素を溶出するように配置された、前記ジアゼニウムジオレート基、S−ニトロシル化基若しくはO−ニトロシル化基、又はこれらの任意の組み合わせを介して酸化窒素(NO)を装填された、L−PEI(線状ポリエチレンイミン)である、請求項1〜4のいずれか1項記載の装置。
- 前記酸化窒素溶出ポリマーが、アミノセルロース、アミノデキストラン、キトサン、アミノ化キトサン、ポリエチレンイミン、PEI−セルロース、ポリプロピレンイミン、ポリブチレンイミン、ポリウレタン、ポリ(ブタンジオールスペルメート)、ポリ(イミノカーボネート)、ポリペプチド、カルボキシメチルセルロース(CMC)、ポリスチレン、ポリ(塩化ビニル)及びポリジメチルシロキサン、又はこれらの任意の組み合わせを含む群より選択され、記載のポリマーが、多糖主鎖又はセルロース主鎖にグラフトされている、請求項1〜3のいずれか1項記載の装置。
- 前記装置が、前記体の前記部位へ適用するために適合される、サック/シース(10、14)、ソックス(24)、パッチ/パッド(30)及びテープ/コーティング(20、22)からなる群より選択される形態を有する、請求項1〜3のいずれか1項記載の装置。
- 前記サック/シース(10、14)、ソックス(24)、パッチ/パッド(30)又はテープ/コーティング(20、22)が、使用時に、前記体の前記部位に前記酸化窒素(NO)を溶出するように構成された前記酸化窒素(NO)溶出ポリマーを含む、ポリエチレン、ポリプロピレン、ポリアクリロニトリル、ポリウレタン、ポリビニルアセテート、ポリ乳酸、デンプン、セルロース、ポリヒドロキシアルカノエート、ポリエステル、ポリカプロラクトン、ポリビニルアルコール、ポリスチレン、ポリエーテル、ポリカーボネート、ポリアミド、ポリオレフィン、ポリ(アクリル酸)、カルボキシメチルセルロース(CMC)、タンパク質に基づくポリマー、ゼラチン、生分解性ポリマー、綿及びラテックス、又はこれらの任意の組み合わせを含む、請求項7記載の装置。
- 前記プロトン供与体が、水、血液、リンパ液、胆汁、メタノール、エタノール、プロパノール、ブタノール、ペンタノール、ヘキサノール、フェノール、ナフトール、ポリオール、ホスフェート、スクシネート、カーボネート、アセテート、ホルメート、プロピオネート、ブチレート、脂肪酸及びアミノ酸、又はこれらの任意の組み合わせを含む群より選択される、請求項1〜8のいずれか1項記載の装置。
- 前記装置が、プロトン供与体に付されたときに部分的に崩壊可能である、請求項1〜9のいずれか1項記載の装置。
- 前記ポリマーが銀を含む、請求項1、2又は3記載の装置。
- 前記酸化窒素溶出ポリマーが、繊維、ナノ粒子又は微小球の形態で装置に含まれる、請求項1、2又は3記載の装置。
- 前記繊維、ナノ粒子又は微小球が、ゲル、クリーム、泡若しくはヒドロゲル、又はこれらの組み合わせと一体化している、請求項12記載の装置。
- 前記ナノ粒子又は微小球が、ポリエチレン、ポリプロピレン、ポリアクリロニトリル、ポリウレタン、ポリビニルアセテート、ポリ乳酸、デンプン、セルロース、ポリヒドロキシアルカノエート、ポリエステル、ポリカプロラクトン、ポリビニルアルコール、ポリスチレン、ポリエーテル、ポリカーボネート、ポリアミド、ポリオレフィン、ポリ(アクリル酸)、カルボキシメチルセルロース(CMC)、タンパク質に基づくポリマー、ゼラチン、生分解性ポリマー、綿及びラテックス、又はこれらの任意の組み合わせを含む群より選択される材料と一体化しているか、又はそれらに封入されている、請求項12記載の装置。
- 前記ポリマーが、使用されるときに薬剤溶出パッチの効果増強体として作用するように構成されている、請求項1又は2記載の装置。
- 前記担体材料が、ポリエチレン、ポリプロピレン、ポリアクリロニトリル、ポリウレタン、ポリビニルアセテート、ポリ乳酸、デンプン、セルロース、ポリヒドロキシアルカノエート、ポリエステル、ポリカプロラクトン、ポリビニルアルコール、ポリスチレン、ポリエーテル、ポリカーボネート、ポリアミド、ポリオレフィン、ポリ(アクリル酸)、カルボキシメチルセルロース(CMC)、タンパク質に基づくポリマー、ゼラチン、生分解性ポリマー、綿及びラテックス、又はこれらの任意の組み合わせからなる群より選択される、請求項1、2又は3記載の装置。
- 前記担体材料がヒドロゲルである、請求項1、2又は3記載の装置。
- 前記プロトン供与体担体部材が、プロトン供与体バッグ、密閉プロトン供与体スポンジ、又はマイクロカプセル化水である、請求項1、2又は3記載の装置。
- 前記酸化窒素溶出ポリマーが、第二級アミンを主鎖に含むか、又は第二級アミンを側鎖として含む、請求項1、2又は3記載の装置。
- 陽性リガンドが第二級アミンの隣接原子に位置している、請求項19記載の装置。
- 吸収剤を含む、請求項1又は16記載の装置。
- 前記吸収剤が、ポリアクリレート、ポリエチレンオキシド、カルボキシメチルセルロース(CMC)、微晶質セルロース、綿若しくはデンプン、又はこれらの任意の組み合わせを含む群より選択される、請求項21記載の装置。
- カチオンを含み、前記カチオンが酸化窒素溶出ポリマーを安定化する、請求項1、16、20又は21記載の装置。
- 前記カチオンが、Na+、K+、Li+、Be2+、Ca2+、Mg2+、Ba2+及び/若しくはSr2+、又はこれらの任意の組み合わせを含む群より選択される、請求項23記載の装置。
- 前記美容適用が、暦年齢、環境要因、及び皮膚の生理的機能の変化により引き起こされる前記部位の美容治療を含んでおり、前記皮膚の生理的機能の変化は、乾癬、皮膚炎、セルライト、ウイルス攻撃、及び細菌攻撃のいずれかにより引き起こされる、請求項1〜24のいずれか1項記載の装置。
- 前記酸化窒素(NO)溶出ポリマーが、酸化窒素の用量が前記酸化窒素溶出ポリマーから前記部位へ溶出するように、前記体の部位と接触するように配置されている、請求項25記載の装置。
- 請求項1記載の体の部位に美容的に適用されるように構成された装置の製造方法であって、
プロトン供与体に接触したときに酸化窒素(NO)の用量を溶出するように構成された酸化窒素(NO)溶出ポリマーを選択すること、
前記装置が、前記NO溶出ポリマーが使用時に酸化窒素(NO)を溶出するときに、前記部位を前記酸化窒素に暴露するように構成されるように、前記酸化窒素(NO)溶出ポリマーを被覆として前記装置の少なくとも一部に展開すること、
プロトン供与体を含んでおり、活性化されたときにプロトン供与体を前記装置に放出するように構成されたプロトン供与体担体部材を展開すること、を含み、
前記ポリマーが、前記プロトン供与体と接触すると前記酸化窒素(NO)を放出するように活性化可能である、方法。 - 酸化窒素(NO)の前記美容用量の溶出を調節及び制御するように構成された担体材料を選択すること、
NO溶出ポリマーを、前記担体材料が前記装置の使用時に酸化窒素(NO)の前記用量の溶出を調節及び制御するように、前記担体材料により、酸化窒素(NO)溶出材料に組み込むことを含む、請求項27記載の製造方法。 - 塩化窒素(NO)に対して低い透過性を有するか又は透過性を有さない材料を、前記美容標的部位から離れるように配置されることが意図される装置の側面に、使用時に酸化窒素の溶出が前記部位へ向かうように適用することを含む、請求項27又は28記載の製造方法。
- 前記展開が、NO溶出ポリマーの電界紡糸、空気紡糸、ガス紡糸、湿潤紡糸、乾燥紡糸、溶融紡糸又はゲル紡糸を含む、請求項27〜29のいずれか1項記載の製造方法。
- 前記酸化窒素(NO)溶出ポリマーの前記選択が、複数個の酸化窒素(NO)溶出ポリマー粒子、ナノ繊維、ナノ粒子又は微小球を選択することを含む、請求項27〜30のいずれか1項記載の製造方法。
- 前記担体材料による前記NO溶出ポリマーの前記組み込みが、前記装置の酸化窒素溶出特性を予め定義するため、前記NO溶出ポリマーを前記担体材料と一体化すること、前記NO溶出ポリマーを前記担体材料と一緒に紡糸すること、又は前記NO溶出ポリマーを前記担体材料の上に乗せて紡糸することを含む、請求項27〜31のいずれか1項記載の製造方法。
- 銀を前記装置と一体化することを更に含む、請求項27記載の製造方法。
- 前記プロトン供与体担体部材が、プロトン供与体バッグ、密閉プロトン供与体スポンジ、又はマイクロカプセルである、請求項27記載の製造方法。
- 前記適用が、パターン糊付け、又は前記マイクロカプセルの上にNO溶出材料を紡糸することを含む、請求項34記載の製造方法。
- マイクロカプセルを第1のフィルム、テープ又はシースの形態にすること、
前記NO溶出材料を第2のフィルム、テープ又はシースの形態にすること、及び
マイクロカプセルの第1のフィルム、テープ又はシースを、前記NO溶出材料の第2のフィルム、テープ又はシースに糊付けすること、を含む請求項34記載の製造方法。 - 前記糊付けが、糊のない場所を含むパターンが得られるようなパターン糊付けを含む、請求項36記載の製造方法。
- マイクロカプセルを第1のフィルム、テープ又はシースの形態にすること、及びプロトン供与体を含有するマイクロカプセルのフィルム、テープ又はシースの上に、NO溶出材料を直接紡糸することを含む、請求項34記載の製造方法。
- NO溶出材料が前記プロトン供与体に付されてNOを溶出するように、マイクロカプセルが破壊されるときを示すように構成された、活性化インジケータを提供することを含む、請求項34記載の製造方法。
- 活性化インジケータの前記提供が、マイクロカプセルの中に着色剤を提供すること、マイクロカプセルの材料を選択すること、マイクロカプセルが壊れるときに音を出すことに適した前記マイクロカプセルの壁厚を選択すること、マイクロカプセルの中に芳香材料を混合すること、プロトン供与体と接触したときに色を変える物質を提供することのいずれかであることを含む、請求項39記載の製造方法。
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-
2006
- 2006-02-13 WO PCT/EP2006/050884 patent/WO2006100154A1/en active Application Filing
- 2006-02-13 DE DE602006006432T patent/DE602006006432D1/de active Active
- 2006-02-13 US US11/909,152 patent/US9427605B2/en active Active
- 2006-02-13 JP JP2008502364A patent/JP5042209B2/ja active Active
- 2006-02-13 ES ES06708224T patent/ES2326387T3/es active Active
- 2006-02-13 DK DK06708224T patent/DK1871433T3/da active
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CA2603828A1 (en) | 2006-09-28 |
JP2008534468A (ja) | 2008-08-28 |
PL1871433T3 (pl) | 2009-09-30 |
DK1871433T3 (da) | 2009-08-10 |
ATE429255T1 (de) | 2009-05-15 |
US20160256366A1 (en) | 2016-09-08 |
ES2326387T3 (es) | 2009-10-08 |
US9427605B2 (en) | 2016-08-30 |
US20080311163A1 (en) | 2008-12-18 |
EP1871433A1 (en) | 2008-01-02 |
WO2006100154A1 (en) | 2006-09-28 |
DE602006006432D1 (de) | 2009-06-04 |
EP1871433B1 (en) | 2009-04-22 |
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