SU1447284A3 - Способ получени производного @ 3Н @ -имидазо- @ 5,1- @ -1,2,3,5-тетразин-4-она - Google Patents

Способ получени производного @ 3Н @ -имидазо- @ 5,1- @ -1,2,3,5-тетразин-4-она Download PDF

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Publication number
SU1447284A3
SU1447284A3 SU823482389A SU3482389A SU1447284A3 SU 1447284 A3 SU1447284 A3 SU 1447284A3 SU 823482389 A SU823482389 A SU 823482389A SU 3482389 A SU3482389 A SU 3482389A SU 1447284 A3 SU1447284 A3 SU 1447284A3
Authority
SU
USSR - Soviet Union
Prior art keywords
imidazo
tetrazin
solid
carbamoyl
solution
Prior art date
Application number
SU823482389A
Other languages
English (en)
Russian (ru)
Inventor
Лант Эдвард
Фрэнкис Грахам Стивенс Малкольм
Стоун Роберт
Роберт Харри Вулдридж Кеннет
Original Assignee
Мэй Энд Бейкер Лимитед (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мэй Энд Бейкер Лимитед (Фирма) filed Critical Мэй Энд Бейкер Лимитед (Фирма)
Application granted granted Critical
Publication of SU1447284A3 publication Critical patent/SU1447284A3/ru
Priority to LV930621A priority Critical patent/LV5511A3/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SU823482389A 1981-08-24 1982-08-23 Способ получени производного @ 3Н @ -имидазо- @ 5,1- @ -1,2,3,5-тетразин-4-она SU1447284A3 (ru)

Priority Applications (1)

Application Number Priority Date Filing Date Title
LV930621A LV5511A3 (lv) 1981-08-24 1993-06-19 Ú3H¾-imidazo-Ú5,1-a¾-1,2,3,5-tetrazin-4-ona atvasinajumu iegusanas panemiens

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8125791 1981-08-24

Publications (1)

Publication Number Publication Date
SU1447284A3 true SU1447284A3 (ru) 1988-12-23

Family

ID=10524141

Family Applications (1)

Application Number Title Priority Date Filing Date
SU823482389A SU1447284A3 (ru) 1981-08-24 1982-08-23 Способ получени производного @ 3Н @ -имидазо- @ 5,1- @ -1,2,3,5-тетразин-4-она

Country Status (29)

Country Link
JP (1) JPS5843975A (enExample)
KR (1) KR890000094B1 (enExample)
AT (1) AT380256B (enExample)
AU (1) AU571430B2 (enExample)
BE (1) BE894175A (enExample)
CA (1) CA1197247A (enExample)
CH (1) CH655114A5 (enExample)
DE (2) DE19975037I2 (enExample)
DK (1) DK161147C (enExample)
ES (1) ES515176A0 (enExample)
FI (1) FI73434C (enExample)
FR (1) FR2511679A1 (enExample)
GB (1) GB2104522B (enExample)
GE (1) GEP19960641B (enExample)
GR (1) GR76863B (enExample)
HU (1) HU186107B (enExample)
IE (1) IE53408B1 (enExample)
IL (1) IL66606A (enExample)
IT (1) IT1152505B (enExample)
LT (1) LT2436B (enExample)
LU (1) LU84347A1 (enExample)
LV (2) LV5511A3 (enExample)
NL (2) NL192739C (enExample)
NZ (1) NZ201668A (enExample)
OA (1) OA07174A (enExample)
SE (1) SE448543B (enExample)
SU (1) SU1447284A3 (enExample)
UA (1) UA5971A1 (enExample)
ZA (1) ZA826120B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
RU2166946C2 (ru) * 1995-09-25 2001-05-20 Санофи-Синтелабо Инк. Состав, содержащий 1,2,4-бензотриазин-3-амин-1,4-диоксид, для парентерального введения и способ лечения с его применением
RU2462466C1 (ru) * 2011-06-24 2012-09-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Замещенные азоло[1,2,4,5]тетразины - ингибиторы актинобактериальных серин-треониновых протеинкиназ

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
FR2531958B1 (fr) * 1982-08-17 1986-10-31 May & Baker Ltd Nouveaux derive
US4517182A (en) * 1983-05-24 1985-05-14 Warner-Lambert Company 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
EP1706407A2 (en) 2003-12-30 2006-10-04 Chemagis Ltd. Novel crystalline forms of temozolomide
EP1845973B1 (en) 2005-01-21 2015-08-12 Astex Therapeutics Limited Pharmaceutical compounds
PE20080695A1 (es) 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
EP2213673B1 (en) 2007-10-23 2013-06-05 Msd K.K. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
PE20091101A1 (es) * 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
EP2367828B1 (en) * 2008-11-24 2014-06-11 Reliance Life Sciences Pvt., Ltd. Process for the preparation of tetrazine derivatives
US8481503B2 (en) 2009-03-06 2013-07-09 Merck Sharp & Dohme Corp. Combination cancer therapy with an AKT inhibitor and other anticancer agents
CA2763766A1 (en) 2009-06-23 2010-12-29 Pharminox Limited 3-substituted-8-substituted-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use
EP2766041B1 (en) 2011-10-12 2018-12-05 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies
CN120661674A (zh) 2016-03-15 2025-09-19 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合
KR101847342B1 (ko) * 2017-05-08 2018-04-11 (주)센텍코리아 웨어러블 체지방 연소량 측정기
US20240400572A1 (en) * 2021-09-23 2024-12-05 Yale University Compounds and methods for treating cancers that are mgmt deficient regardless of mmr status

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2932305A1 (de) * 1979-08-09 1981-02-26 Basf Ag Azolo- eckige klammer auf 5,1-d eckige klammer zu - eckige klammer auf 1,2,3,5 eckige klammer zu -tetrazin-4-one und verfahren zur herstellung dieser verbindungen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Tveit К,М., Fodstad О., Olsnes S., Rinl А. In vitro sensitivity of Inmati inelanoma xenografts to cytotoxic drugs. Correlation with in vivo che- mosepsitivity. Inst. I.Cancer. 26, i980i p.. 717-722. Патент СССР f 1227117, pi. С 07 H 15/24, 22.08,81. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
RU2166946C2 (ru) * 1995-09-25 2001-05-20 Санофи-Синтелабо Инк. Состав, содержащий 1,2,4-бензотриазин-3-амин-1,4-диоксид, для парентерального введения и способ лечения с его применением
RU2462466C1 (ru) * 2011-06-24 2012-09-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Замещенные азоло[1,2,4,5]тетразины - ингибиторы актинобактериальных серин-треониновых протеинкиназ

Also Published As

Publication number Publication date
FI73434C (fi) 1987-10-09
NL192739C (nl) 1998-01-06
LT2436B (lt) 1994-02-15
SE448543B (sv) 1987-03-02
FI822921A0 (fi) 1982-08-23
IL66606A0 (en) 1982-12-31
LV5621A3 (lv) 1994-05-10
CH655114A5 (fr) 1986-03-27
UA5971A1 (uk) 1994-12-29
FI73434B (fi) 1987-06-30
FR2511679A1 (fr) 1983-02-25
NL990010I1 (nl) 1999-07-01
KR890000094B1 (ko) 1989-03-07
DE3231255A1 (de) 1983-03-03
IE53408B1 (en) 1988-11-09
IT1152505B (it) 1987-01-07
DK161147C (da) 1991-11-18
AU571430B2 (en) 1988-04-21
IT8222938A0 (it) 1982-08-23
DK377882A (da) 1983-02-25
SE8204817D0 (sv) 1982-08-23
FI822921L (fi) 1983-02-25
NL8203286A (nl) 1983-03-16
LU84347A1 (fr) 1983-06-07
ES8400438A1 (es) 1983-11-01
BE894175A (fr) 1983-02-23
NZ201668A (en) 1985-08-16
ES515176A0 (es) 1983-11-01
NL990010I2 (nl) 1999-09-01
CA1197247A (fr) 1985-11-26
GB2104522B (en) 1985-06-12
DE3231255C2 (enExample) 1992-02-27
JPS5843975A (ja) 1983-03-14
IL66606A (en) 1987-07-31
DE19975037I2 (de) 2001-06-13
KR840001175A (ko) 1984-03-28
NL192739B (nl) 1997-09-01
LV5511A3 (lv) 1994-03-10
OA07174A (fr) 1984-04-30
JPH045029B2 (enExample) 1992-01-30
HU186107B (en) 1985-06-28
ATA319182A (de) 1985-09-15
FR2511679B1 (enExample) 1985-02-01
AU8749382A (en) 1983-03-03
ZA826120B (en) 1983-07-27
IE822026L (en) 1983-02-24
GEP19960641B (en) 1996-11-15
DK161147B (da) 1991-06-03
IT8222938A1 (it) 1984-02-23
GB2104522A (en) 1983-03-09
SE8204817L (sv) 1983-02-25
AT380256B (de) 1986-05-12
GR76863B (enExample) 1984-09-04

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