SK284207B6 - New lipid ester of nucleoside monophosphates and their use as immunosupressive drugs - Google Patents

New lipid ester of nucleoside monophosphates and their use as immunosupressive drugs Download PDF

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Publication number
SK284207B6
SK284207B6 SK1518-96A SK151896A SK284207B6 SK 284207 B6 SK284207 B6 SK 284207B6 SK 151896 A SK151896 A SK 151896A SK 284207 B6 SK284207 B6 SK 284207B6
Authority
SK
Slovakia
Prior art keywords
hydrogen
halogen
alkyl
group
carbon atoms
Prior art date
Application number
SK1518-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK151896A3 (en
Inventor
Dieter Herrmann
Hans-Georg Opitz
Harald Zilch
Alfred Mertens
Original Assignee
Heidelberg Pharma Holding Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Holding Gmbh filed Critical Heidelberg Pharma Holding Gmbh
Publication of SK151896A3 publication Critical patent/SK151896A3/sk
Publication of SK284207B6 publication Critical patent/SK284207B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
SK1518-96A 1994-05-28 1995-05-23 New lipid ester of nucleoside monophosphates and their use as immunosupressive drugs SK284207B6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4418690A DE4418690A1 (de) 1994-05-28 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
PCT/EP1995/001951 WO1995032984A1 (fr) 1994-05-28 1995-05-23 Nouveaux esters lipidiques de monophosphates de nucleosides et leur utilisation comme medicaments immunosuppresseurs

Publications (2)

Publication Number Publication Date
SK151896A3 SK151896A3 (en) 1997-06-04
SK284207B6 true SK284207B6 (en) 2004-11-03

Family

ID=6519215

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1518-96A SK284207B6 (en) 1994-05-28 1995-05-23 New lipid ester of nucleoside monophosphates and their use as immunosupressive drugs

Country Status (27)

Country Link
US (1) US6025343A (fr)
EP (2) EP1229040B8 (fr)
JP (1) JP3802057B2 (fr)
KR (1) KR100279087B1 (fr)
CN (1) CN1168735C (fr)
AT (2) ATE249472T1 (fr)
AU (1) AU688516B2 (fr)
BR (1) BR9507785A (fr)
CA (1) CA2190983C (fr)
CZ (1) CZ291846B6 (fr)
DE (3) DE4418690A1 (fr)
DK (2) DK0763049T3 (fr)
ES (2) ES2199250T3 (fr)
FI (1) FI117673B (fr)
HU (1) HU220336B (fr)
IL (1) IL113865A (fr)
MX (1) MX9605809A (fr)
NO (1) NO308998B1 (fr)
NZ (1) NZ287434A (fr)
PL (1) PL185290B1 (fr)
PT (2) PT763049E (fr)
RU (1) RU2165429C2 (fr)
SK (1) SK284207B6 (fr)
TW (1) TW420686B (fr)
UA (1) UA45339C2 (fr)
WO (1) WO1995032984A1 (fr)
ZA (1) ZA954374B (fr)

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AU674639B2 (en) * 1994-12-13 1997-01-02 Akira Matsuda 3'-substituted nucleoside derivatives
WO1999051613A1 (fr) * 1998-04-03 1999-10-14 Medivir Ab Promedicaments de produits pharmaceutiques contenant du phosphore
JP2002528554A (ja) 1998-11-05 2002-09-03 サントル・ナシオナル・ドウ・ラ・ルシエルシユ・シアンテイフイク Ｂ型肝炎ウイルス活性を持ったヌクレオシド
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
DE19855963A1 (de) * 1998-12-04 2000-06-08 Herbert Schott Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung
US7026469B2 (en) 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
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US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
WO2002057498A1 (fr) * 2001-01-22 2002-07-25 Emergen, Inc. Acides nucleiques enrichis isotopiquement et leurs methodes associees de production et de purification
US6881831B2 (en) 2001-05-16 2005-04-19 Migenix Inc. Nucleic acid-based compounds and methods of use thereof
WO2003044035A1 (fr) * 2001-11-21 2003-05-30 Ganymed 256 Vermögensverwaltungs Gmbh Derives phospholipides de nucleosides utilises comme medicaments antitumoraux
WO2006068760A2 (fr) 2004-11-19 2006-06-29 The Regents Of The University Of California Pyrazolopyrimidines anti-inflammatoires
US8101745B2 (en) 2004-12-16 2012-01-24 The Regents Of The University Of California Lung-targeted drugs
EP1835916B1 (fr) 2004-12-30 2009-04-01 Medivir Ab Composes utiles dans le traitement du vih
GB0505781D0 (en) 2005-03-21 2005-04-27 Univ Cardiff Chemical compounds
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ITRM20050391A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti analoghi della 6-tioguanosina trifosfato, loro uso in campo medico e procedimento per la loro preparazione.
WO2008127226A2 (fr) 2006-04-04 2008-10-23 The Regents Of The University Of California Antagonistes de kinase p13
GB0608876D0 (en) 2006-05-05 2006-06-14 Medivir Ab Combination therapy
US7378401B2 (en) * 2006-07-14 2008-05-27 Heidelberg Pharma Gmbh Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases
CA2717788A1 (fr) 2007-07-09 2009-01-15 Eastern Virginia Medical School Derives nucleosidiques substitues ayant des proprietes antivirales et antimicrobiennes
WO2009046448A1 (fr) 2007-10-04 2009-04-09 Intellikine, Inc. Entités chimiques et leurs utilisations thérapeutiques
KR101897881B1 (ko) 2008-01-04 2018-09-12 인텔리카인, 엘엘씨 특정 화학 물질, 조성물 및 방법
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
JP5547099B2 (ja) 2008-03-14 2014-07-09 インテリカイン， エルエルシー キナーゼ阻害剤および使用方法
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
CN102124009B (zh) 2008-07-08 2014-07-23 因特利凯公司 激酶抑制剂及其使用方法
JP5731978B2 (ja) 2008-09-26 2015-06-10 インテリカイン， エルエルシー 複素環キナーゼ阻害剤
US8697709B2 (en) 2008-10-16 2014-04-15 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476282B2 (en) 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
CA2760791C (fr) 2009-05-07 2017-06-20 Intellikine, Inc. Composes heterocycliques et leurs utilisations
WO2011047384A2 (fr) 2009-10-16 2011-04-21 The Regents Of The University Of California Procédés d'inhibition de l'activité ire1
WO2011146882A1 (fr) 2010-05-21 2011-11-24 Intellikine, Inc. Composés chimiques, compositions et procédés pour modulation de kinases
CA2817577A1 (fr) 2010-11-10 2012-05-18 Infinity Pharmaceuticals, Inc. Composes heterocycliques et utilisations de ceux-ci
KR101875720B1 (ko) 2011-01-10 2018-07-09 인피니티 파마슈티칼스, 인코포레이티드 이소퀴놀린온 및 이의 고체 형태의 제조 방법
CN106619647A (zh) 2011-02-23 2017-05-10 因特利凯有限责任公司 激酶抑制剂的组合及其用途
KR20140063605A (ko) 2011-07-19 2014-05-27 인피니티 파마슈티칼스, 인코포레이티드 헤테로사이클릭 화합물 및 그의 용도
JP6027610B2 (ja) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環式化合物及びその使用
AR091790A1 (es) 2011-08-29 2015-03-04 Infinity Pharmaceuticals Inc Derivados de isoquinolin-1-ona y sus usos
MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
EP2900673A4 (fr) 2012-09-26 2016-10-19 Univ California Modulation de ire1
WO2014143643A1 (fr) 2013-03-15 2014-09-18 The Regents Of The University Of California, A California Corporation Diesters phosphonates nucléosidiques acycliques
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
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EP3052485B1 (fr) 2013-10-04 2021-07-28 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
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Also Published As

Publication number Publication date
CZ347796A3 (en) 1997-04-16
EP1229040B8 (fr) 2003-11-05
DK1229040T3 (da) 2003-12-22
ES2199250T3 (es) 2004-02-16
DK0763049T3 (da) 2003-07-28
IL113865A (en) 2008-12-29
EP1229040B1 (fr) 2003-09-10
TW420686B (en) 2001-02-01
HU220336B (hu) 2001-12-28
UA45339C2 (uk) 2002-04-15
ATE236189T1 (de) 2003-04-15
FI964727A0 (fi) 1996-11-27
NO308998B1 (no) 2000-11-27
EP1229040A2 (fr) 2002-08-07
SK151896A3 (en) 1997-06-04
CA2190983A1 (fr) 1995-12-07
ZA954374B (en) 1996-11-29
RU2165429C2 (ru) 2001-04-20
DE69531749T2 (de) 2004-07-29
US6025343A (en) 2000-02-15
PL317380A1 (en) 1997-04-01
CZ291846B6 (cs) 2003-06-18
ATE249472T1 (de) 2003-09-15
PT763049E (pt) 2003-08-29
WO1995032984A1 (fr) 1995-12-07
JP3802057B2 (ja) 2006-07-26
MX9605809A (es) 1997-12-31
DE69530197D1 (de) 2003-05-08
CN1168735C (zh) 2004-09-29
BR9507785A (pt) 1997-09-23
KR970703354A (ko) 1997-07-03
PT1229040E (pt) 2003-12-31
AU688516B2 (en) 1998-03-12
NO965054D0 (no) 1996-11-27
JPH10500964A (ja) 1998-01-27
PL185290B1 (pl) 2003-04-30
CA2190983C (fr) 2006-08-15
NO965054L (no) 1997-01-28
FI964727A (fi) 1996-11-27
HU9603269D0 (en) 1997-01-28
ES2206429T3 (es) 2004-05-16
DE69530197T2 (de) 2004-01-29
EP0763049A1 (fr) 1997-03-19
EP0763049B1 (fr) 2003-04-02
AU2615495A (en) 1995-12-21
WO1995032984A8 (fr) 2003-01-16
IL113865A0 (en) 1995-08-31
DE4418690A1 (de) 1996-01-11
FI117673B (fi) 2007-01-15
NZ287434A (en) 1998-01-26
HUT75340A (en) 1997-05-28
CN1154111A (zh) 1997-07-09
EP1229040A3 (fr) 2002-08-21
DE69531749D1 (de) 2003-10-16
KR100279087B1 (ko) 2001-01-15

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100523