SU1482522A3 - Способ получени замещенных 1-(1-фенилциклобутил)-алкиламинов или их фармакологически приемлемых солей - Google Patents

Способ получени замещенных 1-(1-фенилциклобутил)-алкиламинов или их фармакологически приемлемых солей Download PDF

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SU1482522A3
SU1482522A3 SU823426748A SU3426748A SU1482522A3 SU 1482522 A3 SU1482522 A3 SU 1482522A3 SU 823426748 A SU823426748 A SU 823426748A SU 3426748 A SU3426748 A SU 3426748A SU 1482522 A3 SU1482522 A3 SU 1482522A3
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USSR - Soviet Union
Prior art keywords
methyl
hydrogen
ether
alkyl
phenylcyclobutyl
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SU823426748A
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English (en)
Russian (ru)
Inventor
Эдвард Джеффри Джеймс
Козлик Антонин
Чарльз Вилмшерст Эрик
Original Assignee
Дзе Бутс Компани Лимитед (Фирма)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26279045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SU1482522(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дзе Бутс Компани Лимитед (Фирма) filed Critical Дзе Бутс Компани Лимитед (Фирма)
Application granted granted Critical
Publication of SU1482522A3 publication Critical patent/SU1482522A3/ru
Priority to LTRP1010A priority Critical patent/LT2518B/xx
Priority to LV931267A priority patent/LV5454A3/xx
Priority to LV931266A priority patent/LV5453A3/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/227—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C07C49/237—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/567—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
SU823426748A 1981-04-06 1982-04-05 Способ получени замещенных 1-(1-фенилциклобутил)-алкиламинов или их фармакологически приемлемых солей SU1482522A3 (ru)

Priority Applications (3)

Application Number Priority Date Filing Date Title
LTRP1010A LT2518B (lt) 1981-04-06 1993-09-20 (1-arilciklobutil)-alkaliminu arba ju farmaciskai priimtinu drusku gavimo budas
LV931267A LV5454A3 (lv) 1981-04-06 1993-11-25 (1-Arilciklobutil)-alkilaminu vai to farmakologiski derigu salu iegusanas metode
LV931266A LV5453A3 (lv) 1981-04-06 1993-11-25 Aizietotu 1-(1-fenilciklobutil)-alkilaminu vai to farmakologiski derigu salu iegusanas metode

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8110709 1981-04-06
GB8110710 1981-04-06

Publications (1)

Publication Number Publication Date
SU1482522A3 true SU1482522A3 (ru) 1989-05-23

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ID=26279045

Family Applications (2)

Application Number Title Priority Date Filing Date
SU823426748A SU1482522A3 (ru) 1981-04-06 1982-04-05 Способ получени замещенных 1-(1-фенилциклобутил)-алкиламинов или их фармакологически приемлемых солей
SU853834158A SU1461372A3 (ru) 1981-04-06 1985-01-09 Способ получени (1-арилциклобутил)-алкиламинов или их фармакологически приемлемых солей

Family Applications After (1)

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SU853834158A SU1461372A3 (ru) 1981-04-06 1985-01-09 Способ получени (1-арилциклобутил)-алкиламинов или их фармакологически приемлемых солей

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2358719C2 (ru) * 1999-08-11 2009-06-20 Сепракор Инк. Композиции, содержащие ингибиторы обратного захвата допамина, и способы их применения
RU2479572C2 (ru) * 2008-04-08 2013-04-20 Бейджинг Йангу Сентури Фармаси Ко., ЛТД Получение и применение производных фенилциклобутиламида и их стереоизомеров
RU2642074C2 (ru) * 2011-12-30 2018-01-24 Ревива Фармасьютикалс, Инк. Композиции, синтез и способы применения производных фенилциклоалкилметиламина
RU2783708C2 (ru) * 2017-08-11 2022-11-16 Норион Кемикалз Интернэшнл Б.В. Способ производства этиленаминовых соединений

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GB8412480D0 (en) * 1984-05-16 1984-06-20 Elliott M Pesticides
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GB8531071D0 (en) * 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
GB8704777D0 (en) * 1987-02-28 1987-04-01 Boots Co Plc Medical treatment
JP2675573B2 (ja) * 1988-03-31 1997-11-12 科研製薬株式会社 脳機能改善剤
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GB9309749D0 (en) * 1993-05-12 1993-06-23 Boots Co Plc Therapeutic agents
US5459164A (en) * 1994-02-03 1995-10-17 Boots Pharmaceuticals, Inc. Medical treatment
DE19518988A1 (de) * 1995-05-29 1996-12-05 Basf Ag Verwendung arylsubstituierter Cyclobutylalkylamine zur Behandlung der Fettleibigkeit
GB9524681D0 (en) * 1995-12-02 1996-01-31 Knoll Ag Chemical process
GB9619757D0 (en) * 1996-09-21 1996-11-06 Knoll Ag Chemical process
GB9619962D0 (en) * 1996-09-25 1996-11-13 Knoll Ag Medical treatment
GB9619961D0 (en) * 1996-09-25 1996-11-13 Knoll Ag Medical treatment
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US6331571B1 (en) 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
AU2007200334B8 (en) * 1998-08-24 2010-10-21 Sepracor, Inc. Methods of using and compositions comprising dopamine reuptake inhibitors
US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
BG65170B1 (bg) * 1999-03-17 2007-05-31 Knoll Gmbh Използване на n-заместени производни на 1-[1-(4-хлорофенил)циклобутил]-3-метилбутиламин за производство на лекарство за лечение на разстройства при храненето
US6552087B1 (en) 1999-03-19 2003-04-22 Abbott Gmbh & Co. Kg Therapeutic agent comprising (+)-sibutramine
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FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
KR100606533B1 (ko) 2004-08-27 2006-08-01 한올제약주식회사 시부트라민의 개선된 합성방법
KR100606534B1 (ko) 2004-11-01 2006-08-01 한올제약주식회사 생산성을 향상시킨 시부트라민의 개선된 합성방법
KR100618176B1 (ko) * 2004-12-02 2006-09-01 휴먼팜 주식회사 시부트라민 주석산염, 이의 제조 방법 및 이를 포함하는약학적 조성물
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MX2009002781A (es) 2006-09-15 2009-03-30 Reviva Pharmaceuticals Inc Sintesis, metodos de uso y composiciones de cicloalquilmetilaminas .
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2358719C2 (ru) * 1999-08-11 2009-06-20 Сепракор Инк. Композиции, содержащие ингибиторы обратного захвата допамина, и способы их применения
RU2479572C2 (ru) * 2008-04-08 2013-04-20 Бейджинг Йангу Сентури Фармаси Ко., ЛТД Получение и применение производных фенилциклобутиламида и их стереоизомеров
RU2642074C2 (ru) * 2011-12-30 2018-01-24 Ревива Фармасьютикалс, Инк. Композиции, синтез и способы применения производных фенилциклоалкилметиламина
RU2783708C2 (ru) * 2017-08-11 2022-11-16 Норион Кемикалз Интернэшнл Б.В. Способ производства этиленаминовых соединений

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GB2098602A (en) 1982-11-24
ES519032A0 (es) 1984-03-01
PL136242B1 (en) 1986-02-28
ES511152A0 (es) 1983-04-16
GR76697B (enExample) 1984-08-28
NO821087L (no) 1982-10-07
ES8403097A1 (es) 1984-03-01
DE3212682A1 (de) 1982-10-21
ES519031A0 (es) 1984-08-16
FI77223C (fi) 1989-02-10
ES8407002A1 (es) 1984-08-16
ATA132582A (de) 1986-08-15
SG67287G (en) 1988-02-19
IT1235758B (it) 1992-09-28
IE820481L (en) 1982-10-06
CS245782A2 (en) 1985-08-15
DK161770C (da) 1992-02-10
NL8201347A (nl) 1982-11-01
DE3212682C2 (enExample) 1992-03-26
LU84070A1 (fr) 1983-06-07
PT74580A (en) 1982-04-01
IE52768B1 (en) 1988-02-17
MY8800048A (en) 1988-12-31
UA7838A1 (uk) 1995-12-26
ZW4982A1 (en) 1982-11-03
PL240079A1 (en) 1983-09-12
PH22762A (en) 1988-12-12
CA1248955A (en) 1989-01-17
NO156785C (no) 1987-11-25
BG40651A3 (en) 1986-01-15
ES519029A0 (es) 1984-08-01
RO89436A2 (ro) 1986-06-30
HU186582B (en) 1985-08-28
IT8248157A0 (it) 1982-04-02
NZ200178A (en) 1985-07-31
KR830010065A (ko) 1983-12-26
UA7589A1 (uk) 1995-09-29
DK146482A (da) 1982-10-07
FI821197L (fi) 1982-10-07
YU6385A (en) 1985-08-31
ES519030A0 (es) 1984-08-01
FI821197A0 (fi) 1982-04-05
KE3753A (en) 1987-10-02
CS244672B2 (en) 1986-08-14
SE8202166L (sv) 1982-11-25
IL65257A0 (en) 1983-12-30
SU1461372A3 (ru) 1989-02-23
BG40652A3 (en) 1986-01-15
KR900000274B1 (ko) 1990-01-24
ES8305678A1 (es) 1983-04-16
YU75082A (en) 1985-08-31
PL139120B1 (en) 1986-12-31
NO156785B (no) 1987-08-17
DD208348A5 (de) 1984-05-02
YU44253B (en) 1990-04-30
SE452611B (sv) 1987-12-07
RO84802A (ro) 1984-09-29
PT74580B (en) 1983-12-23
RO84802B (ro) 1984-10-30
JO1184B1 (en) 1983-11-30
FI77223B (fi) 1988-10-31
YU44336B (en) 1990-06-30
GB2098602B (en) 1984-08-22
NL192201C (nl) 1997-03-04
PL235832A1 (en) 1983-09-12
CY1408A (en) 1988-04-22
HK13888A (en) 1988-02-26
ES8406414A1 (es) 1984-08-01
CH652117A5 (fr) 1985-10-31
FR2504920B1 (fr) 1985-06-28
DK161770B (da) 1991-08-12
GEP19970661B (en) 1997-01-04
AU545595B2 (en) 1985-07-18
AT382612B (de) 1987-03-25
IN155773B (enExample) 1985-03-09
AU8221382A (en) 1982-10-14
ES8406413A1 (es) 1984-08-01
FR2504920A1 (fr) 1982-11-05
NL192201B (nl) 1996-11-01

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