GB2125402B - New tetrazine derivatives - Google Patents

New tetrazine derivatives

Info

Publication number
GB2125402B
GB2125402B GB08321942A GB8321942A GB2125402B GB 2125402 B GB2125402 B GB 2125402B GB 08321942 A GB08321942 A GB 08321942A GB 8321942 A GB8321942 A GB 8321942A GB 2125402 B GB2125402 B GB 2125402B
Authority
GB
United Kingdom
Prior art keywords
tetrazine derivatives
new
new tetrazine
derivatives
tetrazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08321942A
Other versions
GB2125402A (en
GB8321942D0 (en
Inventor
Ghouse Unissa Baig
Malcolm Francis Graham Stevens
Edward Lunt
Christopher Gregory Newton
Brian Leslie Pedgrift
Christopher Smith
Colin Geoffrey Straw
Roger John Aitchison Walsh
Peter James Warren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838306904A external-priority patent/GB8306904D0/en
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Priority to GB08321942A priority Critical patent/GB2125402B/en
Publication of GB8321942D0 publication Critical patent/GB8321942D0/en
Publication of GB2125402A publication Critical patent/GB2125402A/en
Application granted granted Critical
Publication of GB2125402B publication Critical patent/GB2125402B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
GB08321942A 1982-08-17 1983-08-15 New tetrazine derivatives Expired GB2125402B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB08321942A GB2125402B (en) 1982-08-17 1983-08-15 New tetrazine derivatives

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB8223583 1982-08-17
GB8223580 1982-08-17
GB8226169 1982-09-14
GB838306904A GB8306904D0 (en) 1983-03-14 1983-03-14 Compositions of matter
GB08321942A GB2125402B (en) 1982-08-17 1983-08-15 New tetrazine derivatives

Publications (3)

Publication Number Publication Date
GB8321942D0 GB8321942D0 (en) 1983-09-14
GB2125402A GB2125402A (en) 1984-03-07
GB2125402B true GB2125402B (en) 1985-11-13

Family

ID=27516482

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08321942A Expired GB2125402B (en) 1982-08-17 1983-08-15 New tetrazine derivatives

Country Status (1)

Country Link
GB (1) GB2125402B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517182A (en) * 1983-05-24 1985-05-14 Warner-Lambert Company 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
SG143062A1 (en) * 2001-01-18 2008-06-27 Schering Corp Synthesis of temozolomide and analogs
CN1269819C (en) 2001-01-18 2006-08-16 先灵公司 Synthesis of temozolomide and analogs
CN1727340B (en) * 2004-07-29 2011-05-18 天津帝士力投资控股集团有限公司 Temozolomide 8-carboxylic ester, and combination
CA2664052C (en) 2006-09-29 2015-01-20 Cipla Limited An improved process for the preparation of temozolomide and analogs
PE20091101A1 (en) 2007-12-18 2009-07-26 Pharminox Ltd 3-SUBSTITUTED-4-OXO-3,4-DIHYDRO-IMIDAZO [5,1-d] [1,2,3,5-TETRACINE-8-CARBOXYL ACID AMIDES AND ITS USE
JP2012530775A (en) 2009-06-23 2012-12-06 ファーミノックス リミテッド 3-substituted-8-substituted-3H-imidazo [5,1-d] [1,2,3,5-tetrazin-4-one compounds and uses thereof
WO2012085501A1 (en) * 2010-12-20 2012-06-28 Pharminox Limited 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA07174A (en) * 1981-08-24 1984-04-30 May & Baker Ltd New imidazotetrazionones, their preparation and medicines containing them.

Also Published As

Publication number Publication date
GB2125402A (en) 1984-03-07
GB8321942D0 (en) 1983-09-14

Similar Documents

Publication Publication Date Title
GB8603901D0 (en) Derivatives
GB8328755D0 (en) 3-aryl-5-pyrazole derivatives
GB8410727D0 (en) Azet-2-one derivatives
GB8300400D0 (en) 5-methylthiopyrimidine derivatives
GB2128188B (en) Propynylaminoisoxazole derivatives
EP0096296A3 (en) 1-sulfo-2-oxoazetidine derivatives
HK30486A (en) Halogenbiphenyl derivatives
GB8329554D0 (en) 7-carboxymethoxyphenylacet-amido-3-cephem derivatives
GB8321880D0 (en) Desoxyuridine derivatives
EP0100250A3 (en) Methylflavone derivatives
GB2132617B (en) Propynlaminothiazole derivatives
GB2125402B (en) New tetrazine derivatives
GB8326244D0 (en) Vinylthioacetamido oxacephalosporin derivatives
GB8330016D0 (en) 2-piperazinyl-quinazoline derivatives
GB2123815B (en) Aletheine derivatives
GB8325762D0 (en) Thiatriazine derivatives
GB2131803B (en) Oxacephalosporin derivatives
GB8612237D0 (en) Chleosterol derivatives
GB2121786B (en) 23-demycinosyldesmycosin derivatives
GB2116170B (en) 23-0-acyl-23-demycinosyldesmycosin derivatives
GB8324348D0 (en) 28-methyl-brassino-steroid derivatives
GB8328614D0 (en) Epoxycarbacyclin derivatives
ZA836003B (en) New tetrazine derivatives
GB8326187D0 (en) 15-cycloaliphatic derivatives
GB2124216B (en) Eburnane derivatives

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee