ES8400438A1 - Procedimiento para preparar derivados de (3h)-imidazo(5,1-d)-1,2,3,5-tetrazin-4-ona. - Google Patents

Procedimiento para preparar derivados de (3h)-imidazo(5,1-d)-1,2,3,5-tetrazin-4-ona.

Info

Publication number
ES8400438A1
ES8400438A1 ES515176A ES515176A ES8400438A1 ES 8400438 A1 ES8400438 A1 ES 8400438A1 ES 515176 A ES515176 A ES 515176A ES 515176 A ES515176 A ES 515176A ES 8400438 A1 ES8400438 A1 ES 8400438A1
Authority
ES
Spain
Prior art keywords
carbon atoms
groups
group
denotes
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515176A
Other languages
English (en)
Other versions
ES515176A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Publication of ES515176A0 publication Critical patent/ES515176A0/es
Publication of ES8400438A1 publication Critical patent/ES8400438A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 3H-IMIDAZO 5,1,D -1,2,3,5, TETRAZIN-4-ONA.SE HACE REACIONAR UN COMPUESTO (II) CON UN ISOCIANATO R3NCO DONDE R3 ES UN GRUPO ALQUILO, ALQUENILO O ALQUINILO CON AL MENOS 6 ATOMOS DE CARBONO, INSUSTITUIDO O SUSTITUIDO POR HALOGENO, GRUPO ALCOXI, ALQUILTIO, ALQUILSULFINILO Y ALQUILSULFONILO CONTENIENDO COMO MAXIMO 4 ATOMOS DE CARBONO Y GRUPOS FENILO OPCIONALMENTE SUSTITUIDO; R3 PUEDE SER TAMBIEN UN GRUPO CICLOALQUILO CON 3 A 8 ATOMOS DE CARBONO. SE OBTIENE EL COMPUESTO (I) DONDE R1 PUEDE SER UN GRUPO CICLOALQUILO Y R2 UN GRUPO CARBAMOILO.
ES515176A 1981-08-24 1982-08-23 Procedimiento para preparar derivados de (3h)-imidazo(5,1-d)-1,2,3,5-tetrazin-4-ona. Expired ES8400438A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8125791 1981-08-24

Publications (2)

Publication Number Publication Date
ES515176A0 ES515176A0 (es) 1983-11-01
ES8400438A1 true ES8400438A1 (es) 1983-11-01

Family

ID=10524141

Family Applications (1)

Application Number Title Priority Date Filing Date
ES515176A Expired ES8400438A1 (es) 1981-08-24 1982-08-23 Procedimiento para preparar derivados de (3h)-imidazo(5,1-d)-1,2,3,5-tetrazin-4-ona.

Country Status (29)

Country Link
JP (1) JPS5843975A (es)
KR (1) KR890000094B1 (es)
AT (1) AT380256B (es)
AU (1) AU571430B2 (es)
BE (1) BE894175A (es)
CA (1) CA1197247A (es)
CH (1) CH655114A5 (es)
DE (2) DE19975037I2 (es)
DK (1) DK161147C (es)
ES (1) ES8400438A1 (es)
FI (1) FI73434C (es)
FR (1) FR2511679A1 (es)
GB (1) GB2104522B (es)
GE (1) GEP19960641B (es)
GR (1) GR76863B (es)
HU (1) HU186107B (es)
IE (1) IE53408B1 (es)
IL (1) IL66606A (es)
IT (1) IT1152505B (es)
LT (1) LT2436B (es)
LU (1) LU84347A1 (es)
LV (2) LV5511A3 (es)
NL (2) NL192739C (es)
NZ (1) NZ201668A (es)
OA (1) OA07174A (es)
SE (1) SE448543B (es)
SU (1) SU1447284A3 (es)
UA (1) UA5971A1 (es)
ZA (1) ZA826120B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
FR2531958B1 (fr) * 1982-08-17 1986-10-31 May & Baker Ltd Nouveaux derive
US4517182A (en) * 1983-05-24 1985-05-14 Warner-Lambert Company 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
US7615632B2 (en) 2003-12-30 2009-11-10 Chemagis Ltd. Crystalline forms of temozolomide
JP5475235B2 (ja) 2005-01-21 2014-04-16 アステックス・セラピューティクス・リミテッド 医薬化合物
PE20080695A1 (es) 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
JPWO2009054332A1 (ja) 2007-10-23 2011-03-03 萬有製薬株式会社 ピリドン置換ジヒドロピラゾロピリミジノン誘導体
PE20091101A1 (es) * 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
CA2744560A1 (en) * 2008-11-24 2010-05-27 Reliance Life Sciences Pvt. Ltd. Process for the preparation of tetrazine derivatives
US8481503B2 (en) 2009-03-06 2013-07-09 Merck Sharp & Dohme Corp. Combination cancer therapy with an AKT inhibitor and other anticancer agents
JP2012530775A (ja) 2009-06-23 2012-12-06 ファーミノックス リミテッド ３−置換−８−置換−３Ｈ−イミダゾ［５，１−ｄ］［１，２，３，５−テトラジン−４−オン化合物及びその使用
RU2462466C1 (ru) * 2011-06-24 2012-09-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Замещенные азоло[1,2,4,5]тетразины - ингибиторы актинобактериальных серин-треониновых протеинкиназ
EP2766041B1 (en) 2011-10-12 2018-12-05 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies
KR20230042756A (ko) 2016-03-15 2023-03-29 오리존 지노믹스 에스.에이. 고형 종양의 치료에 사용하기 위한 lsd1 억제제의 조합물
KR101847342B1 (ko) * 2017-05-08 2018-04-11 (주)센텍코리아 웨어러블 체지방 연소량 측정기

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2932305A1 (de) * 1979-08-09 1981-02-26 Basf Ag Azolo- eckige klammer auf 5,1-d eckige klammer zu - eckige klammer auf 1,2,3,5 eckige klammer zu -tetrazin-4-one und verfahren zur herstellung dieser verbindungen

Also Published As

Publication number Publication date
KR890000094B1 (ko) 1989-03-07
LV5511A3 (lv) 1994-03-10
OA07174A (fr) 1984-04-30
IE53408B1 (en) 1988-11-09
NL990010I2 (nl) 1999-09-01
NL8203286A (nl) 1983-03-16
FI822921L (fi) 1983-02-25
ES515176A0 (es) 1983-11-01
DE19975037I2 (de) 2001-06-13
GB2104522B (en) 1985-06-12
LU84347A1 (fr) 1983-06-07
DK377882A (da) 1983-02-25
GB2104522A (en) 1983-03-09
CH655114A5 (fr) 1986-03-27
IT8222938A0 (it) 1982-08-23
NL192739C (nl) 1998-01-06
NZ201668A (en) 1985-08-16
DE3231255A1 (de) 1983-03-03
LT2436B (lt) 1994-02-15
IE822026L (en) 1983-02-24
LV5621A3 (lv) 1994-05-10
AU571430B2 (en) 1988-04-21
JPS5843975A (ja) 1983-03-14
FI73434B (fi) 1987-06-30
SE8204817D0 (sv) 1982-08-23
UA5971A1 (uk) 1994-12-29
HU186107B (en) 1985-06-28
FR2511679B1 (es) 1985-02-01
DK161147B (da) 1991-06-03
ZA826120B (en) 1983-07-27
JPH045029B2 (es) 1992-01-30
SU1447284A3 (ru) 1988-12-23
NL192739B (nl) 1997-09-01
DE3231255C2 (es) 1992-02-27
FI73434C (fi) 1987-10-09
SE448543B (sv) 1987-03-02
DK161147C (da) 1991-11-18
AT380256B (de) 1986-05-12
FR2511679A1 (fr) 1983-02-25
GEP19960641B (en) 1996-11-15
SE8204817L (sv) 1983-02-25
IL66606A (en) 1987-07-31
FI822921A0 (fi) 1982-08-23
AU8749382A (en) 1983-03-03
IT1152505B (it) 1987-01-07
IL66606A0 (en) 1982-12-31
GR76863B (es) 1984-09-04
BE894175A (fr) 1983-02-23
ATA319182A (de) 1985-09-15
CA1197247A (fr) 1985-11-26
NL990010I1 (nl) 1999-07-01
KR840001175A (ko) 1984-03-28

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Legal Events

Date Code Title Description
SPCF Request for supplementary protection certificate filed

Free format text: TEMOZOLOMIDE (TEMODAL)

Spc suppl protection certif: C9900027

Filing date: 19990726

SPCG Supplementary protection certificate granted

Free format text: TEMOZOLOMIDE (TEMODAL)

Spc suppl protection certif: C9900027

Filing date: 19990726

Expiry date: 20080719

Effective date: 20020610