RO84802B - Procedeu pentru obtinerea unor (1-aril-ciclobutil)-alchilamine - Google Patents

Procedeu pentru obtinerea unor (1-aril-ciclobutil)-alchilamine

Info

Publication number
RO84802B
RO84802B RO107119A RO10711982A RO84802B RO 84802 B RO84802 B RO 84802B RO 107119 A RO107119 A RO 107119A RO 10711982 A RO10711982 A RO 10711982A RO 84802 B RO84802 B RO 84802B
Authority
RO
Romania
Prior art keywords
carbon atoms
radical
alkyl radical
alkylamines
cyclobutyl
Prior art date
Application number
RO107119A
Other languages
English (en)
Other versions
RO84802A (ro
Inventor
James Edward Jeffery
Antonin Kozlik
Eric Charles Wilmshurst
Original Assignee
The Boots Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26279045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO84802(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Boots Company Limited filed Critical The Boots Company Limited
Publication of RO84802A publication Critical patent/RO84802A/ro
Publication of RO84802B publication Critical patent/RO84802B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/227—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C07C49/237—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/567—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

Procedeul pentru obtinerea unor (1-aril-ciclobutil)-alchilamine cu formula generala I: (vezi formula) în care n reprezinta 0 sau 1, cînd n = 0, R1 reprezinta un radical alchil cu catena liniara sau ramificata cu 1...6 atomi de carbon, un radical cicloalchil cu 3...7 atomi de carbon, un radical cicloalchil are 3...6 atomi de carbon si radicalul alchil are 1...3 atomi de carbon, un radical alchenil sau alchinil cu 2...6 atomi de carbon sau o grupare cu formula generala II: (vezi formula) în care R9 si R10 pot fi identici sau diferiti si reprezinta un atom de H, halogen sau un radical alcoxi cu 1...3 atomi de carbon, iar cînd n = 1, R1 reprezinta un atom de H, un radical alchil cu 1...3 atomi de carbon, R2 reprezinta H sau un radical alchil cu 1...3 atomi de 0, R3 reprezinta un atom de H, un radical alchil cu catena liniara sau ramificata continînd 1...4 atomi de carbon, un radical alchenil cu 3...6 atomi de carbon...
RO107119A 1981-04-06 1982-04-01 Procedeu pentru obtinerea unor (1-aril-ciclobutil)-alchilamine RO84802B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8110709 1981-04-06
GB8110710 1981-04-06

Publications (2)

Publication Number Publication Date
RO84802A RO84802A (ro) 1984-09-29
RO84802B true RO84802B (ro) 1984-10-30

Family

ID=26279045

Family Applications (2)

Application Number Title Priority Date Filing Date
RO107119A RO84802B (ro) 1981-04-06 1982-04-01 Procedeu pentru obtinerea unor (1-aril-ciclobutil)-alchilamine
RO82114421A RO89436A2 (ro) 1981-04-06 1982-04-01 Procedeu pentru prepararea unor(laril-ciclobutil)-alchilamine

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO82114421A RO89436A2 (ro) 1981-04-06 1982-04-01 Procedeu pentru prepararea unor(laril-ciclobutil)-alchilamine

Country Status (40)

Country Link
KR (1) KR900000274B1 (ro)
AT (1) AT382612B (ro)
AU (1) AU545595B2 (ro)
BG (2) BG40652A3 (ro)
CA (1) CA1248955A (ro)
CH (1) CH652117A5 (ro)
CS (1) CS244672B2 (ro)
CY (1) CY1408A (ro)
DD (1) DD208348A5 (ro)
DE (1) DE3212682A1 (ro)
DK (1) DK161770C (ro)
ES (5) ES8305678A1 (ro)
FI (1) FI77223C (ro)
FR (1) FR2504920B1 (ro)
GB (1) GB2098602B (ro)
GE (1) GEP19970661B (ro)
GR (1) GR76697B (ro)
HK (1) HK13888A (ro)
HU (1) HU186582B (ro)
IE (1) IE52768B1 (ro)
IL (1) IL65257A0 (ro)
IN (1) IN155773B (ro)
IT (1) IT1235758B (ro)
JO (1) JO1184B1 (ro)
KE (1) KE3753A (ro)
LU (1) LU84070A1 (ro)
MY (1) MY8800048A (ro)
NL (1) NL192201C (ro)
NO (1) NO156785C (ro)
NZ (1) NZ200178A (ro)
PH (1) PH22762A (ro)
PL (2) PL139120B1 (ro)
PT (1) PT74580B (ro)
RO (2) RO84802B (ro)
SE (1) SE452611B (ro)
SG (1) SG67287G (ro)
SU (2) SU1482522A3 (ro)
UA (2) UA7589A1 (ro)
YU (2) YU44336B (ro)
ZW (1) ZW4982A1 (ro)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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IE56000B1 (en) * 1982-09-30 1991-03-13 Boots Co Plc 1-arylcyclobutylalkylamine compounds
IE56001B1 (en) * 1982-09-30 1991-03-13 Boots Co Plc 1-arylcyclobutylmethylamine compounds
GB8412480D0 (en) * 1984-05-16 1984-06-20 Elliott M Pesticides
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
GB8501192D0 (en) * 1985-01-17 1985-02-20 Boots Co Plc Therapeutic agents
US5157021A (en) * 1985-03-15 1992-10-20 Novo Nordisk A/S Insulin derivatives and pharmaceutical preparations containing these derivatives
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
GB2184122B (en) * 1985-12-17 1989-10-18 Boots Co Plc N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl butylamine hydrochloride monohydrate
GB8531071D0 (en) * 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
GB8704777D0 (en) * 1987-02-28 1987-04-01 Boots Co Plc Medical treatment
JP2675573B2 (ja) * 1988-03-31 1997-11-12 科研製薬株式会社 脳機能改善剤
WO1994000114A1 (en) * 1992-06-23 1994-01-06 Sepracor Inc. Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine
GB9309749D0 (en) * 1993-05-12 1993-06-23 Boots Co Plc Therapeutic agents
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GB9524681D0 (en) 1995-12-02 1996-01-31 Knoll Ag Chemical process
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KR100536750B1 (ko) * 2002-10-05 2005-12-16 한미약품 주식회사 시부트라민 메탄술폰산염의 결정성 반수화물을 포함하는약학 조성물
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
KR100606533B1 (ko) 2004-08-27 2006-08-01 한올제약주식회사 시부트라민의 개선된 합성방법
KR100606534B1 (ko) 2004-11-01 2006-08-01 한올제약주식회사 생산성을 향상시킨 시부트라민의 개선된 합성방법
KR100618176B1 (ko) * 2004-12-02 2006-09-01 휴먼팜 주식회사 시부트라민 주석산염, 이의 제조 방법 및 이를 포함하는약학적 조성물
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FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
WO2010082216A2 (en) * 2008-12-08 2010-07-22 Matrix Laboratories Ltd Novel salts of sibutramine and their crystal forms
JP5696156B2 (ja) 2009-11-02 2015-04-08 ファイザー・インク ジオキサ−ビシクロ［３．２．１］オクタン−２，３，４−トリオール誘導体
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FR2993561B1 (fr) * 2012-07-17 2014-10-31 Servier Lab Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels

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Also Published As

Publication number Publication date
NL8201347A (nl) 1982-11-01
DD208348A5 (de) 1984-05-02
ES519029A0 (es) 1984-08-01
NO821087L (no) 1982-10-07
YU6385A (en) 1985-08-31
DK146482A (da) 1982-10-07
FR2504920B1 (fr) 1985-06-28
ES519030A0 (es) 1984-08-01
HK13888A (en) 1988-02-26
GB2098602A (en) 1982-11-24
HU186582B (en) 1985-08-28
BG40652A3 (en) 1986-01-15
SU1461372A3 (ru) 1989-02-23
IT8248157A0 (it) 1982-04-02
IT1235758B (it) 1992-09-28
NO156785B (no) 1987-08-17
IE52768B1 (en) 1988-02-17
CS245782A2 (en) 1985-08-15
CH652117A5 (fr) 1985-10-31
FI77223B (fi) 1988-10-31
CS244672B2 (en) 1986-08-14
PL235832A1 (en) 1983-09-12
GB2098602B (en) 1984-08-22
ES511152A0 (es) 1983-04-16
ES8407002A1 (es) 1984-08-16
ES519032A0 (es) 1984-03-01
ZW4982A1 (en) 1982-11-03
NO156785C (no) 1987-11-25
MY8800048A (en) 1988-12-31
PL136242B1 (en) 1986-02-28
DE3212682C2 (ro) 1992-03-26
FI821197A0 (fi) 1982-04-05
GR76697B (ro) 1984-08-28
YU44253B (en) 1990-04-30
CY1408A (en) 1988-04-22
UA7838A1 (uk) 1995-12-26
IL65257A0 (en) 1983-12-30
FI77223C (fi) 1989-02-10
NL192201C (nl) 1997-03-04
IN155773B (ro) 1985-03-09
LU84070A1 (fr) 1983-06-07
KE3753A (en) 1987-10-02
DE3212682A1 (de) 1982-10-21
ES8406413A1 (es) 1984-08-01
NZ200178A (en) 1985-07-31
NL192201B (nl) 1996-11-01
ATA132582A (de) 1986-08-15
FI821197L (fi) 1982-10-07
YU75082A (en) 1985-08-31
AU545595B2 (en) 1985-07-18
PT74580B (en) 1983-12-23
PL240079A1 (en) 1983-09-12
SE452611B (sv) 1987-12-07
DK161770C (da) 1992-02-10
IE820481L (en) 1982-10-06
AU8221382A (en) 1982-10-14
UA7589A1 (uk) 1995-09-29
ES519031A0 (es) 1984-08-16
BG40651A3 (en) 1986-01-15
PL139120B1 (en) 1986-12-31
YU44336B (en) 1990-06-30
RO84802A (ro) 1984-09-29
AT382612B (de) 1987-03-25
DK161770B (da) 1991-08-12
JO1184B1 (en) 1983-11-30
GEP19970661B (en) 1997-01-04
SG67287G (en) 1988-02-19
ES8406414A1 (es) 1984-08-01
FR2504920A1 (fr) 1982-11-05
PH22762A (en) 1988-12-12
KR900000274B1 (ko) 1990-01-24
KR830010065A (ko) 1983-12-26
ES8305678A1 (es) 1983-04-16
SE8202166L (sv) 1982-11-25
CA1248955A (en) 1989-01-17
RO89436A2 (ro) 1986-06-30
ES8403097A1 (es) 1984-03-01
PT74580A (en) 1982-04-01
SU1482522A3 (ru) 1989-05-23

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