SI9420046B - Postopek za kristalizacijo Iopamidola - Google Patents
Postopek za kristalizacijo Iopamidola Download PDFInfo
- Publication number
- SI9420046B SI9420046B SI9420046A SI9420046A SI9420046B SI 9420046 B SI9420046 B SI 9420046B SI 9420046 A SI9420046 A SI 9420046A SI 9420046 A SI9420046 A SI 9420046A SI 9420046 B SI9420046 B SI 9420046B
- Authority
- SI
- Slovenia
- Prior art keywords
- lopamidol
- solvent
- butanol
- sec
- purified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI931720A IT1257001B (it) | 1993-07-30 | 1993-07-30 | Processo per la cristalizzazione dello iopamidolo |
| IT000760 IT1269339B (it) | 1994-04-20 | 1994-04-20 | Processo per la cristallizzazione dello iopamidolo |
| PCT/EP1994/002415 WO1995004031A1 (en) | 1993-07-30 | 1994-07-22 | Process for the crystallization of iopamidol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9420046A SI9420046A (en) | 1996-10-31 |
| SI9420046B true SI9420046B (sl) | 2003-10-31 |
Family
ID=26331032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9420046A SI9420046B (sl) | 1993-07-30 | 1994-07-22 | Postopek za kristalizacijo Iopamidola |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US5571941A (da) |
| JP (1) | JP3299045B2 (da) |
| KR (1) | KR100355211B1 (da) |
| CN (1) | CN1035940C (da) |
| AT (1) | AT404832B (da) |
| AU (1) | AU690138B2 (da) |
| BE (1) | BE1008403A4 (da) |
| CA (1) | CA2128942C (da) |
| CH (1) | CH686783A5 (da) |
| CZ (1) | CZ289300B6 (da) |
| DE (1) | DE4426818A1 (da) |
| DK (1) | DK172074B1 (da) |
| ES (1) | ES2102312B1 (da) |
| FI (1) | FI960400A0 (da) |
| FR (1) | FR2708601B1 (da) |
| GB (1) | GB2280436B (da) |
| GR (1) | GR940100366A (da) |
| HU (1) | HU217023B (da) |
| IE (1) | IE80675B1 (da) |
| IL (1) | IL110391A (da) |
| NL (1) | NL194272C (da) |
| NO (1) | NO304226B1 (da) |
| NZ (1) | NZ271632A (da) |
| PT (1) | PT101554B (da) |
| RU (1) | RU2135462C1 (da) |
| SE (1) | SE9402595L (da) |
| SI (1) | SI9420046B (da) |
| WO (1) | WO1995004031A1 (da) |
| ZA (1) | ZA945472B (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL110391A (en) | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the formation of infamidol |
| US6310243B1 (en) * | 1994-09-23 | 2001-10-30 | Nycomed Imaging As | Iodinated x-ray contrast media |
| PT101720A (pt) * | 1995-06-08 | 1997-01-31 | Hovione Sociedade Quimica S A | Processo para a purificacao e cristalizacao de iopamidol |
| AU6516196A (en) * | 1995-07-04 | 1997-02-05 | Recordati S.A. | A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylene-glycol |
| BR9606624A (pt) * | 1995-09-08 | 1997-11-11 | Bracco Int Bv | Processo para a cristalização de (s)-n,n'-bisÚ2-hidróxi-1-(hidroximetil)etil¾-5-Ú(2-hidróxi-1-oxopropil)amino¾-2,4,6-triiodo-1,3-benzonodicar-boxamida a partir de água |
| PT101919B (pt) * | 1996-09-30 | 2000-01-31 | Hovione Sociedade Quimica Sa | Um processo para a purificacao de tohexol |
| CZ299420B6 (cs) * | 1997-02-11 | 2008-07-23 | Bracco International B. V. | Zpusob krystalizace iopamidolu |
| GB9720969D0 (en) | 1997-10-02 | 1997-12-03 | Nycomed Imaging As | Process |
| KR20000031642A (ko) * | 1998-11-09 | 2000-06-05 | 강재헌 | 이오파미돌의 결정화 방법 |
| US6265610B1 (en) | 1999-01-12 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Contrast media for angiography |
| US6803485B2 (en) | 1999-02-26 | 2004-10-12 | Bracco Imaging S.P.A. | Process for the preparation of iopamidol |
| IT1319671B1 (it) | 2000-12-01 | 2003-10-23 | Bracco Spa | Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino) |
| DE102005059191B4 (de) * | 2005-12-05 | 2008-02-07 | Bayer Schering Pharma Ag | Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen |
| KR100976097B1 (ko) * | 2008-12-05 | 2010-08-16 | 주식회사 대웅제약 | 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법 |
| AU2010232556A1 (en) * | 2009-04-02 | 2011-11-03 | Allergan, Inc. | Prostaglandin E receptor antagonists |
| WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
| DE102012104679A1 (de) | 2011-05-30 | 2012-12-06 | Westfälische Wilhelms-Universität Münster | Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli |
| SG11201504201RA (en) | 2012-12-19 | 2015-07-30 | Ge Healthcare As | Purification of x-ray contrast agents |
| KR102128423B1 (ko) * | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (da) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
| DE3150916A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" |
| US5204086A (en) * | 1982-10-01 | 1993-04-20 | Nycomed Imaging As | X-ray contrast agent |
| KR960016747B1 (ko) * | 1987-05-22 | 1996-12-20 | 브라코 인터내셔날 비. 브이 | 5-아실아미노-2,4,6-트리요오도-또는 트리브로모-벤조산 유도체의 제조 방법 |
| IT1248741B (it) * | 1991-02-26 | 1995-01-26 | Bracco Spa | Processo di concentrazione e di purificazione di composti organici |
| IL110391A (en) | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the formation of infamidol |
-
1994
- 1994-07-20 IL IL11039194A patent/IL110391A/en not_active IP Right Cessation
- 1994-07-22 NZ NZ271632A patent/NZ271632A/en not_active IP Right Cessation
- 1994-07-22 KR KR1019960700580A patent/KR100355211B1/ko not_active IP Right Cessation
- 1994-07-22 GR GR940100366A patent/GR940100366A/el unknown
- 1994-07-22 WO PCT/EP1994/002415 patent/WO1995004031A1/en active Application Filing
- 1994-07-22 RU RU96105070A patent/RU2135462C1/ru active
- 1994-07-22 HU HU9600191A patent/HU217023B/hu unknown
- 1994-07-22 SI SI9420046A patent/SI9420046B/sl unknown
- 1994-07-22 CN CN94192930A patent/CN1035940C/zh not_active Expired - Lifetime
- 1994-07-22 AU AU75321/94A patent/AU690138B2/en not_active Expired
- 1994-07-25 GB GB9414912A patent/GB2280436B/en not_active Expired - Lifetime
- 1994-07-25 ZA ZA945472A patent/ZA945472B/xx unknown
- 1994-07-26 NL NL9401229A patent/NL194272C/nl not_active IP Right Cessation
- 1994-07-26 PT PT101554A patent/PT101554B/pt not_active IP Right Cessation
- 1994-07-26 CH CH02354/94A patent/CH686783A5/it not_active IP Right Cessation
- 1994-07-26 FR FR9409238A patent/FR2708601B1/fr not_active Expired - Lifetime
- 1994-07-27 CA CA002128942A patent/CA2128942C/en not_active Expired - Lifetime
- 1994-07-28 DE DE4426818A patent/DE4426818A1/de not_active Ceased
- 1994-07-29 SE SE9402595A patent/SE9402595L/xx not_active Application Discontinuation
- 1994-07-29 CZ CZ19941831A patent/CZ289300B6/cs not_active IP Right Cessation
- 1994-07-29 AT AT0150594A patent/AT404832B/de not_active IP Right Cessation
- 1994-07-29 DK DK089294A patent/DK172074B1/da not_active IP Right Cessation
- 1994-07-29 BE BE9400717A patent/BE1008403A4/fr not_active IP Right Cessation
- 1994-07-29 JP JP17811594A patent/JP3299045B2/ja not_active Expired - Lifetime
- 1994-07-29 ES ES09401679A patent/ES2102312B1/es not_active Expired - Fee Related
- 1994-07-29 IE IE940609A patent/IE80675B1/en not_active IP Right Cessation
- 1994-07-29 US US08/281,985 patent/US5571941A/en not_active Ceased
-
1996
- 1996-01-29 FI FI960400A patent/FI960400A0/fi not_active Application Discontinuation
- 1996-01-29 NO NO960376A patent/NO304226B1/no not_active IP Right Cessation
-
1997
- 1997-02-07 US US08/797,610 patent/USRE36433E/en not_active Expired - Lifetime
-
1998
- 1998-08-25 US US09/139,894 patent/US6506938B1/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI9420046B (sl) | Postopek za kristalizacijo Iopamidola | |
| JPH02503556A (ja) | ５‐アシルアミノ‐２，４，６‐トリヨード‐または‐トリブロモ‐ベンゾイックアシッド誘導体の製造方法およびその製造方法によって得られる新規の５‐アシルアミノ‐２，４，６‐トリヨードまたは‐トリブロモ‐ベンゾイックアシッド誘導体 | |
| JPS61297A (ja) | オレイン酸の製造法 | |
| AU654341B2 (en) | New polyiodated compounds, method of preparation, contrast product containing them | |
| US5419815A (en) | Process for purifying fatty acid amides | |
| AU695662B2 (en) | Process for the purification and crystallisation of Iopamidol | |
| US3966712A (en) | Process for the purification of caprolactam | |
| US2802777A (en) | Process of purifying crude 2-pyrrolidone | |
| US5489708A (en) | Synthesis of ioversol | |
| KR100812657B1 (ko) | 2-클로로-5-클로로메틸 티아졸의 정제방법 | |
| JP4102465B2 (ja) | ベンゾフェノンイミン反応器流出液から水およびアンモニアを除去する方法 | |
| JP3291991B2 (ja) | Ｏ，ｓ−ジメチル ｎ−アセチルホスホルアミドチオエートの精製法 | |
| ES2417055T3 (es) | Preparación y purificación de estabilizantes de hidroxilamina | |
| US3123607A (en) | Recovery of diazabicyclo-octane | |
| EP0641764B1 (de) | Verfahren zur Herstellung von Hydroxyalkylaminonitrobenzol-Derivaten | |
| DK147917B (da) | Tricykliske 2,4,6-trijodanilider til anvendelse som roentgenkontrastmidler, og roentgenkontrastmiddel omfattende disse forbindelser | |
| US5756816A (en) | Process for the production of phenol derivatives | |
| EP0432797B1 (en) | Process for purification of 3,4,5,6-tetrahydrophthalic anhydride | |
| DE2224505A1 (de) | Verfahren zur reinigung von caprolactam | |
| JPS57109757A (en) | Purification of 2-methyleneglutaronitrile | |
| KR810000230B1 (ko) | 니트로치환 아미노안식향산 아미드류의 제조법 | |
| US3338973A (en) | Purification of unsymmetrical tetrahaloacetones | |
| US2925433A (en) | Process for the preparation of dinitroacetates | |
| JPH09316025A (ja) | （メタ）アクリル酸およびそのエステルの重合防止法 | |
| EP0842141A1 (en) | A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylen-glycol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date |