WO2008036067A3 - Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents - Google Patents

Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents Download PDF

Info

Publication number
WO2008036067A3
WO2008036067A3 PCT/US2006/027763 US2006027763W WO2008036067A3 WO 2008036067 A3 WO2008036067 A3 WO 2008036067A3 US 2006027763 W US2006027763 W US 2006027763W WO 2008036067 A3 WO2008036067 A3 WO 2008036067A3
Authority
WO
WIPO (PCT)
Prior art keywords
amides
carboxylic acid
thiazolidinone
cancer agents
serine
Prior art date
Application number
PCT/US2006/027763
Other languages
French (fr)
Other versions
WO2008036067A2 (en
Inventor
Duane D Miller
Veeresa Gududuru
James T Dalton
Eunju Hurh
Original Assignee
Univ Tennessee Res Foundation
Univ Ohio State Res Found
Duane D Miller
Veeresa Gududuru
James T Dalton
Eunju Hurh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tennessee Res Foundation, Univ Ohio State Res Found, Duane D Miller, Veeresa Gududuru, James T Dalton, Eunju Hurh filed Critical Univ Tennessee Res Foundation
Priority to EP06851619A priority Critical patent/EP1926487A2/en
Publication of WO2008036067A2 publication Critical patent/WO2008036067A2/en
Publication of WO2008036067A3 publication Critical patent/WO2008036067A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides according to formulae (I) and (II) are disclosed where the various substituent groups are as defined in the specification. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
PCT/US2006/027763 2005-07-19 2006-07-19 Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents WO2008036067A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06851619A EP1926487A2 (en) 2005-07-19 2006-07-19 Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70065305P 2005-07-19 2005-07-19
US60/700,653 2005-07-19

Publications (2)

Publication Number Publication Date
WO2008036067A2 WO2008036067A2 (en) 2008-03-27
WO2008036067A3 true WO2008036067A3 (en) 2009-02-12

Family

ID=39201002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027763 WO2008036067A2 (en) 2005-07-19 2006-07-19 Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents

Country Status (2)

Country Link
EP (1) EP1926487A2 (en)
WO (1) WO2008036067A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
DK2959900T3 (en) 2008-06-16 2017-06-26 Univ Tennessee Res Found CONNECTION TO TREATMENT OF CANCER
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
EP3064204A1 (en) 2010-03-01 2016-09-07 GTx, Inc. Compounds for treatment of cancer
KR102040476B1 (en) * 2012-03-26 2019-11-06 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 Efficient synthesis of ethylenedicysteine-sugar conjugates for imaging and therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225102A1 (en) * 2002-04-08 2003-12-04 Torrent Pharmaceuticals Ltd. Novel compounds and therapeutic uses thereof
WO2005049591A1 (en) * 2003-11-18 2005-06-02 University Of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225102A1 (en) * 2002-04-08 2003-12-04 Torrent Pharmaceuticals Ltd. Novel compounds and therapeutic uses thereof
WO2005049591A1 (en) * 2003-11-18 2005-06-02 University Of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof

Also Published As

Publication number Publication date
EP1926487A2 (en) 2008-06-04
WO2008036067A2 (en) 2008-03-27

Similar Documents

Publication Publication Date Title
WO2006032342A3 (en) Carbonyl compound-containing drug and the use thereof
WO2009046842A3 (en) Thiazol derivatives for treating cancer
WO2006028525A3 (en) [3.2.0] heterocyclic compounds and methods of using the same
WO2009046841A8 (en) Piperidine and piperazine derivatives for treating tumours
SE0401971D0 (en) Piperidne derivatives
WO2007081974A3 (en) Viral hepatitis treatment
DE602006014579D1 (en) HETEROALKYL-TIED PYRIMIDINE DERIVATIVES
WO2006086562A3 (en) Phenylazetidinone derivatives
WO2005004818A3 (en) Heterocyclic compounds and their use as anticancer agents
WO2006107451A3 (en) Honokiol derivatives for the treatment of proliferative disorders
WO2005110994A8 (en) Substituted pyrazolyl urea derivatives useful in the treatment of cancer
WO2004075864A3 (en) Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
WO2007109279A3 (en) Tetrahydropyridothienopyrimidine compounds and methods of use thereof
WO2007130075A8 (en) Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
WO2006100082A3 (en) Substituted oxindol derivatives, drugs containing said derivatives and the use thereof
IL196543A (en) Pyridazinone derivatives and pharmaceutical compositions comprising them for use in the treatment of disorders
TW200738241A (en) Pyridazine derivatives
TW200700391A (en) Pyridine-2-carboxamide derivatives as mglur5 antagonists
WO2007044084A3 (en) Heterocyclic inhibitors of mek and methods of use thereof
WO2008101682A3 (en) Iminipyridine derivatives and their uses as microbiocides
EA200700096A1 (en) DERIVATIVES 2-CARBAMID-4-PHENYL THIAZOLE, METHOD FOR THEIR PRODUCTION AND THEIR APPLICATION IN THERAPY
MX2009003985A (en) Phenylacetamides useful as protein kinase inhibitors.
WO2007097981A3 (en) Alpha carbolines and uses thereof
DE602004024213D1 (en) Aminopropanolderivate
WO2008036067A3 (en) Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006851619

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06851619

Country of ref document: EP

Kind code of ref document: A2