SK284826B6 - 7-Nitro-9-substituovaný amino-6-demetyl-6-deoxytetracyklíny a spôsoby ich výroby - Google Patents

7-Nitro-9-substituovaný amino-6-demetyl-6-deoxytetracyklíny a spôsoby ich výroby Download PDF

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Publication number
SK284826B6
SK284826B6 SK1149-99A SK114999A SK284826B6 SK 284826 B6 SK284826 B6 SK 284826B6 SK 114999 A SK114999 A SK 114999A SK 284826 B6 SK284826 B6 SK 284826B6
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SK
Slovakia
Prior art keywords
group
alkyl
amino
carbon atoms
substituted
Prior art date
Application number
SK1149-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK114999A3 (en
Inventor
Joseph J. Hlavka
Phaid-Eng Sum
Yakov Gluzman
Ving J. Lee
Adma A. Ross
Original Assignee
Wyeth Holdings Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25092264&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK284826(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Holdings Corporation filed Critical Wyeth Holdings Corporation
Publication of SK114999A3 publication Critical patent/SK114999A3/sk
Publication of SK284826B6 publication Critical patent/SK284826B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Moulding By Coating Moulds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
SK1149-99A 1991-10-04 1992-09-30 7-Nitro-9-substituovaný amino-6-demetyl-6-deoxytetracyklíny a spôsoby ich výroby SK284826B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77157691A 1991-10-04 1991-10-04

Publications (2)

Publication Number Publication Date
SK114999A3 SK114999A3 (en) 2000-07-11
SK284826B6 true SK284826B6 (sk) 2005-12-01

Family

ID=25092264

Family Applications (2)

Application Number Title Priority Date Filing Date
SK1149-99A SK284826B6 (sk) 1991-10-04 1992-09-30 7-Nitro-9-substituovaný amino-6-demetyl-6-deoxytetracyklíny a spôsoby ich výroby
SK2984-92A SK280837B6 (sk) 1991-10-04 1992-09-30 Tricyklické diazepíny, spôsob ich výroby, ich použitie a farmaceutický prípravok na ich báze

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK2984-92A SK280837B6 (sk) 1991-10-04 1992-09-30 Tricyklické diazepíny, spôsob ich výroby, ich použitie a farmaceutický prípravok na ich báze

Country Status (28)

Country Link
EP (1) EP0536515B1 (fi)
JP (1) JP3186863B2 (fi)
KR (1) KR100269072B1 (fi)
CN (1) CN1048240C (fi)
AT (1) ATE211128T1 (fi)
AU (1) AU654049B2 (fi)
BR (1) BR1100853A (fi)
CA (1) CA2079692C (fi)
CL (1) CL2004001623A1 (fi)
CZ (2) CZ284209B6 (fi)
DE (4) DE69232302T4 (fi)
DK (1) DK0536515T3 (fi)
ES (1) ES2168254T3 (fi)
FI (1) FI114911B (fi)
HK (1) HK1011348A1 (fi)
HU (2) HU219973B (fi)
IL (3) IL103320A (fi)
LU (1) LU91279I2 (fi)
MX (1) MX9205532A (fi)
NL (1) NL300244I2 (fi)
NO (3) NO301472B1 (fi)
NZ (1) NZ244585A (fi)
PL (4) PL172282B1 (fi)
PT (1) PT536515E (fi)
SG (1) SG52361A1 (fi)
SK (2) SK284826B6 (fi)
TW (1) TW275616B (fi)
ZA (1) ZA927607B (fi)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
AU1279095A (en) * 1994-02-17 1995-09-04 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP1240133B1 (en) 1999-09-14 2006-04-19 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
HUP0300082A2 (en) * 2000-03-31 2003-05-28 Paratek Pharmaceuticals 7- and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline derivatives, process for their preparation and use and pharmaceutical compositions containing them
EP2308863A1 (en) * 2000-05-15 2011-04-13 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
CZ2003344A3 (cs) 2000-07-07 2003-05-14 Trustees Of Tufts College 9-Substituované minocyklinové sloučeniny
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EA013835B1 (ru) 2001-03-13 2010-08-30 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
WO2002072506A2 (en) 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1399414B1 (en) * 2001-04-24 2010-01-13 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP1408987B1 (en) 2001-07-13 2013-04-10 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
EP2322501B1 (en) 2002-01-08 2015-08-05 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
JP2005526754A (ja) * 2002-03-08 2005-09-08 パラテック ファーマシューティカルズ インコーポレイテッド アミノメチル置換されたテトラサイクリン化合物
EP2319828A3 (en) 2003-07-09 2011-07-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
SI1753713T1 (sl) 2004-05-21 2017-01-31 President And Fellows Of Harvard College Sinteza tetraciklinov in njihovih analogov
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
JP2009507793A (ja) * 2005-08-31 2009-02-26 ワイス グリシルサイクリンの９−アミノカルボニル置換誘導体
WO2007133798A2 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
MX2010005519A (es) 2007-11-29 2010-06-11 Actelion Pharmaceuticals Ltd Derivados de acido fosfonico y su uso como antagonista del receptor p2 y12.
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TWI585071B (zh) 2008-05-23 2017-06-01 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
PT2682387E (pt) * 2008-08-08 2016-02-03 Tetraphase Pharmaceuticals Inc Compostos de tetraciclina substituídos com c7-flúor
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
DK2427425T3 (en) 2009-05-08 2017-06-12 Tetraphase Pharmaceuticals Inc tetracycline
PL2470500T3 (pl) 2009-08-28 2018-03-30 Tetraphase Pharmaceuticals, Inc. Związki tetracyklinowe
MX347919B (es) 2010-05-12 2017-05-17 Rempex Pharmaceuticals Inc * Composiciones de tetraciclina.
CN103635456B (zh) * 2011-07-26 2016-03-09 山东亨利医药科技有限责任公司 替加环素衍生物
EP2890673B1 (en) 2012-08-31 2018-11-14 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
WO2015071299A2 (en) 2013-11-12 2015-05-21 Galenicum Health S.L. Stable pharmaceutical compositions
KR20240058958A (ko) 2016-10-19 2024-05-07 테트라페이즈 파마슈티컬스, 인코포레이티드 에라바사이클린의 결정질 형태

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
CA2079692C (en) 2004-06-08
NL300244I1 (nl) 2007-01-02
SK298492A3 (en) 1995-03-08
DE122006000058I1 (de) 2007-01-18
IL119590A (en) 1999-03-12
IL103320A0 (en) 1993-03-15
HU9203110D0 (en) 1992-12-28
HK1011348A1 (en) 1999-07-09
HU219973B (hu) 2001-10-28
IL103320A (en) 1998-12-06
CL2004001623A1 (es) 2005-06-03
CZ284159B6 (cs) 1998-08-12
PT536515E (pt) 2002-05-31
NZ244585A (en) 1995-07-26
FI924454A (fi) 1993-04-05
DE69232302T4 (de) 2003-02-13
KR100269072B1 (ko) 2000-10-16
CZ309397A3 (cs) 1998-09-16
PL176333B1 (pl) 1999-05-31
SG52361A1 (en) 1998-09-28
CZ298492A3 (en) 1993-05-12
IL119590A0 (en) 1997-02-18
PL175957B1 (pl) 1999-03-31
LU91279I2 (fr) 2006-12-11
NO2017037I1 (no) 2017-08-01
DE122006000058I2 (de) 2007-09-13
NO2006015I2 (no) 2011-03-14
TW275616B (fi) 1996-05-11
CZ284209B6 (cs) 1998-09-16
PL172282B1 (pl) 1997-08-29
MX9205532A (es) 1993-04-01
NO2017037I2 (no) 2017-08-01
CN1072172A (zh) 1993-05-19
AU654049B2 (en) 1994-10-20
ATE211128T1 (de) 2002-01-15
JPH05255219A (ja) 1993-10-05
BR1100853A (pt) 1999-12-07
FI114911B (fi) 2005-01-31
NO301472B1 (no) 1997-11-03
NO2006015I1 (no) 2006-11-27
EP0536515B1 (en) 2001-12-19
DK0536515T3 (da) 2002-04-08
SK280837B6 (sk) 2000-08-14
KR930007894A (ko) 1993-05-20
NL300244I2 (nl) 2007-01-02
ZA927607B (en) 1993-04-13
PL173311B1 (pl) 1998-02-27
DE69232302D1 (de) 2002-01-31
FI924454A0 (fi) 1992-10-02
EP0536515A1 (en) 1993-04-14
PL296143A1 (en) 1993-05-31
NO923857D0 (no) 1992-10-02
JP3186863B2 (ja) 2001-07-11
NO923857L (no) 1993-04-05
AU2618392A (en) 1993-04-08
HU211172A9 (en) 1995-11-28
ES2168254T3 (es) 2002-06-16
HUT63145A (en) 1993-07-28
CA2079692A1 (en) 1993-04-05
SK114999A3 (en) 2000-07-11
CN1048240C (zh) 2000-01-12
DE69232302T2 (de) 2002-08-14

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