ATE532777T1 - Substituierte chromanderivate, medikamente und anwendungen in der therapie - Google Patents

Substituierte chromanderivate, medikamente und anwendungen in der therapie

Info

Publication number
ATE532777T1
ATE532777T1 AT05779877T AT05779877T ATE532777T1 AT E532777 T1 ATE532777 T1 AT E532777T1 AT 05779877 T AT05779877 T AT 05779877T AT 05779877 T AT05779877 T AT 05779877T AT E532777 T1 ATE532777 T1 AT E532777T1
Authority
AT
Austria
Prior art keywords
derivatives
chromeder
medications
therapy
substituted
Prior art date
Application number
AT05779877T
Other languages
English (en)
Inventor
Andrew Heaton
Alan James Husband
Original Assignee
Marshall Edwards Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/AU2004/001619 external-priority patent/WO2005049008A1/en
Priority claimed from AU2005201855A external-priority patent/AU2005201855B2/en
Application filed by Marshall Edwards Inc filed Critical Marshall Edwards Inc
Application granted granted Critical
Publication of ATE532777T1 publication Critical patent/ATE532777T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52Adding ingredients
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/382,3-Dihydro derivatives, e.g. isoflavanones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT05779877T 2004-09-21 2005-09-21 Substituierte chromanderivate, medikamente und anwendungen in der therapie ATE532777T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61130004P 2004-09-21 2004-09-21
PCT/AU2004/001619 WO2005049008A1 (en) 2003-11-19 2004-11-19 Combinational radiotherapy and chemotherapy compositions and methods
AU2005201855A AU2005201855B2 (en) 2004-09-21 2005-05-03 Chroman derived compounds and formulations thereof for use in therapy
PCT/AU2005/001435 WO2006032085A1 (en) 2004-09-21 2005-09-21 Substituted chroman derivatives, medicaments and use in therapy

Publications (1)

Publication Number Publication Date
ATE532777T1 true ATE532777T1 (de) 2011-11-15

Family

ID=36089770

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05779877T ATE532777T1 (de) 2004-09-21 2005-09-21 Substituierte chromanderivate, medikamente und anwendungen in der therapie

Country Status (11)

Country Link
US (6) US7601855B2 (de)
EP (2) EP2407462B1 (de)
CN (1) CN101056868B (de)
AT (1) ATE532777T1 (de)
AU (1) AU2005287865B2 (de)
CA (1) CA2581316C (de)
IL (1) IL182034A (de)
MX (1) MX2007003216A (de)
NO (1) NO20072004L (de)
NZ (1) NZ553834A (de)
WO (1) WO2006032085A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2407462B1 (de) 2004-09-21 2014-07-30 Marshall Edwards, Inc. Substituierte Chromanderivate, Medikamente und therapeutische Verwendung
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
ATE496921T1 (de) * 2005-03-24 2011-02-15 Novogen Res Pty Ltd Isoflavonoiddimere
AU2008229617A1 (en) * 2007-03-16 2008-09-25 Novogen Research Pty Ltd Method for inducing autophagy
US20120039917A1 (en) * 2008-08-29 2012-02-16 Alan James Husband Immunomodulating activities
EP2635121B1 (de) 2010-11-01 2020-01-08 MEI Pharma, Inc. Isoflavonoidverbindungen und verfahren zur behandlung von krebs
US20120251630A1 (en) * 2011-03-29 2012-10-04 Marshall Edwards, Inc. Remission therapy of cancer with isoflavonoids
US8911935B2 (en) 2011-10-17 2014-12-16 New York University Mitochondria and human immunodefiency virus type 1
KR101459195B1 (ko) 2012-12-28 2014-11-07 경기대학교 산학협력단 항암 활성을 갖는 4-니트로알킬크로만 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물
SG11201604490SA (en) 2014-02-07 2016-07-28 Novogen ltd Functionalised benzopyran compounds and use thereof
HUE054998T2 (hu) 2015-02-02 2021-10-28 Mei Pharma Inc Kombinációs terápiák emlõrák kezelésében való alkalmazásra
JP2019513828A (ja) 2016-04-06 2019-05-30 ノクソファーム リミティド 改善された薬物動態を有するイソフラボノイド組成物
CA3058492A1 (en) * 2016-04-06 2017-10-12 Noxopharm Limited Radiotherapy improvements
AU2021247415A1 (en) 2020-03-30 2022-09-29 Noxopharm Limited Methods for the treatment of inflammation associated with infection
WO2023090829A1 (ko) * 2021-11-17 2023-05-25 엘젠테라퓨틱스 주식회사 Mll1-wdr5 상호작용을 조절하는 저분자 화합물 및 이의 용도
WO2024232597A1 (ko) * 2023-05-10 2024-11-14 엘젠테라퓨틱스 주식회사 Wdr5를 분해하는 4-크로만온 화합물 및 이의 용도
CN118005595B (zh) * 2023-05-24 2024-10-29 内蒙古大学 具有烯丙醇结构色满衍生物的合成及抗肿瘤活性

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340276A (en) * 1964-04-01 1967-09-05 Ciba Geigy Corp 3, 4-diphenyl-chromans
DE1518002C3 (de) * 1965-01-02 1975-01-23 Merck Patent Gmbh, 6100 Darmstadt Isoflavane und Isoflavene und Verfahren zu Ihrer Herstellung sowie diese enthaltende Arzneimittel
DE1543749A1 (de) * 1966-02-16 1969-12-11 Merck Ag E Verfahren zur Herstellung von 3,4-cis-4-Aryl-isoflavanen
GB1433013A (de) 1973-06-08 1976-04-22
US4264509A (en) 1977-06-08 1981-04-28 Z-L Limited Partnership Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same
US4157984A (en) * 1977-06-08 1979-06-12 Z-L Limited Antioxidants, antioxidant compositions and methods of preparing and using same
US4218489A (en) * 1977-06-08 1980-08-19 Z-L Limited Partnership Antioxidants, antioxidant compositions and methods of preparing and using same
US4232122A (en) * 1979-01-17 1980-11-04 Z-L Limited Partnership Antioxidants, antioxidant compositions and methods of preparing and using same
US4234577A (en) * 1979-03-19 1980-11-18 Z-L Limited Partnership Ergostadientriols, compositions containing same, and methods of preparing and using same
US4368264A (en) * 1979-03-19 1983-01-11 Z-L Limited Partnership Fermentation methods of preparing ergostadientriols
US4366248A (en) * 1979-04-11 1982-12-28 Z-L Limited Partnership Fermentation method of preparing antioxidants
US4390559A (en) * 1979-04-11 1983-06-28 Z-L Limited Partnership Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same
US4366082A (en) * 1979-04-11 1982-12-28 Z-L Limited Partnership Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same
US4447622A (en) * 1981-09-22 1984-05-08 Council Of Scientific And Industrial Research Rafi Marg Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and derivatives thereof
US4644012A (en) 1983-12-21 1987-02-17 Takeda Chemical Industries, Ltd. Treatment for osteoporosis
GB8626344D0 (en) 1986-11-04 1986-12-03 Zyma Sa Bicyclic compounds
MX13485A (es) 1987-10-19 1993-05-01 Pfizer Procedimiento para obtener tetralinas, cromados y compuestos relacionados, sustituidos
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
DE69023906T2 (de) 1990-08-09 1996-04-11 Council Scient Ind Res Benzopyrane und Verfahren zu deren Herstellung.
WO1994008986A1 (en) 1992-10-21 1994-04-28 Pfizer, Inc. Enantiomeric cis-3-(4,6-dihydroxychroman-3-yl-methyl)benzoic acids
US5280040A (en) * 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
US5451603A (en) 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
US5389646A (en) * 1993-12-30 1995-02-14 Zymogenetics, Inc. Methods for treatment and prevention of bone loss using 2,3-benzopyrans
US5792776A (en) 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
HUP9800521A3 (en) 1995-01-13 1999-12-28 Novo Nordisk As Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or propylaxis of hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia or hypercholesterolaemia or arteriosclerosis
HUP9702244A3 (en) 1995-01-13 1999-12-28 Novo Nordisk As Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders
CA2208868A1 (en) 1995-01-13 1996-07-18 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of idiopathic or physiologic gynaecomastia
TW448046B (en) 1995-01-20 2001-08-01 Novo Nordisk As Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of obesity
AU4329196A (en) 1995-01-20 1996-08-07 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for vasodilatory treatment or prophylaxis
KR19980701549A (ko) 1995-01-20 1998-05-15 슈타르 피아 퇴행성 뇌질환의 치료 또는 예방용 약학적 조성물의 제조를 위한 3,4-디페닐크로만의 이용(use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of cerebral degenerative disorders)
US5849461A (en) * 1995-08-01 1998-12-15 Shin-Etsu Chemical Co., Ltd. Chemically amplified positive resist composition
IL124882A0 (en) 1996-01-11 1999-01-26 Novo Nordisk As Use of 3, 4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms
US5883118A (en) 1996-01-11 1999-03-16 Nova Nordisk A/S Prostatic carcinoma
US5726202A (en) 1996-01-11 1998-03-10 Novo Nordisk A/S Benign prostatic hypertrophy
US5747059A (en) 1996-01-11 1998-05-05 Novo Nordisk A/S Atrophy of skin/mucous membrane
US5756539A (en) * 1996-07-11 1998-05-26 Novo Nordis A/S 3, 4-diphenyl chromans for inhibiting one or more psychiatric disorders
JP2000514443A (ja) 1996-07-12 2000-10-31 ノボ ノルディスク アクティーゼルスカブ 眼内圧を下げるための医薬組成物の製造のための3,4―ジフェニルクロマンの使用
JP2000514441A (ja) 1996-07-12 2000-10-31 ノボ ノルディスク アクティーゼルスカブ 月経前症候群の1又は複数の症状を抑制するための医薬組成物の製造のための3,4―ジフェニルクロマンの使用
US5780502A (en) * 1996-07-12 1998-07-14 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibiting one or more symptoms of premenstrual syndrome
AUPO203996A0 (en) 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
GB9621757D0 (en) 1996-10-18 1996-12-11 Ciba Geigy Ag Phenyl-substituted bicyclic heterocyclyl derivatives and their use
WO1998018770A1 (en) 1996-10-28 1998-05-07 Novo Nordisk A/S A process for the preparation of (-)-3,4-trans-diarylchromans
US6316494B1 (en) * 1996-10-28 2001-11-13 Novo Nordisk A/S cis3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ZA979649B (en) 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
US6043269A (en) * 1996-10-28 2000-03-28 Novo Nordisk A/S cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
CA2270113A1 (en) * 1996-10-28 1998-05-07 Poul Jacobsen Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5919817A (en) * 1996-10-28 1999-07-06 Novo Nordisk A/S Cis-3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
EP0934297A1 (de) 1996-10-28 1999-08-11 Novo Nordisk A/S $i(CIS)-3,4-CHROMANDERIVATE ZUR VORBEUGUNG ODER BEHANDLUNGVON OESTROGENBEZOGENEN KRANKHEITEN ODER SYNDROMEN
US5985306A (en) * 1996-10-28 1999-11-16 Novo Nordisk A/S (+)-enantiomers of cis-3,4-chroman derivatives useful in prevention or treatment of estrogen diseases or syndromes
WO1998018779A1 (en) 1996-10-28 1998-05-07 Novo Nordisk A/S Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5958967A (en) * 1996-10-28 1999-09-28 Novo Nordisk A/S Cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
CA2269936A1 (en) 1996-10-28 1998-05-07 Lise Brown Christiansen Novel trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5994390A (en) * 1996-10-28 1999-11-30 Novo Nordisk Trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ZA979644B (en) 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
JP2001502704A (ja) 1996-10-28 2001-02-27 ノボ ノルディスク アクティーゼルスカブ エストロゲン関連疾患又は症候群の予防又は処置において有用な新規cis―3,4―クロマン誘導体の新規の(―)―鏡像異性体
ES2188908T3 (es) 1996-10-28 2003-07-01 Novo Nordisk As Derivados de cis-3,4-cromano utiles para la prevencion o tratamiento de sindromes relacionados con el estrogenos.
EP0944613B1 (de) * 1996-12-13 2002-10-09 Chugai Seiyaku Kabushiki Kaisha Benzopyranderivate
AU5550498A (en) 1997-01-29 1998-08-18 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical compositionfor inhibiting one or more psychiatric disorders
ZA98681B (en) 1997-01-29 1998-07-29 Novo Nordisk As Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibition senescense-associated motor impairment
AU5550298A (en) 1997-01-29 1998-08-25 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical compositionfor increasing libido in post-menopausal women
WO1999049862A1 (en) 1998-03-30 1999-10-07 The University Of Mississippi Isoflavones for treating giardiasis and malaria
JP2002512807A (ja) 1998-04-28 2002-05-08 ノボ ノルディスク アクティーゼルスカブ (−)−3.4−トランス−ジアリールクロマンを得るための酵素的分割
FR2778404B1 (fr) 1998-05-06 2000-06-30 Hoechst Marion Roussel Inc Derives du dihydro ou tetrahydronaphtalene, et les compositions pharmaceutiques les renfermant
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
KR20000001793A (ko) 1998-06-13 2000-01-15 이경하 신규한 벤조피란 또는 티오벤조피란 유도체
AUPP868599A0 (en) 1999-02-15 1999-03-11 Novogen Research Pty Ltd Production of isoflavone derivatives
AUPQ008299A0 (en) 1999-04-30 1999-05-27 G.J. Consultants Pty Ltd Isoflavone metabolites
AUPQ266199A0 (en) 1999-09-06 1999-09-30 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
WO2001026651A2 (en) 1999-10-14 2001-04-19 Endorecherche, Inc. Selective estrogen receptor modulators in the treatment or reduction of the risk of acquiring hypertension, cardiovascular diseases, and insulin resistance
WO2001042233A1 (en) * 1999-12-13 2001-06-14 Chugai Seiyaku Kabushiki Kaisha Optically active chroman and thiochroman derivatives
SK9592002A3 (en) 2000-01-28 2003-12-02 Endorech Inc A method for reduction or elimination of the incidence of menopausal symptoms, method of treatment or decreasing the risk of an acquiring disease, a pharmaceutical composition and a kit
FI20001593A7 (fi) 2000-07-03 2002-01-04 Orion Yhtymo Oyj Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
NZ527144A (en) * 2001-01-24 2005-03-24 Chiesi Farmaceutici S 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
AU2002323098A1 (en) 2001-08-11 2003-03-03 Bristol-Myers Squibb Pharma Company Selective estrogen receptor modulators
AUPR846401A0 (en) 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
JP2005524630A (ja) * 2002-01-14 2005-08-18 ノルディック・ビオサイエンス・エー/エス エストロゲン受容体を介する軟骨破壊の抑制
MXPA04009896A (es) 2002-04-09 2005-06-17 Novogen Res Pty Ltd Metodos terapeuticos y composiciones que implican estructuras de tipo isoflav-3-eno e isoflavano.
AU2002951833A0 (en) 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
JP2007525485A (ja) 2003-11-19 2007-09-06 ノボゲン リサーチ ピーティーワイ リミテッド 複合的な放射線治療及び化学治療の組成物及び方法
JP4976649B2 (ja) 2004-09-21 2012-07-18 マーシャル エドワーズ,インク. 化合物
EP2407462B1 (de) 2004-09-21 2014-07-30 Marshall Edwards, Inc. Substituierte Chromanderivate, Medikamente und therapeutische Verwendung
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
WO2006032086A1 (en) 2004-09-21 2006-03-30 Novogen Research Pty Ltd Chroman derivatives, medicaments and use in therapy
AU2008229617A1 (en) 2007-03-16 2008-09-25 Novogen Research Pty Ltd Method for inducing autophagy
US20120039917A1 (en) 2008-08-29 2012-02-16 Alan James Husband Immunomodulating activities
EP2635121B1 (de) 2010-11-01 2020-01-08 MEI Pharma, Inc. Isoflavonoidverbindungen und verfahren zur behandlung von krebs
US20120251630A1 (en) 2011-03-29 2012-10-04 Marshall Edwards, Inc. Remission therapy of cancer with isoflavonoids

Also Published As

Publication number Publication date
NZ553834A (en) 2010-03-26
US20060074127A1 (en) 2006-04-06
EP2407462A1 (de) 2012-01-18
CN101056868A (zh) 2007-10-17
US20160287555A1 (en) 2016-10-06
CA2581316A1 (en) 2006-03-30
US9381186B2 (en) 2016-07-05
US20120114766A1 (en) 2012-05-10
US7601855B2 (en) 2009-10-13
AU2005287865B2 (en) 2012-02-16
US9138478B2 (en) 2015-09-22
MX2007003216A (es) 2008-03-10
US20150352074A1 (en) 2015-12-10
CN101056868B (zh) 2012-05-02
US20090317490A1 (en) 2009-12-24
AU2005287865A1 (en) 2006-03-30
EP1794141A4 (de) 2009-05-27
US20140170243A1 (en) 2014-06-19
NO20072004L (no) 2007-05-30
EP1794141A1 (de) 2007-06-13
IL182034A (en) 2012-10-31
US8697891B2 (en) 2014-04-15
EP2407462B1 (de) 2014-07-30
EP1794141B1 (de) 2011-11-09
CA2581316C (en) 2013-09-10
WO2006032085A1 (en) 2006-03-30
US8084628B2 (en) 2011-12-27
IL182034A0 (en) 2007-07-24

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