SK281707B6 - Deriváty erytromycínu, spôsob ich výroby, medziprodukty, farmaceutické kompozície s ich obsahom a ich použitie - Google Patents

Deriváty erytromycínu, spôsob ich výroby, medziprodukty, farmaceutické kompozície s ich obsahom a ich použitie Download PDF

Info

Publication number
SK281707B6
SK281707B6 SK1402-96A SK140296A SK281707B6 SK 281707 B6 SK281707 B6 SK 281707B6 SK 140296 A SK140296 A SK 140296A SK 281707 B6 SK281707 B6 SK 281707B6
Authority
SK
Slovakia
Prior art keywords
methyl
butanamine
dideoxy
formula
alpha
Prior art date
Application number
SK1402-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK140296A3 (en
Inventor
Constantin Agouridas
Jean-Francois Chantot
Alexis Denis
D'ambrieres Solange Gouin
Martret Odile Le
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of SK140296A3 publication Critical patent/SK140296A3/sk
Publication of SK281707B6 publication Critical patent/SK281707B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
SK1402-96A 1994-05-03 1995-05-02 Deriváty erytromycínu, spôsob ich výroby, medziprodukty, farmaceutické kompozície s ich obsahom a ich použitie SK281707B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9405368A FR2719587B1 (fr) 1994-05-03 1994-05-03 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000565 WO1995029929A1 (fr) 1994-05-03 1995-05-02 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
SK140296A3 SK140296A3 (en) 1998-04-08
SK281707B6 true SK281707B6 (sk) 2001-07-10

Family

ID=9462785

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1402-96A SK281707B6 (sk) 1994-05-03 1995-05-02 Deriváty erytromycínu, spôsob ich výroby, medziprodukty, farmaceutické kompozície s ich obsahom a ich použitie

Country Status (43)

Country Link
US (2) US5635485A (de)
EP (1) EP0680967B1 (de)
JP (4) JP2992540B2 (de)
KR (1) KR100312267B1 (de)
CN (2) CN1052984C (de)
AP (1) AP558A (de)
AT (1) ATE172203T1 (de)
AU (1) AU684027B2 (de)
BG (1) BG63087B1 (de)
BR (1) BR9507700A (de)
CA (1) CA2189271C (de)
CZ (1) CZ293455B6 (de)
DE (2) DE10299001I1 (de)
DK (1) DK0680967T3 (de)
DZ (1) DZ1878A1 (de)
EE (1) EE03263B1 (de)
ES (1) ES2122472T3 (de)
FI (1) FI111263B (de)
FR (1) FR2719587B1 (de)
GE (1) GEP19991538B (de)
HK (1) HK1010732A1 (de)
HU (2) HU227493B1 (de)
IL (1) IL113245A (de)
LU (1) LU90872I2 (de)
LV (1) LV11739B (de)
MA (1) MA23534A1 (de)
MD (1) MD1233C2 (de)
NL (1) NL300077I1 (de)
NO (2) NO308853B1 (de)
NZ (1) NZ285416A (de)
OA (1) OA10319A (de)
PL (1) PL182034B1 (de)
RO (1) RO113350B1 (de)
RU (1) RU2144036C1 (de)
SI (1) SI0680967T1 (de)
SK (1) SK281707B6 (de)
TJ (1) TJ313B (de)
TN (1) TNSN95049A1 (de)
TW (1) TW341573B (de)
UA (1) UA51618C2 (de)
WO (1) WO1995029929A1 (de)
YU (1) YU49235B (de)
ZA (1) ZA953501B (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69633289T2 (de) * 1995-06-27 2006-01-12 Takeda Pharmaceutical Co. Ltd. 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ATE296832T1 (de) * 1996-09-04 2005-06-15 Abbott Lab 6-o-substituierte ketoliden mit antibakteriellen wirkung
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
AU5299499A (en) 1998-09-22 2000-04-10 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
TR200102129T2 (tr) 1998-12-10 2002-01-21 Pfizer Products Inc. Karbamat ve karbazat ketolid antibiyotikleri.
CZ20012675A3 (cs) * 1999-01-27 2002-04-17 Pfizer Products Inc. Ketolidová antibiotika
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
MXPA01010521A (es) 1999-04-16 2003-08-19 Johnson & Johnson Antibacteriales de cetolidos.
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6395710B1 (en) 1999-04-16 2002-05-28 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
WO2000071557A1 (en) * 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
AU2001282105A1 (en) 2000-08-22 2002-03-04 Basilea Pharmaceutica Ag New macrolides with antibacterial activity
FR2821747B1 (fr) * 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Suspension de telithromycine a gout masque
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
CN1665831A (zh) 2002-07-08 2005-09-07 普利瓦研究院有限公司 作为甾类/非甾类抗炎、抗肿瘤和抗病毒活性分子载体的新化合物、组合物
RS20050008A (en) 2002-07-08 2007-06-04 Pliva-Istraživački Institut D.O.O., New compounds,compositions and methods for treatment of inflammatory diseases and conditions
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
WO2004009059A1 (en) * 2002-07-19 2004-01-29 Aventis Pharma S.A. Taste masked oral composition of telithromycin
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
US6916934B2 (en) * 2003-02-11 2005-07-12 Aventis Pharma Deutschland Gmbh Process for preparing pyridine-substituted amino ketal derivatives
US7601695B2 (en) * 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
WO2004096823A2 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
US20050101548A1 (en) * 2003-09-12 2005-05-12 Xiaodong Lin Antimicrobial derivatives
GB0402578D0 (en) * 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
EP2716647A3 (de) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Makrocyclische Verbindungen Und Verfahren Zu Deren Herstellung Und Anwendung
SI1742957T1 (sl) * 2004-04-28 2008-04-30 Alembic Ltd Postopek za pripravo telitromicina
EP1794171A2 (de) * 2004-07-28 2007-06-13 Ranbaxy Laboratories, Ltd. Ketolidderivate als antibakterielle wirkstoffe
WO2006046112A2 (en) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
AP2007004026A0 (en) * 2004-12-21 2007-06-30 Pfizer Prod Inc Macrolides
CN102290174A (zh) * 2005-02-08 2011-12-21 株式会社村田制作所 表面安装型负特性热敏电阻
FR2882522B1 (fr) 2005-02-25 2007-04-13 Aventis Pharma Sa Composition pharmaceutique solide comprenant de la telithromycine
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007039914A2 (en) * 2005-10-06 2007-04-12 Alembic Limited Novel polymorphs of telithromycin
WO2007049296A2 (en) * 2005-10-28 2007-05-03 Alembic Limited Amorphous form of telithromycin
WO2007059307A2 (en) * 2005-11-15 2007-05-24 Teva Pharmaceutical Industries Ltd. Crystalline and amorphous forms of telithromycin
EP1957508A2 (de) * 2005-11-23 2008-08-20 Ranbaxy Laboratories Limited Ketolid-derivate als antibakterielle agentien
EP1954294A2 (de) * 2005-11-23 2008-08-13 Ranbaxy Laboratories Limited Verwendung von makrolid-derivaten zur behandlung von akne
WO2007060618A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Macrolides derivatives as antibacterial agents
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
GB0600238D0 (en) * 2006-01-06 2006-02-15 Sandoz Ag Organic compounds
EP1985620A4 (de) * 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd 10a-AZALIDVERBINDUNG
JP2010501541A (ja) 2006-08-24 2010-01-21 ウォックハート リサーチ センター 抗菌活性を有する新規マクロライド及びケトライド
WO2008023383A1 (en) * 2006-08-25 2008-02-28 Alembic Limited Novel process for the preparation of telithromycin
ES2306590B1 (es) * 2006-12-15 2009-08-07 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.
JPWO2009019868A1 (ja) * 2007-08-06 2010-10-28 大正製薬株式会社 １０ａ、１２位架橋型１０ａ−アザライド化合物
US20090075917A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched telithromycin
EP2200480B1 (de) 2007-09-20 2015-03-11 Herman Miller, Inc. Sitzstruktur
EP2220104A1 (de) * 2007-10-25 2010-08-25 Sandoz AG Verfahren zur herstellung von telithromycin
AU2008316830B2 (en) * 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US8299035B2 (en) * 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
DK2358379T3 (en) * 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
ES2561332T3 (es) 2009-05-27 2016-02-25 Wockhardt Limited Compuestos cetólidos que tienen actividad antimicrobiana
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
CA2793884C (en) 2010-03-22 2019-09-10 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
DK2571506T3 (en) 2010-05-20 2017-08-28 Cempra Pharmaceuticals Inc PROCEDURES FOR THE MANUFACTURE OF MACROLIDES AND KETOLIDES AND INTERMEDIATES
EP2613630A4 (de) * 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc Wasserstoffbindung zur formung von fluorketoliden zur behandlung von krankheiten
WO2012076989A1 (en) 2010-12-09 2012-06-14 Wockhardt Limited Ketolide compounds
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
EP2681222B1 (de) 2011-03-01 2018-02-28 Wockhardt Limited Verfahren zur herstellung von ketolidzwischenprodukte
CN103619863B (zh) 2011-03-22 2016-03-16 沃克哈特有限公司 酮内酯化合物的制备方法
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
CN105524132B (zh) * 2014-09-30 2019-07-02 中国医学科学院药物研究所 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用
DE102015201783A1 (de) 2015-02-02 2016-08-04 Friedrich Baur Verfahren zur Herstellung eines Füllstoffs aus Textilfasern sowie Textil mit einem solchen Füllstoff
CN107129514B (zh) * 2016-03-02 2019-12-13 中国医学科学院药物研究所 红霉素a酮内酯类抗生素衍生物、其制备方法及应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
EP0034116A3 (de) * 1980-02-11 1981-09-02 Berlex Laboratories, Inc. N-(3-Phenoxy-2-hydroxypropyl)benzimidazol-1-alkanamine
US4434174A (en) * 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4568687A (en) * 1983-02-28 1986-02-04 American Cyanamid Company N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
US4489089A (en) * 1983-04-06 1984-12-18 American Cyanamid Company Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
ZA84949B (en) * 1983-04-06 1984-09-26 American Cyanamid Co Substituted-n-(2-4-(1h-imidazol-1-yl)alkyl)substituted amides
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
DE3540376A1 (de) * 1985-11-14 1987-05-21 Bayer Ag Verfahren zur inhibierung der wasserstoffinduzierten korrosion von metallischen werkstoffen
DE3750023T2 (de) * 1986-10-29 1994-09-29 Pfizer Verfahren zur Herstellung von 2-(1-Pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)Thiazol und dessen kristallinisches Dihydrochlorid-Trihydrat.
DE3930669A1 (de) * 1989-09-14 1991-03-28 Basf Ag Verfahren zur herstellung von uretdiongruppen aufweisenden polyisocyanaten
JP2899028B2 (ja) * 1989-12-01 1999-06-02 協和醗酵工業株式会社 ジベンゾオキセピン誘導体
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
DE69127457T2 (de) * 1990-11-28 1998-01-22 Taisho Pharmaceutical Co Ltd 6-0-methylerythromycin a-derivat
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
TW444018B (en) * 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Also Published As

Publication number Publication date
ATE172203T1 (de) 1998-10-15
NO964654D0 (no) 1996-11-04
CA2189271C (fr) 2005-12-27
ZA953501B (en) 1996-05-02
AP9500744A0 (en) 1995-07-31
HK1010732A1 (en) 1999-06-25
IL113245A (en) 1999-11-30
TJ313B (en) 2001-08-06
JP2992540B2 (ja) 1999-12-20
JPH0853489A (ja) 1996-02-27
CZ321496A3 (en) 1997-08-13
JP2007269810A (ja) 2007-10-18
DE69505296T2 (de) 1999-04-22
PL182034B1 (pl) 2001-10-31
DE10299001I2 (de) 2012-07-05
MX9605208A (es) 1997-09-30
JP2007045847A (ja) 2007-02-22
JP3998828B2 (ja) 2007-10-31
OA10319A (fr) 1997-10-07
NL300077I1 (nl) 2002-03-01
BR9507700A (pt) 1997-08-19
DZ1878A1 (fr) 2002-02-17
NO2001027I1 (no) 2002-01-28
MA23534A1 (fr) 1995-12-31
HU219599B (hu) 2001-05-28
HU227493B1 (en) 2011-07-28
HU9603038D0 (en) 1997-01-28
NO964654L (no) 1996-11-04
CN1088709C (zh) 2002-08-07
MD1233B1 (en) 1999-05-31
FI964395A (fi) 1996-10-31
JPH11152296A (ja) 1999-06-08
EP0680967B1 (de) 1998-10-14
EP0680967A1 (de) 1995-11-08
LU90872I2 (fr) 2002-03-12
YU27095A (sh) 1998-05-15
EE03263B1 (et) 2000-04-17
CA2189271A1 (fr) 1995-11-09
YU49235B (sh) 2004-12-31
BG100951A (en) 1997-08-29
SK140296A3 (en) 1998-04-08
DE10299001I1 (de) 2012-07-05
US5635485A (en) 1997-06-03
HUT75698A (en) 1997-05-28
WO1995029929A1 (fr) 1995-11-09
US6100404A (en) 2000-08-08
DK0680967T3 (da) 1999-06-23
AU2449995A (en) 1995-11-29
HU9904687D0 (en) 2000-03-28
SI0680967T1 (en) 1999-02-28
KR100312267B1 (ko) 2002-06-22
JP4658902B2 (ja) 2011-03-23
FR2719587B1 (fr) 1996-07-12
AU684027B2 (en) 1997-11-27
LV11739A (lv) 1997-04-20
CN1151746A (zh) 1997-06-11
CZ293455B6 (cs) 2004-05-12
UA51618C2 (uk) 2002-12-16
FR2719587A1 (fr) 1995-11-10
NO308853B1 (no) 2000-11-06
LV11739B (en) 1997-08-20
BG63087B1 (bg) 2001-03-30
IL113245A0 (en) 1995-07-31
FI111263B (fi) 2003-06-30
RO113350B1 (ro) 1998-06-30
ES2122472T3 (es) 1998-12-16
NZ285416A (en) 1997-07-27
CN1229082A (zh) 1999-09-22
DE69505296D1 (de) 1998-11-19
CN1052984C (zh) 2000-05-31
RU2144036C1 (ru) 2000-01-10
JP4750755B2 (ja) 2011-08-17
AP558A (en) 1996-11-07
TNSN95049A1 (fr) 1996-02-06
FI964395A0 (fi) 1996-10-31
MD1233C2 (ro) 2000-10-31
PL317071A1 (en) 1997-03-03
GEP19991538B (en) 1999-03-05
TW341573B (en) 1998-10-01

Similar Documents

Publication Publication Date Title
SK281707B6 (sk) Deriváty erytromycínu, spôsob ich výroby, medziprodukty, farmaceutické kompozície s ich obsahom a ich použitie
SK284079B6 (sk) Deriváty erytromycínu, postup ich prípravy a ich použitie ako liečiv
JP4102440B2 (ja) 新規なエリスロマイシン誘導体、それらの調製方法及びそれらの医薬品としての使用
US6440941B1 (en) Derivatives of erythromycin, their preparation process and their use as medicaments
US6313101B1 (en) Derivatives of erythromycin, their preparation process and their use as medicaments
FR2732684A1 (fr) Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
MXPA96005208A (en) New derivatives of erythromycin, its procedure of preparation and its application as medicamen
CZ417699A3 (cs) Nové deriváty erythromycinu, způsob jejich přípravy a jejich použití jako léčiv

Legal Events

Date Code Title Description
MK4A Patent expired

Expiry date: 20150502

SPCE Expiry of an spc

Spc suppl protection certif: 4 3-2002

Expiry date: 20161108

Effective date: 20161108