SI9620106B - Bioloski materiali za preprecevanje post-kirurskih adhezij, ki se sestojijo iz derivatov hialuronske kisline - Google Patents

Bioloski materiali za preprecevanje post-kirurskih adhezij, ki se sestojijo iz derivatov hialuronske kisline Download PDF

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Publication number
SI9620106B
SI9620106B SI9620106A SI9620106A SI9620106B SI 9620106 B SI9620106 B SI 9620106B SI 9620106 A SI9620106 A SI 9620106A SI 9620106 A SI9620106 A SI 9620106A SI 9620106 B SI9620106 B SI 9620106B
Authority
SI
Slovenia
Prior art keywords
hyaluronic acid
composite material
esterified
material according
derivative
Prior art date
Application number
SI9620106A
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English (en)
Other versions
SI9620106A (sl
Inventor
Daniele Pressato
Alessandra Pavesio
Lanfranco Callegaro
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT95PD000166 external-priority patent/IT1284425B1/it
Priority claimed from IT95PD000167 external-priority patent/IT1284426B1/it
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Publication of SI9620106A publication Critical patent/SI9620106A/sl
Publication of SI9620106B publication Critical patent/SI9620106B/sl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Abstract

Novi biomateriali so v bistvu doloceni z esterificiranimi derivati hialuronske kisline s precno povezanimi derivati hialuronske kisline, za uporabo na podrocju kirurgije, bolj natancno za uporabo pri preventivi post-kirurskih adhezij.

Description

* V tem dokumentu so objavljeni spremenjeni zahtevki patenta 9620106 A. Zahtevki so bili spremenjeni na podlagi ugotovitvene odločbe, izdane po členu 93(l)(b)

Claims (8)

1. Kompozitni biomaterial za preventivo post kirurške adhezije tkiva, značilen po tem, da vsebuje benzil ester hialuronske kisline, kjer je 75% do 99% karboksilnih skupin hialuronske kisline esterificiranih z radikalom benzila, do 25% karboksilnih skupin pa je esterif iciranih z alkilnim radikalom Cio do C20 alifatskega alkohola, kjer je esterificiranih manj kot 80% karboksilnih skupin in je omenjeni biomaterial v obliki gela, membrane, mreže iz tkanega ali netkanega tkiva ali kombinacije slednjih.
2. Kompozitni biomaterial po zahtevku 1, značilen po tem, da je omenjeni derivat benzil ester, katerega 80% karboksi skupin je esterificiranih z benzilno skupino.
3. Kompozitni material po zahtevku 1, značilen po tem, da je omenjeni derivat benzil ester, katerega 75% karboksilnih skupin je esterificiranih z benzilno skupino, ostalih 25% karboksilnih skupin pa je esterif iciranih z alifatskim ostankom C10-20 alifatskega alkohola.
4. Kompozitni material po zahtevku 3, značilen po tem, da je omenjeni alkohol stearinski ali palmitinski alkohol.
5. Uporaba kompozitnega materiala, po zahtevkih od 1 do 4 ali kompozitnega materiala, ki vsebuje samodejno prečno povezani derivat hialuronke skupine, kjer je 0.5 do 20% karboksilnih skupin hialuronske kisline prečno povezanih z hidroksilno skupino iste ali različne molekule hialuronske kisline, značilna po tem, da je omenjeni material v obliki gela, membrane, mreže iz tkanega ali netkanega tkiva ali kombinacija naštetih za pripravo kompozicije za preprečevanje post kirurške adhezije tkiva.
6. Uporaba po zahtevku 5, značilna po tem, da ima omenjeni samodejno prečno povezani derivat od 4,5% do 5,0% prečno povezanih karboksilnih skupin hialuronske kisline.
7. Kompozitni material po zahtevkih od 1 do 4 ali uporaba po zahtevkih 5 in 6, značilen po tem, da kompozitni material nadalje obsega nebiološko razgradljiv sintetični polimer.
8. Kompozitni material po zahtevku 7, značilen po tem, da je omenjeni sintetični polimer izbran iz skupine, ki obsega polipropilen, polietilen, poliester in politetrafluoroetilen.
SI9620106A 1995-08-29 1996-08-29 Bioloski materiali za preprecevanje post-kirurskih adhezij, ki se sestojijo iz derivatov hialuronske kisline SI9620106B (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT95PD000166 IT1284425B1 (it) 1995-08-29 1995-08-29 Articoli sanitari e chirurgici essenzialmente costituiti da esteri del l'acido ialuroico
IT95PD000167 IT1284426B1 (it) 1995-08-29 1995-08-29 Articoli sanitari e chirurgici essenzialmente costituiti da derivati autoreticolati dell'acido ialuronico
PCT/EP1996/003805 WO1997007833A2 (en) 1995-08-29 1996-08-29 Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives

Publications (2)

Publication Number Publication Date
SI9620106A SI9620106A (sl) 1999-06-30
SI9620106B true SI9620106B (sl) 2005-12-31

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SI9620106A SI9620106B (sl) 1995-08-29 1996-08-29 Bioloski materiali za preprecevanje post-kirurskih adhezij, ki se sestojijo iz derivatov hialuronske kisline

Country Status (23)

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US (2) US6723709B1 (sl)
EP (1) EP0850074B1 (sl)
JP (2) JPH11511344A (sl)
KR (1) KR100515314B1 (sl)
CN (1) CN1301139C (sl)
AT (1) ATE297230T1 (sl)
AU (1) AU718484B2 (sl)
BR (1) BR9610996A (sl)
CA (1) CA2230530C (sl)
CZ (1) CZ293968B6 (sl)
DE (1) DE69634823T2 (sl)
ES (1) ES2244975T3 (sl)
HK (1) HK1015714A1 (sl)
HU (1) HU226962B1 (sl)
IL (1) IL123500A (sl)
NO (1) NO311605B1 (sl)
NZ (1) NZ316944A (sl)
PL (1) PL186859B1 (sl)
PT (1) PT850074E (sl)
RU (1) RU2177332C2 (sl)
SI (1) SI9620106B (sl)
TR (1) TR199800353T1 (sl)
WO (1) WO1997007833A2 (sl)

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US7504386B2 (en) 2009-03-17
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