FI73434C - Foerfarande foer framstaellning av /3h/-imidazo-/5,1-d/-1,2,3,5-tetrazin-4-onderivat med terapeutisk verkan. - Google Patents

Foerfarande foer framstaellning av /3h/-imidazo-/5,1-d/-1,2,3,5-tetrazin-4-onderivat med terapeutisk verkan. Download PDF

Info

Publication number
FI73434C
FI73434C FI822921A FI822921A FI73434C FI 73434 C FI73434 C FI 73434C FI 822921 A FI822921 A FI 822921A FI 822921 A FI822921 A FI 822921A FI 73434 C FI73434 C FI 73434C
Authority
FI
Finland
Prior art keywords
eller
imidazo
tetrazin
med
general formula
Prior art date
Application number
FI822921A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI73434B (fi
FI822921L (fi
FI822921A0 (fi
Inventor
Edward Lunt
Malcolm Francis Graham Stevens
Robert Stone
Kenneth Robert Harr Wooldringe
Original Assignee
May & Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May & Baker Ltd filed Critical May & Baker Ltd
Publication of FI822921A0 publication Critical patent/FI822921A0/fi
Publication of FI822921L publication Critical patent/FI822921L/fi
Application granted granted Critical
Publication of FI73434B publication Critical patent/FI73434B/fi
Publication of FI73434C publication Critical patent/FI73434C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI822921A 1981-08-24 1982-08-23 Foerfarande foer framstaellning av /3h/-imidazo-/5,1-d/-1,2,3,5-tetrazin-4-onderivat med terapeutisk verkan. FI73434C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8125791 1981-08-24
GB8125791 1981-08-24

Publications (4)

Publication Number Publication Date
FI822921A0 FI822921A0 (fi) 1982-08-23
FI822921L FI822921L (fi) 1983-02-25
FI73434B FI73434B (fi) 1987-06-30
FI73434C true FI73434C (fi) 1987-10-09

Family

ID=10524141

Family Applications (1)

Application Number Title Priority Date Filing Date
FI822921A FI73434C (fi) 1981-08-24 1982-08-23 Foerfarande foer framstaellning av /3h/-imidazo-/5,1-d/-1,2,3,5-tetrazin-4-onderivat med terapeutisk verkan.

Country Status (29)

Country Link
JP (1) JPS5843975A (es)
KR (1) KR890000094B1 (es)
AT (1) AT380256B (es)
AU (1) AU571430B2 (es)
BE (1) BE894175A (es)
CA (1) CA1197247A (es)
CH (1) CH655114A5 (es)
DE (2) DE19975037I2 (es)
DK (1) DK161147C (es)
ES (1) ES8400438A1 (es)
FI (1) FI73434C (es)
FR (1) FR2511679A1 (es)
GB (1) GB2104522B (es)
GE (1) GEP19960641B (es)
GR (1) GR76863B (es)
HU (1) HU186107B (es)
IE (1) IE53408B1 (es)
IL (1) IL66606A (es)
IT (1) IT1152505B (es)
LT (1) LT2436B (es)
LU (1) LU84347A1 (es)
LV (2) LV5511A3 (es)
NL (2) NL192739C (es)
NZ (1) NZ201668A (es)
OA (1) OA07174A (es)
SE (1) SE448543B (es)
SU (1) SU1447284A3 (es)
UA (1) UA5971A1 (es)
ZA (1) ZA826120B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
FR2531958B1 (fr) * 1982-08-17 1986-10-31 May & Baker Ltd Nouveaux derive
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
US4517182A (en) * 1983-05-24 1985-05-14 Warner-Lambert Company 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
WO2005063757A2 (en) * 2003-12-30 2005-07-14 Chemagis Ltd. Novel crystalline forms of temozolomide
MX2007008781A (es) 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
PE20080695A1 (es) 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JPWO2009054332A1 (ja) 2007-10-23 2011-03-03 萬有製薬株式会社 ピリドン置換ジヒドロピラゾロピリミジノン誘導体
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
JP2012509868A (ja) * 2008-11-24 2012-04-26 リライアンス ライフ サイエンシズ ピーヴィーティー リミティッド テトラジン誘導体の製造方法
EP2403339B1 (en) 2009-03-06 2017-01-18 Merck Sharp & Dohme Corp. Combination cancer therapy with an akt inhibitor and other anticancer agents
PL2445915T3 (pl) 2009-06-23 2016-10-31 Związki 3-podstawionego-8-podstawionego-3H imidazo[5,1-d][1,2,3,5 tetrazyn]-4-onu i ich zastosowanie
RU2462466C1 (ru) * 2011-06-24 2012-09-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Замещенные азоло[1,2,4,5]тетразины - ингибиторы актинобактериальных серин-треониновых протеинкиназ
US20140271657A1 (en) 2011-10-12 2014-09-18 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies
MX2018011102A (es) 2016-03-15 2019-01-10 Oryzon Genomics Sa Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para uso en el tratamiento de tumores solidos.
KR101847342B1 (ko) * 2017-05-08 2018-04-11 (주)센텍코리아 웨어러블 체지방 연소량 측정기

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2932305A1 (de) * 1979-08-09 1981-02-26 Basf Ag Azolo- eckige klammer auf 5,1-d eckige klammer zu - eckige klammer auf 1,2,3,5 eckige klammer zu -tetrazin-4-one und verfahren zur herstellung dieser verbindungen

Also Published As

Publication number Publication date
NZ201668A (en) 1985-08-16
DE3231255A1 (de) 1983-03-03
KR840001175A (ko) 1984-03-28
NL192739C (nl) 1998-01-06
CA1197247A (fr) 1985-11-26
CH655114A5 (fr) 1986-03-27
AT380256B (de) 1986-05-12
GR76863B (es) 1984-09-04
AU8749382A (en) 1983-03-03
GEP19960641B (en) 1996-11-15
IL66606A0 (en) 1982-12-31
SU1447284A3 (ru) 1988-12-23
DE3231255C2 (es) 1992-02-27
OA07174A (fr) 1984-04-30
IL66606A (en) 1987-07-31
ES515176A0 (es) 1983-11-01
DE19975037I2 (de) 2001-06-13
SE8204817D0 (sv) 1982-08-23
NL990010I2 (nl) 1999-09-01
LV5511A3 (lv) 1994-03-10
BE894175A (fr) 1983-02-23
LU84347A1 (fr) 1983-06-07
LT2436B (lt) 1994-02-15
IE822026L (en) 1983-02-24
DK377882A (da) 1983-02-25
GB2104522B (en) 1985-06-12
FI73434B (fi) 1987-06-30
DK161147B (da) 1991-06-03
SE448543B (sv) 1987-03-02
HU186107B (en) 1985-06-28
IT8222938A0 (it) 1982-08-23
IT1152505B (it) 1987-01-07
JPS5843975A (ja) 1983-03-14
LV5621A3 (lv) 1994-05-10
FR2511679A1 (fr) 1983-02-25
FI822921L (fi) 1983-02-25
NL192739B (nl) 1997-09-01
ATA319182A (de) 1985-09-15
ZA826120B (en) 1983-07-27
NL990010I1 (nl) 1999-07-01
AU571430B2 (en) 1988-04-21
GB2104522A (en) 1983-03-09
IE53408B1 (en) 1988-11-09
NL8203286A (nl) 1983-03-16
DK161147C (da) 1991-11-18
FR2511679B1 (es) 1985-02-01
SE8204817L (sv) 1983-02-25
KR890000094B1 (ko) 1989-03-07
ES8400438A1 (es) 1983-11-01
JPH045029B2 (es) 1992-01-30
FI822921A0 (fi) 1982-08-23
UA5971A1 (uk) 1994-12-29

Similar Documents

Publication Publication Date Title
FI73434C (fi) Foerfarande foer framstaellning av /3h/-imidazo-/5,1-d/-1,2,3,5-tetrazin-4-onderivat med terapeutisk verkan.
US5260291A (en) Tetrazine derivatives
US4608383A (en) Cardioactive pyrazole and imidazole aryloxypropanolamines
EP0313724B1 (en) Bis (acyloxymethyl) imidazole Derivative
US3995039A (en) Pyrazolo [1,5-a] [1,3,5] triazines
US4757148A (en) Intermediate 1-(2-nitro-1-imidazolyl)-3-substituted amino-2-propanols and the corresponding 2,3-butanediols
US5407940A (en) New ellipticine compounds
EP0252682A2 (en) Tetrazines
SU1287752A3 (ru) Способ получени имидазо /1,2- @ / пиримидинов или их аддитивных солей с кислотами
GB2125402A (en) New tetrazine derivatives
CN113692306B (zh) 基于胸腺嘧啶核酸碱基的三唑并嘧啶类及其制造方法
JPS6310788A (ja) ３−アミノピラゾロ〔３，４−ｄ〕ピリミジン誘導体
US4916137A (en) 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders
CZ285584B6 (cs) 2,4,8-Trisubstituvané-3H,6H-1,4,5a,8a tetraazaacenaftylen-3,5-(4H)-diony a 2,4,8 trisubstiuované-4,5-dihydro-5-thioxo-3H,6H-1,4,5a ,8a-tetraazaacenaftylen-3-ony
Moinet-Hedin et al. In vitro cytotoxicity of carbazole derivatives. V. 9-Halogeno-substituted 5, 11-dimethyl-6H-pyrido [3, 2-b] carbazoles
PL92579B1 (en) Bis piperazino-androstanes - as muscle relaxants[FR2194434A1]
US3939174A (en) Certain 3-oxo-2-aryl-5,6-dihydro-4(H)-pyrrolo-(1,2-C)(1,2,3)triazolium compounds
KURASAWA et al. Synthesis of 4-Substituted 1, 2-Dihydropyridazino [3, 4-b] quinoxalines from 3-(N, N-Dimethylaminocarbonyl) furo [2, 3-b] quinoxaline
CA1254563A (en) Imidazo ¬5,1-d| tetrazin-1,2,3,5 one-derivatives and related products, processes for their preparation and composition containing said derivatives
SU1468902A1 (ru) Способ получени пирано @ 3,4-в @ индолов
Hara et al. Cyclic isothioureido compounds. II. Reaction of trans‐3a, 4, 5, 9b‐tetrahydronaphth [1, 2‐d]‐imidazoline‐2‐thiones with α‐bromoketones
EP0193944A1 (en) Derivatives of 5-fluorouracil
Safonova et al. Study of nitrogen-and sulfur-containing heterocycles. 54. Properties and conversions of pyrimido [4, 5-b]-1, 4-benzothiazepines. Synthesis of a novel heterocyclic system: Pyrimido [5, 4-c] isoquinoline
JPS59106485A (ja) アクリダノン誘導体

Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: CANCER RESEARCH CAMPAIGN TECHNOLOGY

SPCG Supplementary protection certificate granted

Spc suppl protection certif: L114

Extension date: 20070822

MA Patent expired

Owner name: CANCER RESEARCH CAMPAIGN TECHNOLOGY